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Preoperative pancreatic resection score:a preliminary prospective validation from Spain

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 667-668页

作者： Mario Rodriguez-Lopez Martin Bailon-Cuadrado Francisco J Tejero-Pintor Baltasar Perez-Saborido enrique Asensio-diaz Asterio Barrera-Rebollo General and Digestive Surgery Department Rio Hortega University HospitalDulzaina 247012ValladolidSpain

To the Editor：We read with outstanding interest the article by Celik et al. It is the first external description of the Hamburg＇s preoperative pancreatic resection （PREPARE） score since it was published in 2014 by Uzunoglu et al. According to the latter authors, it is necessary to stratify risk of major morbidity and mortality before performing a pancreatic resection, and PREPARE score is a simple index, validated in a multicenter cohort of patients undergoing this group of technically demanding procedures.

关键词： Preoperative pancreatic resection score

Effect of Substrate Temperature on Structural and Photoluminescence Properties of ZnO：SiOx Composites

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材料科学与工程（中英文A版） 2011年第6期1卷 828-832页

作者： Roberto Lopez Godofredo Garcia Tomas diaz enrique Rosendo Hector Juarez Mauricio Pacio ReinaGaleazzi CIDS-ICUAP Benemerita Universidad Autonoma de Puebla Puebla Mexico

Using zinc oxide (ZnO) powder and quartz rods as solid sources and molecular hydrogen (H2) as reactant gas, ZnO: SiOx composites were grown by hot filament chemical vapor deposition (HFCVD) technique. The absorbance spectra showed the formation of ZnO: SiOx composite in the studied temperature range. The crystalline quality of the ZnO lattice in the structure of the composite gradually lost by increasing the substrate temperature. Visible emission from blue to near-infrared region was found in the photoluminescence spectra of the composite formed at 1,100 °C. The contribution of blue, green, yellow and orange emissions present in the photoluminescence spectra of the composite formed at 1,100 °C was attributed to recombination centers produced by the presence of point defects in the structure of ZnO network. This result suggests that the ZnO in the ZnO: SiOx composite obtained at substrate temperature of 1,100 °C has an amorphous phase.

关键词：复合材料结构二氧化硅氧化锌发光性能衬底温度热丝化学气相沉积光致发光光谱基板温度

A multi-crossover and adaptive island based population algorithm for solving routing problems

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第11期14卷 815-821页

作者： Eneko OSABA enrique ONIEVA Roberto CARBALLEDO Fernando diaz Asier PERALLOS Xiao ZHANG Deusto Institute of Technology (DeustoTech) University of Deusto

We propose a multi-crossover and adaptive island based population algorithm(MAIPA).This technique divides the entire population into subpopulations,or demes,each with a different crossover function,which can be switched according to the *** addition,MAIPA reverses the philosophy of conventional genetic *** gives priority to the autonomous improvement of the individuals(at the mutation phase),and introduces dynamism in the crossover *** subpopulation begins with a very low value of crossover probability,and then varies with the change of the current generation number and the search performance on recent *** mechanism helps prevent premature *** this research,the effectiveness of this technique is tested using three well-known routing problems,i.e.,the traveling salesman problem(TSP),capacitated vehicle routing problem(CVRP),and vehicle routing problem with backhauls(VRPB).MAIPA proves to be better than a traditional island based genetic algorithm for all these three problems.

关键词： Island model Adaptive algorithm Combinatorial optimization Vehicle routing problems Intelligent transportation systems

Constructive thinking,rational intelligence and irritable bowel syndrome

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World Journal of Gastroenterology 2009年第25期15卷 3106-3113页

作者： enrique Rey Marta Moreno Ortega Monica Olga Garcia Alonso Manuel diaz-Rubio Department of Digestive Diseases Hospital Clinico San Carlos (IMSALUD)and Faculty of MedicineComplutense University

AIM:To evaluate rational and experiential intelligence in irritable bowel syndrome (IBS) ***:We recruited 100 subjects with IBS as per Rome criteria(50 consulters and 50 non-consulters) and 100 healthy controls,matched by age,sex and educational *** and controls completed a clinical questionnaire(including symptom characteristics and medical consultation)and the following tests:rational-intelligence(Wechsler Adult Intelligence Scale,3rd edition);experiential intelligence(Constructive Thinking Inventory);personality(NEO personality inventory); psychopathology(MMPI-2),anxiety(state-trait anxiety inventory)and life events(social readjustment rating scale).Analysis of variance was used to compare the test results of IBS-sufferers and controls,and a logistic regression model was then constructed and adjusted for age,sex and educational level to evaluate any possible association with ***: No differences were found between IBS cases and controls in terms of IQ (102.0 ±10.8 vs 102.8±12.6), but IBS sufferers scored significantly lower in global constructive thinking (43.7±9.4 vs 49.6±9.7). In the logistic regression model, global constructive thinking score was independently linked to suffering from IBS [OR 0.92 (0.87-0.97)], without significant OR for total ***: IBS subjects do not show lower rational intelligence than controls, but lower experiential intelligence is nevertheless associated with IBS.

