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Laparoscopic resection vs laparoscopic radiofrequency ablation for the treatment of small hepatocellular carcinomas: A single-center analysis

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World Journal of Gastroenterology 2017年第4期23卷 653-660页

作者： Marco Casaccia Gregorio Santori Giuliano Bottino Pietro Diviacco enzo Andorno Department of Surgery IRCCSSan Martino University Hospital-ISTUniversity of Genoa Department of Surgical Sciences and Integrated Diagnostics School of MedicineUniversity of Genoa

AIMTo compare survival and recurrence after laparoscopic liver resection (LLR) and laparoscopic radiofrequency ablation (LRFA) for the treatment of small hepatocellular carcinoma (HCC).METHODSBetween June 1, 2005 and November 30, 2010, 46 patients (62.26 ± 8.55 years old; female/male: 12/34) treated for small HCC were enrolled following strict criteria. Patients with better liver function and larger tumors were referred for LLR (n = 24), while those with poorer liver function and multiple tumors were referred for LRFA (n = 22), and they were then followed for similar durations (44.74 ± 21.3 mo for LLR vs 40.27 ± 30.8 mo for LRFA).RESULTSThe LLR and LRFA groups were homogeneous with regard to age, sex, etiology of liver cirrhosis, and AFP levels. The overall survival (OS) and disease-free survival (DFS) probability was 0.354 and 0.260, respectively. A significantly higher OS was observed in the LLR group (LLR: 0.442; LRFA: 0.261; P = 0.048), whereas no statistical difference was found for DFS (LLR: 0.206; LRFA: 0.286; P = 0.205). In the LRFA group was treated a greater number of nodules (LLR: 1.41 ± 0.77; LRFA: 2.72 ± 1.54; P *** preliminary results confirm the superiority of hepatic resection on thermoablation in the treatment of small HCC in selected patients, when both approaches are made laparoscopically. LLR showed better results compared to LRFA in terms of OS. These data need to be confirmed by further studies on a larger number of patients.

关键词： Hepatocellular carcinoma Laparoscopic liver resection Laparoscopic radiofrequency ablation Survival Disease-free survival

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Does alcohol have any effect on male reproductive Function？ A review of literature

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Asian Journal of Andrology 2013年第2期15卷 221-225,I0006页

作者： Sandro La Vignera Rosita A Condorelli Giancarlo Balercia enzo Vicari Aldo E Calogero Section of Endocrinology Andrology and Internal Medicine Department of Medical and Pediatric Sciences University of Catania Catania 95123 Italy Department of tnternat Medicine and Applied Biotechnologies Politechnic University of Marche Ancona 60100 Italy

Although alcohol is widely used, its impact on the male reproductive function is still controversial. Over the years, many studies have investigated the effects of alcohol consumption on sperm parameters and male infertility. This article reviews the main preclinical and clinical evidences. Studies conducted on the experimental animal have shown that a diet enriched with ethanol causes sperm parameter abnormalities, a number of alterations involving the reproductive tract inhibition, and reduced mouse oocyte in vitro fertilization rate. These effects were partly reversible upon discontinuation of alcohol consumption. Most of the studies evaluating the effects of alcohol in men have shown a negative impact on the sperm parameters. This has been reported to be associated with hypotestosteronemia and low-normal or elevated gonadotropin levels suggesting a combined central and testicular detrimental effect of alcohol. Nevertheless, alcohol consumption does not seem to have much effect on fertility either in in vitro fertilization programs or population-based studies. Finally, the genetic background and other concomitant, alcohol consumption-related conditions influence the degree of the testicular damage. In conclusion, alcohol consumption is associated with a deterioration of sperm parameters which may be partially reversible upon alcohol consumption discontinuation.

关键词： alcohol HPT hypothalamic-pituitary-testicular axis male infertility reproductive function sperm parameters spermatogenesis teratozoospermia

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Furazolidone therapy for Helicobacter pylori:Is it effective and safe?

