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Analysis of core protein clusters identifies candidate variable sites conferring metronidazole resistance in Helicobacter pylori

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Gastroenterology Report 2019年第1期7卷 42-49,I0002页

作者： eng-guan chua Aleksandra W.Debowski KMary Webberley Fanny Peters Binit Lamichhane Mun-Fai Loke Jamuna Vadivelu Chin-Yen Tay Barry J.Marshall Michael J.Wise The Marshall Centre for Infectious Diseases Research and Training University of Western AustraliaPerthWestern AustraliaAustralia School of Biomedical Sciences Faculty of Health and Medical SciencesUniversity of Western AustraliaPerthWestern AustraliaAustralia Department of Medical Microbiology University of MalayaKuala LumpurWilayah PersekutuanMalaysia Shenzhen Dapeng New District Kuichong People Hospital ShenzhenGuangdongChina UM Marshall Centre University of MalayaKuala LumpurWilayah PersekutuanMalaysia School of Computer Science and Software engineering University of Western AustraliaPerthWestern AustraliaAustralia

Background:Metronidazole is one of the first-line drugs of choice in the standard triple therapy used to eradicate Helicobacter pylori ***,the global emergence of metronidazole resistance in Hp poses a major challenge to health *** of RdxA is known to be a major mechanism of conferring metronidazole resistance in ***,metronidazole resistance can also arise in *** strains expressing functional RdxA protein,suggesting that there are other mechanisms that may confer resistance to this ***:We performed whole-genome sequencing on 121 *** clinical strains,among which 73 were ***-alignment analysis of core protein clusters derived from clinical strains containing full-length RdxA was *** sites in each alignment were statistically compared between the resistant and susceptible groups to determine candidate genes along with their respective amino-acid changes that may account for the development of metronidazole resistance in ***:Resistance due to RdxA truncation was identified in 34%of metronidazole-resistant *** of core protein clusters derived from the remaining 48 metronidazole-resistant strains and 48 metronidazole-susceptible identified four variable sites significantly associated with metronidazole *** sites included R16H/C in RdxA,D85N in the inner-membrane protein RclC(HP0565),V265I in a biotin carboxylase protein(HP0370)and A51V/T in a putative threonylcarbamoyl–AMP synthase(HP0918).Conclusions:Our approach identified new potential mechanisms for metronidazole resistance in *** that merit further investigation.

关键词： Helicobacter pylori metronidazole antibiotic resistance whole-genome sequencing core protein clusters sequence alignment

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VEGO:A novel design towards customizable and adjustable head-mounted display for VR

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Virtual Reality & Intelligent Hardware 2020年第5期2卷 443-453页

作者： Jia Ming LEE Xinxing XIA Clemen OW Felix chua Yunqing guan Singapore Institute of Technology 138683Singapore Shanghai University Shanghai 200444China University of Glasgow 567739Singapore DigiPen Institute 139660Singapore

Background Virtual Reality(VR)technologies have advanced fast and have been applied to a wide spectrum of sectors in the past few *** can provide an immersive experience to users by generating virtual images and displaying the virtual images to the user with a head-mounted display(HMD)which is a primary component of ***,an HMD contains a list of hardware components,e.g.,housing pack,micro LCD display,microcontroller,optical lens,*** of VR HMD to accommodate the user's inter-pupil distance(IPD)and the user's eye focus power are important for the user's experience with *** Although various methods have been developed towards IPD and focus adjustments for VR HMD,the increased cost and complexity impede the possibility for users who wish to assemble their own VR HMD for various purposes,e.g.,DIY teaching,*** our paper,we present a novel design towards building a customizable and adjustable HMD for VR in a cost-effective *** design methodology is adopted,and the VR HMD can be easily printed with 3D *** design also features adjustable IPD and variable distance between the optical lens and the *** can help to mitigate the vergence and accommodation conflict *** A prototype of the customizable and adjustable VR HMD has been successfully built up with off-the-shelf components.A VR software program running on Raspberry Pi board has been developed and can be utilized to show the VR effects.A user study with 20 participants is conducted with positive feedback on our novel *** Modular design can be successfully applied for building up VR HMD with 3D *** helps to promote the wide application of VR at affordable costs while featuring flexibility and adjustability.

