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Sustainability criteria of apicultural industry:evidence from Iran

Ecosystem Health and Sustainability 2020年第1期6卷 617-629,616页

作者： Mohammad Kazem Rahimi enayat abbasi Masoud Bijani Gholamhosein Tahmasbi Ali Akbar Azimi Dezfouli Department of Agricultural Extension and Education College of AgricultureTarbiat Modares University(TMU)TehranIran Animal Science Research Institute(ASRI) Agricultural ResearchEducation and Extension Organization(AREEO)KarajIran Agricultural Planning Economicsand Rural Development Research Institute(APERDRI)Ministry of Agriculture-JihadTehranIran

This study aimed to determine the sustainability criteria of the beekeeping industry in Iran,which was performed using three-stage classical Delphi *** participants were 32 experts in beekeeping industry who were purposefully selected using the snowball sampling *** criteria identified,after three Delphi stages,consisted of 70 items,which were categorized into 13 general criteria and into four economic,environmental,social,and institutional *** general criteria were presented in the form of a conceptual model,including:farmers’environmental behavior quality,beekeepers'environmental behavior quality,the quality of marketing and sales of beekeeping productions,productivity and performance improvement,amount of monetization from pollinations'right,the amount of monetization of byproducts and value added,employment rate and job stability,the level of social development of stakeholders,the quality of the role-playing of non-governmental stakeholders,the quality of extension and education new sciences and technologies to stakeholders,comprehensiveness of laws and programs,quality of role-playing of stakeholder non-governmental organizations,and the quality of the roleplaying of governmental institutions *** them,a comprehensive perception of the necessary criteria for the sustainability of Iran's beekeeping industry can be obtained and a comprehensive program can be designed for its implementation.

关键词： Sustainable apiculture agricultural sustainability conceptual model Delphi technique

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Synthesis of 6-chloro and 6-fluoro-4-hydroxyl-2-quinolone and their azo disperse dyes

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Chinese Chemical Letters 2010年第5期21卷 542-546页

作者： enayat O'llah Moradi-e-Rufchahi Department of Chemistry Faculty of ScienceIslamic Azad UniversityLahijan BranchLahijanIran

In this study,6-chloro-4-hydroxy-2-quinolone and 6-flouro-4-hydroxy-2-quinolone were synthesized from corresponding *** compounds were coupled with some diazotized aromatic amines to give the corresponding azo disperse *** structures of the quinolone derivatives and new azo dyes were confirmed by UV-vis,FT-IR,;H NMR and elemental analysis.

关键词： Azo dyes Hydroxy quinolone Heterocyclic amines Solvatochromism Polyphosphoric acid Heterocyclic dyes

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Hepatitis B virus genotypes and lamivudine resistance mutations in Jordan

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World Journal of Gastroenterology 2008年第47期14卷 7231-7234页

作者： Hani A Masaadeh Wail A Hayajneh enayat A Alqudah Department of Pathology Faculty of MedicineJordan University of Science and TechnologyIrbid 22110Jordan Department of Pediatrics Faculty of MedicineJordan University of Science and TechnologyIrbid 22110Jordan Faculty of Applied Medical Sciences Jordan University of Science and TechnologyIrbid 21110Jordan

AIM:To investigate and identify prevalent hepatitis B virus(HBV) genotypes and to explore lamivudine-resistant mutations among treated and untreated patients in ***:A total of 107 cases with chronic hepatitis B were recruited from different medical centers in *** tests were preformed for all cases using a microparticle enzyme *** Genotyping was performed for 70 cases using Line probe genotyping *** YMDD mutations were explored for 20 cases(4 were lamivudine naive) using the INNO-LiPA HBV DR ***:Genotype D was the only detected genotype.A total of 6 YMDD mutations were detected in 5 treated patients(31%) while one mutation was detected in the naive *** percent of cases were positive for HBeAg and had statistically significant higher levels of serum ***:HBV genotype D appears to be the only circulating type in Jordanian *** YMDD mutations were detected in 31% of lamivudine-treated cases with similar patterns to those found in the *** also found a relatively low prevalence of HBeAg expression among examined cases(17%).Awareness of these serologic,genotypic and resistance patterns might help in the formulation of management plans and for predicting clinical *** larger scale studies are needed to confirm our results and to examine possible associations among clinical,serologic,and genetic patterns of HBV infections in Jordan.

