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Chinese Optics Letters 2017年第9期15卷 71-75页

作者： encai ji Mingming Nie qiang Liu State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision Instrument Tsinghua University Beijing 100084 China

A high pulse repetition frequency（PRF）, high energy Ho：YAG laser directly pumped by a Tm-doped fiber laser and its application to a mid-infrared ZnGeP_2（ZGP） optical parametric oscillator（OPO） is *** maximum polarized 2.09 μm laser pulse energy is 13.46 mJ at a PRF of 1 k Hz. The corresponding peak power reaches 504 kW. In a double-resonant ZGP-OPO, a maximum mid-infrared laser pulse energy of 1.25 m J,corresponding to a peak power of 79 kW, is accomplished at a PRF of 3 kHz. The nonlinear conversion efficiency reaches 41.7%. The nonlinear slope efficiency reaches 53.3%.

关键词： OPO YAG Ho PRF mJ polarized 2.09 m fiber-bulk holmium laser and its application to a mid-infrared ZnGeP2 optical parametric oscillator

Generation of nanosecond 2.65μm pulses and pulse narrowing in fiber-bulk Ho3+:YAG laser pumped gain-switched Cr^2+:Cd Se laser

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Chinese Optics Letters 2020年第3期18卷 50-56页

作者： Hengkang Zhang encai ji Bin Zhang Yi Chen Baoquan Yao Qiang Liu Key Laboratory of Photonic Control Technology(Tsinghua University) Ministry of EducationBeijing 100084China State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China School of Electronic and Information Engineering Harbin Institute of TechnologyShenzhen 518055China National Key Laboratory of Tunable Laser Technology Harbin Institute of TechnologyHarbin 150001China

The generation of mid-infrared pulsed lasers was achieved in a Ho3+:YAG laser pumped gain-switched Cr^2+:Cd Se laser system with the shortest pulse duration of 4.15 *** a pump pulse duration of 50 ns and pump power of 2.7 W,the gain-switched Cr^2+:Cd Se laser achieved over 10 times pulse narrowing,obtaining the maximum peak power of 5.7 k *** optical-to-optical conversion efficiency was 3.7%,which could be further improved with better crystal surface polishing *** laser central wavelength was measured to be 2.65μm with a bandwidth(FWHM)of 50 *** addition,the parameter optimization for suppressing the pulse tail was discussed,while the long cavity and high output transmissivity contributed to obtaining the single-peak pulses.

关键词： Cr^2+:CdSe laser gain-switching pulse narrowing mid-infrared

Ultimate capacity analysis of cladding-pumped 10/130 Tm:fiber laser

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Chinese Optics Letters 2020年第5期18卷 36-39页

作者： encai ji jie Shi Congwen Zha jing Zeng Xinwu Zhou Zhengdi He Yong Yao Qitao Lü School of Electronic and Information Engineering Harbin Institute of TechnologyShenzhen 518055China Han's Laser Technology Industry Group Co. Ltd.Shenzhen 518055China Sino-German College of Intelligent Manufacturing Shenzhen Technology UniversityShenzhen 518118China

The ultimate capacity of a cladding-pumped 10/130 Tm:fiber is experimentally investigated with a 793 nm laser diode bidirectionally pumped amplifier. The laser system works stably at the output powers of 52 W,65 W, and 87 W. Eventually, the damage of the amplifier occurs when the output power reaches about 103.5 W with a total incident pump power of 176.8 W. Considering the incident seed power of 12.3 W,the amplifier conversion efficiency is estimated to be about 51.6% before it is damaged. With valuable exploration, we achieve the first air-cooling 60 W Tm:fiber laser at 1945.845 nm with a spectral linewidth of 0.4 *** laser power stability reaches 1.24% during a continuous test time of >65 h. The beam quality is measured as M_x^2=1.16 and M_y^2=1.14.

关键词： double cladding Tm:fiber all-fiber laser

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直接泵浦中红外Ho:BYF激光器综述

中国科技论文 2015年第5期10卷 503-507,519页

作者：吉恩才汪露柳强巩马理清华大学精密仪器系光子与电子技术研究中心北京100084

利用传统受激辐射原理及一级振荡结构直接获得中红外3~5μm波段的激光输出,相比于利用光参量振荡的方法,其总体设计原理以及整体机械结构更加简单。但是由于能够获得此波段激光输出的增益介质亦或高效泵浦源的稀缺,使得直接泵浦中红外... 详细信息

利用传统受激辐射原理及一级振荡结构直接获得中红外3~5μm波段的激光输出,相比于利用光参量振荡的方法,其总体设计原理以及整体机械结构更加简单。但是由于能够获得此波段激光输出的增益介质亦或高效泵浦源的稀缺,使得直接泵浦中红外激光器的发展进程较为缓慢。针对一种能够获得波长在3.9μm左右激光输出的增益介质——Ho：BYF（掺钬氟化钆钡）及其构成激光器的主要研究进展与关键技术问题进行了详细介绍。

