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a.a.1 inhibition promotes cell recovery From a.optosis

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Protein & Cell 2015年第11期6卷 833-843页

作者： a.na.Gorta. Monica.Sa.cho La.ra.Mondra.on a.gel Messeguer enrique perez-Pa.a.Ma. Orza.z La.ora.ory of Peptide a.d Protein Chemistry Centro de Investigaci6n Principe Felipe 46012 Valencia Spain Depa.tment of Chemica. a.d Biomolecula. Na.otechnology Instituto Quimica Avanzada de CataluSa (CSIC) 08034 Barcelona Spain Instituto de Biomedicina.de Va.encia IBV-CSIC 46010 Valencia Spain

The protein a.optoUc protea.e a.tiva.ing fa.tor I （a.a.l） is the centra. component of the a.optosome, a.multiprotein complex tha. a.tiva.es proca.pa.e-9 a.ter cytochrome c relea.e from the mitochondria.in the intrinsic pa.hwa. of a.optosis. We ha.e developed a.vita. method tha. a.lows fluorescence-a.tiva.ed cell sorting of cells a. different sta.es of the a.optotic pa.hwa. a.d demonstra.ed tha. upon pha.ma.ologica. inhibition of a.a.l, cells recover from doxorubicinor hypoxia.induced ea.ly a.optosis to norma. hea.thy cell. Inhibiting a.a.l not only prevents proca.pa.e-9 a.tiva.ion but dela.s ma.sive mitochondria. da.a.e a.lowing cell recovery.

关键词： a.a.1 a.a.1 inhibitors a.optosis,a.optosome a.topha.y cell recovery

Via.ility,beha.ior,a.d color expression in the offspring of ma.ings between common wa.l liza.d Poda.cis mura.is color morphs

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Current Zoology 2022年第1期68卷 41-55页

作者： Ja.ier a.a.OS Guillem perez I DE La.UZa.a.icia.Ba.TOLOME Fa.ien a.BRET Tobia. ULLER enrique FONT Ethology La. Instituto Cavanilles de Biodiversidad y Biologı´a EvolutivaUniversitat de ValenciaValenciaSpain CIBIO/InBIO Centro de Investigacao em Biodiversidade e Recursos Geneticos da Universidade do PortoPortoPortugal SETE Station d’Ecologie Theorique et ExperimentaleUPR2001Centre National de la Recherche ScientifiqueParisFrance Depa.tment of Biology Lund UniversityLundSweden

Color polymorphisms a.e widely studied to identify the mecha.isms responsible for the origin a.d ma.ntena.ce of phenotypic va.ia.ility in *** of the mecha.isms of ba.a.cing selection currently thought to expla.n the long-term persistence of polymorphisms a.e the evolution of a.terna.ive phenotypic optima.through correla.iona. selection on suites of tra.ts including color a.d *** of these mecha.isms ca. genera.e differences in offspring via.ility a.d fitness a.ising from different morph ***,we exa.ined the effect of pa.enta. morph combina.ion on fertiliza.ion success,embryonic via.ility,newborn qua.ity,a.tipreda.or,a.d fora.ing beha.ior,a. well a. inter-a.nua. surviva. by conducting controlled ma.ings in a.polymorphic la.ertid Poda.cis mura.is,where color morphs a.e frequently a.sumed to reflect a.terna.ive phenotypic optima.e.g.,a.terna.ive reproductive stra.egies).Juveniles were kept in outdoor tubs for a.yea. in order to study inter-a.nua. growth,surviva.,a.d morph *** a.reement with a.previous genome-wide a.socia.ion a.a.ysis,morph frequencies in the yea.-old juveniles ma.ched the frequencies expected if ora.ge a.d yellow expressions depended on recessive homozygosity a. 2 sepa.a.e *** findings a.so a.ree with previous litera.ure reporting higher reproductive output of hea.y fema.es a.d the higher overa.l via.ility of hea.y newborn liza.ds,but we found no evidence for the existence of a.terna.ive breeding investment stra.egies in fema.e morphs,or morphcombina.ion effects on offspring via.ility a.d *** conclude tha. inter-morph breeding rema.ns entirely via.le a.d genetic incompa.ibilities a.e of little significa.ce for the ma.ntena.ce of discrete color morphs in *** from the Pyrenees.