关键词：综合征智慧理性逻辑回归模型肠教育水平 IBS 症状特点

Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease

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World Journal of Gastroenterology 2009年第22期15卷 2768-2777页

作者： Eduardo Vilar Gomez Luis Calzadilla Bertot Bienvenido Gra Oramas enrique Arus Soler Raimundo Llanio Navarro Javier diaz Elias Oscar Villa Jiménez Maria del Rosario Abreu Vazquez Department of Hepatology National Institute of Gastroenterology Department of Pathology National Institute of Gastroenterology Department of Gastroenterology National Institute of Gastroenterology Deparment of Gastroenterology The"Calixto Garcia"Hospital Department of Biostatistics National Institute of Gastroenterology

AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic ***:We prospectively evaluated the survival of 172 cirrhotic *** model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards *** was applied to estimate 12-,52-and 104-wk *** model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation ***,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was *** proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,*** addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients.

关键词：模型预测肝病末期患者临床生化应用

Use of new technologies for the promotion of physical activity in patients with mental illness:A systematic review

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World Journal of Psychiatry 2023年第4期13卷 182-190页

作者： Margarita Guerrero-Jiménez Marta Ruiz Luis Gutiérrez-Rojas Laura Jiménez-Muñoz enrique Baca-Garcia Alejandro Porras-Segovia Department of Psychiatry Hospital Clínico San CecilioGranada 18014Spain Department of Psychiatry Hospital Rey Juan CarlosMóstoles 28933MadridSpain Department of Psychiatry Hospital Universitario Jiménez DíazMadrid 28040Spain Department of Psychiatry Fundación Jiménez DiazMadrid 28040Spain

BACKGROUND Physical exercise is an underutilized tool for the management of mental *** technologies have made a breakthrough in health care,and one of its possible applications(apps)could be that of customizing exercise programs for special populations,such as patients with mental ***,the app of the so-called e-health to mental health care is still *** To know the efficacy of apps to promote physical activity in patients with mental *** We conducted a systematic review of the PubMed and Embase databases with the aim of exploring the use of new technologies for the enhancement of physical exercise in patients with a psychiatric *** the selection process,10 articles were included in the *** The most commonly used devices in this type of intervention are wearable devices and web *** results in terms of effectiveness and acceptability were obtained in most of the *** Our findings suggest that the use of new technologies in mental health represents a feasible strategy with great potential in clinical practice.

关键词： e-health m-health Physical exercise Mobile applications Wearable device

Preclinical Efficacy of Nimotuzumab, an Anti-Egfr Monoclonal Antibody as a Single Agent Therapy in Human GBM u87mg Xenografts

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Journal of Cancer Therapy 2012年第4期3卷 245-255页

作者： Arlhee diaz Rances Blanco Margit Lemm Iduna Fichtner Kalet Leon enrique Montero Center of Molecular Immunology Havana Cuba Max Delbrück Center for Molecular Medicine. Berlin Germany

Background: The poor prognosis of patients with high-grade glioma multiform (GBM) has led investigators to the search of new therapeutic strategies. Current treatment includes surgery when possible, radiotherapy and chemotherapy. Molecular-targeted therapies are in the process of clinical testing, and promising agents include monoclonal antibodies. Our study examined the antitumor activity of three different single therapies in nude mice bearing both subcutaneous and orthotopic brain xenografts of the U87MG human GBM cell line. Methods: Cell culture, Histology, Immunohistochemistry, Animal experiments, Statistical analysis. Results: Different groups of treatment included nimotuzumab, a humanized monoclonal antibody that inhibits the EGFR tyrosine kinase activity, or total body irradiation, or the chemotherapeutic agent temozolomide (TMZ). For the control group animals received saline solution instead of the antibody. For the subcutaneous model, only nimotuzumab or TMZ produced a significant delay in tumor growth. In the intracranial model, unlike TMZ, the systemic administration of the antibody did not reduce the tumor growth, despite both therapies inhibited the formation of microsatellites in the brain of mice. The antitumor activity of nimotuzumab was accompanied by a decrease in the microvessel density and the proliferative activity of tumor cells. TMZ only inhibited the tumor cell proliferation but not the formation of new tumor-associated microvessels in xenografts. For radiation therapy, neither antiproliferative nor antiangiogenic activity was found, in accordance with the lack of antitumor activity. Only nimotuzumab reduced the frequency of chemo and radioresistant CD133+ population. Conclusion: Our results illustrate the potential efficacy of nimotuzumab as a single agent against an EGFR-amplified human GBM, a tumor resistant to the therapy with all well-known forms of treatment.

