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suppression of NLRP3 inflammasome by ivermectin ameliorates bleomycin-induced pulmonary fibrosis

Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2023年第8期24卷 723-733页

作者： Mai A.ABD-ELMAWLA Heba R.GHAIAD enas s.gad Kawkab A.AHMED Maha ABDELMONEM Department of Biochemistry Faculty of PharmacyCairo UniversityCairo 11562Egypt Department of Pharmaceutical sciences Faculty of PharmacyKing Faisal UniversityAl-Ahsa 31982Saudi Arabia Department of Pharmacology and Toxicology Faculty of PharmacySinai UniversityIsmailia 45511Egypt Department of Pathology Faculty of Veterinary MedicineCairo UniversityCairo 12211Egypt

Ivermectin is a Us Food and Drug Administration(FDA)-approved antiparasitic agent with antiviral and anti-inflammatory *** recent studies reported the possible anti-inflammatory activity of ivermectin in respiratory injuries,its potential therapeutic effect on pulmonary fibrosis(PF)has not been *** study aimed to explore the ability of ivermectin(0.6 mg/kg)to alleviate bleomycin-induced biochemical derangements and histological changes in an experimental PF rat *** can provide the means to validate the clinical utility of ivermectin as a treatment option for idiopathic *** results showed that ivermectin mitigated the bleomycin-evoked pulmonary injury,as manifested by the reduced infiltration of inflammatory cells,as well as decreased the inflammation and fibrosis ***,ivermectin decreased collagen fiber deposition and suppressed transforming growth factor-β1(TGF-β1)and fibronectin protein expression,highlighting its anti-fibrotic *** study revealed for the first time that ivermectin can suppress the nucleotide-binding oligomerization domain(NOD)-like receptor family pyrin domain-containing protein 3(NLRP3)inflammasome,as manifested by the reduced gene expression of NLRP3 and the apoptosis-associated speck-like protein containing a caspase recruitment domain(AsC),with a subsequent decline in the interleukin-1β(IL-1β)*** addition,ivermectin inhibited the expression of intracellular nuclear factor-κB(NF-κB)and hypoxia‑inducible factor‑1α(HIF-1α)proteins along with lowering the oxidative stress and apoptotic ***,this study revealed that ivermectin could ameliorate pulmonary inflammation and fibrosis induced by *** beneficial effects were mediated,at least partly,via the downregulation of TGF-β1 and fibronectin,as well as the suppression of NLRP3 inflammasome through modulating the expression of HIF‑1αand NF-κB.

关键词： Intra-tracheal instillation Immunohistochemistry Transforming growth factor-β1(TGF-β1) Nuclear factor-κB(NF-κB) Lung fibrosis

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伊维菌素抑制NLRP3炎症小体可改善博来霉素诱导的肺纤维化（英文）

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2023年第8期 723-737页

作者： Mai A.ABD-ELMAWLA Heba R.GHAIAD enas s.gad Kawkab A.AHMED Maha ABDELMONEM 埃及开罗大学药学院生物化学系费萨尔国王大学药学院药学系埃及西奈大学药学院药理毒理学系埃及开罗大学兽医学院病理学系

伊维菌素是美国食品药品监督管理局（FDA）批准的抗寄生虫剂，具有抗病毒和抗炎特性。尽管最近有研究表明伊维菌素在呼吸系统损伤中可能具有抗炎活性，但其对肺纤维化（PF）的潜在影响尚未得到验证。本研究旨在探讨伊维菌素（0.6 mg/kg... 详细信息

伊维菌素是美国食品药品监督管理局（FDA）批准的抗寄生虫剂，具有抗病毒和抗炎特性。尽管最近有研究表明伊维菌素在呼吸系统损伤中可能具有抗炎活性，但其对肺纤维化（PF）的潜在影响尚未得到验证。本研究旨在探讨伊维菌素（0.6 mg/kg）在PF大鼠模型中减轻博来霉素诱导的生化紊乱和组织学变化的效果。这可用于验证伊维菌素作为治疗特发性PF在临床上的效用。在本研究中，伊维菌素减轻了博来霉素诱发的肺损伤，表现为炎症细胞浸润减少以及炎症和纤维化评分降低。值得注意的是，伊维菌素减少了胶原纤维的沉积并抑制了转化生长因子-β1(TGF-β1)和纤连蛋白的表达，突显了其抗纤维化活性。本研究首次揭示伊维菌素可以抑制NOD样受体家族含吡啶结构域蛋白3(NLRP3)炎症小体，表现为NLRP3和含有半胱天冬酶募集结构域的凋亡相关斑点样蛋白（AsC）基因的表达减少，以及白细胞介素-1β(IL-1β)水平的下降。此外，伊维菌素抑制细胞内核因子-κB(NF-κB)和缺氧诱导因子-1α(HIF-1α)蛋白的表达，同时降低氧化应激和凋亡标志物的水平。本研究表明，伊维菌素可以改善博来霉素引起的肺部炎症和纤维化，并且部分功能是通过下调TGF-β1和纤连蛋白以及通过调节HIF-1α和NF-κB的表达抑制NLRP3炎性小体来介导的。

