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[Determination of 12 halogenated organic pollutants in edible fish by ultra performance liquid chromatography-high resolution mass spectrometry combined with ultrasound-assisted extraction and gel permeation chromatography purification]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 68-77页

作者： Yi-Zhe Zhu Rui-Fen Zheng Zi-Hao fan Ling Liu Jing-Yao Ye Kai Wang Cai-Ming Tang Research Center for Eco-Environmental Engineering Dongguan University of Technology Dongguan 523808 China. Guangdong Key Laboratory of Environmental Resources Utilization and Protection Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China.

Halogenated organic pollutants (HOPs) have attracted considerable attention owing to their persistence, bioaccumulation, and toxicity. The development of methods to detect HOPs in fish is challenging owing to the compositional complexity of fish matrices, which contain high levels of lipids and relatively low concentrations of HOPs. In addition, the lipophilicity of most HOPs renders their extraction difficult. Moreover, the simultaneous determination of multiple HOPs to achieve the high-throughput screening of these analytes is complex. In this study, a reliable and efficient pretreatment method based on ultrasound-assisted extraction, gel permeation chromatography purification, and ultra performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) was developed for the determination of 12 HOPs in edible fish. The procedures of sample extraction and purification and LC-HRMS detection parameters were optimized to improve the performance of the method. Fresh fish samples were thoroughly rinsed with water, and non-edible parts, including the skin, bones, and phosphorus, were removed. The fish were weighed, cut into small pieces, and vacuum freeze-dried for 48 h. Subsequently, a freeze grinder was used to grind the dried fish into a fine powder. Exactly 2 g of the fish powder was weighed, fortified with isotope-labeled internal standards of the HOPs, and allowed to stand for 5 min. Methanol-acetonitrile (1∶1, v/v) was then added, followed by vortex mixing and ultrasonication. After centrifugation, the supernatant was transferred to a fresh tube. The extraction process was repeated twice and all extracts were combined. The extract was evaporated under a gentle nitrogen flow and redissolved in a mixture of ethyl acetate-cyclohexane (1∶1, v/v). The sample mixture was cleaned using gel permeation chromatography, and the eluate was collected and concentrated under a nitrogen flow. Sample residuals were reconstituted with water-methanol (1∶1, v/v) prior to

关键词： edible fish gel permeation chromatography (GPC) halogenated organic pollutants (HOPs) ultra performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS)

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei Shu-Hui fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Flight dynamics modeling of a small ducted fan aerial vehicle based on parameter identifcation

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Chinese Journal of Aeronautics 2013年第6期26卷 1439-1448页

作者： Wang Zhengjie Liu Zhijun fan Ningjun Guo Meifang School of Mechatronical Engineering Beijing Institute of Technology North Institute for Science & Technical Information

This paper presents a simple and useful modeling method to acquire a dynamics model of an aerial vehicle containing unknown parameters using mechanism modeling,and then to design different identifcation experiments to identify the parameters based on the sources and features of its unknown *** on the mathematical model of the aerial vehicle acquired by modeling and identifcation,a design for the structural parameters of the attitude control system is carried out,and the results of the attitude control flaps are verifed by simulation experiments and flight tests of the aerial *** of the mathematical simulation and flight tests show that the mathematical model acquired using parameter identifcation is comparatively accurate and of clear mechanics,and can be used as the reference and basis for the structural design.

