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Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： Antonio Masone Chiara Zucchelli enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Experimental rigs for testing components of advanced industrial applications

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Friction 2019年第1期7卷 59-73页

作者： enrico CIULLI Department of Civil and Industrial Engineering University of Pisa

This paper presents experimental rigs of the Research Centre for the Mechanics of Turbomachinery of the Department of Civil and Industrial Engineering of the University of Pisa. Most of them were designed and constructed to allow investigations of real machine components and to furnish more realistic results than basic tribological test rigs. Tilting pad journal bearings, as well as gears and complete gearboxes for advanced industrial applications, can be tested using the rigs described in the paper. A novel test rig with a power rating of approximately 1 MW allows investigations of the static and dynamic characteristics of high-performance tilting pad journal bearings for turbomachinery. A twin disc machine and closed loop gear test rig are used to investigate the different kinds of wear mechanisms occurring in gears. Functional and durability tests on planetary gearboxes for new turbo-fan engines could be performed using another novel large test rig. A circulating power configuration was adopted for most of the rigs so that only the power needed to cover the friction losses has to be supplied, while the circulating power can be more than 20 times higher. All the test rigs include very complex load applications and lubrication plants, as well as dedicated control and data acquisition systems. The rigs and related plants were designed and constructed through strong and fruitful collaborations between the university and some large and small–medium companies. Despite some limitations in the publication of the results as a result of the industrial sensitivity of the data, the synergy among these different actors was stimulating and fundamental for the realization of new advanced industrial applications.

关键词： experimental rigs tilting pad journal bearings twin disc machine gears gearboxes

Single-particle spectral function of the Hubbard chain:frustration induced

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Chinese Physics B 2009年第6期18卷 2475-2480页

作者：王竞 enrico Arrigoni Department of Physics Fudan University Institute of Theoretical Physics and Computational Physics Graz University of Technology

The one-electron spectral function of a frustrated Hubbard chain is computed by making use of the cluster perturbation theory. The spectral weight we found turns out to be strongly dependent on the frustrating next-nearest-neighbor hopping t′. A frustration induced pseudogap arises when the system evolves from a gapful Mott insulator to a gapless conductor for an intermediate value of the frustration parameter ｜t′｜. Furthermore, the opening of a pseudogap in the density of states already in the metallic side leads to a continuous opening of the true gap in the insulator. For the hole-doped case, the pseudogap is pinned at the Fermi energy, while the Mott gap is shifted in energy with increasing Hubbard interaction U. The separation of the pseudogap and Mort gap in the hole-doped system demonstrates the validity of the existence of a pseudogap.

关键词： cluster perturbation theory pseudogap metal-insulator transitions

Optimized design and integration of energy storage in Solar-Assisted Ground-Source Heat Pump systems

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Building Simulation 2023年第10期16卷 1933-1948页

作者： Maria Ferrara enrico Fabrizio Department of Energy Politecnico di TorinoTurin10121Italy

The integrated use of multiple renewable energy sources to increase the efficiency of heat pump systems,such as in Solar Assisted Geothermal Heat Pumps(SAGHP),may lead to significant benefits in terms of increased efficiency and overall system performance especially in extreme climate contexts,but requires careful integrated optimization of the different system *** particular,thermal storages take a fundamental role in optimizing the integration of renewable energy sources and the system *** work investigates the potential design optimization of a SAGHP system in a mountain site by exploring many different alternatives to optimize the mutual relationship between the solar field,the geothermal field and the water thermal *** is done through an original simulation-based multi-objective optimization framework considering energy efficiency and economic feasibility,which allows appraising the impact of the different design alternatives on the overall system performance and on the dynamics of the different system *** identify a set of optimized system configurations that optimize the integrated exploitation of the different thermal sources showing a potential increase of the overall system performance leading to 34%lower global cost compared to the initial *** robustness of the optimal design solutions is reported with respect to the current context of high economic uncertainty.

关键词： thermal storage geothermal energy heat pumps building simulation artificial intelligence cost optimization energy flexibility

Evolution of computers and simulations: from science and technology to the foundations of society

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Science China Chemistry 2014年第10期57卷 1317-1329页

作者： CLEMENTI enrico International Academy of Quantum Molecular Science

We consider the relevance of computer hardware and simulations not only to science and technology but also to social life. Evolutionary processes are part of all we know, from the physical and inanimate world to the simplest or most complex biological system. Evolution is manifested by land mark discoveries which deeply affect our social life. Demographic pressure, demand for improved living standards and devastation of the natural environment pose new and complex challenges. We believe that the implementation of new computational models based on the latest scientific methodology can provide a reasonable chance of overcoming today's social problems. To ensure this goal, however, we need a change of mindset, placing findings obtained from modern science above traditional concepts and beliefs. In particular, the type of modeling used with success in computational sciences must be extended to allow simulations of novel models for social life.

