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Strategies that regulate LSD1 for novel therapeutics

Acta Pharmaceutica Sinica B 2024年第4期14卷 1494-1507页

作者： Meng Li Mengge Dai Bing Cheng Shaotong Li enhui Guo Junwei Fu Ting ma Bin Yu School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450000China Pingyuan Laboratory State Key Laboratory of Antiviral DrugsHenan Normal UniversityXinxiang 453007China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Histone methylation plays crucial roles in regulating chromatin structure and gene transcrip-tion in epigenetic modifications.Lysine-specific demethylase 1(LSD1),the first identified histone de-methylase,is universally overexpressed in various diseases.LSD1 dysregulation is closely associated with cancer,viral infections,and neurodegenerative diseases,etc.,making it a promising therapeutic target.Several LSD1 inhibitors and two small-molecule degraders(UM171 and BEA-17)have entered the clinical stage.LSD1 can remove methyl groups from histone 3 at lysine 4 or lysine 9(H3K4 or H3K9),resulting in either transcription repression or activation.While the roles of LSD1 in transcrip-tional regulation are well-established,studies have revealed that LSDl can also be dynamically regulated by other factors.For example,the expression or activity of LSD1 can be regulated by many proteins that form transcriptional corepressor complexes with LSD1.Moreover,some post-transcriptional modifica-tions and cellular metabolites can also regulate LSD1 expression or its demethylase activity.Therefore,in this review,we will systematically summarize how proteins involved in the transcriptional corepressor complex,various post-translational modifications,and metabolites act as regulatory factors for LSD1 ac-tivity.

关键词： LSD1 regulation Transcription repression Transcription activation the Corepressor complex Post-transcriptional modifications Metabolites

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Chemical-NIR dual-powered CuS/Pt nanomotors for tumor hypoxia modulation,deep tumor penetration and augmented synergistic phototherapy

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Journal of materials Science & Technology 2023年第17期148卷 171-185页

作者： Wenjun Wang enhui ma Pengyu Tao Xiaoyu Zhou Yujuan Xing Liang Chen Yingying Zhang Jingjing Li Kai Xu Hong Wang Shaohui Zheng School of Medical Imaging Xuzhou Medical UniversityXuzhou 221006China School of Chemical Engineering&Technology China University of Mining and TechnologyXuzhou 221116China Department of Radiology Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004China

The complex tumor microenvironment(TME)with the characteristics of severe hypoxia,enriched hydro-gen peroxide(H_(2)O_(2))and dense nature significantly restricted the therapeutic efficacy of nanomedicine in cancer treatment.Synthetic micro/nanomotors have shown multiple versatility in modulating the abnor-mal TME and overcoming the limited penetration in solid tumor.Herein,we constructed a chemical-NIR dual-propelled nanomotor based on CuS/Pt Janus nanoparticles with IR820 encapsulation for hypoxia alle-viation,deep tumor penetration and augmented synergistic photodynamic(PDT)and photothermal ther-apy(PTT).The deposited Pt effectively catalyzed tumor endogenous H_(2)O_(2) into oxygen,which extremely relieved the tumor hypoxia state and allowed the chemical propulsion of nanomotors.Under NIR irra-diation,the Janus nanomotors exhibited more obvious movement via efficient photothermal conversion.Such autonomous motion significantly improved the tumoral accumulation of nanomotors and facilitated much deeper penetration inside tumor in vivo.In addition,enriched oxygen also promoted the genera-tion of reactive oxygen species(ROS)for augment of PDT,which achieved satisfied antitumor effect in combination with the PTT treatment.Therefore,this strategy based on CuS/Pt Janus nanomotors would provide an innovative dimension for considerable applications in effective cancer management.