关键词： Aerodynamics Experimental aerodynamics Flight vehicle design Multidisciplinary design optimization Structural design

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Automatic and Rapid Throughflow-Based Optimal Design Method for Multi-Stage Axial-Flow Compressors

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Journal of Thermal Science 2025年第1期 77-91页

作者： LEI fan ZHANG Xiawen JU Yaping ZHANG Chuhua Department of Fluid Machinery and Engineering School of Energy and Power EngineeringXi'an Jiaotong University Production and Environmental Department China Huaneng Group.Co.Ltd. State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Jiaotong University

Throughflow design has the advantages of less time consumption and large optimization space,and thus is the corner stone of advanced design system of multi-stage axial-flow *** majority of relevant studies were limited to the throughflow inverse designs,and quite few works have been till now devoted to the throughflow optimal *** this work,an automatic and rapid throughflow-based optimal design method is proposed for axial-flow compressors in which a throughflow inverse design solver is embedded in optimal genetic algorithm to improve the design efficiency of axial-flow *** types of design parameters in the throughflow inverse design of axial-flow compressors,i.e.,swirl and shroud curve,are simultaneously used to optimize both the blade shape and flow *** proposed method is validated by the redesign optimization of the benchmark axial-flow compressor NASA Stage 35,and the CFD predictions show that the throughflow-based optimization leads to 1.18% efficiency benefit at design *** proposed method is then utilized to the two-dimensional throughflow optimal design of a large-scale 6.5-stage axial-flow industrial *** optimal design results are confirmed by CFD predictions,indicating that the proposed method can effectively improve the design adiabatic efficiency of the compressors by 1.09% within a few minutes on desk-top *** throughflow design implications are also obtained for advanced axial-flow industrial *** work could enhance the capability of throughflow design method and has engineering application value to explore the throughflow optimization space of multi-stage axial-flow compressors.

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外柔内刚,鲠直持正,秉持气节——明清江南士大夫人文精神的一个面相

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史学集刊 2025年第1期 52-62页

作者：范金民张彭欣南京大学历史学院江苏南京210023

人们心目中的江南士大夫形象,无论峨冠博带的饱学之士,擅长鸿篇巨制的文学侍从之臣,还是娴熟典故参赞朝政的藻饰能手,能言善辩的博雅君子,似乎儒雅有之而缺乏胆气,温婉有之而少阳刚之气,小心谨慎有余而开拓进取殊少,驰骋疆场斩将搴旗者... 详细信息

人们心目中的江南士大夫形象,无论峨冠博带的饱学之士,擅长鸿篇巨制的文学侍从之臣,还是娴熟典故参赞朝政的藻饰能手,能言善辩的博雅君子,似乎儒雅有之而缺乏胆气,温婉有之而少阳刚之气,小心谨慎有余而开拓进取殊少,驰骋疆场斩将搴旗者更加罕见。这其实只是江南士大夫治国理政、行为出入的一个面相,远非江南士大夫人文精神的基本面貌。江南士大夫外表貌似柔弱,内心实无比强大,态度似乎和顺,意志则极为坚定,往往是外柔内刚,力重千钧。他们学养丰厚,恂恂儒雅,其实是非分明,原则问题绝不退让;其谈吐多温文尔雅,少见其过激举动,但事关国家兴亡和社稷安危等大事,则虽九死而不悔,多能置生死利害而不顾。

关键词：明清江南士大夫人文面相外柔内刚

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高速公路对绿色经济效率的影响分析--基于产业结构优化视角

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生态经济 2025年第1期41卷 114-122页

作者：樊建强谢靖雯长安大学经济与管理学院陕西西安710064

当前中国高速公路建设布局日趋完善,探究如何发挥其对地区产业结构优化的有力支持,进而助力绿色经济发展转型具有重要意义。论文基于2006—2019年中原城市群27个城市的面板数据,运用超效率SBM模型测算其绿色经济效率,从产业结构优化的... 详细信息

当前中国高速公路建设布局日趋完善,探究如何发挥其对地区产业结构优化的有力支持,进而助力绿色经济发展转型具有重要意义。论文基于2006—2019年中原城市群27个城市的面板数据,运用超效率SBM模型测算其绿色经济效率,从产业结构优化的视角实证分析了高速公路对绿色经济效率的影响,并以产业结构优化为中介与门槛变量,进一步探讨产业结构优化对于高速公路影响绿色经济效率的门槛效应。研究结果表明:中原城市群高速公路与绿色经济效率间呈现先抑制后促进的“U”型关系;产业结构优化在高速公路和绿色经济效率间发挥部分中介作用;产业结构优化存在单一门槛效应,随着产业结构优化水平的提升,高速公路对绿色经济效率由抑制作用转为促进作用。

