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Atypical cutaneous lesions in advanced-stage Hodgkin lymphoma: A case report

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World Journal of Clinical Cases 2019年第17期7卷 2513-2518页

作者： Fulvio Massaro Angela Ferrari enrico Zendri Magda Zanelli Francesco Merli Hematology Azienda Unità Sanitaria Locale IRCCS di Reggio Emilia

BACKGROUND Cutaneous involvement in Hodgkin lymphoma (HL) is a rare *** cases have been reported in literature,most describing paraneoplastic *** very few papers have described primary HL skin infiltration,reporting a wide range of clinical presentations that frequently include ulcers;plaques,nodules and papules have also been *** SUMMARY We report the case of a 56-year-old man who presented fever,multiple adenomegalies of neck and axilla and thick serpiginous skin lesions involving bilateral pectoral *** an initial diagnostic workup for a suspected active infectious disease,a lymph node biopsy was performed,which showed a neoplastic invasion from a mixed cellularity classical *** same histological pattern was described in a cutaneous biopsy of the chest *** other staging procedures performed revealed an advanced disease,with unfavourable clinical prognostic *** patient was prescribed 6 cycles of ABVD chemotherapy scheme (doxorubicin,bleomycin,vinblastine,dacarbazine),a regiment that requires demonstration of metabolic response achievement at the interim PET/CT scan to confirm continuation or to change therapeutic *** Skin involvement in HL is a rare finding and may represent a challenging clinical presentation due to extremely various types of lesions observed.

关键词： Hodgkin lymphoma Skin lesions Advanced stage ABVD Case report

Primary vitreoretinal lymphoma masquerading as acute posterior multifocal placoid pigment epitheliopathy

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1243-1244页

作者： Francesca Frongia Claudio Iovino Nathalie Cassoux enrico Peiretti Department of Surgical Sciences Eye Clinic University of Cagliari Radiation Oncology Department Institut Curie

Dear Editor,Primary vitreoretinal lymphoma（PVRL）is a rare form of ocular malignancy and it is usually considered as a subset of primary central nervous system lymphoma（PCNSL）.An insidious onset associated with del... 详细信息

关键词： Figure Primary vitreoretinal lymphoma masquerading as acute posterior multifocal placoid pigment epitheliopathy

Influence of High-Speed Milling Process on Mechanical and Microstructural Properties of Ultrafine Grained Profiles Produced by Linear Flow Splitting

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Transactions of Nanjing University of Aeronautics and Astronautics 2017年第4期34卷 349-356页

作者： Abele Eberhard Müller Clemens Turan Emrah Niehuesbernd Joern Bruder enrico Falk Florian Institute of Production Management Technology and Machine Tools(PTW)Technische Universitt Darmstadt Physical Metallurgy(PhM) Technische Universitt Darmstadt

The effects of milling parameters on the surface quality,microstructures and mechanical properties of machined parts with ultrafine grained(UFG)gradient microstructures are *** effects of the cutting speed,feed per tooth,cutting tool geometry and cooling strategy are *** has been found that the surface quality of machined grooves can be improved by increasing the cutting ***,cryogenic cooling with CO_2 exhibits no significant improvement of surface *** and hardness investigations revealed similar microstructure and hardness variations near the machined groove walls for both utilized tool ***,cryogenic cooling can decrease more far-ranging hardness reductions due to high process temperatures,especially in the UFG regions of the machined parts,whilst it cannot prevent the drop in hardness directly at the groove walls.

关键词： high-speed milling ultrafine grained microstructure linear flow splitting hardness

Optimization of a dynamic uncertain causality graph for fault diagnosis in nuclear power plant

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Nuclear Science and Techniques 2017年第3期28卷 59-67页

作者： Yue Zhao Francesco Di Maio enrico Zio Qin Zhang Chun-Ling Dong Jin-Ying Zhang Institute of Nuclear and New Energy Technology of Tsinghua University Beijing 100084 China Energy Department Politecnico di Milano 20156 MilanItaly Chair System Science and the Energy Challenge Fondation Electricite′ de France (EDF) CentraleSupe′lec Universite Paris Saclay 92290 Chatenay-Malabry France Department of Computer Science and Technology Tsinghua University Beijing 100084 China Department of Economic and Management North China Electric Power University Beijing 102206 China