关键词： Hepatitis B virus Genotypes Lamivudine YMDD mutation Jordan

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Seismicity and Seismotectonics of Jeddah-Makkah Region, West-Central Saudi Arabia

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Journal of Earth Science 2015年第5期26卷 746-754页

作者： Mohammed Fnais Abdullah Al-Amri Kamal Abdelrahman enayat Abdelmonem Sherif El-Hady Geology & Geophysics Dept. College of Science King Saud University Seismology Dept. National Research Institute of Astronomy and Geophysics Geophysics Dept. College of Earth Sciences King Abdul Aziz University

Jeddah-Makkah regionis have been suffering from earthquake crisis where some moderate to destructive earthquakes have been recorded. These earthquake activities are oriented along major faults or clustered in certain spots. Moreover, these earthquake events have annual recurrence periods, so the identification of these seismogenic source zones is of utmost importance for mapping the most hazardous localities which should be avoided in the future urban planning. Historical and instrumental earthquakes have been collected from national and international data centers and unified in catalogue. The existence of microearthquakes inland suggests that there is a significant level of tectonic activity at away from the axial trough of the Red Sea. Then, seismogenic source zones have been defined depending on the major tectonic trends; distribution of earthquake epicenters, seismicity rate（a ＆ b- values） and fault plane solution of major earthquakes. It is concluded that Jeddah-Makkah region is affected by the outlined five seismogenic source zones; three of these zones aligned of the main Red Sea axial trough（southwestern Jeddah, western Jeddah, and northwestern Jeddah zones）, while the other two zones are located in the land area of the region（Thewal-Rabegh and Jeddah-Makkah zones）. These inland zones correlated well with the main trends of major tectonics which refleet the reactivation of tectonic movements along these fault trends. The Red Sea zones are in agreement with the main path of the axial trough. The range of b-value in these identified zones is 0.65 to 1.03 through these identified zones. The area characterized by higher b-values could be indicative of a relative low stress regime which was a result of resulting from the stress release by the earthquakes. Whereas, the areas of lower b-values can be considered as an evidence of a relatively higher stress regime associated with a dominantly extensional stresses. Based on aforementioned, the region is suffering from

关键词： seismicity seismotectonic source zones b-value Jeddah

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Antibacterial effect and physicochemical properties of essential oil of Zataria multiflora Boiss

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Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 439-442页

作者： Mansour Amin enayat Kalantar Neda Mohammad-Saeid Behzad Ahsan Department of Microbiology School of MedicineAhwaz Jundishapur University of Medical SciencesAhwazIran Kurdistan Liver and Digestive Research Center Kurdistan University of Medical SciencesSanandajIran

ObjectiveTo evaluate the antibacterial effect and physicochemical properties of essential oil of Zataria multiflora Boiss.MethodsAntibacterial activity of essential oil of Zataria multiflora Boiss was assessed by agar disc diffusion and minimal inhibitory concentration(MIC) was tested by E test.ResultsThe essential oil of Zataria multiflora Boiss was effective on pathogenic bacteria particularly Staphylococcus aureus (S. aureus). The MIC values of the target cultures ranged from 0.39 mg/mL to 1.56 mg/mL. The physicochemical properties like effects of pH, temperature, detergents, and enzymes on the activity of essential oil from Zataria multiflora Boiss were also determined. The essential oil was quite stable to temperature as tested against S. aureus and Escherichia coli (E. coli). The essential oil was very stable over a wide range of pH. The antibacterial activity of essential oil was insensitive to various protein-denaturing detergents (Such as Tween 80, Tween 20, Triton 100, etc.) and enzymes (namely proteinase K, trypsin, lipase, and lysosyme).ConclusionsA potential use of the essential oil from Zataria multiflora Boiss is suggested. More studies including further purification, mass spectra, nuclear magnetic resonance (NMR) and evaluation of toxicity are needed for confirmation of this suggestion.

