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Subclinical atherosclerosis is linked to small intestinal bacterial overgrowth via vitamin K2-dependent mechanisms

World Journal of Gastroenterology 2017年第7期23卷 1241-1249页

作者： Francesca Romana Ponziani Maurizio Pompili enrico di stasio Maria Assunta Zocco Antonio Gasbarrini Roberto Flore Internal Medicine Gastroenterology and HepatologyAgostino Gemelli Hospital Biochemistry Agostino Gemelli Hospital Internal Medicine and Vascular Medicine Agostino Gemelli Hospital

To assess the rate of matrix Gla-protein carboxylation in patients with small intestinal bacterial overgrowth (SIBO) and to decipher its association with subclinical *** with suspected SIBO who presented with a low risk for cardiovascular disease and showed no evidence of atherosclerotic plaques were included in the study. A glucose breath test was performed in order to confirm the diagnosis of SIBO and vascular assessment was carried out by ultrasound examination. Plasma levels of the inactive form of MGP (dephosphorylated-uncarboxylated matrix Gla-protein) were quantified by ELISA and vitamin K2 intake was estimated using a food frequency ***-nine patients were included in the study. SIBO was confirmed in 12/39 (30.8%) patients who also presented with a higher concentration of dephosphorylated-uncarboxylated matrix Gla-protein (9.5 μg/L vs 4.2 μg/L; P = 0.004). Arterial stiffness was elevated in the SIBO group (pulse-wave velocity 10.25 m/s vs 7.68 m/s; P = 0.002) and this phenomenon was observed to correlate linearly with the levels of dephosphorylated-uncarboxylated matrix Gla-protein (β = 0.220, R2 = 0.366, P = 0.03). Carotid intima-media thickness and arterial calcifications were not observed to be significantly elevated as compared to *** is associated with reduced matrix Gla-protein activation as well as arterial stiffening. Both these observations are regarded as important indicators of subclinical atherosclerosis. Hence, screening for SIBO, intestinal decontamination and supplementation with vitamin K2 has the potential to be incorporated into clinical practice as additional preventive measures.

关键词： Small intestinal bacterial overgrowth Vitamin K Dysbiosis Atherosclerosis Cardiovascular disease risk

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Incidence of umbilical vein catheter-associated thrombosis of the portal system: A systematic review and meta-analysis

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World Journal of Hepatology 2021年第11期13卷 1802-1815页

作者： Iliana Bersani Fiammetta Piersigilli Giulia Iacona Immacolata Savarese Francesca Campi Andrea Dotta Cinzia Auriti enrico di stasio Matteo Garcovich Medical and Surgical Neonatology Bambino GesùChildren's HospitalRome 00165Italy Department of Neonatology Cliniques Universitaires Saint LucUniversitèCatholique de LouvainBruxelles 1200Belgium Faculty of Medicine Imperial College LondonLondon SW72AZUnited Kingdom Department of Biochemistry and Clinical Biochemistry Fondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRoma 00168Italy CEMAD digestive disease Center Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD digestive disease Center UniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND The use of umbilical venous catheters(UVCs)in the perinatal period may be associated with severe complications,including the occurrence of portal vein thrombosis(PVT).AIM To assess the incidence of UVC-related PVT in infants with postnatal age up to three *** A systematic and comprehensive database searching(PubMed,Cochrane Library,Scopus,Web of Science)was performed for studies from 1980 to 2020(the search was last updated on November 28,2020).We included in the final analyses all peer-reviewed prospective cohort studies,retrospective cohort studies and casecontrol *** reference lists of included articles were hand-searched to identify additional studies of *** were considered eligible when they included infants with postnatal age up to three months with UVC-associated *** estimates were pooled by using random effects *** quality of included studies was assessed using the Newcastle-Ottawa *** systematic review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis(PRISMA)*** Overall,16 studies were considered eligible and included in the final *** data confirmed the relevant risk of UVC-related *** mean pooled incidence of such condition was 12%,although it varied across studies(0%-49%).In 15/16 studies(94%),diagnosis of thrombosis was made accidentally during routine screening controls,whilst in 1/16 study(6%)targeted imaging assessments were carried out in neonates with clinical concerns for a *** position was investigated by abdominal ultrasound(US)alone in 1/16(6%)studies,by a combination of radiography and abdominal US in 14/16(88%)studies and by a combination of radiography,abdominal US and echocardiography in 1/16(6%)*** To the best of our knowledge,this is the first systematic review specifically investigating the incidence of UVC-related *** use of UVCs requires a high index of su

关键词： Portal vein thrombosis Umbilical venous catheter Portal system thrombosis Hepatic thrombosis Neonate Incidence

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