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Increased circulating zonulin in children with biopsy-proven nonalcoholic fatty liver disease

World Journal of Gastroenterology 2014年第45期20卷 17107-17114页

作者： Lucia Pacifico enea bonci Lidia Marandola Sara Romaggioli Stefano Bascetta Claudio Chiesa Department of Pediatrics and Child Neuropsychiatry Sapienza University of Rome Department of Experimental Medicine Sapienza University of Rome Institute of Translational Pharmacology National Research Council

AIM:To investigate the potential association of circulating zonulin with the stage of liver disease in obese children with biopsy-confirmed nonalcoholic fatty liver disease(NAFLD).METHODS:A case-control study was performed.Cases were 40 obese children with NAFLD.The diagnosis of NAFLD was based on magnetic resonance imaging(MRI)with high hepatic fat fraction(HFF≥5%),and confirmed by liver biopsy with≥5%of hepatocytes containing macrovesicular fat.Controls were selected from obese children with normal levels of aminotransferases,and without MRI evidence of fatty liver as well as of other causes of chronic liver diseases.Controls were matched(1-to 1)with the cases on age,gender,pubertal stage and as closely as possible on body mass index-standard deviation score.All participants underwent clinical examination,laboratory testsincluding zonulin,inflammatory and metabolic parameters,and MRI for measurement of HFF and visceral adipose tissue.RESULTS:Zonulin values were significantly greater in obese subjects with NAFLD than in those without NAFLD[median(interquartile range),4.23(3.18-5.89)vs 3.31(2.05-4.63),P<0.01].In patients with NAFLD,zonulin concentrations increased significantly with the severity of steatosis and the Spearman’s coefficient revealed a positive correlation between zonulin values and steatosis(r=0.372,P<0.05);however,we did not find a significant correlation between zonulin and lobular inflammation(P=0.23),ballooning(P=0.10),fibrosis score(P=0.18),or presence of nonalcoholic steatohepatitis(P=0.17).Within the entire study population,zonulin levels were positively associated with gamma-glutamyl transferase,2-h insulin,HFF,and negatively associated with whole-body insulin sensitivity index(WBISI),after adjustment for age,gender and pubertal status.When the associations were restricted to the group of NAFLD patients,2-h insulin,hepatic fat,and WBISI retained statistical significance.CONCLUSION:Circulating zonulin is increased in children and adolescents with NAFLD and correlates with the severity of ste

关键词： Zonulin Intestinal permeability Nonalco-holic fatt

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Probiotics for the treatment of Helicobacter pylori infection in children

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World Journal of Gastroenterology 2014年第3期20卷 673-683页

作者： Lucia Pacifico John Frederick Osborn enea bonci Sara Romaggioli Rossella Baldini Claudio Chiesa Department of Pediatrics and Child Neuropsychiatry Sapienza University of Rome Department of Health Sciences and Infectious Diseases Sapienza University of Rome Department of Experimental Medicine Sapienza University of Rome Department of Human Anatomy Sapienza University of Rome Institute of Translational Pharmacology National Research Council

The combination of a proton pump inhibitor and two antibiotics(clarithromycin plus amoxicillin or metronidazole)has been the recommended first-line therapy since the first guidelines for Helicobacter pylori(H.pylori)infection in children were published.In recent years,the success of eradication therapies has declined,in part due to the development of H.pylori resistant strains.Alternative anti-H.pylori treatments are currently becoming more popular than the traditional eradication methods.Components that may be used either as a monotherapy or,in combination with antimicrobials,resulting in a more effective anti-H.pylori therapy have been investigated in depth by several researchers.One of the potential therapies is probiotic cultures;promising results have been observed in initial studies with numerous probiotic strains.Nevertheless,many questions remain unanswered.In this article,we comprehensively review the possible mechanisms of action of probiotics on H.pylori infection,and present the results of published studies using probiotics as possible agents to control H.pylori infection in children.The effect of the addition of probiotics to the standard H.pylori eradication therapy for the prevention of antibiotic associated side-effects is also discussed.

关键词： Helicobacter pylori Children Probiotics Eradicatio

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Assessment of recharge capacity potential of groundwater using comparative multi-criteria decision analysis approaches

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Journal of Geographical Sciences 2022年第4期32卷 735-756页

作者： Ionut MINEA Daniel BOICU Oana-Elena CHELARIU Marina IOSUB Andrei enea Alexandru Ioan Cuza University of Iasi RomaniaFaculty of Geography and Geology Alexandru Ioan Cuza University of Iasi RomaniaThe Institute of Interdisciplinary ResearchDepartment of Exact Sciences and Natural Sciences Alexandru Ioan Cuza University of Iasi Integrated Centre of Environmental Science Studies in the North Eastern Region-CERNESIM