关键词： Antibacterial effect Physico–chemical properties Zataria multiflora Boiss

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Neuroprotection by misoprostol against rotenone-induced neurotoxicity in rat brain

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Asian Pacific Journal of Tropical Medicine 2018年第1期11卷 40-47页

作者： Omar M.E.Abdel-Salam Amany A Sleem Eman R Youness Nadia A Mohammed enayat A Omara Department of Toxicology and Narcotics National Research Centre Department of Pharmacology National Research Centre Department of Medical Biochemistry National Research Centre Department of Pathology National Research Centre

Objective: To investigate the effect of the prostaglandin E1 analogue misoprostol on oxidative stress and neurodegeration caused by subcutaneous rotenone administration in rats. Methods:Rotenone was administered in a dose of 1.5 mg/kg every other day for 2 weeks. Starting from the 1 st day of rotenone injection, rats were subcutaneously treated with misoprostol at doses of10, 100 or 1 000 μg/kg. Rats were evaluated for brain lipid peroxidation(malondialdehyde:MDA), reduced glutathione(GSH), nitric oxide(NO) levels, and paraoxonase-1(PON-1) *** concentrations of the anti-apoptotic protein B cell/lymphoma-2(Bcl-2) were determined in the striatum. Histopathologic examination and the expression of inducible nitric oxide synthase(iNOS) in the cerebral cortex and striatum were also performed. Results: Compared with the vehicle-treated group, rotenone caused a significant increase in brain lipid proxidation(MDA)by 61%(P<0.05) accompanied by an increase in NO by 73.1%(P<0.05) and a decrease in GSH concentration by 29.4%(P<0.05). In addition, brain PON-1 activity significantly decreased by63.0%(P<0.05) and striatal Bcl-2 significantly decreased by 27.9%(P<0.05) with respect to the corresponding control value. Brain sections from rotenone treated rats showed extensive dark pyknotic and apoptotic nuclei in neurons, shrunken cytoplasm and perineuronal *** also caused pronounced expression of iNOS in the cerebral cortex and *** with misoprostol at doses of 100 and 1 000 μg/kg resulted in decreased brain MDA(by 16.5%-23.0%)(P<0.05) and NO levels(by 37.1%-40.7%)(P<0.05) and increased GSH concentrations(by 18.8%-30.1%)(P<0.05). PON-1 activity was significantly increased by80.0%-114.8%(P<0.05) by misoprostol at 100 and 1 000 μg/kg, respectively. In addition,misoprostol treatment restored striatal Bcl-2 concentrations to its normal value. Misoprostol treatment resulted in markedly reduced brain injury and decreased iNOS expression in the cereb

关键词： Misoprostol Rotenone Brain oxidative stress B cell/lymphoma-2 Paraoxonase

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Role of zinc as an antioxidant and anti-inflammatory to relieve cadmium oxidative stress induced testicular damage in rats

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Asian Pacific Journal of Tropical Biomedicine 2016年第12期6卷 1056-1064页

作者： Samir Abd El-Monem Bashandy enayat Abdel Aziz Omara Hossam Ebaid Mohamed Mahmoud Amin Mahmoud Sanad Soliman Department of Pharmacology Medical DivisionNational Research Centre Department of Pathology National Research Centre Department of Zoology College of ScienceKing Saud University Department of Zoology Faculty of ScienceEl-Minia University Department of Therapeutic Chemistry National Research Centre

Objective:To investigate the role of zinc in reducing the deleterious effects of cadmium on male ***:Rats were injected subcutaneously with CdCl_2 and ZnCl_2 at dose level of2.2 mg/kg(1/40 of LD50 of cadmium per day).Results:The rats treated with cadmium exhibited a significant increase in levels of testicular malondialdehyde,tumor necrosis factor-alpha,nitrogen oxide and inducible nitrogen oxide synthase immunostaining reaction,as well as an elevation of blood hydroperoxide and follicle stimulating *** addition,a significant decrease in testicular ascorbic acid,zinc,reduced glutathione,catalase,superoxide dismutase,sex organ weight,plasma testosterone and luteinizing hormone were observed in the cadmium *** motility and count were decreased with cadmium treatment,while sperm abnormalities elevated *** treatment was found to mitigate the toxic effects of cadmium on oxidative stress,spermatogenesis,sex hormones,and inflammatory *** injected with cadmium showed intense histopathological *** manifested protective role and markedly reduced tissues damage induced by ***:The protective effect of zinc can be attributed to its antioxidant and antiinflammatory properties.