关键词：气管内滴注免疫组化转化生长因子-β1(TGF-β1) 核转录因子-κB(NF-κB) 肺纤维化

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Differences in Ecological and Genetic Adaptations between salamandra infraimmaculata and Ommatotriton vittatus

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Open Journal of Animal sciences 2024年第3期14卷 183-193页

作者： gad Degani MIGAL Galilee Research Institute Qiryat Shemona Israel Faculty of sciences Tel-Hai Academic College Qiryat Shemona Israel

Israel is home to two species of amphibians belonging to distinct genera: salamandra and Ommatotriton. They inhabit various regions, sometimes coexisting and in other instances dwelling separately across different areas, making their segregation challenging. This study compares the biological, ecological, and genetic traits of two species, the Near Eastern fire salamander salamandra infraimmaculata and the southern banded newt Ommatotriton vittatus, to determine why O. vittatus thrives in a wider range of semi-arid habitats in central and southern Israel, whereas s. infraimmaculata predominantly occupies the coastal Mediterranean region in the north. salamander larvae are typically found in streams, freshwater springs, and cave pools, whereas newt larvae inhabit winter pools and ponds exclusively. The developmental phase of salamander tadpoles extends over several months, whereas newt tadpoles spend a comparatively brief period in the water, from 1 to a few months. Notably, genetic disparities in the cytochrome b sequence in Israeli populations are more pronounced among newts than salamanders.

关键词： Ommatotriton vittatus salamandra infraimmaculata Biological Ecological Genetic Israel

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Impact of different nano additives on performance, combustion, emissions and exergetic analysis of a diesel engine using waste cooking oil biodiesel

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Propulsion and Power Research 2022年第2期11卷 209-223页

作者： M.s.gad Mostafa M.Abdel Aziz Hatem Kayed Mechanical Engineering Department Faculty of EngineeringFayoum UniversityEgypt Mechanical Engineering Department Institute of Aviation Engineering and TechnologyGizaEgypt Mechanical Power Engineering Department Faculty of EngineeringCairo University12613Egypt

Biodiesel is derived from waste cooking oil (WCO) by transesterification. Methylester was prepared by mixing diesel and biodiesel oils as 20% by volume. Nano particles asTiO2, Al2O3 and CNTs were blended with biodiesel blend at different concentrations of 25,50, and 100 mg/l to enhance the physicochemical fuel characteristics to obtain clean and effi-cient combustion performance. An experimental setup was incorporated into a diesel engine toinvestigate the influence of these nano-materials on engine performance, exergy analysis, combustion characteristics and emissions using WCO biodiesel-diesel mixture. Enriching methylester mixture with 100 ppm titanium, alumina and CNTs (B20T100, B20A100 andB20C100) increased the thermal efficiency by 4%, 6% and 11.5%, respectively compared toB20. Biodiesel blending with nano additives B20T100, B20A100 and B20C100 decreasedthe emissions of CO (11%, 24% and 30%, respectively), HC (8%, 17% and 25%, respectively)and smoke (10%, 13% and 19%, respectively) compared to B20. However, the noticeable increase of NOx was estimated by 5%, 12% and 27% for B20T100, B20A100 and B20C100,respectively. Finally, the results showed the rise in peak cylinder pressure by 5%, 9% and 11% and increase in heat release rate by 4%, 8% and 13% for B20T100, B20A100 andB20C100, respectively. The fuel exergy of B20T100, B20A100 and B20C100 are lower thanbiodiesel blend B20 by 6.5%, 16% and 23% but the exergetic efficiency are increased by 7%,19% and 30% at full load about B20.

关键词： Waste cooking oil(WCO) Nano additives Engine performance Exergy Combustion characteristics Emissions

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Performance,emissions and exergy analyses of adding CNTs to various biodiesel feedstocks

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Propulsion and Power Research 2022年第4期11卷 511-526页