关键词： constraints for Homo Sapiens evolution of continents human life electronic computers knowledge the scientificmethod vs. tradition computational chemistry inter-disciplinary science

Imprinted membranes for sustainable separation processes

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Frontiers of Chemical Science and Engineering 2021年第4期15卷 775-792页

作者： Laura Donato enrico Drioli Research Institute on Membrane Technology CNR-ITMUniversity of Calabria87030 Rende(CS)Italy Department of Engineering and of the Environment University of Calabria87030 Rende(CS)Italy College of Chemical Engineering Nanjing Tech UniversityNanjing 211816China Centre of Excellence in Desalination Technology King Abdulaziz UniversityJeddah 21589Saudi Arabia

The rapid industrial growth and the necessity of recovering and recycling raw materials increased the interest in the production of highly selective and efficient separation *** this perspective,a relevant input was given by the membrane-based technology and the production of imprinted membranes,which possess specific recognition properties at molecular and ionic level,offers the possibility of developing sustainable and green ***,the integration of imprinted membranes with traditional or membrane-based approaches is a promising strategy in the logic of process intensification,which means the combination of different operations in a single *** work discusses the concept and separation mechanisms of imprinted ***,it presents an overview of their application in organic solvent nanofiltration,for the removal of toxic agents and recovery solvent,as well as valuable *** recent advances in water treatment,such as pesticide removal and recovery of metal ions,are also ***,potential applications of imprinted membranes in hybrid processes are highlighted,and a look into the future of membrane separations for water treatment and recovery of critical raw materials is offered.

关键词： sustainable processes membrane separation molecular recognition imprinted membranes water treatment

Ligninolytic Peroxidase-Like Activity of a Synthetic Metalloporphine Immobilized onto Mercapto-Grafted Crosslinked PVA Inspired by the Active Site of Cytochrome P450

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催化学报 2011年第11期32卷 1663-1666页

作者： Paolo ZUCCA Antonio RESCIGNO enrico SANJUST Dipartimento di Scienze e Tecnologie Biomediche Università di Cagliari Monserrato 09042 Italy Consorzio per lo Sviluppo dei Sistemi a Grande Interfase Sesto Fiorentino 50019 Italy

A synthetic metalloporphine was immobilized onto a PVA-based and mercapto-grafted solid support, emulating the active site of cytochrome P450. Its ligninolytic peroxidase-like catalytic activity was studied. The coordinated mercapto ligand significantly affected the catalytic features of the catalyst because the oxidation of lignin-model compounds was very slow by comparison with imidazoleand pyridine-coordinated immobilized metalloporphines. Conversely, the catalyst efficiently bleached several industrial dyes and thus demonstrated promising activity for this application. Based on this altered substrate specificity the oxygen-donor catalytic route seems to be more favorable than a single electron oxidation pathway.

关键词： porphine porphyrin lignin peroxidase cytochrome P450 biomimetic

Superlubricity on the nanometer scale

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Friction 2014年第2期2卷 106-113页

作者： Ernst MEYER enrico GNECCO Department of Physics University of BaselKlingelbergstr.824056 BaselSwitzerland IMDEA Nanociencia Campus Universitario de CantoblancoCalle Faraday 928049 MadridSpain

The transition from atomic stick-slip to continuous sliding has been observed in a number of *** extended contacts are moved in different directions,so-called structural lubricity is observed when the two surface lattices are ***,a“superlubric”state of motion can be achieved if the normal force is reduced below a certain threshold,the temperature is increased,or the contact is actuated *** processes have been partially demonstrated using atomic force microscopy,and they can be theoretically understood by proper modifications of the Prandtl−Tomlinson model.

关键词： structural lubricity dynamic superlubricity atomic force microscopy friction force microscopy themolubricity Prandtl−Tomlinson model

Advanced modeling of embedded piezo-electric transducers for the health-monitoring of layered structures

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International Journal of Smart and Nano Materials 2020年第4期11卷 325-342页

作者： enrico Zappino Erasmo Carrera Department of Mechanical and Aerospace Engineering Politecnico di TorinoMul2 Research GroupTorinoItaly

The present paper presents an innovative approach for the numerical modeling of piezo-electric transducers for the health-monitoring of layered *** numerical approach has been developed in the frameworks of the Carrera Unified *** computa-tional tool allows refined numerical models to be derived in a unified and efficient *** use of higher-order models and the cap-ability to connect different kinematic models using the node-depen-dent kinematic approach has led to an efficient modeling technique for global-local *** approach can refine the model only in those regions where it is required,e.g.,the areas where piezo-electric transducers are *** model has been used to study embedded and surface-mounted *** accuracy of the pre-sent model has been verified by comparing the current results with numerical and experimental data from the *** mod-eling solutions have been developed,mixing one-,two-and threedimensional finite *** results show that the use of the present modeling technique allows the computational cost to be reduced with respect to the classical approaches preserving the ccuracy of the results in the critical areas.

关键词： Carrera Unified Formulation Embedded Sensor Health Monitoring Layered Structures Refined models