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Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： Antonio Masone Chiara Zucchelli enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Use of anticoagulation reversal therapy in the emergency department:a single-center real-life retrospective study

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World Journal of Emergency Medicine 2023年第1期14卷 56-58页

作者： Jacopo Davide Giamello Andrea Pisano fabrizio Corsini Remo Melchio Luca Bertolaccini enrico Lupia Giuseppe Lauria School of Emergency Medicine University of TurinTurin 10100Italy Department of Emergency Medicine Santa Croce e Carle HospitalCuneo 12100Italy Department of Internal Medicine Santa Croce e Carle HospitalCuneo 12100Italy Department of Thoracic Surgery IEOEuropean Institute of Oncology IRCCSMilan 20141Italy Department of Emergency Medicine Cittàdella Salute e della Scienza HospitalTurin 10126Italy Department of Medical Sciences University of TurinTurin 10100Italy

The incidence of atrial fibrillation(AF)and deep vein thrombosis/pulmonary embolism(DVT/PE)has increased in the last decades as a consequence of global aging and th refinement of diagnostic techniques;thus,the consumption o anticoagulant drugs has increased significantly.[1,2]Prescription of direct oral anticoagulants(DOACs)have overtaken thos of vitamin K antagonists(VKA)since the mid-2010s.[3]Consequently,the incidence of these drugs’side effects has also increased;the most relevant side effect in terms of morbidity and mortality is *** addition to critically ill bleeding patients,another indication of anticoagulant reversal therapy is the need for emergency surgery or for a procedure with high risk of bleeding.

关键词： drugs vitamin mortality

Hepatic resection beyond barcelona clinic liver cancer indication:When and how

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World Journal of Hepatology 2016年第11期8卷 513-519页

作者： Mattia Garancini enrico Pinotti Stefano Nespoli fabrizio Romano Luca Gianotti Vittorio Giardini Department of Surgery Hepatobiliopancreatic UnitSan Gerardo HospitalUniversity of Milano Bicocca

Hepatocellular carcinoma(HCC)is the main common primary tumour of the liver and it is usually associated with *** barcelona clinic liver cancer(BCLC)classification has been approved as guidance for HCC treatment algorithms by the European Association for the Study of Liver and the American Association for the Study of Liver *** to this algorithm,hepatic resection should be performed only in patients with small single tumours of 2-3 cm without signs of portal hypertension(PHT)or *** classification has been criticised and many studies have shown that multiple tumors and large tumors,as wide as those with macrovascular infiltration and PHT,could benefit from liver ***,treatment guidelines should be revised and patients with intermediate/advanced stage HCC,when technically resectable,should receive the opportunity to be treated with radical surgical ***,the surgical treatment of HCC on cirrhosis is complex:The goal to be oncologically radical has always to be balanced with the necessity to minimize organ *** aim of this review was to analyze when and how liver resection could be indicated beyond BCLC *** particular,the role of multidisciplinary approach to assure a proper indication,of the intraoperative ultrasound for intraoperative restaging and resection guidance and of laparoscopy to minimize surgical trauma have been enhanced.

关键词： Hepatocellular carcinoma Liver surgery Hepatic resection Multiple hepatocellular carcinoma Cirrhosis Barcelona clinic liver cancer Multidisciplinary approach Intraoperative ultrasound Laparoscopy Portal hypertension

Experimental rigs for testing components of advanced industrial applications

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Friction 2019年第1期7卷 59-73页

作者： enrico CIULLI Department of Civil and Industrial Engineering University of Pisa

