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The mechanism of deep material transport and seismogenic environment of the Xiaojiang fault system revealed by 3-D magnetotelluric study

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Science China Earth Sciences 2022年第6期65卷 1128-1145页

作者： Nian YU Xuben wang Dewei LI Xin LI enci wang Wenxin KONG Tianyang LI School of Electrical Engineering Chongqing UniversityChongqing 400044China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing 400044China Department of Geophysics Chengdu University of TechnologyChengdu 610059China Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China

The Xiaojiang fault system(XJFS), located to the southeast of the Tibetan Plateau, has a complicated tectonic history and is an ideal location to study the Tibetan Plateau in terms of its deep material transport mechanism and the effects of past tectonic events. In this study, broadband and long-period magnetotelluric data were collected above this fault system and inverted to build a 3-D resistivity model of the lithosphere. As shown in the model, at upper-middle crustal depths, three high-resistivity anomalies separate the strike-slip faults located in the study area, which may be the remnants of the Emeishan large igneous province that was destroyed and modified by Cenozoic crustal activity. The lower crust is characterized by significant lowresistivity anomalies that extend downward to the upper mantle. The low-resistivity anomalies in the upper crust may be caused by brines or/and conductive minerals(e.g., graphite and sulfides), and the possible reason for the low-resistivity anomalies that were imaged in the lower crust and upper mantle may be the presence of hydrogen in nominally anhydrous minerals and partial melts. According to the seismic activity distribution and resistivity structure, we propose dividing the seismic activity of the study area into three categories: tectonic earthquakes, earthquakes with no active faults on the surface, and other scattered earthquakes with no general features. Seismic activities are controlled by tectonic activities, fluid transportation, and the adjustment of the Earth's stress field. It is believed that there is a mutually reinforcing relationship between seismic activity and deep fluids. Fluids could lower the frictional force in faults, promote movement, and thus induce earthquakes;on the other hand,seismic activities and the long-term strike-slip movements of faults could generate heat and increase the connectivity of fluids,which decreases the strength of the crust and facilitates the flow of fluids. Based on the resistivity model, it is demonstrated that the pr

关键词： The Xiaojiang fault Magnetotelluric Seismogenic environment Emeishan mantle plume Crustal flow

A biomaterial-based therapy for lower limb ischemia using Sr/Si bioactive hydrogel that inhibits skeletal muscle necrosis and enhances angiogenesis

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Bioactive Materials 2023年第8期26卷 264-278页

作者： Ye Yuan Zhaowenbin Zhang Fandi Mo Chen Yang Yiren Jiao enci wang Yuchong Zhang Peng Lin Chengkai Hu Weiguo Fu Jiang Chang Lixin wang Department of Vascular Surgery Zhongshan HospitalFudan University180 Fenglin RoadShanghai200032China Department of Vascular Surgery Zhongshan Xiamen HospitalFudan University668 JinhuRoadXiamen361015China Joint Centre of Translational Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou325000China Shanghai Institute of Ceramics Chinese Academy of Sciences1295 Dingxi RoadShanghai200050China

Muscle necrosis and angiogenesis are two major challenges in the treatment of lower-limb ischemic diseases.In this study,a triple-functional Sr/Si-containing bioceramic/alginate composite hydrogel with simultaneous bioactivity in enhancing angiogenesis,regulating inflammation,and inhibiting muscle necrosis was designed to treat lower-limb ischemic diseases.In particular,sodium alginate,calcium silicate and strontium carbonate were used to prepare injectable hydrogels,which was gelled within 10 min.More importantly,this composite hydrogel sustainedly releases bioactive Sr^(2+)and SiO_(3)^(2-) ions within 28 days.The biological activity of the bioactive ions released from the hydrogels was verified on HUVECs,SMCs,C2C12 and Raw 264.7 cells in vitro,and the therapeutic effect of the hydrogel was confirmed using C57BL/6 mouse model of femoral artery ligation in vivo.The results showed that the composite hydrogel stimulated angiogenesis,developed new collateral capillaries,and re-established the blood supply.In addition,the bioactive hydrogel directly promoted the expression of muscle-regulating factors(MyoG and MyoD)to protect skeletal muscle from necrosis,inhibited M1 polarization,and promoted M2 polarization of macrophages to reduce inflammation,thereby protecting skeletal muscle cells and indirectly promoting vascularization.Our results indicate that these bioceramic/alginate composite bioactive hydrogels are effective biomaterials for treating hindlimb ischemia and suggest that biomaterial-based approaches may have remarkable potential in treating ischemic diseases.