关键词： CuS/Pt Janus nanomotors Chemical-NIR dual-propulsion Deep tumor penetration Hypoxia alleviation Synergistic PDT and PTT

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考虑动态能耗的无人机采收菠萝田间收集点优化配置研究

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沈阳农业大学学报 2024年第3期55卷 343-353页

作者：马瑞峻马宏震伍恩慧陈瑜李呈辉洪苑乾华南农业大学工程学院广州510642

为了深化无人机在田间菠萝采收和运输过程中的应用,探索无人机悬停放置菠萝到收集箱中的技术方案。无人机的续航能力限制菠萝采收工作的完成,而对续航能力影响最大的因素是无人机的载重,提出在田间设立菠萝收集点,并确定收集点的最优设... 详细信息

为了深化无人机在田间菠萝采收和运输过程中的应用,探索无人机悬停放置菠萝到收集箱中的技术方案。无人机的续航能力限制菠萝采收工作的完成,而对续航能力影响最大的因素是无人机的载重,提出在田间设立菠萝收集点,并确定收集点的最优设立数量及位置,以确保菠萝采收工作的有效完成。在研究方法上,基于K-means算法寻找最佳收集点位置及分组方式,建立无人机采收菠萝的能耗及成本模型,通过编写程序对模型进行求解,并以无人机续航能力为约束条件,确定了无人机采收菠萝的最大覆盖范围和菠萝采摘数量。通过比较不同设立数量和位置的收集点方案,得出综合最优的结果。在不更换无人机电池的情况下,1台农业无人机采收菠萝约480个,采收面积约44m^(2)。随着收集点设立数量增加,无人机总路程和总能耗呈稳步下降状态,总成本呈稳步上升状态,分析发现667 m^(2)菠萝地设立15个固定位置的收集点时总能耗、总路程和总成本达到均衡最优。无人机采收菠萝的收集点配置优化方案,可为应用无人机进行田间作物采收及运输时收集点的数量和选址提供建设性意见。

关键词：菠萝农业无人机动态能耗收集点配置续航能力

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Pt/Beta催化剂上Pt金属中心/酸中心浓度比对加氢异构化性能的影响

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石油学报（石油加工） 2024年第1期40卷 12-22页

作者：郭凯马爱增罗一斌王子健邢恩会李金芝李大东中石化石油化工科学研究院有限公司北京100083

以工业Beta沸石为载体,负载不同含量的Pt,得到了不同金属中心/酸中心浓度比(c_(M)/c_(A))的催化剂,对其进行物化表征,并以正庚烷为模型化合物对不同c_(M)/c_(A)催化剂进行异构化反应性能评价。结果表明:Pt粒子均匀地负载在沸石的外表面... 详细信息

以工业Beta沸石为载体,负载不同含量的Pt,得到了不同金属中心/酸中心浓度比(c_(M)/c_(A))的催化剂,对其进行物化表征,并以正庚烷为模型化合物对不同c_(M)/c_(A)催化剂进行异构化反应性能评价。结果表明:Pt粒子均匀地负载在沸石的外表面上,对沸石结构没有影响,酸性略有下降。对于催化剂的正庚烷异构化反应活性,当催化剂c_(M)/c_(A)小于0.037时,反应过程由金属中心数量控制,产生大量多支链异构体产物和裂化产物;当c_(M)/c_(A)大于0.285时,反应过程由酸中心数量控制,有氢解反应发生。在反应压力为0.4 MPa、反应温度为207℃、质量空速为1.0 h^(-1)、氢/烃摩尔比为5、催化剂质量为1.0 g的条件下,当催化剂c_(M)/c_(A)为0.266、正庚烷转化率为70.75%时,异构体总选择性为95.14%,总收率为67.31%,其中多支链异构体收率为15.63%,裂化产物收率低于5%。

关键词： Beta沸石异构化反应 Pt含量正庚烷金属中心酸中心

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On the collection and integration of SARS-CoV-2 genome data

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生物安全与健康(英文) 2023年第4期5卷 204-210页

作者： Lina ma Wei Zhao Tianhao Huang enhui Jin Gangao Wu Wenming Zhao Yiming Bao China National Center for Bioinformation Beijing 100101China National Genomics Data Center&CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Genome data of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential for virus diagnosis,vaccine development,and variant surveillance.To archive and integrate worldwide SARS-CoV-2 genome data,a series of resources have been constructed,serving as a fundamental infrastructure for SARS-CoV-2 research,pandemic prevention and control,and coronavirus disease 2019(COVID-19)therapy.Here we present an over-view of extant SARS-CoV-2 resources that are devoted to genome data deposition and integration.We review deposition resources in data accessibility,metadata standardization,data curation and annotation;review integrative resources in data source,de-redundancy processing,data curation and quality assessment,and variant annotation.Moreover,we address issues that impede SARS-CoV-2 genome data integration,including low-complexity,inconsistency and absence of isolate name,sequence inconsistency,asynchronous update of genome data,and mismatched metadata.We finally provide insights into data standardization consensus and data submission guidelines,to promote SARS-CoV-2 genome data sharing and integration.