Fault diagnostics is important for safe operation of nuclear power plants(NPPs). In recent years, data-driven approaches have been proposed and implemented to tackle the problem, e.g., neural networks, fuzzy and neurofuzzy approaches, support vector machine, K-nearest neighbor classifiers and inference methodologies. Among these methods, dynamic uncertain causality graph(DUCG)has been proved effective in many practical cases. However, the causal graph construction behind the DUCG is complicate and, in many cases, results redundant on the symptoms needed to correctly classify the fault. In this paper, we propose a method to simplify causal graph construction in an automatic way. The method consists in transforming the expert knowledge-based DCUG into a fuzzy decision tree(FDT) by extracting from the DUCG a fuzzy rule base that resumes the used symptoms at the basis of the FDT. Genetic algorithm(GA) is, then, used for the optimization of the FDT, by performing a wrapper search around the FDT: the set of symptoms selected during the iterative search are taken as the best set of symptoms for the diagnosis of the faults that can occur in the system. The effectiveness of the approach is shown with respect to a DUCG model initially built to diagnose 23 faults originally using 262 symptoms of Unit-1 in the Ningde NPP of the China Guangdong Nuclear Power Corporation. The results show that the FDT, with GA-optimized symptoms and diagnosis strategy, can drive the construction of DUCG and lower the computational burden without loss of accuracy in diagnosis.

关键词： Dynamic uncertain causality graph Fault diagnosis Classification Fuzzy decision tree Genetic algorithm Nuclear power plant

Standardization issues in botanicals:A metabolomic and in silico approach to Monascus purpureus food supplements

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Food Bioscience 2022年第6期50卷 1064-1073页

作者： Laura Righetti Luca Dellafiora enrico Rolli Chiara Dall’Asta Renato Bruni Dipartimento di Scienze degli Alimenti e del Farmaco University of ParmaParco Area delle Scienze27a43124ParmaItaly Dipartimento di Scienze Chimiche della Vita e della Sostenibilità AmbientaleUniversity of ParmaParco Area delle Scienze11a43124ParmaItaly

A metabolomic strategy was explored to profile 33 Monascus purpureus botanicals,revealing low standardization levels in terms of monacolins and Monascus pigments.A fast and highly accurate screening method was applied by means of UHPLC-TWIMS-QTOF,enabling the monitoring of 36 monacolins and 8 *** confirmed that very different fermentation processes are used for red yeast rice production,resulting in erratic profiles and large variability among ***,minor monacolins represented on average a 37%(range 8–54%)of the sum of monacolins and *** and dihydromonacolins were spanning from 7 to 43%with as many as 26 products containing a relative percentage exceeding 20%.Total pigments average ranged between traces and 65%,with a percentage exceeding 20%in 12 *** silico docking results showed that monacolins other than Monacolin K had lower but not negligeable inhibitory potential for 3-hydroxy-3-methylglutaryl coenzyme A reductase for precise structural *** results confirms that standardization of Monascus purpureus botanicals is dubious and strict quality control must be *** the same time,they reinforce the opportunity to take advantage of new metabolomic tools to properly describe raw materials or food supplements used in investigations and clinical trials,suggesting extensive phytochemical analysis beyond the mere quantification of Monacolin K.

关键词： Food supplements Metabolomics Monacus pigments Monacolins Ion mobility Standardization

PSA as the driving biomarker to manage low-and intermediate-risk prostate cancer patients in clinical practice

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Asian Journal of Andrology 2024年第6期26卷 567-568页

作者： enrico Ricevuto Celeste Morgani Fabrizia Seri Gemma Bruera Oncology Territorial Care Unit S.Salvatore HospitalUniversity of L’AquilaL’Aquila 67100Italy Department of Biotechnological and Applied Clinical Sciences University of L’AquilaL’Aquila 67100Italy

Prostate cancer risk stratification relies on several clinical factors. Low-risk patients, characterized by T1–T2a stage, Gleason score (GS) ≤6, and prostate-specific antigen (PSA) <10 ng ml−1, exhibit an excellent prognosis and are suitable for active surveillance (AS). Regular monitoring is essential for these patients, including PSA tests every 3–6 months, annual digital rectal exams (DRE), and prostate biopsies every 6–12 months, followed by less frequent biopsies every 2–5 years. Epstein criteria, which consider GS ≤6, PSA density (PSAD) <0.15 ng ml−2, limited tumor involvement in cores, and absence of high-risk features, help predict pathologic and biochemical relapse-free survival and guide AS management.