关键词： Virtual reality Head mounted display Vergence accommodation conflict Inter-pupil distanc

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Properties ofπ-skew Graphs with Applications

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Acta Mathematica Sinica,english Series 2021年第4期37卷 641-656页

作者： Zhang Dong OUYANG Feng Ming DONG Rui Xue ZHANG eng guan TAY School of Mathematics and Computational Sciences Hu’nan First Normal UniversityChangsha 410205P.R.China Mathematics and Mathematics Education National Institute of EducationNanyang Technological University637616Singapore

The skewness of a graph G,denoted by sk(G),is the minimum number of edges in G whose removal results in a planar *** is an important parameter that measures how close a graph is to planarity,and it is complementary,and computationally equivalent,to the Maximum Planar Subgraph *** any connected graph G on p vertices and q edges with girth g,one can easily verify that sk(G)≥π(G),whereπ(G)=[q−g/g−2(p−2)],and the graph G is said to beπ-skew if equality *** concept ofπ-skew was first proposed by *** and ***π-skew graphs with girth 3 are precisely the graphs that contain a triangulation as a spanning *** purpose of this paper is to explore the properties ofπ-skew *** families ofπ-skew graphs are obtained by applying these properties,including join of two graphs,complete multipartite graphs and Cartesian product of two *** also discuss the threshold for the existence of a spanning *** other results some sufficient conditions regarding the regularity and size of a graph,which ensure a spanning triangulation,are given.

关键词： Skewness of graph crossing number of graph Cartesian product join product π-skew

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Epinephrine injection therapy versus a combination of epinepnrine injection and endoscopic hemoclip in the treatment of bleeding ulcers

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World Journal of Gastroenterology 2005年第7期11卷 1044-1047页

作者： Tju-Siang chua Kwong-Ming Fock Tay-Meng Ng eng-Kiong Teo Jessica Yi-Lyn Tan Tiing-Leong Ang Division of Gastroenterology

AIM: To assess the efficacy of hemoclip application in combination with epinephrine injection in the treatment of bleeding peptic ulcers and to compare the clinical outcomes between patients treated with such a combination therapy and those treated with epinephrine injection ***: A total of 293 patients (211 males, 82females) underwent endoscopic therapy for bleeding peptic ulcers. Of these, 202 patients (152 males, 50females) received epinephrine injection therapy while 91patients (59 males, 32 females) received combination therapy. The choice of endoscopic therapy was made by the endoscopist. Hemostatic rates, rebleeding rates, need for emergency surgery and 30-d mortality were the outcome measures ***: Patients who received combination therapy were significantly older (mean age 66±16 years, range24-90 years) and more suffered from chronic renal failure compared to those who received epinephrine injection therapy alone (mean age 61±17 years, range 21-89 years).Failure to achieve permanent hemostasis was 4% in the group who received epinephrine injection alone and 11%in the group who received combination therapy. When the differences in age and renal function between the two treatment groups were taken into account by multivariate analysis, the rates of initial hemostasis,rebleeding rates, need for surgery and 30-d mortality for both treatment options were not significantly ***: Combination therapy of epinephrine injection with endoscopic hemoclip application is an effective method of achieving hemostasis in bleeding peptic ulcer diseases. However, superiority of combination therapy over epinephrine injection alone, could not be demonstrated.

关键词： Bleeding peptic ulcer Epinephrine Endoscopic hemoclip Combination therapy

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波浪条件下单桩冲刷大比尺试验研究

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清华大学学报（自然科学版） 2024年第4期64卷 619-625页

作者：宫恩宇陈松贵陈鑫张凯豪管大为郑金海中国农业大学水利与土木工程学院北京100083 天津水运工程科学研究院天津300456 中国农业大学北京市供水管网系统安全与节能工程技术研究中心北京100083 佛山恒益热电有限公司佛山528100 河海大学海岸灾害及防护教育部重点实验室南京210024

发展海上风电技术在国家“双碳”战略中具有重要意义,单桩冲刷深度的预测是海上风电单桩冲刷研究的热点。受比尺效应的影响,传统的小比尺物理模型通常会导致冲刷深度预测公式的适用性受到限制。为此,该文在1∶13的大比尺物理模型中开展... 详细信息

发展海上风电技术在国家“双碳”战略中具有重要意义,单桩冲刷深度的预测是海上风电单桩冲刷研究的热点。受比尺效应的影响,传统的小比尺物理模型通常会导致冲刷深度预测公式的适用性受到限制。为此,该文在1∶13的大比尺物理模型中开展了局部冲刷试验,研究了不规则波条件下,KC(Keulegan-Carpenter)为4~9时,单桩周围的平衡冲刷深度和冲刷坑体积。研究发现,通过改进KC的计算方法,能够提高现有公式在不规则波条件下预测平衡冲刷深度的准确度。此外,提出了单桩周围局部平衡冲刷深度和冲刷坑体积的公式,为单桩防护施工时的抛石冗余量估算提供了简便的预测方法。