Groundwater resources have always been some of the most valuable resources of human settlements.Climate changes and ever-increasing water demands registered in the last century have led to diminishing levels of groundwater reserves,as well as reduced recharging potential.Therefore,in order to use groundwater aquifers in a sustainable manner,it is required to identify areas with higher replenishing potential.The current study addresses the issue of generating a map for identifying differently ranked groundwater recharging potential values,in the aquifers of the Moldavian Plain region,Romania.For the purpose of conducting the analysis,maps were created through GIS based multi-criteria Analytic Hierarchy Process(AHP)and Catastrophe Theory(CT),with seven relevant,thematic,spatial layers:precipitation distribution,lithological strata,soil texture,declivity,drainage density,land use and the distribution of groundwater level tendencies.The results of the two methods of analysis are similar.Prediction differences are of maximum 3%,in the case of extreme classes(very bad and very good)and in the case of middle classes the deviation is not greater than 0.4%.Following the validation of the results generated by the two methods that were applied,it was observed that the predictions offered by CT are more accurate.This aspect can be based on the fact that the main factors that contribute to the prediction are different.This type of workflow emphasizes the necessity of implementing appropriate groundwater management plans for mitigating reservoir scarcity/depletion,and recommending sustainable solutions for future groundwater exploitation practices.

关键词： analytic hierarchy process catastrophe theory groundwater recharge potential groundwater vulnerability Innovative Trend Analysis

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The Effects of Job Insecurity, Emotional Exhaustion, and Met Expectations on Hotel Employees’ Pro-Environmental Behaviors: Test of a Serial Mediation Model

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International Journal of Mental Health Promotion 2023年第2期25卷 287-307页

作者： Osman M.Karatepe Raheleh Hassannia Tuna Karatepe Constanţa enea Hamed Rezapouraghdam Faculty of Tourism Eastern Mediterranean UniversityGazimagusa99628Turkey Department of Management and Business Administration Faculty of Economics“Constantin Brancusi”University of Targu-JiuTargu-Jiu210135Romania

There are a plethora of empirical pieces about employees’pro-environmental behaviors.However,the extant literature has either ignored or not fully examined various factors(e.g.,negative or positive non-green workplace factors)that might affect employees’pro-environmental behaviors.Realizing these voids,the present paper proposes and tests a serial mediation model that examines the interrelationships of job insecurity,emotional exhaustion,met expectations,and proactive pro-environmental behavior.We used data gathered from hotel customer-contact employees with a time lag of one week and their direct supervisors in China.After presenting support for the psychometric properties of the measures via confirmatory analysis in LISREL 8.30,the abovementioned linkages were gauged using the PROCESS plug-in for statistical package for social sciences.The findings delineated support for the hypothesized associations.Specifically,emotional exhaustion and met expectations partly mediated the effect of job insecurity on proactive pro-environmental behavior.More importantly,emotional exhaustion and met expectations serially mediated the influence of job insecurity on proactive pro-environmental behavior.These findings have important theoretical implications as well as significant implications for diminishing job insecurity,managing emotional exhaustion,increasing met expectations,and enhancing ecofriendly behaviors.

关键词： Emotional exhaustion hotel customer-contact employees job insecurity met expectations pro-environmental behavior

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Strengthening and Restoration of Historical Structures Mirahor Ilyas Beg Mosque in Korca

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Journal of Literature and Art Studies 2013年第12期3卷 809-818页

作者： enea Mustafaraj Yavuz Yardlm Epoka Univei'sity Tirana Albania Epoka University Tirana Albania

The Mirahor Ilyas Beg Mosque, built in 1496 in Korca, is one of a few Ottoman mosques still existing in Albania and the only Ottoman monument in the city. The mosque was built using cut stone and brick. It has a strong image; a cubic mass rising over a square plan. Inside there are found pictures of the mosque in the past and different famous mosques. During its existence, it was damaged from many earthquakes occurring at this area. Due to amortization, the mosque"s structural properties were weakened and architectural values were dimmed. Proper strengthening methods need to be applied, not only to improve structural conditions, but also to preserve architectural features of the mosque. In this paper assessment of existing conditions of the structure is carried out. Based on the obtained results, solutions for the structural problems are investigated. As for restoration, the repair methods to be applied were examined taking into consideration at what extent the historical values of the building will be preserved. The proposed strengthening methods are the ones which would affect the least the mosque"s historical values.

