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Necroptosis in global cerebral ischemia: a role for endoplasmic reticulum stress

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Neural Regeneration Research 2020年第3期15卷 455-456页

作者： enrique font-Belmonte Paloma González-Rodríguez Arsenio Fernández-López Area de Biologia Celular Instituto de BiomedicinaUniversidad de LeonLeonSpain Neural Therapies SL Edificio Institutos de InvestigacionCampus de VegazanaLeonSpain

Necroptosis has been reported in the last years as a type of regulated cell death that can be ignited by a number of specific death receptors,such as FAS,tumor necrosis factor receptor 1(TNFR1),or pathogen recognition *** cell death subroutine is involved in the response to stress and in homeostatic functions,such as the maintenance of adult T-cell balance(Galluzzi et al.,2018).Dead receptor activation leads to the recruitment of protein complexes that act as nodes of signaling that can elicit different pathways driving to death or survival,depending on the cell conditions.

关键词： death cerebral ischemia

Viability,behavior,and color expression in the offspring of matings between common wall lizard Podarcis muralis color morphs

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Current Zoology 2022年第1期68卷 41-55页

作者： Javier ABALOS Guillem PEREZ I DE LANUZA Alicia BARTOLOME Fabien AUBRET Tobias ULLER enrique font Ethology Lab Instituto Cavanilles de Biodiversidad y Biologı´a EvolutivaUniversitat de ValenciaValenciaSpain CIBIO/InBIO Centro de Investigacao em Biodiversidade e Recursos Geneticos da Universidade do PortoPortoPortugal SETE Station d’Ecologie Theorique et ExperimentaleUPR2001Centre National de la Recherche ScientifiqueParisFrance Department of Biology Lund UniversityLundSweden

Color polymorphisms are widely studied to identify the mechanisms responsible for the origin and maintenance of phenotypic variability in *** of the mechanisms of balancing selection currently thought to explain the long-term persistence of polymorphisms are the evolution of alternative phenotypic optima through correlational selection on suites of traits including color and *** of these mechanisms can generate differences in offspring viability and fitness arising from different morph ***,we examined the effect of parental morph combination on fertilization success,embryonic viability,newborn quality,antipredator,and foraging behavior,as well as inter-annual survival by conducting controlled matings in a polymorphic lacertid Podarcis muralis,where color morphs are frequently assumed to reflect alternative phenotypic optima(e.g.,alternative reproductive strategies).Juveniles were kept in outdoor tubs for a year in order to study inter-annual growth,survival,and morph *** agreement with a previous genome-wide association analysis,morph frequencies in the year-old juveniles matched the frequencies expected if orange and yellow expressions depended on recessive homozygosity at 2 separate *** findings also agree with previous literature reporting higher reproductive output of heavy females and the higher overall viability of heavy newborn lizards,but we found no evidence for the existence of alternative breeding investment strategies in female morphs,or morphcombination effects on offspring viability and *** conclude that inter-morph breeding remains entirely viable and genetic incompatibilities are of little significance for the maintenance of discrete color morphs in *** from the Pyrenees.

关键词： alternative breeding strategies color polymorphism controlled matings lizard behavior morph ontogeny newborn viability

Neuroprotective effects of meloxicam on transient brain ischemia in rats:the two faces of anti-inflammatory treatments

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Neural Regeneration Research 2023年第9期18卷 1961-1967页

作者： Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano enrique font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez JoséManuel Gonzalo-Orden Arsenio Fernández-López Área de Biología Celular Instituto de BiomedicinaCampus de Vegazana s/nUniversidad de LeónLeónSpain Neural Therapies SL.Edif.Institutos de Investigación.Planta baja.Local B43.Campus de Vegazana s/n.León.Spain Department of Medicina Cirugía y Anatomía VeterinariaUniversity of LeónLeónSpain Department of Pharmacology Tulane University School of MedicineNew OrleansLAUSA Department of Neurology David Geffen School of Medicine at University of California(UCLA)Los AngelesCAUSA Department of Life Sciences Imperial College London(ICL)LondonUK Department of Clinical and Movement Neurosciences UCL Queen Square Institute of NeurologyLondonUK

The inflammato ry response plays an important role in neuroprotection and regeneration after ischemic *** use of non-ste roidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental *** this context,the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stro ke,but its ability to inhibit both cyclooxygenase isoforms(1 and 2) could be a promising strategy to modulate postischemic *** study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats,measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged *** show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ***,meloxicam treatment modulated glial scar reactivity,which matched with an increase in axonal ***,this treatment decreased the formation of neuronal progenitor *** study discusses the dual role of anti-inflammatory treatments after stro ke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies.