关键词： Zinc Cadmium Oxidative stress Immunohistochemistry Sperms Inflammatory markers

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Protective effect of Citrus reticulata peel extract against potassium dichromate-induced reproductive toxicity in rats

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Asian pacific Journal of Reproduction 2019年第6期8卷 267-275页

作者： Samir AE Bashandy Omar A-H Ahmed-Farid enayat AOmara Sayed AEl-Toumy Josline YSalib Pharmacology Department National Research Centre33 El-Bohouth St.DokkiP.O.12622GizaCairoEgypt Physiology Department National Organization for Drug Control and ResearchCairoEgypt Pathology Department National Research CentreCairoEgypt Chemistry of Tannins Department National Research CentreCairoEgypt

Objective:To study the protective effect of Citrus reticulata peel extract against potassium dichromate-induced reproductive impairment in male Wistar ***:A total of 35 male Wistar rats were equally divided into 5 *** control group orally received an equivalent volume of saline(1 mL);group 2 was given potassium dichromate at 10 mg/kg/body weight(b.w.)orally for eight weeks;group 3 and 4 orally received Citrus reticulata peel extract at 200 and 400 mg/kg/***,followed by treatment with potassium *** 5 was administered with 400 mg/kg/*** reticulata peel extract *** parameters including oxidative stress(malondialdehyde,antioxidant enzymes),sex hormones(testosterone,luteinizing hormone,follicle-stimulating hormone)and inflammation indexes(tumor necrosis factor-alpha,inter leukin 6)were *** characteristics(sperm morphology,motility and count)were also ***:The decrease of male sex hormones concentration in plasma(testosterone,luteinizing hormone),testicular antioxidant parameters(reduced glutathione,catalase,superoxide dismutase,carnitine),sperm motility and sperm count induced by potassium dichromate was mitigated by Citrus reticulata peel ***,the peel extract alleviated the increase of sperm abnormalities,follicle-stimulating hormone,testicular malondialdehyde,tumor necrosis factor-alpha and nitric oxide levels caused by potassium *** sections of rats treated with the potassium dichromate were characterized by some histopathological changes as disorganization of spermatogonial cell layers and deformation of Leydig cells.A positive immune-reaction for p53 was observed in testicular cells of the rats treated with potassium *** extract of Citrus reticulata peel improved the testicular histology and decreased p53 positive immune-reaction in potassium dichromate administered ***:Citrus reticulata peel extract can alleviate the reproductive toxicity t

关键词： Citrus reticulatapeel extract Potassium dichromate Sperm Testicular function Oxidative stress Anti-inflammatory

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The involvement of interleukin-22 in the expression of pancreatic beta cell regenerative Reg genes

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Cell Regeneration 2013年第1期2卷 7-17页

作者： Thomas Hill Olga Krougly enayat Nikoopour Stacey Bellemore Edwin Lee-Chan Lynette A Fouser David J Hill Bhagirath Singh Department of Microbiology and Immunology University of Western OntarioLondonONCanada Inflammation and Immunology Biotherapeutics Research and DevelopmentPfizerCambridgeMA 02140USA Department of Physiology and Pharmacology University of Western OntarioLondonONCanada Lawson Health Research Institute LondonONCanada Centre for Human Immunology University of Western OntarioLondonONCanada Robarts Research Institute University of Western OntarioLondonONCanada

