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A Case Report of Alendronate Treatment over 20 Years on Osteoporosis and Literature Review

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Case Reports in Clinical Medicine 2018年第6期7卷 430-440页

作者： Jinmei Deng enjing chen Suming Jie Xiuzhen Cai Dongmei Cai Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Osteoporosis The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Osteoporosis is commonly seen in aged people, but not much attention is paid to it. Patient compliance is challenged by many factors, including long-time treatment and high rates of fatality and disability caused by fragility fractures. With age-related changes, the treatment will last for a lifetime. A clinical case of postmenopausal patient who had received incontinuous treatment of alendronate for 20 years was studied in this article. As the level of compliance varied in different treatment phases, the curative outcome of this patient was altered. This study also presented a literature review to discuss the current situation, treatment and compliance of osteoporosis in China and the corresponding influences on bone mineral density (BMD) and prognosis. Hopefully, this study can increase physicians’ awareness of osteoporosis in clinical treatment and its pharmacotherapy and treatment course.

关键词： Osteoporosis Alendronate BMD Treatment Course Compliance Prognosis

Sequential Treatment Reduces the Acute Phases of Adverse Effect of Zoledronic Acid in First Time Users

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Open Journal of Preventive Medicine 2018年第7期8卷 189-205页

作者： Jinmei Deng Dongmei Cai Suming Jie enjing chen Xiuzhen Cai Yanbing Li Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Endocrinology The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Objective: To investigate whether sequential regimen such as traditional anti-reabsorption medications followed by zoledronic acid could reduce the side effects after initiation of zoledronic acid in postmenopausal osteoporosis patients. Methods: A total of 156 postmenopausal osteoporosis patients who presented at our osteoporosis outpatient clinic were enrolled in this study. They were randomly divided into four groups: the control group, alendronate group, calcitonin group, and raloxifene group. All participants were treated with Caltrate 600 mg per day and calcitriol 0.25 ug per day as a baseline treatment, followed by administrating 5 mg/100 mL of zoledronic acid intravenously for one single time three months afterwards. During the abovementioned course of three months, the alendronate group received 70 mg of alendronate sodium orally once a week, the calcitonin group received nasal spray form of salmon calcitonin 10iu daily, the raloxifene group received 60mg of raloxifene orally daily, and the control group received nothing but only the baseline treatment. We tested parameters such as β-cross, blood calcium level, renal function both pre and post zoledronic acid treatment. We also documented those side effects that typically occurred within one week of treatment initiation, which included the proportion, severity, onset time, and duration of the fever, demand for pain medication, severity of bone and joint pain, flu-like symptoms, arrhythmia, blood calcium level, and kidney function impairment. We also evaluated how willing the patients were to receive a second dose of zoledronic acid. Then we did comparative analysis between control group and sequential group. Results: The side effects such as fever, bone and joint pain, flu-like symptoms after zoledronic acid treatment in alendronate group and calcitonin group were all significantly lower than that in control group, while raloxifene group showed no significant difference compared to that in the control group

关键词： Zoledronic Acid Alendronate Sodium Raloxifene Calcitonin Postmenopausal Osteoporosis Adverse Reaction

The Role of Health Education in Improving Patient Compliance with Zoledronic Acid

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Open Journal of Nursing 2018年第10期8卷 709-716页

作者： Suming Jie Jinmei Deng Ermei Jie enjing chen Caixia Lin Xiuzhen Cai Dongmei Cai Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Endocrinology The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Objective: To define the role of health education in improving patient compliance with Zoledronic Acid for osteoporosis treatment and management and draw closer attention of patients and physicians to the importance of health education. Methods: A total of 198 postmenopausal patients with osteoporosis who were admitted by the osteoporosis outpatient clinic of our hospital and had the first administration of Zoledronic Acid in 2015 were invited to participate in the follow-up visit that involved questions concerning the frequency of health education and the questionnaire survey on osteoporosis in 2015 and the administration of Zoledronic Acid during the past three years. The patients were divided into five groups according to the frequency of health education to compare the survey results of each group in 2015 and 2018 and investigate the differences in the scores and frequency of administration among the five groups. Results: Among the 198 patients, there were 182 attending the follow-up visit. In terms of the frequency of health education (FREQ = 0, 1, 2, 3, 4), these patients were divided into five groups of 47, 63, 35, 18 and 19 members respectively. After three years of treatment, the questionnaire score of each group was higher than the pre-treatment level and the difference showed statistical significance (p Conclusion: Health education is an effective approach to influence a patient’s knowledge connected to relevant diseases in a positive way and improve patient compliance with Zoledronic Acid treatment. An enhanced health education program can be developed to assist the patients in chronic disease management.