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World Journal of Gastroenterology 2009年第15期15卷 1914-1915页

作者： Vincenzo De Francesco enzo Ierardi Cesare Hassan Angelo Zullo Gastroenterology Unit "Riuniti"Hospital Gastroenterology and Digestive Endoscopy Nuovo Regina Margherita Hospital

Some aspects related with the use of furazolidone as a rescue therapy for Helicobacter pylori （H pylorl） infection should be remarked, especially regarding its potential oncologic risk. The inclusion of furazolidone... 详细信息

关键词： Helicobacter pylori Therapy Furazolidone Rescue therapy

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Effect of corneal light scatter on vision: a review of the literature

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 459-464页

作者： Leopoldo Spadea Giorgia Maraone Francesca Verboschi enzo Maria Vingolo Daniele Tognetto Department of Biotechnology and Medical-Surgical Sciences "Sapienza" University of Rome Eye Clinic Ospedale MaggioreUniversity of Trieste

The cornea is the transparent connective tissue window at the front of the *** physiological role of the cornea is to conduct external light into the eye,focus it,together with the lens,onto the retina,and to provide rigidity to the entire ***,good vision requires maintenance of the transparency and proper refractive shape of the *** surface structures irregularities can be associated with wavefront aberrations and scattering *** scattering in the human cornea causes a reduction of visual *** fact,the cornea must be transparent and maintain a smooth and stable curvature since it contributes to the major part of the focusing power of the *** most cases,a simple examination of visual acuity cannot demonstrate the reduction of visual quality secondary light *** fact,clinical techniques for examining the human cornea in vivo have greatly expanded over the last few *** measurement of corneal back scattering qualifies the degree of corneal *** measurement of corneal forward-scattering quantifies the amount of visual impairment that is produced by the alteration of *** aim of this study was to review scattering in the human cornea and methods of measuring it.

关键词： cornea haze light photorefraetive keratectomy scattering vision

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Artifi cial neural networks in the recognition of the presence of thyroid disease in patients with atrophic body gastritis

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World Journal of Gastroenterology 2008年第4期14卷 563-568页

作者： Edith Lahner Marco Intraligi Massimo Buscema Marco Centanni Lucy Vannella enzo Grossi Bruno Annibale Department of Digestive and Liver Disease University "La Sapienza"2nd Medical SchoolOspedale Sant'AndreaRomeItaly Semeion Research Center Rome Italy Endocrinology Unit Department of Experimental Medicine and PathologyUniversity "La Sapienza"Polo PontinoLatinaItaly Bracco Imaging Spa MilanItaly

AIM: To investigate the role of artifi cial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients. METHODS: A dataset of 29 input variables of 253 atrophic body gastritis patients was applied to artifi cial neural networks (ANNs) using a data optimisation procedure (standard ANNs,T&T-IS protocol,TWIST protocol). The target variable was the presence of thyroid disease. RESULTS: Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specifi city of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. The optimization procedures (T&T-IS and TWIST protocol) improved the performance of the recognition task yielding a mean accuracy,sensitivity and specifi city of 74.7% and 75.8%,78.8% and 81.8%,and 70.5% and 69.9%,respectively. The increase of sensitivity of the TWIST protocol was statistically signifi cant compared to T&T-IS. CONCLUSION: This study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status.

关键词： Atrophic body gastritis Thyroid disease Artificial neural networks

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Seminal vesicles and diabetic neuropathy： ultrasound evaluation in patients with couple infertility and different levels of glycaemic control

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Asian Journal of Andrology 2011年第6期13卷 872-876页

作者： Sandro La Vignera Rosita A Condorelli enzo Vicari Rosario D＇Agata Aldo E Calogero Section of Endocrinology Andrology and Internal Medicine and Master＇s Program in Andrological Human Reproduction and Biotechnology Sciences Department of Interna Medicine and Systemic Diseases University of Catania Catania 95123 Italy

The aim of this study was to evaluate the ultrasound characteristics of the seminal vesicles （SVs） of infertile patients with diabetes mellitus （DM） and diabetic neuropathy （DN） and to investigate possible changes in ultrasound characteristics related to glycaemic control. To accomplish this, 45 infertile patients with type 2 DM and symptomatic DN were selected. Twenty healthy fertile men and 20 patients with idiopathic oligoasthenoteratozoospermia without DM represented the control groups. DM patients were arbitrarily divided into three groups according to glycaemic control level （A=glycosylated haemoglobin 〈7%; B =glycosylated haemoglobin between 7% and 10%; C=glycosylated haemoglobin 〉 10%）. Patients underwent prostate-vesicular transrectal ultrasonography and sperm analysis. The following SV ultrasound parameters were recorded：（i） body antero-posterior diameter （APD）; （ii） fundus APD; （iii） parietal thicknesses of the right and left SVs; and （iv） the number of polycyclic areas within both SVs. We then calculated the following parameters：（i） fundus/body （F/B） ratio; （ii） difference of the parietal thickness between the right and the left SV; and （iii） pre- and post-ejaculatory APD difference. All DM patients had a higher FIB ratio compared to controls （P〈0.05）. Group C had a higher FIB ratio compared to the other DM groups （P〈0.05）. All DM patients had a lower pre- and post-ejaculatory difference of the body SV APD compared to controls （P〈0.05）. Groups A and B had a similar pre- and post-ejaculatory difference of the body SV APD, whereas this difference was lower in Group C （P〈0.05）. In conclusion, infertile DM patients with DN showed peculiar SV ultrasound features suggestive of functional atony, and low glycaemic control was associated with greater expression of these features.