Background:In Type 1 diabetes,the insulin-producingβ-cells within the pancreatic islets of Langerhans are *** showed previously that immunotherapy with Bacillus Calmette-Guerin(BCG)or complete Freund’s adjuvant(CFA)of non-obese diabetic(NOD)mice can prevent disease process and pancreaticβ-cell *** was associated with increased islet Regenerating(Reg)genes expression,and elevated IL-22-producing Th17 T-cells in the ***:We hypothesized that IL-22 was responsible for the increased Reg gene expression in the *** therefore quantified the Reg1,Reg2,and Reg3δ(INGAP)mRNA expression in isolated pre-diabetic NOD islets treated with *** measured IL-22,and IL-22 receptor(R)-αmRNA expression in the pancreas and spleen of pre-diabetic and diabetic NOD *** results showed:1)Reg1 and Reg2 mRNA abundance to be significantly increased in IL-22-treated islets in vitro;2)IL-22 mRNA expression in the pre-diabetic mouse pancreas increased with time following CFA treatment;3)a reduced expression of IL-22Rαfollowing CFA treatment;4)a down-regulation in Reg1 and Reg2 mRNA expression in the pancreas of pre-diabetic mice injected with an IL-22 neutralizing antibody;and 5)an increased isletβ-cell DNA synthesis in vitro in the presence of ***:We conclude that IL-22 may contribute to the regeneration ofβ-cells by up-regulating Regenerating Reg1 and Reg2 genes in the islets.

关键词： Adjuvant immunotherapy Interleukin-22 Regenerating(Reg)genes Beta-cell regeneration Type 1 diabetes

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Amoxicillin–clavulanic acid induced sperm abnormalities and histopathological changes in mice

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Asian Pacific Journal of Tropical Biomedicine 2017年第9期7卷 809-816页

作者： Maha A. Fahmy Ayman A. Farghaly enayat A. Omara Zeinab M. Hassan Fawzia A.E. Aly Souria M. Donya Aziza A.E. Ibrahim Elsayed M. Bayoumy Department of Genetics and Cytology National Research CentreDokkiGizaEgypt Department of Pathology National Research CentreDokkiGizaEgypt Department of Chemistry of Natural Compounds National Research CentreDokkiGizaEgypt Hydrobiology Department National Research CentreDokkiGizaEgypt Biology Department Girls Science CollegeUniversity of DammamSaudi Arabia

Objective: To explore the genotoxic potential and histopathological changes induced in liver, kidney, testis, brain and heart after using the antibiotic drug amoxicillin/clavulanic acid(4:1).Methods: The study included chromosomal aberration analysis in bone-marrow and mouse spermatocytes, induction of sperm morphological abnormalities and histopathological changes in different body organs. The drug was administrated orally at a dose of81 mg/kg body weight twice daily(Total = 162 mg/kg/day) for various periods of time equivalent to 625 mg/men(twice daily).Results: The results revealed non-significant chromosomal aberrations induced after treatment with amoxicillin/clavulanic acid(AC) in both bone marrow and mouse spermatocytes after 7 and 10 days treatment. On the other hand, statistically significant percentages of sperm morphological abnormalities were recorded. Such percentage reached 8.10 ± 0.55, 9.86 ± 0.63 and 12.12 ± 0.58 at the three time intervals tested(7, 14 and 35 days after the 1 st treatment respectively)(treatment performed for 5 successive days) compared with 2.78 ± 0.48 for the control. The results also revealed histopathological changes in different body organs after AC treatment which increased with the prolongation of the period of therapy. Congestion of central vain, liver hemorrhage and hydropic changes in hepatocytes were noticed in the liver. Degenerative changes were found in kidney glomerulus and tubules while testis showed atrophy of seminiferous tubules, and reduction of spermatogenesis. AC also induced neurotoxicity and altered brain neurotransmitter levels. Hemorrhage in the myocardium, disruption of cardiac muscle fibers and pyknotic nuclei in cardiomyocytes were recorded as side effects of AC in heart ***: The results concluded that AC treatment induced sperm morphological abnormalities and histopathological changes in different body organs. Clinicians must be aware of such results while describing the drug.

关键词： Amoxicillin/clavulanic acid Genotoxicity Sperm abnormalities Histopathological changes

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