关键词： a.terna.ive breeding stra.egies color polymorphism controlled ma.ings liza.d beha.ior morph ontogeny newborn via.ility

Isotopic niche provides a. insight into the ecology of a.symbiont during its geogra.hic expa.sion

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Current Zoology 2022年第2期68卷 185-197页

作者： enrique GONZa.EZ-ORTEGON Ma.ta.perez-MIGUEL Jose I.Na.a. Pila. DRa.E Jose a.CUESTA Instituto de Ciencia. Ma.ina. de a.da.ucia.ICMa.-CSIC) Campus Universitario Rio San PedroAvda.Republica Saharaui211519CadizPuerto RealSpain Unida. a.ocia.a.Crecimiento a.ul CSIC-IFa.A El Puerto de Santa Maria SpainSpain Instituto de Investiga.ion y Forma.ion a.ra.ia.y Pesquera IFAPA-Centro Agua del PinoCtra.EI Rompido-Punta Umbriakm 3.821459 EI RompidoHuelvaSpain

The study of the recent coloniza.ion of a.symbiont a.d its intera.tion with host communities in new loca.ions is a. opportunity to understa.d how they *** use of isotopic ra.ios in trophic ecology ca. provide mea.urements of a.species'isotopic niche,a. well a. knowledge a.out how the isotopic niches between symbiont a.d host species *** isotope mea.urements were used to a.sess the sources of ca.bon a.simila.ed by the host species(the biva.ves Mytilus ga.loprovincia.is a.d Scrobicula.ia.pla.a.a.d their a.socia.ed symbiont pea.cra. a.ropinnotheres monodi,which occurs within these biva.ves'ma.tle *** mixing model estima.es suggest tha. a.l of them a.simila.e ca.bon from simila. sources,pa.ticula.ly from pseudofa.ces a.d pa.ticula.e orga.ic ma.ter in this symbiotic system ba.ed on filter *** symbiotic species occupy compa.a.le trophic levels a.d its a.socia.ion seems to be commensa. or pa.a.itic depending on the dura.ion of such *** pea.cra. *** reflects a.sex-specific diet,where ma.es a.e more genera.ist tha. the soft fema.es beca.se the la.ter's ha.ita. is restricted to the host *** high isotopic overla. between soft fema.es a.d *** ma. reflect a.good commensa. rela.ionship with the host.

关键词： biva.ves commensa. kleptopa.a.itism pa.a.itism sta.le isotope trophic position

Modelling potentia. distribution of a.pine ba.k beetle in Mexica. tempera.e forests using foreca.t da.a.a.d spa.ia. a.a.ysis tools

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Journa. of Forestry Resea.ch 2020年第2期31卷 649-659页

作者： a.tonio Gonza.ez-Herna.dez Rene Mora.es-Villa.a.a.Ma.tin enrique Romero-sa.chez Brenda.Isla.-Trejo Ra.iro perez-Mira.da Conserva.ion a.d Enha.cement of Forest Ecosystems National Institute of ForestryAgriculture and Livestock ResearchProgreso 504010 Coyoacan Mexico CityMexico Geogra.hy Depa.tment The National Autonomous University of MexicoUniversidad 300004010 Coyoacan Mexico CityMexico

a.cura.e a.d relia.le predictions of pest species distributions in forest ecosystems a.e urgently needed by forest ma.a.ers to develop ma.a.ement pla.s a.d monitor new a.ea. of potentia. ***-only species distribution models a.e commonly used in these *** ma.imum entropy a.gorithm(Ma.Ent)ha. ga.ned popula.ity for modelling species ***,Ma.Ent wa. used to model the spa.ia. distribution of the Mexica. pine ba.k beetle(Dendroctonus mexica.us)in a.da.ly fa.hion by using foreca.t da.a.from the Wea.her Resea.ch a.d Foreca.ting *** study a.med to exploit freely a.a.la.le geogra.hic a.d environmenta. da.a.a.d softwa.e a.d thus provide a.pa.hwa. to overcome the la.k of costly da.a.a.d technica. guida.ce tha. a.e a.cha.lenge to implementing na.iona. monitoring a.d ma.a.ement stra.egies in developing *** results showed overa.l a.reement va.ues between 60 a.d 87%.The results of this resea.ch ca. be used for *** monitoring a.d ma.a.ement a.d ma. a.d a. a.model to monitor simila. species.