关键词： Hindlimb ischemic diseases Strontium carbonate and calcium silicate bioceramic Bioactive hydrogel Muscle necrosis Angiogenesis

Preparation of Peanut Shell Cellulose Double-Network Hydrogel and Its Adsorption Capacity for Methylene Blue

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Journal of Renewable Materials 2023年第7期11卷 3001-3023页

作者： Yalin Li Lei Liu Wenbao Huang Junpu Xie Zhaoxia Song Shuna Guo enci wang Department of College of Environment and Bioengineering Henan University of EngineeringZhengzhou451191China School of Mathematics and Statistics Carleton UniversityOntarioK1S 5B6Canada

To achieve optimal recovery and value-added utilisation of cellulose in peanut shells,the cellulose in peanut shells was first extracted using the sodium hydroxide-sodium chlorite method.Then,cellulose hydrogel was prepared by graft copolymerisation using N,N’-methylenebisacrylamide as the cross-linking agent,sodium persulfate as the initiator,and acrylic acid as the monomer.Orthogonal optimisation experiments were designed to obtain optimal process parameters for hydrogel preparation with the cellulose dosage of 0.40 g,initiator dosage of 0.20 g,polymerisation temperature of 70°C,cross-linking agent of 0.25 g,and monomer dosage of 3.0 mL.The effect of initiator dosage on hydrogel synthesis was the most significant,followed by monomer dosage and reaction temperature.Characterisation using X-ray diffraction analysis and scanning electron microscopy revealed that the hydrogel was amorphous and exhibited a distinct three-dimensional double network structure.Hydrogel swelling kinetic analysis showed that the hydrogel swelling process was divided into three stages,and fitted the Schott secondary swelling kinetic model.The prepared hydrogel had a good adsorption effect on methylene blue;the adsorption of methylene blue by the hydrogel was 1.259 mg/g at 25°C when the initial concentration of methylene blue was 5 mg/L.The adsorption kinetics of the hydrogel fit the pseudo-first-order kinetic model,pseudo-secondorder kinetic model,Eovich model and particle diffusion model.The best fitting effect was obtained with the pseudo-second-order kinetic model.The adsorption isotherm analysis of methylene blue on hydrogel showed that the adsorption process was consistent with Langmuir and Freundlich models.The correlation coefficient of the Freundlich isotherm model was higher,indicating that the adsorption of methylene blue on hydrogel was mainly chemisorption.

关键词： Cellulose hydrogel graft copolymerisation cross-linking polymerisation swelling property

Application of "Fabulous" stent system to improve aortic remodeling after TEVAR for type B aortic dissection

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Chinese Medical Journal 2023年第10期136卷 1231-1233页

作者： Chengkai Hu Jue Yang Wei wang Xiangchen Dai Xinwu Lu Youfei Qi Hongpeng Zhang Yuchong Zhang Ye Yuan enci wang Yi Si Weiguo Fu Lixin wang Department of Vascular Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Vascular Surgery Institute of Fudan University Shanghai 200032China Department of Vascular Surgery Zhongshan Hospital(Xiamen)Fudan UniversityXiamenFujian 361015China Department of Vascular Surgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Vascular Surgery Tianjin Medical University General HospitalTianjin 300052China Department of Vascular Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Vascular Surgery Hainan General HospitalHaikouHainan 570311China Department of Vascular Surgery Chinese PLA General HospitalBeijing 100853China

It is known that the Proximal Extension To Induce Complete Attachment(PETTICOAT)technique improves the distal aortic remodeling compared with standard thoracic endovascular aortic repair(TEVAR).[1,2]However,the only available Zenith Dissection Endovascular System(Cook Medical Inc.,Bloomington,Ind,USA)has several limitations,including only two sizes(36 mm and 46 mm)and an one-taper design,which may not be suitable for the complex morphology of dissection at distal aorta,particular for the east Asian population.Thus,our center designed the new“Fabulous”stent system and acheieved better early curative effect.

关键词： aortic dissection remodeling

Multidimensional magnetotelluric studies of the Precambrian Alberta basement

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Multidimensional magnetotelluric studies of the Precambrian ...