关键词： diabetes glycaemic control infertility neuropathy seminal vesicles

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Gastroesophageal reflux disease management according to contemporary international guidelines:A translational study

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World Journal of Gastroenterology 2011年第9期17卷 1160-1166页

作者： Fabio Pace Gabriele Riegler Annalisa de Leone Patrizia Dominici enzo Grossi the EMERGE Study Group Division of Gastroenterology Department of Clinical Sciences 'L. Sacco' UniversityHospital 74-20157 Milano Italy 'Magrassi-Lanzara' Department of Clinicaland Experimental Medicine 2nd University of Naples 80100Naples Italy Medical Department BraccoImaging SpA 24100 Milano Italy

AIM:To test the Genval recommendations and the usefulness of a short trial of proton pump inhibitor(PPI) in the initial management and maintenance treatment of gastroesophageal reflux disease(GERD)patients. METHODS:Five hundred and seventy seven patients with heartburn were *** completing a psychometric tool to assess quality of life(PGWBI)and a previously validated GERD symptom questionnaire (QUID),patients were grouped into those with esophagitis(EE,n=306)or without mucosal damage (NERD,n=271)according to endoscopy results. The study started with a 2-wk period of high dose omeprazole(omeprazole test);patients responding to this PPI test entered an acute phase(3 mo)of treatment with any PPI at the standard ***,those patients with a favorable response to the standard PPI dose were maintained on a half PPI dose for a further 3-mo period. RESULTS:The test was positive in 519(89.9%)patients,with a greater response in EE patients(96.4%) compared with NERD patients(82.6%)(P=0.011). Both the percentage of completely asymptomatic patients,at 3 and 6 mo,and the reduction in heartburn intensity were significantly higher in the EE compared with NERD patients(P<0.01).Finally,the mean PGWBI score was significantly decreased before and increased after therapy in both subgroups when compared with the mean value in a reference Italian population. CONCLUSION:Our study confirms the validity of the Genval guidelines in the management of GERD patients. In addition,we observed that the overall response to PPI therapy is lower in NERD compared to EE patients.

关键词： Gastroesophageal reflux disease Proton pump inhibitors Nonerosive gastroesophageal reflux Questionnaire Quality of life

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Is there a real diagnostic impact of elastosonography and contrast-enhanced ultrasonography in the management of thyroid nodules?

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第3期14卷 195-206页

作者： Massimo GIUSTI Davide ORLANDI Giulia MELLE Barbara MASSA enzo SILVESTRI Francesco MINUTO Gianni TURTULICI Endocrine Unit San Martino University Hospital Radiology Unit Evangelico Hospital Cytopathology and Pathology Unit San Martino University Hospital

Ultrasonography(US) and the new applications US elastography(USE) and contrast-enhanced US(CEUS) are used in the screening of thyroid nodules,for which fine-needle aspiration biopsy(FNAB) is the best single diagnostic *** aim of the study was to compare the sensitivity,specificity,positive predictive value(PPV),and accuracy of the four examinations in nodules with cytological and histological *** study used data from US,FNAB,USE(elasticity(ELX 2/1) index),and CEUS(Peak index and time to peak(TTP) index) evaluated in 73 thyroid nodules in 63 consecutive patients likely to undergo ***-histological correlation was available for 38 *** correlation emerged between nodule size and cytological results.A significant(P=0.03) positive correlation between cumulative US findings and cytological results was *** addition,significant correlations between cumulative US findings and cytology(P=0.02) and between cumulative US findings and histology(P<0.0001) were *** showed the best specificity and PPV,and FNAB the best *** was no significant difference in the ELX 2/1 index,Peak index,or TTP index among nodules subdivided according to cytological *** significant correlation was found between ELX 2/1 index,Peak index,and TTP index,on the one hand,and nodule size,US cumulative findings,cytology,and histology on the other *** sensitivity of the ELX 2/1 index was high,but its specificity was very *** accuracy and PPV of USE were lower than those of the other *** the correlation between Peak index and cumulative US findings reached a value close to *** ultimate aim is to minimise unnecessary *** and FNAB continue to play a central diagnostic *** use of a US score showed high specificity and *** specificity of FNAB was low in this selected series because of the numbers of indeterminate cytological *** and CEUS are innovative techniques that need to be standa