关键词：光电子技术直接泵浦中红外激光掺钬氟化钇钡晶体

VITA MARKⅡ牙科玻璃陶瓷超快激光铣削工艺

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激光与光电子学进展 2020年第5期57卷 157-165页

作者：胡培鑫姚路吕启涛吉恩才聂子林何正娣深圳大学应用技术学院广东深圳518000 深圳技术大学中德智能制造学院数字化口腔激光智能制造重点实验室广东深圳518118 大族激光科技产业集团股份有限公司光源事业部广东深圳518000

使用5W红外飞秒激光器对牙科全瓷修复中常用的玻璃陶瓷材料VITA MARKⅡ进行铣削加工实验,系统研究超快激光加工工艺参数对铣削效率以及铣削效果的影响,并利用5W红外飞秒激光器实验结果对20 W红外飞秒激光器铣削效率进行模拟预估。实验... 详细信息

使用5W红外飞秒激光器对牙科全瓷修复中常用的玻璃陶瓷材料VITA MARKⅡ进行铣削加工实验,系统研究超快激光加工工艺参数对铣削效率以及铣削效果的影响,并利用5W红外飞秒激光器实验结果对20 W红外飞秒激光器铣削效率进行模拟预估。实验结果表明,在激光重复频率为100kHz,扫描速度为200mm/s,扫描间距为0.01mm的条件下,5W红外飞秒激光器对VITA MARKⅡ陶瓷的铣削效率最高,为0.0409mm^3/s。加工后的VITA MARKⅡ陶瓷粗糙度为3~5μm,崩边量在50μm以内,斜坡量在100μm以内。该牙科玻璃陶瓷的激光切割阈值约为0.72J/cm^2。推算出20 W红外飞秒激光器对VITA MARKⅡ陶瓷的铣削效率为0.1558mm3/s。上述实验论证了5W激光切割牙科玻璃陶瓷的可行性及有效性,可为20W红外飞秒激光铣削实验样机的搭建提供参考。

关键词：激光器超快激光牙科玻璃陶瓷激光工艺参数铣削效率铣削效果

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掺铥光纤激光器及其碎石应用:进展与展望

激光与光电子学进展 2023年第15期60卷 86-103页

作者：阳优司李丹吉恩才纪孝峰田兵闫平巩马理肖起榕清华大学精密仪器系光子测控技术教育部重点实验室北京100084 密尔医疗科技(深圳)有限公司广东深圳518000 福建医科大学附属三明第一医院福建福州365000 莱凯医疗器械(北京)有限公司北京101300

激光自诞生以来就在众多领域中有着广泛应用,激光碎石技术就是其中之一。相比目前激光碎石技术的“金标准”钬激光器,掺铥碎石光纤激光器在近些年不断发展,而且逐步被证明可实现更快的碎石速率与粉末化碎石、产生较小的碎石反推力、允... 详细信息

激光自诞生以来就在众多领域中有着广泛应用,激光碎石技术就是其中之一。相比目前激光碎石技术的“金标准”钬激光器,掺铥碎石光纤激光器在近些年不断发展,而且逐步被证明可实现更快的碎石速率与粉末化碎石、产生较小的碎石反推力、允许更高的液体灌溉速率等手术优点,同时整机系统支持免水冷工作、高电光效率运转、全光纤高效耦合以及大幅度体积缩减,因此受到了越来越多的关注。本文从连续性、准连续型和纳秒短脉冲型掺铥光纤激光器三个角度出发,详细总结了掺铥光纤激光器的部分重要研究进展及其在碎石领域的研究,介绍了掺铥光纤激光器用于碎石的优势与原理,并展望了未来研究的方向和挑战。

关键词：激光器掺铥光纤激光器掺铥连续光纤激光器掺铥准连续光纤激光器掺铥纳秒短脉冲激光器掺铥激光碎石

Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

Manufacture the conducting polymer with light

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Science China Chemistry 2025年第1期68卷 8-9页

作者： Yang Li Tianyu Li Yan ji Baoguang Liu College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications

Poly(3,4-ethylenedioxythiophene) (PEDOT), heralded as the “king” of conducting polymers, is esteemed in bioelectronics for its mixed electronic and ionic conductivity, mechanical properties compatible with biological tissues, tunable healing ability and stability in diverse environments [1]. Based on additive manufacturing of three-dimensional structures,PEDOT realizes the implementation in the efficient production of flexible bioelectronics, the construction of intricate electrode-neural implantations, and the development of smart brain-computer-interfaces [2].

关键词：

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan Zhang Yi Yang Guangbin ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期68卷 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing Chen jiafu ji Xiaofang Xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

关键词： extrachromosomal DNA cancer therapy tumor heterogeneity drug resistance tumor evolution