关键词：大比尺试验 KC(Keulegan-Carpenter) 平衡冲刷深度冲刷坑体积

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Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review

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World Journal of Gastroenterology 2017年第20期23卷 3589-3606页

作者： Kuan-Yin Lin guan-Jhou Chen Yu-Lin Lee Yi-Chia Huang Aristine Cheng Hsin-Yun Sun Sui-Yuan Chang Chun-eng Liu Chien-Ching Hung Department of Medicine National Taiwan University Hospital Jin-Shan Branch Department of Internal Medicine National Taiwan University Hospital Department of Internal Medicine Changhua Christian Hospital National Taiwan University College of Medicine Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of Medicine Department of Laboratory Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Department of Parasitology National Taiwan University College of Medicine Department of Medical Research China Medical University Hospital China Medical University

Hepatitis A virus(HAV)is one of the most common infectious etiologies of acute hepatitis *** virus is known to be transmitted fecal-orally,resulting in symptoms ranging from asymptomatic infection to fulminant *** can also be transmitted through oral-anal *** from regions of low endemicity for HAV infection often remain susceptible in their ***,clustered HAV infections or outbreaks of acute hepatitis A among men who have sex with men and injecting drug users have been reported in countries of low endemicity for HAV *** duration of HAV viremia and stool shedding of HAV may be longer in human immunodeficiency virus(HIV)-positive individuals compared to HIV-negative individuals with acute hepatitis *** guidelines recommend HAV vaccination for individuals with increased risks of exposure to HAV(such as from injecting drug use,oral-anal sex,travel to or residence in endemic areas,frequent clotting factor or blood transfusions)or with increased risks of fulminant disease(such as those with chronic hepatitis).The seroconversion rates following the recommended standard adult dosing schedule(2doses of HAVRIX 1440 U or VAQTA 50 U administered6-12 mo apart)are lower among HIV-positive individuals compared to HIV-negative *** the response rates may be augmented by adding a booster dose at week 4 sandwiched between the first dose and the 6-mo dose,the need of booster vaccination remain less clear among HIV-positive individuals who have lost anti-HAV antibodies.

关键词： Epidemiology Viral hepatitis Acute hepatitis Fecal-oral transmission Oral-anal sex Men who have sex with men Injecting drug use Immunosuppression Immunization

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A comparison of the clinical, demographic and psychiatric profiles among patients with erosive and non-erosive reflux disease in a multi-ethnic Asian country

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World Journal of Gastroenterology 2005年第23期11卷 3558-3561页

作者： Tiing-Leong Ang Kwong-Ming Fock Tay-Meng Ng eng-Kiong Teo Tju-Siang chua Jessica Tan Division of Gastroenterology

AIM:To examine the clinical spectrum of gastroesophageal reflux disease (GERD) and compare erosive (ERD) with non-erosive (NERD) in terms of clinical, demographic and psychiatric profiles. METHODS: Patients with reflux symptoms were enrolled and stratified to NERD and ERD after endoscopy (LA classification). Patients with ERD presenting with dyspepsia were included. Patients on proton pump inhibitors (PPI) or H2 receptor antagonists before endoscopy were excluded. Demographic data, Helicobacter pylori(H pylori) status and presence of minor psychiatric morbidity (based on General Health Questionnaire-28) were analyzed. RESULTS: Among 690 patients screened, 533 were eligible for analysis (male to female ratio: 3:2; Chinese: 75.4%; Malay: 9.8%; Indian: 14.8%). Clinical spectrum of GERD: N: 40.5%; A: 46%; B: 9.2%; C: 2.1%; D: 0.6%; Barrett's esophagus: 1.7%. Compared to patients with NERD, patients with ERD were significantly older (45 vs 39.4 years), more likely to be male (64.4% vs 53.7%), tended to smoke (19.6% vs 9.7%), less likely to have minor psychiatric morbidity (26.4 vs 46.7%) and were more likely to respond to PPI (79.7 vs 66.8%). There was also a trend towards a higher BMI (24.5 vs 23.5). Race, alcohol consumption and H pylori status were not significant. On multivariate analysis, age and presence of minor psychiatric morbidity remained with significant differences. CONCLUSION: The majority of patients who have typical symptoms of GERD have NERD or mild erosive reflux disease. Compared to patients with erosive reflux disease, patients with NERD were younger and had a higher prevalence of minor psychiatric morbidity.