关键词：绿色经济效率高速公路产业结构优化超效率SBM 中原城市群

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基于Radix-4 Booth编码的并行乘法器设计

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郑州大学学报（工学版） 2025年第1期46卷 26-33页

作者：范文兵周健章郑州大学电气与信息工程学院河南郑州450001

速度和面积是评价乘法器单元性能优劣的两个基本指标。针对当前乘法器设计难以平衡版图面积和传输延时的问题,采用Radix-4 Booth算法,设计了一种新型的16位有符号定点乘法器。在部分积生成过程中,首先改进对乘数的取补码电路,然后优化... 详细信息

速度和面积是评价乘法器单元性能优劣的两个基本指标。针对当前乘法器设计难以平衡版图面积和传输延时的问题,采用Radix-4 Booth算法,设计了一种新型的16位有符号定点乘法器。在部分积生成过程中,首先改进对乘数的取补码电路,然后优化基数为4的改进Booth编码器和解码器,此结构采用较少的逻辑门资源,并且易对输入比特进行并行化处理。在Wallace压缩电路中,对符号扩展位进行预处理并设计新的压缩器结构,优化整个Wallace压缩模块。在第二级压缩过程中提前对高位使用纹波进位加法器结构计算,减小了多bit伪和的求和位数。在求和电路中,使用两级超前进位加法器结构,在缩短关键路径传输延时的同时避免增大芯片面积,提高了乘法器的运行速度。新型定点乘法器与已有的乘法器结构相比,减少了12.0%的面积,降低了20.5%的延时。

关键词： Radix-4 Booth编码面积传输延时编码器解码器 Wallace压缩

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血管化类器官的构建策略

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中国组织工程研究 2025年第13期29卷 2774-2783页

作者：刘明昱范文娟海南医学院海南省海口市571199 漯河医学高等专科学校河南省漯河市462002

背景:有效促进类器官内部血管发生是目前类器官培养中的焦点问题,作为一种新近发展的生物培养技术,血管化的类器官在研究活体组织的发育、疾病形成的机制、组织替代疗法以及药物筛选等方面,都有很大的研究和应用价值。目的:对近年来类... 详细信息

背景:有效促进类器官内部血管发生是目前类器官培养中的焦点问题,作为一种新近发展的生物培养技术,血管化的类器官在研究活体组织的发育、疾病形成的机制、组织替代疗法以及药物筛选等方面,都有很大的研究和应用价值。目的:对近年来类器官血管化的方法或策略进行归纳总结,分析类器官血管化形成机制以及构建策略,以期为更加深入地研究类器官的发生机制和为临床转化提供可靠的思路。方法:检索PubMed及中国知网数据库收录的相关文献。英文检索词为“organoids,Vascularization,Vascular,Vascular development,vessel”,中文检索词为“血管发生,血管生成,类器官,干细胞,血管化,预血管化”,最终纳入77篇文献进行归纳总结。结果与结论:①类器官血管化形成机制涉及3个关键因素,即种子细胞、细胞因子与细胞外基质。种子细胞为血管化类器官提供了关键的细胞来源,细胞因子为类器官内部的血管发生起了重要的信号引导作用,细胞外基质为血管细胞提供了外在的生长环境,促进类器官血管化的发生。②血管化类器官的构建策略包括细胞自我重组、微血管碎片渗入、宿主体内移植以及微流控芯片等。体外诱导多能干细胞向血管内皮祖细胞分化能顺利与邻近组织整合并具有血管生成的潜力,故可利用多能干细胞的自我重组功能构建血管化类器官。微血管碎片保留了其细胞复杂性、天然结构和表型可塑性,更利于模拟天然微血管从而促进类器官的血管化。宿主体内移植是目前类器官实现完整血液灌流的最佳方法,而微流控芯片则为实现类器官体外血液供应提供了解决方案。③类器官的多种构建策略如多类干细胞共分化、信号分子的精准调控、微血管渗入和活体宿主移植等,一定程度上在类器官中引入血管成分,使得类器官在功能和成熟度上更接近相应组织。然而缺乏血流灌注仍然是一个难题,迄今为止,仅宿主体内移植才能在类器官中实现有效的血流灌注,因此类器官在血管化方面仍面临许多挑战。