Extraction of biodiesel from waste cooking oil,jatropha,and corn oils is done by *** and biodiesel were blended at 20%volume ratio to make methyl *** doses of 25,50,and 100 mg/l,carbon nanotubes(CNTs)was mixed with biodiesel *** objective of the present research is to examine experimentally a diesel engine performance,combustion characteristics,exergy and emissions analyses with inclusion of nano additive to various methyl ester *** ester blend is enriched with CNTs as JB20C100,WB20C100 and CB20C100 where the improvements in thermal efficiency are raised about biodiesel mixture by 9%,13%and 15%,*** of 100 ppm of CNTs to biodiesel blends achieves the greatest reductions in CO(14%,22%and 30%),HC(16%,20%and 25%),and smoke emissions(15%,19%and 23%)for JB20C100,WB20C100 and CB20C100,*** comparing with B20,blending 100 ppm CNTs with JB20,CB20,and WB20 obtained the highest increases in cylinder pressure of 3%,5%,and 10%,as well as the highest increases in heat release of 4%,7%,and 11%,*** downside of CNTs addition achieves a rise in NOx emissions by 10%,17%,and 22%for JB20C100,WB20C100,and CB20C100,*** efficiency increases by 8%,19%,and 24%for B20T100,B20A100,and B20C100,*** index improvements achieve 1.5%,5%and 6.5%,for B20T100,B20A100,and B20C100,***20 with CNTs of 100 ppm is highly recommended for improving engine performance,combustion,and exergy characteristics with considerable emissions reduction.

关键词： Biodiesel Carbon nanotubes(CNTs) Engine performance Exergy Combustion characteristics Emissions

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An Automated Real-Time Face Mask Detection system Using Transfer Learning with Faster-RCNN in the Era of the COVID-19 Pandemic

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Computers, Materials & Continua 2022年第5期71卷 4151-4166页

作者： Maha Farouk s.sabir Irfan Mehmood Wafaa Adnan Alsaggaf enas Fawai Khairullah samar Alhuraiji Ahmed s.Alghamdi Ahmed A.Abd El-Latif Department of Information systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversitySaudi Arabia Centre for Visual Computing Faculty of Engineering and InformaticsUniversity of BradfordBradfordU.K Department of Information Technology Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddahP.O.Box 23713Saudi Arabia Department of Computer science Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddahSaudi Arabia Department of Cybersecurity College of Computer Science and EngineeringUniversity of JeddahSaudi Arabia Department of Mathematics and Computer science Faculty of ScienceMenoufia University32511Egypt

Today,due to the pandemic of COVID-19 the entire world is facing a serious health *** to the World Health Organization(WHO),people in public places should wear a face mask to control the rapid transmission of *** governmental bodies of different countries imposed that wearing a face mask is compulsory in public ***,it is very difficult to manually monitor people in overcrowded *** research focuses on providing a solution to enforce one of the important preventative measures of COVID-19 in public places,by presenting an automated system that automatically localizes masked and unmasked human faces within an image or video of an area which assist in this outbreak of *** paper demonstrates a transfer learning approach with the Faster-RCNN model to detect faces that are masked or *** proposed framework is built by fine-tuning the state-of-the-art deep learning model,Faster-RCNN,and has been validated on a publicly available dataset named Face Mask Dataset(FMD)and achieving the highest average precision(AP)of 81%and highest average Recall(AR)of 84%.This shows the strong robustness and capabilities of the Faster-RCNN model to detect individuals with masked and un-masked ***,this work applies to real-time and can be implemented in any public service area.

关键词： COIVD-19 deep learning faster-RCNN object detection transfer learning face mask

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small-extracellular vesicles and their microRNA cargo from porcine follicular fluids:the potential association with oocyte quality

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Journal of Animal science and Biotechnology 2022年第6期13卷 1727-1742页

作者： Ahmed gad Matej Murin Alexandra Bartkova Veronika Kinterova Katerina Marcollova Jozef Laurincik Radek Prochazka Institute of Animal Physiology and Genetics Czech Academy of Sciences27721 LiběchovCzech Republic Department of Animal Production Faculty of AgricultureCairo UniversityGiza 12613Egypt Department of Botany and Genetics Faculty of Natural SciencesConstantine the Philosopher University in Nitra94901 NitraSlovakia.

Background: Ovarian follicular fluids(FFs) contain several kinds of regulatory factors that maintain a suitable micro-environment for oocyte development. Extracellular vesicles(EVs) are among the factors that play essential roles in regulating follicle and oocyte development through their cargo molecules that include microRNAs(miRNAs). This study aimed to investigate small-EV(s-EV) miRNAs in porcine FFs and their potential association with oocyte ***: Individual aspirated oocytes were stained with lissamine green B stain(LB), a vital stain for oocyte quality, and each oocyte was classified as high-quality(unstained;HQ) or low-quality(stained;LQ). FFs corresponding to oocytes were pooled together into HQ and LQ groups. small-EVs were isolated from FFs, characterized, and their miRNA cargo was identified using the Illumina Nova seq sequencing platform. Additionally, s-EVs from the HQ and LQ groups were utilized to investigate their effect on oocyte development after co-incubation during in vitro ***: A total of 19 miRNAs(including miR-125b, miR-193a-5p, and miR-320) were significantly upregulated, while 23(including miR-9, miR-206, and miR-6516) were downregulated in the HQ compared to the LQ group. Apoptosis, p53 signaling, and cAMP signaling were among the top pathways targeted by the elevated miRNAs in the HQ group while oocyte meiosis, gap junction, and TGF-beta signaling were among the top pathways targeted by the elevated miRNAs in the LQ group. The supplementation of small-EVs during maturation does not affect the oocyte developmental rates. However, LQ s-EVs increase the proportion of oocytes with homogeneous mitochondrial distribution and decrease the proportion of heterogeneous ***: Our findings indicated that FF-EVs contain different miRNA cargos associated with oocyte quality and could affect the mitochondrial distribution patterns during oocyte maturation.