关键词： Reflux disease Clinical spectrum Psychiatric morbidity

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A Prospective Study of Inpatient Ketamine Subanaesthetic Dose Infusion in Chronic Refractory Pain

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Pain Studies and Treatment 2021年第3期9卷 17-35页

作者： Teik guan Tay Tony Hollins Ben Teo Kok eng Khor James Tekiko Department of Pain Management Prince of Wales Hospital Sydney Australia Prince of Wales Clinical School University of New South Wales Sydney Australia

Background: Inpatient subanaesthetic ketamine infusion for 5 days may improve pain and reduce oral opioid usage in patients with chronic pain. Objective: This study aims to investigate pain and psychological outcomes of ketamine parenteral infusion (0.1 - 0.35 mg/kg/h or maximum 24 mg/hour) for 5 days in patients with chronic refractory pain. The secondary objective is to explore any prognostic pain and psychological factors associated with the successful response to the ketamine treatment. Methodology: A prospective longitudinal study of a small cohort (N = 35) of patients with heterogenous chronic refractory pain conditions was conducted from one week to two months follow-up. Results: Pain Severity was significantly improved from mean 6.5 to 5.1 (t = 3.77, p 𕒷.37, p = 0.002, d = 𕒴.6) at 1-week and 23 (t =𕒶.60, p = 0.016, d =𕒴.5) at 2-month;Pain Catastrophizing (PCS) from 28 to 23 (t = 3.4, p = 0.002;d = 0.6) at 1-week and 21 (t = 2.45, p = 0.022, d = 0.5) at 2-month;Depression from mean 21 to 16 (t = 2.16, p = 0.038, d = 0.4) at 1-week and 16 (t = 3.53, p = 0.002, d = 0.7) at 2-month;and oral Morphine Equivalent Daily Dose (oMEDD) reduced from mean 191 mg/day on admission to 122 mg/day at 1-week (t = 2.38, p = 0.023;d = 0.4) and 93 mg/day at 2-month (t = 2.59, p = 0.016;d = 0.5). There

关键词： Chronic Refractory Pain Ketamine Infusion Chronic Refractory Pain Treat-ment Ketamine Therapy Pharmacotherapy

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东南亚实施沿海综合管理的教训

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人类环境杂志 1998年第8期27卷 599-609页

作者： chua Thia-eng 习晓环国际水产资源中心沿海地区管理规划处(ICLARM)

本文评价东南亚8个沿海综合管理(ICM)计划的实施情况,这些计划是通过ASEAN/US CRM沿海资源管理计划(1986～1992年)和GEF/UNDP/IMO防止和控制东南亚海域海洋污染的区域计划(1994年至今)实施的。评价以常用的性能指数为基础,以测定规划和... 详细信息

本文评价东南亚8个沿海综合管理(ICM)计划的实施情况,这些计划是通过ASEAN/US CRM沿海资源管理计划(1986～1992年)和GEF/UNDP/IMO防止和控制东南亚海域海洋污染的区域计划(1994年至今)实施的。评价以常用的性能指数为基础,以测定规划和实施过程中(过程指数)、减少环境介质造成的压力(压力指数),确保规划持续性进行(可持续性指数)、以及遏止环境恶化或环境质量改善状况(环境状态指数)所取得的成果。所有的8个TCM计划成功地实现了问题识别和规划构成的要求。但是,只有在菲律宾八打雁湾和中国厦门的2个ICM计划达到了实施阶段。作者讨论了ICM计划实施13年的实践经验教训,包括在东南亚7个地区实施的8个ICM计划的产生和实现过程。讨论内容包括ICM的概念,计划的时间期限、执行监督、计划设计、管理问题的选择和重点安排,管理边界、研究和讨论、ICM计划的发展和实施周期、提交地方政府机构、机构组织,公民环境意识以及培养地区人员能力。

关键词：东南亚沿海管理海洋管理海洋规划综合管理

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Speaker-independent recognition of Chinese tones

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Chinese Journal of Acoustics 1993年第2期12卷 142-148页

作者： guan Cuntai and CHEN Yongbin(Dep. of Radio eng., Southeast University, Nanjing 210018)

This paper presents a reliable speaker-independent method of recognizing Chinese tones. An unbiased center-clipping autocorrelation algorithm of pitch period extraction is proposed. A two-dimensional decision vector is used for recognizing Chinese tones by passing the pitch period sequence through the procedures of data selection, error correction, data smoothing and curve fitting. The average correct rate of tone recognition for isolated Chinese syllables is over 98%.

关键词： Tone recognition Pitch detection.

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