关键词： CD133 Epidermal Growth Factor Receptor Glioblastoma Multiforme Nimotuzumab Radiation Temozolomide

Molecular Docking of 4-Tert-buthyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol (LQM319) on Fas Receptor (CD95)

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Journal of Cancer Therapy 2013年第1期4卷 176-181页

作者： Oscar Zuniga Victor HVazquez Ana Maria Velazquez Victor HAbrego Sandra diaz-Barriga Arceo Patricia Ramirez Roberto diaz enrique Angeles Laboratorio de Toxicologia y Genetica Departamento de C.BiologicasFacultad de Estudios Superiores CuautitlanUniversidad Nacional Autonoma de MexicoCuautitlan IzcalliMexico Laboratorio de Quimica Medicinal Departamento de Ciencias Quimicas Facultad de Estudios Superiores Cuautitlan Universidad Nacional Autonoma de MexicoCuautitlan IzcalliMrxico.

The balance between cell proliferation and cell growth characterizes tissue homeostasis on one side and cell death on the other side. Fas receptor-mediated apoptosis is a control mechanism for tissue homeostasis, and avoiding this death pathway predisposes to many human diseases, including cancer. Current therapies for this disease are invasive and do not have the desired effect in the control of the disease. In this context, the search for new drugs that contribute to a better treatment is gaining more relevance. 4-tert-butyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol (LQM319) [1,2] is a drug currently in preclinical stage, and we have shown that it has a hypertensive effect, similar to captopril, in a hypertensive rat model. Different studies have shown that some chemicals that are used as antihypertensive agents have an antineoplastic effect against certain types of cancer, as is the case of hydralazine [3], and captopril [4], among others [5]. On the other hand, it has been reported that morpholine derivatives may activate Fas (CD95)-mediated apoptosis. The aim of the present study was to show the interaction between CD95 (receptor) and thiomorpholine derivatives (ligand) using molecular modeling and docking studies, and to elucidate the possible action mechanism of 4-tert-butyl-bis-(2,6-thiomorpholin-4-ylmethyl)-1-phenol.

关键词： Fas Receptor (CD95) Fas Ligand (FasL) Docking

Construct and Convergent Validity of the OIS-Garcia （Optimist Interactive Style） Scales in a Mexican Population

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Psychology Research 2013年第9期3卷 518-528页

作者： Cirilo H. Garcia Hector L. diaz Arnoldo Tellez Fuensanta Lopez Juan Martinez Lorenzo Sanchez enrique Garcia Universidad Aut6noma de Nuevo Le6n Monterrey M6xico The University of Texas-Pan American Edinburg USA Universidad Autonoma de Nuevo Leon Monterrey Mexico

This is a report of the validation process of two scales that measure the OIS-Garcia (optimist interactive style). An attempt was made to establish construct and convergent validity for these two scales. Towards this end, we relied on the Spanish version of the LOT-R (life orientation test-revised). Participants were 350 relatives of a cancer patient with a mean age of 39.87 years (SD = 14.88) and an age range going from 15 to 79 years. Each of the new versions of the OIS1-Garcia and OIS2-Garcia comprised 10 items. The Chronbach alpha internal consistency coefficients were 0.701 for the OIS1 and 0.633 for the OIS2. The Spearman correlation coefficient among these two tests was 0.438, the correlation among LOT-R and OIS1-Garcia was 0.382, and the correlation among LOT-R and OIS2-Garcia was 0.468. As a result, we were able to partially validate both versions of the OIS-Garcia test. These findings serve as encouragement to develop more culturally sensitive and appropriate measurement instruments for specific cultures or populations.

关键词：西亚收敛墨西哥人口风格定位测试验证过程平均年龄