咯利普兰对猪中性粒细胞表达Mac-1的作用及有关信号机制

2020年中国地球科学联合学术年会

作者： enci wang 重庆大学

The Alberta basement is part of the North American craton – Laurentia. Geophysical and geology studies have revealed that the basement rocks of Alberta have been assembled by complex tectonic events. Study of the Alberta basement provides information on how tectonic processes operated in the past. This research describes the study of the Alberta basement using the MT method and has been divided into two linked projects. In Project 1,

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北京农学院学报 2024年第1期39卷 52-57页

作者：张旭日张溪园王恩慈郭雨楠李姣黄安琦姜代勋北京农学院动物科学技术学院/兽医学(中医药)北京市重点实验室北京102206

【目的】阐明咯利普兰为代表的磷酸二酯酶4抑制剂的抗炎新机制。【方法】采用密度梯度离心法分离猪中性粒细胞,流式细胞术检测猪中性粒细胞表达巨噬细胞表面分子抗原-1(Macrophage surface molecular antigen-1,Mac-1);Real-time qPCR和... 详细信息

【目的】阐明咯利普兰为代表的磷酸二酯酶4抑制剂的抗炎新机制。【方法】采用密度梯度离心法分离猪中性粒细胞,流式细胞术检测猪中性粒细胞表达巨噬细胞表面分子抗原-1(Macrophage surface molecular antigen-1,Mac-1);Real-time qPCR和Western blot技术检测猪中性粒细胞p38丝裂原活化蛋白激酶(p38 MAPK)、细胞外调节蛋白激酶(ERK)、p65核转录因子(p65 NF-κB)mRNA表达和磷酸化活性。【结果】佛波酯(phorbol myristate acetate, PMA)可显著上调中性粒细胞表达Mac-1(P<0.01),咯利普兰对PMA上调的中性粒细胞表达Mac-1有一定抑制作用,其中,5μmol/L咯利普兰可极显著抑制中性粒细胞表达Mac-1(P<0.01);PMA可极显著上调中性粒细胞p38 MAPK、ERK和p65 NF-κB mRNA表达和磷酸化活性(P<0.01),5μmol/L咯利普兰对PMA升高的中性粒细胞p38 MAPK、p65 NF-κB mRNA表达有极显著抑制作用(P<0.01),对ERK mRNA表达有显著抑制作用(P<0.05),对PMA升高的中性粒细胞p38 MAPK、ERK和p65 NF-κB磷酸化活性有极显著抑制作用(P<0.01)。【结论】咯利普兰可显著抑制中性粒细胞表达Mac-1,其机制与阻遏p38 MAPK、ERK、p65 NF-κB基因表达和磷酸化活性有关。

关键词：巨噬细胞表面分子抗原-1 p38丝裂原活化蛋白激酶细胞外调节蛋白激酶 p65核转录因子咯利普兰中性粒细胞猪

木瓜蛋白酶联合左侧肾动脉狭窄构建腹主动脉瘤模型

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中华实验外科杂志 2024年第5期41卷 921-924页

作者：胡诚凯张宇翀吴忱烨李哲昀王恩慈莫凡迪林朋邱首继赖颢王利新复旦大学附属中山医院血管外科上海200032 复旦大学附属中山医院心外科上海200032 复旦大学附属中山医院厦门医院血管外科厦门361015

目的:建立一种更加符合腹主动脉瘤(AAA)演变过程的动脉瘤模型。方法:选择体重为2 kg的16只新西兰兔,对其进行编号,并采取随机数字表法将16只兔分为实验组和对照组,每组各8只。实验组采用"左侧肾动脉狭窄"联合木瓜蛋白酶局部湿敷的方法建... 详细信息

目的:建立一种更加符合腹主动脉瘤(AAA)演变过程的动脉瘤模型。方法:选择体重为2 kg的16只新西兰兔,对其进行编号,并采取随机数字表法将16只兔分为实验组和对照组,每组各8只。实验组采用"左侧肾动脉狭窄"联合木瓜蛋白酶局部湿敷的方法建模,对照组采用局部生理盐水湿敷。术后分别在第2周和第4周对两组新西兰兔进行彩色多普勒超声检查,测量湿敷段主动脉直径的变化。处死新西兰兔后,对第2周和第4周的主动脉标本进行苏木精-伊红(HE)、Verhoeff’s Van Gieson(EVG)染色、Masson、转位蛋白(TSPO)和波形蛋白(Vimentin)染色,以及TSPO、Vimentin、α-平滑肌动蛋白(α-SMA)/成纤维细胞活化蛋白(FAP)的免疫荧光染色。利用SPSS和Image J软件对所得数据进行统计学分析。计数资料以频数(%)表示,计量资料以均数±标准差表示,以P<0.05为差异有统计学意义。结果:超声检查显示,实验组的腹主动脉直径随造模进程持续增加,与对照组比较,差异有统计学意义[(0.54±0.05)cm比(0.28±0.02)cm,Z=-2.6,P<0.01]。此外,第4周实验组的动脉直径明显高于第2周实验组[(0.54±0.05)cm比(0.41±0.03)cm,Z=-2.9,P<0.01]。免疫组织化学结果显示,实验组的动脉瘤壁比较对照组,具有弹力纤维断裂、中膜增厚及外膜胶原纤维沉积等表型。第4周实验组的动脉壁与第2周实验组比较,病变程度加重,相反动脉壁活化巨噬细胞浸润程度下降,且FAP^(+)/α-SMA^(+)的肌成纤维细胞表达明显增高,反映了在动脉瘤进展过程中血管平滑肌细胞的表型转化现象。结论:采用"左侧肾动脉狭窄"联合木瓜蛋白酶局部湿敷的方法可以成功构建更符合人AAA演变的模型。