关键词：类器官血管化血管发生自我重组共培养种子细胞体内移植内皮细胞干细胞综述

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A novel approach to the attitude stabilization structure for ducted-fan operative aerial robots:Finding improvements for modeling error and strong external transient disturbance

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Chinese Journal of Aeronautics 2022年第2期35卷 250-264页

作者： Wei fan Bin XU Changle XIANG Yibo ZHANG Haiyang YANG School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401135China School of Automation Beijing Institute of TechnologyBeijing 100081China

This research concerns a novel attitude stabilization structure for a ducted-fan aerial robot to work against modeling error and strong external transient disturbance,and it focuses on two main control targets:modeling error compensation,and the improvement of disturbance resistance along the rolling *** the first research objective,we proposed an adaptive nominal controller with the reconfigurable control law design based on the estimation of the modeling error found in the *** of simulations and corresponding flight tests verified that the proposed adaptive control structure is robust against both constant and time-varying modeling *** the other research objective,a SAC(Stability Augmentation Control)structure was devised based on the CMG(Control Moment Gyroscope)theory in order to provide extra moment which effectively withstands the transient disturbance beyond the CDG(Critical Disturbance Gain).Furthermore,we studied the corresponding controller for the SAC via the SMC(sliding mode control)theory,while the working mechanism and performance of the SAC were verified through a specially devised prototype.

关键词： Adaptive control Disturbance rejection Ducted-fan aircraft Modeling error Stability augmentation systems

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单原子Pt负载在锐钛矿(001)表面的电光学特性研究

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原子与分子物理学报 2025年第6期42卷 43-50页

作者：靳帆赵志超运城学院应用化学系运城044000 运城学院科研产业部运城044000

基于第一性原理的多体格林函数理论方法,系统探究了锐钛矿TiO_(2)(001)表面负载Pt单原子催化剂的电子结构和光学性质,考虑Pt在完美表面和缺陷表面(O空位)两种基底上的负载.结果发现,Pt会在TiO_(2)禁带中间、价带和导带边缘引入新能级,... 详细信息

基于第一性原理的多体格林函数理论方法,系统探究了锐钛矿TiO_(2)(001)表面负载Pt单原子催化剂的电子结构和光学性质,考虑Pt在完美表面和缺陷表面(O空位)两种基底上的负载.结果发现,Pt会在TiO_(2)禁带中间、价带和导带边缘引入新能级,但不同基底负载的Pt单原子催化剂存在不同的带隙特性.Pt的负载会引起体系光学吸收红移,增大光学吸收范围,延伸光吸收至可见光甚至是红外区域,提升可见光活化的可能性,同时改善体系的激子束缚能,有利于空穴与电子有效分离,这可能是Pt负载后光催化性能提升的原因之一.然而,若在可见光或低能量紫外光激发后,分离的电子与空穴没有及时参与反应,体系衰变回最低激发态,此时极大的激子束缚能可能会加速电子与空穴重组,不利于表面催化反应的进行.负载在O空位的催化剂最低激发态的激子束缚能比完美表面小,重组速率慢.计算结果能够为理解单原子催化剂结构-性能关系提供一些见解.

关键词：二氧化钛 Pt单原子催化剂多体格林函数理论电子结构光吸收

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