关键词： anti-inflammatories astrocyte axonal sprouting cylinder test doublecortin focal brain ischemia glial scar inflammation neuroprotection new neuron generation transient stroke

Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis

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World Journal of Gastroenterology 2010年第27期16卷 3411-3417页

作者： Inmaculada Lopez-font Sabrina Gea-Sorlí enrique de-Madaria Luis M Gutiérrez Miguel Pérez-Mateo Daniel Closa Gastroenterology Unit University General Hospital Alicante Spain Department of Experimental Pathology Institute of Biomedical Research of Barcelona Spanish National Research Council(IIBB-CSIC)Institute of Biomedical Research August Pi Sunyer(IDIBAPS) and Biomedical Research Centre Network on Liver and Digestive Diseases Neurosciences Institute Miguel Hernandez University-Spanish National Research Council(UMH-CSIC)Sant Joan d'Alacant Miguel Hernandez University School of Medicine

AIM:To study the activation of pancreatic and pulmonary mast cells and the effect of mast cell inhibition on the activation of peritoneal and alveolar macrophages during acute ***:Pancreatitis was induced by intraductal infusion of 5% sodium taurodeoxycholate in *** mast cell inhibitor cromolyn was administered intraperitoneally(i.p.) 30 min before pancreatitis *** pancreatic and pulmonary tissue damage was evaluated histologically and mast cells and their state of activation were *** and alveolar macrophages were obtained and the expression of tumor necrosis factor α was *** activity was measured to evaluate the effect of mast cell inhibition on the progression of the inflammatory ***,the effect of plasma on cultured mast cells or macrophages was evaluated in ***:The mast cell stabilizer signif icantly reduced inflammation in the pancreas and lung and the activation of alveolar macrophages but had no effect on peritoneal *** cell degranulation was observed in the pancreas during pancreatitis but no changes were observed in the *** from rats with pancreatitis could activate alveolar macrophages but did not induce degranulation of mast cells in ***:Pancreatic mast cells play an important role in triggering the local and systemic inflammatory response in the early stages of acute *** contrast,lung mast cells are not directly involved in the inflammatory response related to pancreatic damage.

关键词： Cytokines Inflammation Macrophages Mast cells Pancreatitis

Modelling fuel loads of understorey vegetation and forest floor components in pine stands in NW Spain

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Forest Ecosystems 2022年第6期9卷 775-789页

作者： Jose A.Vega Stefano Arellano-Perez Juan Gabriel Alvarez-Gonzalez Cristina Fernandez enrique Jimenez Pedro Cuinas Jose María Fernandez-Alonso Daniel J.Vega-Nieva Fernando Castedo-Dorado Cecilia Alonso-Rego Teresa fontúrbel Ana Daría Ruiz-Gonzalez Centro de Investigacion Forestal de Lourizan PO Box 12736080PontevedraSpain Unidad de Gestion Ambiental y Forestal Sostenible(UXAFORES) Departamento de Ingeniería AgroforestalEscuela Politecnica Superior de IngenieríaUniversidad de Santiago de CompostelaCampus Universitario s/n27002LugoSpain Facultad de Ciencias Forestales Universidad Juarez del Estado de DurangoRío Papaloapan y Blvd.Durango s/nCol.Valle del Sur34120DurangoMexico Departamento de Ingeniería y Ciencias Agrarias Universidad de LeonCampus de Ponferrada24401PonferradaSpain

In this study,310 destructively sampled plots were used to develop two equation systems for the three main pine species in NW Spain(***;*** and ***):one for estimating loads of understorey fuel components by size and condition(live and dead)and another one for forest floor *** systems of equations were simultaneously fitted for estimating fuel loads using overstorey,understorey and forest floor variables as *** systems of equations included both the effect of pine species and the effect of understorey compositions dominated by ferns-brambles or by woody species,due to their obvious structural and physiological *** general,the goodness-of-fit statistics indicated that the estimates were reasonably robust and accurate for all of the fuel *** best results were obtained for total understorey vegetation,total forest floor and raw humus fuel loads,with more than 76%of the observed variability explained,whereas the poorest results were obtained for coarse fuel loads of understory vegetation with a 53%of observed variability *** reduce the overall costs associated with the field inventories necessary for operational use of the models,the additive systems were fitted again using only overstorey variables as potential *** relationships for fine(<6 mm)and total understorey vegetation and total forest floor fuel loads were obtained,indicating the complexity of the forest overstorey-understorey and overstorey-forest floor ***,these models explained around 52%of the observed ***,equations estimating the total understorey vegetation and the total forest floor fuel loads based only on canopy cover were *** models explained only 26%-32%of the observed variability;however,their main advantage is that although understorey vegetation in forested landscapes is largely invisible to remote sensing,canopy cover can be estimated with moderate accuracy,allowin

关键词： Area-based approach Additive equation systems Live and dead fine fuel Pinus pinaster Pinus radiata Pinus sylvestris

First Trimester Uterine Rupture: A Case Report on a Patient with Unsuspected Müllerian Duct Anomaly

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Open Journal of Obstetrics and Gynecology 2021年第7期11卷 917-921页

作者： Rosales H. Diego García B. Julián Valdes R. enrique Cartallier Otone Rojas L. Daniel Valdes M. enrique Montero S. Juan Eliash D. Hector Universidad Andres Bello Santiago Chile Hospital El Pino San Bernardo Chile Universidad de Chile Santiago Chile

Introduction: Mullerian malformations are a group of malformations that result from an alteration of embryonic development. Most cases are asymptomatic, however, in pregnant patients it has been associated with recurrent abortion or premature delivery. Case presentation: 12 + 2 weeks pregnant woman consulted for abdominal pain, vomiting and fever. During the study, a transvaginal ultrasound was performed, where two endometric cavities and a pregnancy in the right horn were observed. The evolution of the patient was torpid, reaching hypovolemic shock, resolved by an emergency laparotomy where the rupture of the right horn was found. Discussion: The bicornuate uterus is the consequence of a partial fusion of the paramesonephric ducts during the fetal development, resulting in two functional uterine horns. Patients with bicornuate uterus may be asymptomatic,font-fami

关键词： Uterine Rupture Müllerian Duct Anomalies Pregnancy Complications