关键词： SARS-CoV-2 resource Genome data Data deposition Data integration Data curation

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Monodomain Liquid Crystals of Two-Dimensional Sheets by Boundary-Free Sheargraphy

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Nano-Micro Letters 2022年第12期14卷 14-26页

作者： Min Cao Senping Liu Qingli Zhu Ya Wang Jingyu ma Zeshen Li Dan Chang enhui Zhu Xin Ming Yingjun Liu Yanqiu Jiang Zhen Xu Chao Gao MOE Key Laboratory of macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang ProvinceZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China Shanxi-Zheda Institute of Advanced materials and Chemical Engineering TaiyuanPeople’s Republic of China State Key Lab of Chemical Engineering College of Chemical and Biological EngineeringZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China

Eliminating topological defects to achieve monodomain liquid crystals is highly significant for the fundamental studies of soft matter and building long-range ordered materials.However,liquid crystals are metastable and sensitive to external stimuli,such as flow,confinement,and electromagnetic fields,which cause their intrinsic polycrystallinity and topological defects.Here,we achieve the monodomain liquid crystals of graphene oxide over 30 cm through boundary-free sheargraphy.The obtained monodomain liquid crystals exhibit large-area uniform alignment of sheets,which has the same optical polarized angle and intensity.The monodomain liquid crystals provide bidirectionally ordered skeletons,which can be applied as lightweight thermal management materials with bidirectionally high thermal and electrical conductivity.Furthermore,we extend the controllable topology of two-dimensional colloids by introducing singularities and disclinations in monodomain liquid crystals.Topological structures with defect strength from−2 to+2 were realized.This work provides a facile methodology to study the structural order of soft matter at a macroscopic level,facilitating the fabrication of metamaterials with tunable and highly anisotropic architectures.

关键词： Monodomain Liquid crystals Graphene oxide Boundary-free sheargraphy Topological structure

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RCoV19:A One-stop Hub for SARS-CoV-2 Genome Data Integration,Variant Monitoring,and Risk Pre-warning

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Genomics, Proteomics & Bioinformatics 2023年第5期21卷 1066-1079页

作者： Cuiping Li Lina ma Dong Zou Rongqin Zhang Xue Bai Lun Li Gangao Wu Tianhao Huang Wei Zhao enhui Jin Yiming Bao Shuhui Song National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 100049China

The Resource for Coronavirus 2019(RCoV19)is an open-access information resource dedicated to providing valuable data on the genomes,mutations,and variants of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).In this updated implementation of RCoV19,we have made significant improvements and advancements over the previous version.Firstly,we have implemented a highly refined genome data curation model.This model now features an automated integration pipeline and optimized curation rules,enabling efficient daily updates of data in RCoV19.Secondly,we have developed a global and regional lineage evolution monitoring platform,alongside an outbreak risk pre-warning system.These additions provide a comprehensive understanding of SARS-CoV-2 evolution and transmission patterns,enabling better preparedness and response strategies.Thirdly,we have developed a powerful interactive mutation spectrum comparison module.This module allows users to compare and analyze mutation patterns,assisting in the detection of potential new lineages.Furthermore,we have incorporated a comprehensive knowledgebase on mutation effects.This knowledgebase serves as a valuable resource for retrieving information on the functional implications of specific mutations.In summary,RCoV19 serves as a vital scientific resource,providing access to valuable data,relevant information,and technical support in the global fight against COVID-19.The complete contents of RCoV19 are available to the public at https://***/ncov/.