关键词： Osteoporosis Health Education Health Management BMD Zoledronic Acid Compliance

血液透析对慢性肾衰竭患者血浆氧化型低密度脂蛋白水平的影响

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临床内科杂志 2005年第6期22卷 400-402页

作者：陈恩静甘华谯林重庆医科大学附属第一医院肾内科 400016

目的探讨血液透析对慢性肾衰竭患者血浆氧化型低密度脂蛋白(oxLDL)水平的影响及其意义。方法用ELISA方法测定血浆oxLDL水平,用全自动生化仪测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)、... 详细信息

目的探讨血液透析对慢性肾衰竭患者血浆氧化型低密度脂蛋白(oxLDL)水平的影响及其意义。方法用ELISA方法测定血浆oxLDL水平,用全自动生化仪测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)、血肌酐(Scr)与血白蛋白(ALB)值。结果慢性肾衰竭组血浆oxLDL水平(3721.8μg/L±1736.8μg/L)明显高于对照组(349.0μg/L±176.5μg/L),P0.05)。53例血液透析患者随机一次透析开始时血浆oxLDL水平高于2705.2μg/L者所占比例(71.69%)与透析结束时(79.25%)比较,差异无显著性(P>0.05)。慢性肾衰竭合并冠心病组血浆oxLDL水平高于2705.2μg/L者所占比例(97.87%,46例)明显高于慢性肾衰竭非合并冠心病组所占比例(8.89%,4例),P<0.05。结论慢性肾衰竭患者血浆oxLDL水平显著高于正常人,血浆oxLDL水平升高可导致其合并冠心病机率增加,血液透析虽是慢性肾衰竭患者肾替代治疗的有效方法,但不能降低血浆oxLDL水平。

关键词：氧化型低密度脂蛋白肾衰竭血液透析

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布鲁杆菌病发病机制及临床诊治研究进展

国际流行病学传染病学杂志 2014年第4期41卷 273-276页

作者：陈恩静翟永贞冯国和中国医科大学附属盛京医院感染科沈阳110004

布鲁杆菌病是一种人畜共患性传染病，人感染布鲁杆菌由于缺乏特异性的临床症状和体征，极易被误诊为其他疾病。布鲁杆菌感染是目前的研究热点，研究者试图从分子水平阐述其致病机制。另外，布鲁杆菌病临床表现发生一些新变化，呈单一或... 详细信息

布鲁杆菌病是一种人畜共患性传染病，人感染布鲁杆菌由于缺乏特异性的临床症状和体征，极易被误诊为其他疾病。布鲁杆菌感染是目前的研究热点，研究者试图从分子水平阐述其致病机制。另外，布鲁杆菌病临床表现发生一些新变化，呈单一或多个器官或系统受累，临床诊断治疗和预防也有新进展。基于此，文章将对布鲁杆菌致病机制以及布鲁杆菌病的临床变化新特点和诊治等方面作一综述。

关键词：布鲁杆菌病发病机制临床特点

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青少年学生家庭体育运动行为的策略研究

湖北体育科技 2016年第12期35卷 1044-1047页

作者：陈肖李恩荆华中师范大学体育学院湖北武汉430079 湖南师范大学体育学院湖南长沙410000

运用文献资料法,从青少年的身体形态、生理功能、身体素质、心理素质、社会适应5个方面阐述家庭体育的重要性。研究发现家庭体育对青少年学生运动行为的影响主要从内在因素和外在因素分析,内在因素表现在家庭父母、家庭情况、家庭环境;... 详细信息

运用文献资料法,从青少年的身体形态、生理功能、身体素质、心理素质、社会适应5个方面阐述家庭体育的重要性。研究发现家庭体育对青少年学生运动行为的影响主要从内在因素和外在因素分析,内在因素表现在家庭父母、家庭情况、家庭环境;外在因素表现在学校体育的制约和社区体育的制约。为此提出青少年学生家庭体育运动行为的策略研究建议应加大对家庭体育的宣传,转变体育观念,提高父母对青少年学生体育活动参与重要性的认识;从城乡两地出发,加大青少年公共服务组织建设;融合家庭、学校、社区体育一体化发展,构建青少年学生体育参与家庭培养体系。

关键词：青少年体育锻炼家庭体育

湖北省青少年竞技体育后备人才培养保障体系发展研究

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四川体育科学 2016年第4期35卷 26-29页

作者：陈肖李恩荆华中师范大学体育学院湖北武汉430079 湖南师范大学体育学院湖南长沙410000

运用文献资料法以及归纳总结研究方法,从科学选材训练保障、资金保障、教育保障、医疗保险保障、退役保障等方面入手,对湖北省青少年竞技体育后备人才培养保障体系进行分析,发现湖北省青少年体育后备人才保障体系存在结构不合理,学训结... 详细信息

