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MRI-Based Patient-Specific Left Ventricular Model to Determine the Effects of Trabeculae Carneae on the Diastolic and Systolic Functions

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医用生物力学 2019年第A1期34卷 19-20页

作者： Fatemeh Fatemifar Marc Feldman Geoffrey Clarke ender finol Haichao Han Department of Mechanical Engineering and Biomedical Engineering Graduate Program University of Texas at San AntonioSan AntonioTX78249USA Department of Medicine 3.Research Imaging InstituteUniversity of Texas HealthScience Center at San AntonioTX78229USA

Introduction Trabeculae carneae are irregular structures that cover the endocardial surfaces of both ventricles of human heart and account for a significant portion of the ventricular ***,the role of trabeculae carneae in left ventricular(LV)function is not well *** reports suggested that trabeculae help squeeze blood from the apical region during systole[1].Our recent study suggests that trabeculae carneae hypertrophy and fibrosis contribute to increased LV stiffness in patients with diastolic heart failure,and severing free-running trabeculae carneae may improve diastolic compliance of the LV[2].Objective To understand the role of trabeculae carneae in the left ventricular diastolic and systolic functions using anatomically detailed patient-specific finite element models of the human ***(1)Image acquisition An explanted human heart was collected from a 63 year old female donor with a history of stroke and congestive heart failure within 24 hours postmortem from South Texas Blood and Tissue Center(San Antonio,TX).The heart was de-identified in accordance with Institutional Review Board(IRB)requirements and informed consent for research was obtained from the donor’s ***-dimensional MRI scanning was conducted on a 3T(128 MHz)MRI system(TIM Trio,Siemens Medical Solutions),comprised of a superconducting magnet with a 60 cm diameter accessible bore,when the heart was submerged in a saline filled plastic container.(2)Finite element analysis Three distinct LV models were derived from the MR *** first model was the intact trabeculated model(TM)which contained all trabeculae carneae and papillary *** high-resolution anatomically detailed 3D model of the LV was segmented from 2D MR images in DICOM format using Mimics(Materialise NV,Leuven,Belgium).The second model was the papillary model(PM),in which the papillary muscles remain intact but most of the trabeculae carneae were excluded in the smoothing *** third

关键词： EF MRI-Based Patient-Specific Trabeculae Carneae the Diastolic and Systolic F Model

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