关键词： SARS-CoV-2 Mutation Variants Surveillance Pre-warning

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路用蓄盐除冰纤维配比设计及除冰性能确定

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交通科技与经济 2024年第1期26卷 51-56页

作者：阳恩慧廖苑淞张晓靖李杰马博男袁飞云邱延峻西南交通大学土木工程学院成都610031 西南交通大学道路工程四川省重点实验室成都610031 四川雅康高速公路有限责任公司成都610041 四川高速公路建设开发集团有限公司成都610041

为解决道路凝冰问题,基于环保、经济、实用等原则,针对适用于沥青路面主动抗凝冰的蓄盐纤维填料的配合比进行设计,并对其相关性能展开研究。通过基于单纯形重心设计的融冰试验和电导率试验对蓄盐除冰材料配比进行探究,并基于融冰试验和... 详细信息

为解决道路凝冰问题,基于环保、经济、实用等原则,针对适用于沥青路面主动抗凝冰的蓄盐纤维填料的配合比进行设计,并对其相关性能展开研究。通过基于单纯形重心设计的融冰试验和电导率试验对蓄盐除冰材料配比进行探究,并基于融冰试验和冻粘剪切试验分析其除冰性能。试验结果表明:选用乙酸钠∶乙酸钾∶甲酸钠=7∶2∶1、复合有机盐∶纤维=3∶1为蓄盐纤维各种成分的最佳配合比;在融冰试验中,蓄盐纤维替换率为66%的除冰材料在较高负温下融冰速率能达到1022 g·(h·m 2)-1,表明其融冰性能良好;凝冰后,蓄盐纤维沥青混合料表面冻粘强度比普通沥青混合料下降33%,能够有效降低冻粘强度。基于最佳配合比,新型路用环保蓄盐除冰材料具有良好的融冰能力和除冰降粘功效。

关键词：道路工程蓄盐除冰融冰试验沥青混合料冻粘强度

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Bifunctional hierarchical NiCoP@FeNi LDH nanosheet array electrocatalyst for industrial-scale high-current-density water splitting

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Journal of materials Science & Technology 2023年第28期159卷 33-40页

作者： Liming Yang Tao Yang enhui Wang Xiangtao Yu Kang Wang Zhentao Du Sheng Cao Kuo-Chih Chou Xinmei Hou Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China MOE Key Laboratory of New Processing Technology for Non-ferrous Metals and materials Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured MaterialsGuangxi UniversityNanning 530004China

Aiming to design and prepare non-noble metal electrocatalysts for hydrogen production at high current density(HCD),NiCoP@FeNi LDH hierarchical nanosheets were deposited on nickel foam progressively us-ing a hydrothermal-phosphorization-electrodeposition process.For hydrogen evolution reaction(HER)and oxygen evolution reaction(OER),NiCoP@FeNi LDH/NF requires only 195 and 230 mV overpotentials to reach 1000 ma cm−2,respectively.For overall water splitting,only 1.70 V is required at 1000 ma cm−2.This is the largest value for non-noble metal-based electrocatalysts reported so far at HCD.The hierarchi-cal structure exhibits good electron transport capability and the porous-macroporous structure enhances the gas release rate,resulting in enhanced hydrogen production at HCD.Especially,the synergistic effect of NiCoP and FeNi LDH contributes to the adsorption-desorption equilibrium of intermediate radicals dur-ing the reaction process and ultimately enhances the catalytic activity.This work provides useful direction for industrial-scale hydrogen production applications at HCD.

关键词： High-current-density Overall water splitting Hydrogen evolution reaction Oxygen evolution reaction

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常见酵母表达系统的菌株及其在猪用疫苗研制中的应用

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福建畜牧兽医 2024年第3期46卷 28-32页

作者：侯恩慧陈秋勇邱镜莉连春红吴学敏马玉芳周伦江王隆柏福建省农业科学院畜牧兽医研究所/福建省畜禽疫病防治工程技术研究中心福州350013 福建农林大学动物科学学院福州350002

近年来,猪类疫病病毒不断发生变异,给全球生猪养殖业造成了巨大的经济损失,疫苗作为最有效的防控手段,其基因工程疫苗研究工作备受关注。本文总结常见酿酒酵母、汉逊酵母和毕赤酵母表达系统菌株的优势及其在猪用疫苗研制中的应用,为今... 详细信息

近年来,猪类疫病病毒不断发生变异,给全球生猪养殖业造成了巨大的经济损失,疫苗作为最有效的防控手段,其基因工程疫苗研究工作备受关注。本文总结常见酿酒酵母、汉逊酵母和毕赤酵母表达系统菌株的优势及其在猪用疫苗研制中的应用,为今后酵母表达系统在研制猪用疫苗方面提供理论参考。

关键词：酵母菌酵母载体系统猪用疫苗

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