关键词：历史建筑清真寺修复结构特性加固方法历史价值阿尔巴尼亚地震损坏

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High-Speed Road Measurement Systems： Integration of Pavement and General Mapping Laser Technologies

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Journal of Civil Engineering and Architecture 2018年第3期12卷 225-234页

作者： enea Sogno Michele Mori Sina S.p.A. Milan 20135 Italy

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空间、时间、自然与地域特色设计——树之博物馆

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景观设计 2012年第2期 8-11页

作者： enea GmbH 吴迪（翻译）

该项目位于苏黎世湖上游，占地面积约为75000平方米，于2010年6月14日正式对公众开放。该项目的椭圆形场地被分割成若干“房间”，每个“房间”自成一体，各具特色，但无不展示着瑞士景观设计师、杰出的树木收藏家Enzoenea精心收藏的各... 详细信息

该项目位于苏黎世湖上游，占地面积约为75000平方米，于2010年6月14日正式对公众开放。该项目的椭圆形场地被分割成若干“房间”，每个“房间”自成一体，各具特色，但无不展示着瑞士景观设计师、杰出的树木收藏家Enzoenea精心收藏的各式树种。该项目旨在向世人展现树木独一无二的美感，让人们意识到它们的珍贵，而更深一层的用意则是借设计师的珍藏帮助游客们进一步认识“时间与空间”，理解这些构成生命的最原始元素的深意，并参悟此类元素如何在这些珍贵的古树上体现得淋漓尽致。

关键词：景观设计师地域特色空间时间博物馆自然占地面积收藏家

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HOT DIPPING ALUMINIZED COATING AS HYDROGEN PERMEATION BARRIER

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Acta Metallurgica Sinica(English Letters) 2001年第6期14卷 435-440页

作者： Z. Y Yao, M. Chini, A. Aiello and G. Benamati (China Institute of Atomic Energy, P.O.Box 275-51, Beijing 1024l3, China) ( Department of Physics, University of Trento, 38100 Trento, Italy) ( enea CR Brasimone, 40032 Camugnano, Bologna, Italy) China Inst. of Atomic Energy P.O. Box 275-51 Beijing 102413 China

The hydrogen permeation experiment of MANET II with hot dipping aluminized coating was performed in temperature range of 573 to 623 K, in gas phase and in liquid Pb-17Li phase. The hydrogen permeation reduction factor (PRF) evaluated in gas phase is 620 at 573 K and 260 at 623 K, and in liquid Pb-17Li phase is 24-45 at 573 K and 12-30 at 623 K. The self-healing of coating is obvious and effective above 673 K. The pressure dependence of permeation flux indicates strong surface contribution. The way of filling hydrogen by continuous flow and/or bubble can increase permeation flux. The result of SEM-EDS shows that the microcrack is on the surface of the wetted part, but not on the not wetted part. The crack is superficial and affects only thin outside layer not penetrate aluminized layer. The surface elemental analysis shows that Al/O atomic ratio changes from 2/3 of not wetted part to about 1 of wetted part. The damage of coating surface seems to be related to the interaction of outside layer with liquid Pb-17Li and thermal stress during heating sample.

关键词： Electroless plating Hydrogen Maraging steel Mechanical permeability

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Transient Behaviour of a Heat Pipe with Extracapillary Circulation

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Tsinghua Science and Technology 2002年第2期7卷 135-145页

作者： G. Canti, G.P. Celata, M. Cumo, M. Furrer enea Energy Department, Rome, Italy enea-Energy Department Rome Italy

Heat pipe devices, for their typical working mode, are particularly suitable for zero gravity applications, and have also been considered for applications in space satellites with nuclear generators because of the absence of active systems for the coolant circulation. The present work reports the results of experimental tests carried out on a heat pipe facility designed to investigate the thermal hydraulic performance of a water heat pipe. The device layout, configuration and geometry, simulate a heat pipe working mode utilizable in space applications under zero gravity conditions. The evaporating section, completely lined (covered) with wicks (sintered stainless steel), and nearly plane shaped, is housed in a cylindrical container. The obtained results show that the system can approach steady state conditions, at a pressure of 4 bar and with a heat flux transferred of about 150 W/cm 2, supporting an electric power step of about 1.8 kW. 

关键词： steady state operating conditions heat pipe transient phrases circulation

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意大利广播电视法的若干问题

法治湖南与区域治理研究

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法治湖南与区域治理研究 2012年第4期9卷 221-247页

作者： Gianpietro Mazzoleni Giulio enea Vigevani 何瑶意大利米兰大学米兰比科卡大学法律系中国传媒大学新媒体研究院

意大利广播电视体系非常有特点,因为有备受争议的政治人物的参与,尤其是国有广播机构———意大利广播电视公司RAI④,它是严格地受控于政府和政党之下的。自从意大利商业电视台在1970年开创以来,在整体无规范的市场环境下,RAI改变了意...

意大利广播电视体系非常有特点,因为有备受争议的政治人物的参与,尤其是国有广播机构———意大利广播电视公司RAI④,它是严格地受控于政府和政党之下的。自从意大利商业电视台在1970年开创以来,在整体无规范的市场环境下,RAI改变了意大利的传媒市场、广告市场以及政治关系。在20世纪中期,一位来自意大利北方、拥有着雄厚的传媒实力的企业家———贝卢斯科尼⑤,在其逐渐成为政治明星以及国家总理的过程中,意大利的商业电视台扮演了非常重要的角色。

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