关键词： Thyroid nodules Cytology Histology Ultrasonography Elastosonography Contrast-enhanced ultrasonography

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Long term results of no- alcohol laser epithelial keratomileusis and photorefractive keratectomy for myopia

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 574-579页

作者： Leopoldo Spadea Francesca Verboschi Vittoria De Rosa Mariella Salomone enzo Maria Vingolo Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome

AIM: To evaluate the long term clinical results of mechanical no-alcohol-assisted laser epithelial keratomileusis(LASEK) versus standard photorefractive keratectomy(PRK) for low-moderate ***: Twenty-five eyes treated with LASEK and twenty-five eyes treated with PRK were evaluated with a mean follow-up duration of 60 mo. Mechanical separation of the epithelium was performed with blunt spatula and without application of alcohol. Laser ablation was performed with the MEL-70 excimer laser. All patients were examined daily until epithelial closure; at 1, 3, 6,and 12 mo, and every year subsequently. Main outcome measures were uncorrected distance visual acuity(UDVA), corrected distance visual acuity(CDVA),manifest refraction, haze, efficacy and safety ***: Twenty-one eyes and 22 eyes completed follow-up of 60 mo in LASEK and PRK group respectively. Manifest refraction at 60 mo follow-up was-0.01 and 0.26 in LASEK and PRK group respectively. In the LASEK group mean UDVA and mean CDVA after60 mo were 20/22 and 20/20 respectively(P >0.01). In the PRK group mean UDVA and mean CDVA at 60 mo follow-up were 20/20 and 20/20 after 60mo(P >0.01). The efficacy indexes were 0.87 and 0.95, and the safety indexes were1.25 and 1.4 respectively for LASEK group and PRK ***: Both standard PRK and no-alcohol LASEK offer safe and effective correction of low-moderate myopia in the long term without any statistically significant difference between the two groups.

关键词： alcohol laser epithelial keratomileusis myopia photorefractive keratectomy

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Pre-endoscopic screening for Helicobacter pylori and celiac disease in young anemic women

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World Journal of Gastroenterology 2009年第22期15卷 2748-2753页

作者： Lucy Vannella Debora Gianni Edith Lahner Antonio Amato enzo Grossi Gianfranco Delle Fave Bruno Annibale Department of Digestive and Liver Disease Hospital Sant'AndreaII School of Medicine University Sapienza Center for Thalassemic Disease of Rome Department of Medical Affair Italian Diagnostic Center Department of Digestive and Liver Disease Hospital Sant’AndreaII School of Medicine University Sapienza

AIM： To evaluate the usefulness of pre-endoscopic serological screening for He//cobacter py/or/ （H py/or/} infection and celiac disease in women aged 〈 50 years affected by iron-deficiency anemia （IDA）. METHODS： One hundred and fifteen women aged 〈 50 years with IDA were tested by human recombinant tissue transglutaminase IgA antibodies （tTG） and anti-H pylori IgG antibodies, tTG and H pylori IgG antibody were assessed using an enzyme-linked immunosorbent assay （ELISA）. All women were invited to undergo upper GI endoscopy. During gastroscopy, biopsies were collected from antrum （n = 3）, gastric body （n = 3） and duodenum （n = 4） in all patients, irrespective of test results. The assessment of gastritis was performed according to the Sydney system and celiac disease was classified by Marsh＇s System. RESULTS： 45.2% women were test-positive： 41 patients positive for H pylori antibodies, 9 patients for tTG and 2 patients for both. The gastroscopy compliance rate of test-positive women was significantly increased with respect to those test- negative （65.4% vs 42.8%; Fisher test P = 0.0239）. The serological results were confirmed by gastroscopy in 100% of those with positive H pylori antibodies, in 50% of those with positive tTG and in 81.5% of test- negative patient. Sensitivity and specificity were 84.8% and 100%, respectively for Hpylori infection and, 80% and 92.8% for tTG. Twenty-eight patients had positive H pylori antibodies and in all the patients, an active Hpylori infection was found. In particular, in 23 out of 28 （82%） patients with positive H pylori antibodies, a likely cause of IDA was found because of the active inflammation involving the gastric body. CONCLUSION： Anti-H pylori IgG antibody and tTG IgA antibody testing is able to select women with IDA to submit for gastroscopy to identify H pylori pangastritis and/or celiac disease, likely causes of IDA.

关键词： Iron deficiency anemia Women Celiac disease Helicobacter pylori gastritis

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