运用文献资料法以及归纳总结研究方法,从科学选材训练保障、资金保障、教育保障、医疗保险保障、退役保障等方面入手,对湖北省青少年竞技体育后备人才培养保障体系进行分析,发现湖北省青少年体育后备人才保障体系存在结构不合理,学训结合受困于现实难境,补助资金投入不足影响实施效果,人力资本产权缺乏重视,体育保障法制化有待提高等问题。为此提出湖北省青少年后备人才保障体系改革应结合湖北省自身的发展,从实际出发,向体育保障的广度和深度挖掘,延伸教育系统的保障作用,加强体育商业保险公司及机构的建设和管理,完善法律法规等相关措施。坚持"以人为本",切实保障湖北省青少年竞技体育后备人才的利益,以此推动湖北省青少年竞技体育后备人才的可持续发展。

关键词：青少年竞技体育后备人才保障

第十三届全运会柔力球竞技单打运动员技术特征分析

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武汉体育学院学报 2020年第2期54卷 65-72页

作者：李恩荆李艳翎陈毅林杨建英湖南师范大学体育学院湖南长沙410006 华中师范大学体育学院湖北武汉430079 浙江经贸职业技术学院基础部浙江杭州310028

柔力球运动员技术水平是决定其竞技能力和运动成绩的关键因素。该研究采用文献资料法、视频统计法、专家访谈法和数理统计法,对目前代表该项目最高竞技水平的第十三届全运会竞技柔力球比赛,男单和女单八强选手的24场比赛的技术使用率、... 详细信息

柔力球运动员技术水平是决定其竞技能力和运动成绩的关键因素。该研究采用文献资料法、视频统计法、专家访谈法和数理统计法,对目前代表该项目最高竞技水平的第十三届全运会竞技柔力球比赛,男单和女单八强选手的24场比赛的技术使用率、落点、得失分和拍次等特征进行统计与分析,深入探索男单和女单选手的技术优缺点与异同点。结论:(1)发球方面,男单以正手发网前球为主,女单以正手发高远球为主,但发球技术的稳定性、落点的准确性、发高远球的高度和远度都有待提升。(2)接发球方面,男单和女单都主要以高接低抛进行前后调动和网前左右调动为主,且男单的抢攻得分能力更为突出。但不论防守还是利用旋转球高点进攻,都存在回球线路单一的问题。(3)相持球方面,男单和女单多以高接低抛进行前后调动和网前左右调动为主,但打法上都偏向保守,进攻意识偏弱。(4)男女得分主要来源于对手的非受迫性失误,失分的主要是自身的非受迫性失误。

关键词：柔力球竞技全运会技术运用得失分特征

二茂铁杂环类化合物的合成及抗三阴性乳腺癌活性研究

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中国现代应用药学 2018年第3期35卷 345-351页

作者：谭娟陈灵彭安林肖静张恩景武汉大学附属同仁医院武汉市第三医院药学部武汉430060

目的设计、合成杂环二茂铁衍生物,并研究其抗三阴性乳腺癌活性。方法以二茂铁查耳酮为先导化合物,对其进行结构改造,合成了一系列含有杂环的二茂铁衍生物,并通过CCK8试剂盒测试化合物抗乳腺癌活性。结果合成了28个二茂铁衍生物,其结构... 详细信息

目的设计、合成杂环二茂铁衍生物,并研究其抗三阴性乳腺癌活性。方法以二茂铁查耳酮为先导化合物,对其进行结构改造,合成了一系列含有杂环的二茂铁衍生物,并通过CCK8试剂盒测试化合物抗乳腺癌活性。结果合成了28个二茂铁衍生物,其结构均通过1H-NMR和MS加以确证。初步的生物活性测试结果表明,所合成的二茂铁衍生物对三阴性乳腺癌MDA-MB-231细胞有较强的选择性和抑制活性,其中咪唑杂环化合物抗肿瘤活性强于相应的吡唑类和嘧啶化合物。尤其是28a[IC50=(1.6±0.23)μmol·L^(-1)]对MDA-MB-231的抑制活性分别是先导化合物3[IC50=(10.7±1.41)μmol·L^(-1)]和他莫昔芬[IC50=(13.7±1.17)μmol·L^(-1)]的6和10倍,同时这些二茂铁衍生物对正常乳腺上皮细胞MCF-10A均没有毒性。结论本研究为开发具有抗三阴性乳腺癌活性的化合物提供了信息和依据。

关键词：二茂铁衍生物合成抗三阴性乳腺癌