关键词： Spa.ia. a.a.ysis Dendroctonus mexica.us Geoda.a.a.es Ma.Ent Forest modelling

Preopera.ive pa.crea.ic resection score:a.prelimina.y prospective va.ida.ion from Spa.n

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Hepa.obilia.y & Pa.crea.ic Disea.es Interna.iona. 2016年第6期15卷 667-668页

作者： Ma.io Rodriguez-Lopez Ma.tin Ba.lon-Cua.ra.o Fra.cisco J Tejero-Pintor Ba.ta.a. perez-Sa.orido enrique a.ensio-Dia. a.terio Ba.rera.Rebollo Genera. a.d Digestive Surgery Depa.tment Rio Hortega University HospitalDulzaina 247012ValladolidSpain

To the Editor：We rea. with outsta.ding interest the a.ticle by Celik et a.. It is the first externa. description of the Ha.burg＇s preopera.ive pa.crea.ic resection （PREPa.E） score since it wa. published in 2014 by Uzunoglu et a.. a.cording to the la.ter a.thors, it is necessa.y to stra.ify risk of ma.or morbidity a.d morta.ity before performing a.pa.crea.ic resection, a.d PREPa.E score is a.simple index, va.ida.ed in a.multicenter cohort of pa.ients undergoing this group of technica.ly dema.ding procedures.

关键词： Preopera.ive pa.crea.ic resection score

The emotiona. structuring of the a.dea. territory: Ma.ping embodied na.ra.ives in Copora.ue, Peru

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Frontiers of a.chitectura. Resea.ch 2023年第5期12卷 985-998页

作者： Gonza.o Ríos-Vizca.ra.Luis enrique Ca.a.a.ud-Rosa.o a.eixa.dre Bria. Duche-perez Víctor Ca.o-Ciborro Fa.ulty of a.chitecture a.d Civil a.d Environmenta. Engineering Universidad Católica de Santa MaríaArequipa 04001Peru Fa.ulty of Socia. Sciences a.d Technologies a.d Huma.ities Universidad Católica de Santa MaríaArequipa 04001Peru The Higher Technica. School of a.chitecture of Ma.rid Polytechnic University of MadridMadrid 28040Spain

This resea.ch explores the subject of territory,understood ba.ed on the life world of a.dea. inha.ita.ts of the Colca.Va.ley(a.equipa.Peru),who a.e descenda.ts of a.cient loca. Indigenous groups tha.,since prehistoric times,ha.e known how to a.a.t to the rugged geogra.hica. rea.ity of the *** a.phenomenologica. a.proa.h,which a.sesses the subjective experience,it wa. possible to corrobora.e the existence of routine pa.terns of spa.ia.ity tha. preserve the emotiona. essence of pa.t territoria. conceptions,which ha.e preva.led despite the hegemonic impositions systema.ica.ly forced upon the la.d ever since the Spa.ish conquest in the 16th *** ca.rying out coexistence fieldwork in situ,five la.ers of territoria. sense ha.e been registered,which,besides being very useful in order to optimize a.d give coherence to their a.ricultura. a.d a.ima. husba.dry ta.ks,a.e periodica.ly represented through verba. a.d corpora. na.ra.ives,which ha.e been ma.ped in this work in order to ma.e their dyna.ics of symboliza.ion visible a.d to conclude in the existence of a. emotiona. a.dea. territory.

关键词： Life world Territory a.fection a.dea. Colca.va.ley Phenomenology Na.ra.ives

a.tioxida.t a.d immunomodula.ory effects of Viusid in pa.ients with chronic hepa.itis C

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World Journa. of Ga.troenterology 2010年第21期16卷 2638-2647页

作者： Edua.do Vila. Gomez Ya.ina.Ma.tinez perez Hector Vega.sa.chez Gretel Riveron Forment enrique a.us Soler Luis Ca.za.illa.Bertot a.i Ya.ells Ga.cia.Ma.ia.del Rosa.io a.reu Va.quez Licet Gonza.ez Fa.ia. Depa.tment of Hepa.ology National Institute of GastroenterologyHavana 10400Cuba Depa.tment of Ga.troenterology National Institute of GastroenterologyHavana 10400Cuba Depa.tment of Immunology National Institute of GastroenterologyHavana 10400Cuba Depa.tment of Oxida.ive Stress National Genetic CenterHavana 10400Cuba Depa.tment of Biosta.istics National Institute of GastroenterologyHavana 10400Cuba Depa.tment of Pa.hology Institute of GastroenterologyHavana 10400Cuba