This paper presents experimental rigs of the Research Centre for the Mechanics of Turbomachinery of the Department of Civil and Industrial Engineering of the University of Pisa. Most of them were designed and constructed to allow investigations of real machine components and to furnish more realistic results than basic tribological test rigs. Tilting pad journal bearings, as well as gears and complete gearboxes for advanced industrial applications, can be tested using the rigs described in the paper. A novel test rig with a power rating of approximately 1 MW allows investigations of the static and dynamic characteristics of high-performance tilting pad journal bearings for turbomachinery. A twin disc machine and closed loop gear test rig are used to investigate the different kinds of wear mechanisms occurring in gears. Functional and durability tests on planetary gearboxes for new turbo-fan engines could be performed using another novel large test rig. A circulating power configuration was adopted for most of the rigs so that only the power needed to cover the friction losses has to be supplied, while the circulating power can be more than 20 times higher. All the test rigs include very complex load applications and lubrication plants, as well as dedicated control and data acquisition systems. The rigs and related plants were designed and constructed through strong and fruitful collaborations between the university and some large and small–medium companies. Despite some limitations in the publication of the results as a result of the industrial sensitivity of the data, the synergy among these different actors was stimulating and fundamental for the realization of new advanced industrial applications.

关键词： experimental rigs tilting pad journal bearings twin disc machine gears gearboxes

Single-particle spectral function of the Hubbard chain:frustration induced

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Chinese Physics B 2009年第6期18卷 2475-2480页

作者：王竞 enrico Arrigoni Department of Physics Fudan University Institute of Theoretical Physics and Computational Physics Graz University of Technology

The one-electron spectral function of a frustrated Hubbard chain is computed by making use of the cluster perturbation theory. The spectral weight we found turns out to be strongly dependent on the frustrating next-nearest-neighbor hopping t′. A frustration induced pseudogap arises when the system evolves from a gapful Mott insulator to a gapless conductor for an intermediate value of the frustration parameter ｜t′｜. Furthermore, the opening of a pseudogap in the density of states already in the metallic side leads to a continuous opening of the true gap in the insulator. For the hole-doped case, the pseudogap is pinned at the Fermi energy, while the Mott gap is shifted in energy with increasing Hubbard interaction U. The separation of the pseudogap and Mort gap in the hole-doped system demonstrates the validity of the existence of a pseudogap.

关键词： cluster perturbation theory pseudogap metal-insulator transitions

Evolution of computers and simulations: from science and technology to the foundations of society

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Science China Chemistry 2014年第10期57卷 1317-1329页

作者： CLEMENTI enrico International Academy of Quantum Molecular Science

We consider the relevance of computer hardware and simulations not only to science and technology but also to social life. Evolutionary processes are part of all we know, from the physical and inanimate world to the simplest or most complex biological system. Evolution is manifested by land mark discoveries which deeply affect our social life. Demographic pressure, demand for improved living standards and devastation of the natural environment pose new and complex challenges. We believe that the implementation of new computational models based on the latest scientific methodology can provide a reasonable chance of overcoming today's social problems. To ensure this goal, however, we need a change of mindset, placing findings obtained from modern science above traditional concepts and beliefs. In particular, the type of modeling used with success in computational sciences must be extended to allow simulations of novel models for social life.

关键词： constraints for Homo Sapiens evolution of continents human life electronic computers knowledge the scientificmethod vs. tradition computational chemistry inter-disciplinary science

Ano malous weak values via a single phot on detection

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Light(Science & Applications) 2021年第6期10卷 963-968页

作者： enrico Rebufello fabrizio Piacentini Alessio Avella Muriel A.de Souza Marco Gramegna Jan Dziewior Eliahu Cohen Lev Vaidman Ivo Pietro Degiovanni Marco Genovese INRIM Strada delle Cacce 911-10135 TorinoItaly. National Institute of Metrology Quality and Technology-INMETROAv.Nossa Senhora das Granas50Duque de CaxiasRJ 25250-020Brazil. Max-Planck-lnstitut fur Quantenoptik Hans-Kopfermann-StraBe 185748 GarchingGermany. Department fur Physik Ludwig-Maximilians-Universitat80797 MunchenGermany. Faculty of Engi neeri ng and the Institute of Nano tech nology and Advanced Materials Bar Ilan UniversityRamat Gan 5290002Israel. Raymond and Beverly Sackler School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel

Is it possible that a measurement of a spin component of a spin-1/2 particle yields the value 100?In 1988 Aharonov,Albert and Vaidman argued that upon pre-and postselection of particular spin states,weakening the coupling of a standard measurement procedure ensures this paradoxical *** theoretical prediction,called weak value,was realised in numerous experiments2-9,but its meaning remains very controversialsince its"anomalous"nature,i.e.z the possibility to exceed the eigenvalue spectrum,as well as its"quantumness"are *** address these questions by presenting the first experiment measuring anomalous weak values with just a single click,without the need for statistical *** measurement uncertainty is significantly smaller than the gap between the measured weak value and the nearest *** clarifying the meaning of weak values,demonstrating their non-statistical,single-particle nature,this result represents a breakthrough in understanding the foundations of quantum measurement,showing unprecedented measurement capability for further applications of weak values to quantum photonics.

关键词： quantum eigenvalue breakthrough

Imprinted membranes for sustainable separation processes

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Frontiers of Chemical Science and Engineering 2021年第4期15卷 775-792页

作者： Laura Donato enrico Drioli Research Institute on Membrane Technology CNR-ITMUniversity of Calabria87030 Rende(CS)Italy Department of Engineering and of the Environment University of Calabria87030 Rende(CS)Italy College of Chemical Engineering Nanjing Tech UniversityNanjing 211816China Centre of Excellence in Desalination Technology King Abdulaziz UniversityJeddah 21589Saudi Arabia

The rapid industrial growth and the necessity of recovering and recycling raw materials increased the interest in the production of highly selective and efficient separation *** this perspective,a relevant input was given by the membrane-based technology and the production of imprinted membranes,which possess specific recognition properties at molecular and ionic level,offers the possibility of developing sustainable and green ***,the integration of imprinted membranes with traditional or membrane-based approaches is a promising strategy in the logic of process intensification,which means the combination of different operations in a single *** work discusses the concept and separation mechanisms of imprinted ***,it presents an overview of their application in organic solvent nanofiltration,for the removal of toxic agents and recovery solvent,as well as valuable *** recent advances in water treatment,such as pesticide removal and recovery of metal ions,are also ***,potential applications of imprinted membranes in hybrid processes are highlighted,and a look into the future of membrane separations for water treatment and recovery of critical raw materials is offered.

关键词： sustainable processes membrane separation molecular recognition imprinted membranes water treatment

Indocyanine green fluorescence angiography during liver and pancreas transplantation: a tool to integrate perfusion statement's evaluation

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 161-166页

作者： fabrizio Panaro enrico Benedetti Guillaume Pineton de Chambrun Hussein Habibeh Piera Leon Hassan Bouyabrine Astrid Herrero Francis Navarro Department of General Surgery Division of TransplantationUniversity of Montpellier-College of MedicineSaint Eloi HospitalMontpellier-Cedex 5France Division of Transplantation University of Illinois Hospital and Health Sciences SystemChicagoILUSA Department of Medicine Division of GastroenterologyHospital St.EloiMontpellier University HospitalAugustin Fliche34295-MontpellierFrance

Background: Indocyanine green (ICG) fluorescence imaging is a promising tool for intraoperative decision-making during surgical procedures, in particular to assess organs perfusion. Methods: We used the ICG fluorescence during liver transplantations in six cirrhotic patients to help assessing the graft biliary duct perfusion in order to identify the appropriate level to perform the anastomosis. We also used ICG fluorescence also in five patients receiving kidney-pancreas transplantation to evaluate the perfusion levels of the duodenal stump of the pancreas graft. Results: Follow-up period for the patients was 12 months. The perioperative period was uneventful, no biliary complications such as leaks or stenosis were reported after liver transplantation, no complications of the entero-enteric anastomoses occurred after pancreatic transplantation. Conclusions: ICG fluorescence seems to safely provide important objectifiable perfusion information during organ transplantation procedures that can integrate surgeon's expertise. In fact, detecting intra-operatively perfusion defects, it allows real time modifications on technical strategies potentially useful to reduce the feared risk of anastomotic leakage and consequent severe complications.

关键词： Indocyanine green (ICG) liver pancreas transplantation perfusion