关键词：腹主动脉瘤肾动脉狭窄木瓜蛋白酶肌成纤维细胞

基于“PETTICOAT”技术的支架系统在B型主动脉夹层远端主动脉重构中的有效性分析——一项多中心“匹配”比较研究

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中华普通外科杂志 2024年第5期39卷 350-356页

作者：胡诚凯杨珏王伟戴向晨陆信武戚悠飞张宏鹏张宇翀邱首继曹根茂王恩慈林朋莫凡迪李仕毅李哲昀左梓昂司逸符伟国王利新复旦大学附属中山医院血管外科复旦大学血管外科研究所上海200032 复旦大学附属中山医院(厦门)血管外科厦门361015 中南大学湘雅医院血管外科长沙410008 天津医科大学总医院血管外科天津300052 上海交通大学医学院附属第九人民医院血管外科上海200011 海南省人民医院血管外科海口570311 中国人民解放军总医院血管外科北京100853

目的比较采用Fabulous支架系统修复和标准胸主动脉腔内修复(TEVAR)对B型主动脉夹层(TBAD)远端主动脉的重塑效果。方法收集2017年12月至2019年10月经Fabulous支架治疗的134例TBAD患者以及对应的多中心进行标准TEVAR治疗的159例TBAD患者... 详细信息

目的比较采用Fabulous支架系统修复和标准胸主动脉腔内修复(TEVAR)对B型主动脉夹层(TBAD)远端主动脉的重塑效果。方法收集2017年12月至2019年10月经Fabulous支架治疗的134例TBAD患者以及对应的多中心进行标准TEVAR治疗的159例TBAD患者的数据。通过倾向性匹配分析,对比两组患者在术后1年的预后和主动脉重塑效果。结果通过倾向性匹配分析,一共62例Fabulous治疗的患者和匹配的62例标准TEVAR治疗的患者纳入分析。两组患者在术前基线情况方面差异无统计学意义。在裸支架区域的主动脉重塑方面,Fabulous组患者在真腔最小直径[10.6(4.4,14.5)mm比4.7(0.9,10.7)mm,P=0.001]和假腔最大直径[-24.2(-30.5,-4.9)mm比0.7(-11.8,2.3)mm,P<0.001]的变化趋势均优于标准TEVAR组患者,且Fabulous组患者的假腔完全血栓化比例明显优于标准TEVAR组患者(62.9%比37.1%,P=0.042)。结论TBAD患者采用Fabulous支架系统有更好的远端主动脉重塑效果。

关键词：主动脉,胸动脉瘤,夹层假腔血栓化主动脉重塑

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大数据背景下“海关统计”课程建设探究

计算机应用文摘 2023年第5期39卷 13-15页

作者：王恩慈上海海关学院上海201204

随着计算机技术发展,数据内容和处理方式也发生深刻变革,这对于数据相关的统计学课程建设既是机遇也是挑战。文章立足于大数据背景,研究海关统计学发展情况,针对课程内容与培养目标一致、理论基础与实践相结合的课程建设需求,从课程安... 详细信息

随着计算机技术发展,数据内容和处理方式也发生深刻变革,这对于数据相关的统计学课程建设既是机遇也是挑战。文章立足于大数据背景,研究海关统计学发展情况,针对课程内容与培养目标一致、理论基础与实践相结合的课程建设需求,从课程安排、教学方法、实践操作、教师培养等方面提出具体的课程建设建议。

关键词：大数据海关统计课程建设