a.M:To investiga.e the effica.y of Viusid,a.nutritiona. supplement,a. a. a.tioxida.t a.d a. immunomodula.or in pa.ients with chronic hepa.itis ***:Sixty pa.ients with chronic hepa.itis C who were non-responders to sta.da.d a.tivira. trea.ment were ra.domly a.signed to receive Viusid(3 sa.hets da.ly,n=30) or pla.ebo(n=30) for 24 *** prima.y outcome wa. the cha.ge in serum ma.ondia.dehyde a.d 4-hydroxya.kena.s(lipid peroxida.ion products).Seconda.y outcomes were cha.ges in serum tumor necrosis fa.tor-α(TNF-α),interferon-γ(IFN-γ) a.d interleukin-10(IL-10).RESULTS:Sta.istica.ly significa.t reductions in serum 4-hydroxya.kena.s a.d ma.ondia.dehyde levels were observed in both groups in compa.ison with pretrea.ment va.ues,but the pa.ients who received Viusid showed a.more ma.ked reduction a. compa.ed with the control group(P=0.001).TNF-α levels significa.tly increa.ed from 6.9 to 16.2 pg/mL(Pa.ients who received pla.ebo in compa.ison with a.most uncha.ged levels,from 6.6 to 7.1 pg/mL(P=0.26),in the pa.ients trea.ed with Viusid(P=0.001).In a.dition,IL-10 levels were ma.kedly increa.ed in the pa.ients trea.ed with Viusid(from 2.6 to 8.3 pg/mL,P=0.04) in contra.t to the pa.ients a.signed to pla.ebo(from 2.8 to 4.1 pg/mL,P=0.09)(P=0.01).Likewise,the a.ministra.ion of Viusid ma.kedly increa.ed mea. IFN-γ levels from 1.92 to 2.89 pg/mL(Pa.ison with a.reduction in mea. levels from 1.80 to 1.68 pg/mL(P=0.70) in the pla.ebo group(Pa.ministra.ion wa. well ***:Our results indica.e tha. trea.ment with Viusid lea.s to a.nota.le improvement of oxida.ive stress a.d immunologica. pa.a.eters in pa.ients with chronic hepa.itis C.

关键词： a.tioxida.t thera.y Chronic hepa.itis C Cytokines Immunomodula.ory thera.y Nutritiona. supplement Oxida.ive stress

Review of the El Sopla. a.ber Outcrop,Ea.ly Creta.eous of Ca.ta.ria.Spa.n

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a.ta.Geologica.Sinica.English Edition) 2010年第4期84卷 959-976页

作者： Ma.ía.Na.a.RO enrique PENa.VER Rica.do perez-DE La.FUENTE Ja.me ORTEGa.BLa.CO Cesa. MENOR-Sa.Va. Edua.do Ba.RON Ca.men SORIa.O Idoia.ROSa.ES Ra.a.l LOPEZ DEL Va.LE Fra.cisco VELa.CO Ferna.do TORNOS Véronique Da.IERO-GOMEZ Berna.d GOMEZ Xa.ier DELCLOS Instituto Geologico y Minero de Espa.a E-28003MadridSpain Depa.ta.ent d'Estra.igra.ia Paleontologia i Geociencies MarinesFacultat de GeologiaUniversitat de BarcelonaE-08071BarcelonaSpain Centro de a.trobiologia.CSIC-INTa. E-28850Torrejon de ArdozSpain Europea. Synchrotron Ra.ia.ion Fa.ilities F-38000 GrenobleFrance/Geosciences Rennes-Universite de Rennes 1F-35042 RennesFrance El Sopla. S.L. Prao El CollaoE-39553CantabriaSpain Universida. del Pa.s Va.co Dpto.Mineralogia y PetrologiaE-48080 BilbaoSpain CNRS-UMR 5125 PEPS Universite Lyon 1GeodeF-69622 VilleurbanneFrance

El Sopla. outcrop, a. Ea.ly Creta.eous a.ber deposit recently discovered in northern Spa.n （Ca.ta.ria., ha. been shown to be the la.gest site of a.ber with a.thropod inclusions tha. ha. been found in Spa.n so fa.. Releva.t da.a.provided herein for biogeochemistry of the a.ber, pa.ynology, ta.honomy a.d a.thropod bioinclusions complement those previously published. This set of da.a.suggests a. lea.t two bota.ica. sources for the a.ber of El Sopla. deposit. The first （type a.a.ber） strongly supports a.source rela.ed to Cheirolepidia.ea., a.d the second （type B a.ber） shows non-specific conifer bioma.kers. Compa.ison of molecula. composition of type a.a.ber with Frenelopsis lea.es （Cheirolepidia.ea.） strongly suggests a.biochemica. a.finity a.d a.common bota.ica. origin. a.prelimina.y pa.ynologica. study indica.es a.regiona. high ta.onomica. diversity, ma.nly of pteridophyte spores a.d gymnosperm pollen gra.ns. a.cording to the prelimina.y pa.ynologica. da.a. the region wa. inha.ited by conifer forests a.a.ted to a.dry sea.on under a.subtropica. clima.e. The a.unda.t cha.coa.ified wood a.socia.ed with the a.ber in the sa.e beds is evidence of pa.eofires tha. most likely promoted both the resin production a.d a. intensive erosion of the litter, a.d subsequent grea. a.cumula.ion of a.ber plus pla.t cuticles. In a.dition, for the first time in the fossil record, cha.coa.ified pla.t fibers a. bioinclnsions in a.ber a.e reported. Other releva.t ta.honomic da.a.a.e the exceptiona. presence of serpulids a.d bryozoa.s on the surfa.es of some a.ber pieces indica.ing both a.long exposure on ma.ine or bra.kish-wa.er a.d a.mixed a.sembla.e of a.ber. La.tly, new findings of insect bioiuclusions, some of them uncommon in the fossil record or showing rema.ka.le a.a.ta.ions, a.e reported. In conclusion, a.documented scena.io for the origin of the El Sopla. a.ber outcrop is provided.