关键词： patients clinical cancer

Adhesive wear mechanisms uncovered by atomistic simulations

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Friction 2018年第3期6卷 245-259页

作者： Jean-Fran?ois MOLINARI Ramin AGHABABAEI Tobias BRINK Lucas FRéROT enrico MILANESE Civil Engineering Department Materials Science Department école Polytechnique Fédérale de Lausanne Department of Engineering-Mechanical Engineering Aarhus Universitet

In this review, we discuss our recent advances in modeling adhesive wear mechanisms using coarse-grained atomistic simulations. In particular, we present how a model pair potential reveals the transition from ductile shearing of an asperity to the formation of a debris particle. This transition occurs at a critical junction size, which determines the particle size at its birth. Atomistic simulations also reveal that for nearby asperities, crack shielding mechanisms result in a wear volume proportional to an effective area larger than the real contact area. As the density of microcontacts increases with load, we propose this crack shielding mechanism as a key to understand the transition from mild to severe wear. We conclude with open questions and a road map to incorporate these findings in mesoscale continuum models. Because these mesoscale models allow an accurate statistical representation of rough surfaces, they provide a simple means to interpret classical phenomenological wear models and wear coefficients from physics-based principles.

关键词： adhesive wear molecular dynamics continuum mechanics

Ionic liquids on uncharged and charged surfaces: In situ microstructures and nanofriction

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Friction 2022年第11期10卷 1893-1912页

作者： Rong AN Yudi WEI Xiuhua QIU Zhongyang DAI Muqiu WU enrico GNECCO Faiz Ullah SHAH Wenling ZHANG Herbert Gleiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China High Performance Computing Department National Supercomputing Center in ShenzhenShenzhen 518055China Otto Schott Institute of Materials Research(OSIM) Friedrich Schiller University JenaJena 07743Germany Chemistry of Interfaces LuleåUniversity of TechnologyLulea 97187Sweden School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China

In situ changes in the nanofriction and microstructures of ionic liquids(ILs)on uncharged and charged surfaces have been investigated using colloid probe atomic force microscopy(AFM)and molecular dynamic(MD)*** representative ILs,[BMIM][BF_(4)](BB)and[BMIM][PF_(6)](BP),containing a common cation,were selected for this *** torsional resonance frequency was captured simultaneously when the nanoscale friction force was measured at a specified normal load;and it was regarded as a measure of the contact stiffness,reflecting in situ changes in the IL microstructures.A higher nanoscale friction force was observed on uncharged mica and highly oriented pyrolytic graphite(HOPG)surfaces when the normal load increased;additionally,a higher torsional resonance frequency was detected,revealing a higher contact stiffness and a more ordered IL *** nanofriction of ILs increased at charged HOPG surfaces as the bias voltage varied from 0 to 8 V or from 0 to−8 *** simultaneously recorded torsional resonance frequency in the ILs increased with the positive or negative bias voltage,implying a stiffer IL layer and possibly more ordered ILs under these *** simulation reveals that the[BMIM]+imidazolium ring lies parallel to the uncharged surfaces preferentially,resulting in a compact and ordered IL *** parallel“sleeping”structure is more pronounced with the surface charging of either sign,indicating more ordered ILs,thereby substantiating the AFM-detected stiffer IL layering on the charged *** in situ observations of the changes in nanofriction and microstructures near the uncharged and charged surfaces may facilitate the development of IL-based applications,such as lubrication and electrochemical energy storage devices,including supercapacitors and batteries.

关键词： microstructure friction contact stiffness charged surfaces ionic liquids(ILs) molecular simulation

SARS-CoV-2 and liver damage:a possible pathogenetic link

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Hepatobiliary Surgery and Nutrition 2020年第3期9卷 322-324页

作者： Ludovico Abenavoli Ivan Gentile Alberto enrico Maraolo Francesco Negro Department of Health Sciences University Magna GraeciaCatanzaroItaly Department of Clinical Medicine and Surgery Section of Infectious Diseases Member of UNESCO Chair on Health Education and Sustainable Development University of Naples"Federico II"NaplesItaly First Division of Infectious Diseases Cotugno HospitalAORN dei ColliNaplesItaly Divisions of Gastroenterology and Hepatology and of Clinical Pathology Geneva University HospitalsGenevaSwitzerland

On December 31,2019,the World Health Organization(WHO)China Country Office,was informed of pneumonia cases of unknown etiology detected in Wuhan,a city of Hubei Province in China.

关键词： China. Wuhan damage