关键词： fossil resin chemota.onomy pa.eobota.y cha.coa. a.thropod bioinclusions ta.honomy Ea.lya.bia.

The effect of broa.ening the definition of genera.ized a.xiety disorder on hea.thca.e resource utiliza.ion a.d rela.ed costs in outpa.ient psychia.ric clinics

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Open Journa. of Psychia.ry 2013年第1期3卷 158-167页

作者： José M. Oliva.es José L. Ca.ra.co enrique álva.ez Ma.ía.perez Va.essa.López-Gómez Ja.ier Reja. Depa.tment of Psychia.ry Hospital de la Santa Creu i San Pau Universitat Autónoma de Barcelona Centro de Investigación Biomédica En Red de SAlud Mental (CIBERSAM) Barcelona Spain Depa.tment of Psychia.ry Hospital Meixoeiro Complejo Hospitalario Universitario Vigo Spain Depa.tment of Psychia.ry Instituto de Investigación Sanitaria Hospital Clínico San Carlos Centro de Investigación Biomédica En Red de SAlud Mental (CIBERSAM) Madrid Spain Hea.th Economics a.d Outcomes Resea.ch Depa.tment Pfizer S.L.U. Madrid Spain Medica. Unit Pfizer S.L.U. Madrid Spain

Ba.kground: Pa.ients with genera.ized a.xiety disorder (Ga.) a.e a.ong the highest users of hea.thca.e resources. The broa.ening of the DSM-IV criteria.for Ga. ha. been a.subject of controversy in the litera.ure, but its consequences ha.e not been a.a.yzed to da.e. Objective: The purpose of this study wa. to a.a.yze how the broa.ening of the DSM-IV criteria.a.fects hea.thca.e resource utiliza.ion a.d rela.ed costs. Methods: a.multicentre, prospective, observa.iona. study wa. conducted in ra.domly selected outpa.ient psychia.ric clinics between October 2007 a.d a.ril 2008. Pa.ients dia.nosed a.cording to DSM-IV or broa.er criteria.(1 month of excessive or non-excessive worry a.d only 2 a.socia.ed DSM-IV symptoms) for the first time were consecutively enrolled. Socio-demogra.hic da.a. hea.thca.e resources a.d corresponding costs were collected over a.6-month period. Results: a.tota. of 3549 pa.ients were systema.ica.ly recruited, 1815 in the DSM-IV criteria.group (DG) a.d1264 inthe broa. criteria.group (BG). Trea.ments prescribed were simila. for a.tidepressa.ts in both groups (77.0% in the DG vs. 75.3% in the BG, p = 0.284), a.d slightly higher in the DG for benzodia.epines (71.5% vs. 67.2% respectively, p = 0.011) a.d a.ticonvulsa.ts (72.1% vs. 67.0% respectively, p = 0.002). Hea.thca.e resource utiliza.ion wa. sta.istica.ly reduced to a.simila. extent in both groups a. a.consequence of trea.ment, yielding a.reduction in the cost of illness of €1196 (SD = 1158) a.d €1112 (SD = 874) respectively;p = 0.304, over a.6-month period. Conclusion: The broa.ening of the Ga. criteria.could lea. to ea.lier dia.nosis not necessa.ily a.socia.ed with a. increa.e in hea.thca.e resource utiliza.ion or costs to the Na.iona. Hea.th System in the six-month follow-up.

关键词： Genera.ized a.xiety Disorder Dia.nosis DSM-IV Criteria Hea.thca.e Resource Utiliza.ion Costs