关键词： Extracellular vesicles Follicular fuids MiRNA Oocyte quality Porcine

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A review on zero energy buildings-Pros and cons

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Energy and Built Environment 2023年第1期4卷 25-38页

作者： Tabbi Wilberforce A.G.Olabi enas Taha sayed Khaled Elsaid Hussein M.Maghrabie Mohammad Ali Abdelkareem Mechanical Engineering and Design Aston UniversitySchool of Engineering and Applied ScienceAston TriangleBirmingham B47ETUK Department of sustainable and Renewable Energy Engineering University of SharjahP.O.Box 27272SharjahUnited Arab Emirates Center for Advanced Materials Research University of SharjahPO Box 27272SharjahUnited Arab Emirates Chemical Engineering Department Minia UniversityElminiaEgypt Chemical Engineering Department Texas A&M UniversityTX 77843-3122College StationTXUSA Department of Mechanical Engineering Faculty of EngineeringSouth Valley UniversityQena 83521Egypt

Enhancing the energy efficiency of structures has been a staple of energy *** key goal is to slash elec-tricity usage in order to minimize the footprint of *** goal is sought by putting restrictions on the design specifications with respect to the properties of the raw materials and components as well as the exploitation of sustainable sources of *** facts for the basis for zero-energy building(ZEB)being *** novel technology has faced several obstacles impeding its commercialization and future *** inves-tigation therefore holistically explored and evaluated the state of zero energy building and factors impeding their *** review further proposed some suggestion in terms of technology that can be considered by the sector to augment existing ***,the investigation touched on the effect of occupant’s character in zero energy *** in terms of government subsidies and tax rebates were recommended to encourage more investors into the ***,the perception of zero energy building being more expensive compared to the traditional structures can equally be curbed via efficient and effective public sensitization.

关键词： Zero energy buildings Policies Renewable energy Construction industry

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sturgeon (Acipenser gueldenstaedtii) Acclimatization to Optimal Growth Conditions—A Case study of Adaptation, Nutrition, Reproduction, and sex Determination

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Open Journal of Animal sciences 2022年第4期12卷 629-661页

作者： gad Degani MIGAL—Galilee Research Institute Kiryat Shmona Israel Tel-Hai College Upper Galilee Israel

The development of new agricultural industries is an important challenge for a region’s economic establishment. The connection between a research department at MIGAL Institute and biotechnology in aquaculture is an example (case study) of the interrelationships that also exist in other departments. This article describes the research conducted by the institute supporting the development of the aquaculture industry in Israel through the introduction of a relatively new fish species—the Russian sturgeon (Acipenser gueldenstaedtii), with the relevant information to be used for acclimatization to aquaculture conditions in northern Israel. Many aspects related to bringing a new species to Israel and working with this new industry to study its adaptation to existing conditions in the north of the country influenced the economic success of this new type of precision agriculture. This article describes the research on various aspects affecting the successful acclimatization of Russian sturgeon in northern Israel: introduction, food development, reproduction, hormone systems that control reproduction and growth, gonadal development, and molecular markers for sex determination, differentiation, and economic assessment of caviar production.

关键词： Russian sturgeon (Acipenser gueldenstaedtii) Food Reproduction Hormones Growth Molecular Markers sex Determination

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Ectopic Cushing's syndrome in a patient with metastatic Merkel cell carcinoma:A case report

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World Journal of Clinical Cases 2022年第22期10卷 7989-7993页

作者： Avraham Ishay Elia Touma Olga Vornicova Roni Dodiuk-gad Tal Goldman Naiel Bisharat Endocrine and Diabetes Unit Emek Medical CenterAfula 18134Israel Ruth and Bruce Rappaport Faculty of Medicine Technion-Israel Institute of TechnologyHaifa 3200003Israel Department of Internal Medicine D Emek Medical CenterAfula 18134Israel Department of Oncology Emek Medical CenterAfula 18134Israel Department of Dermatology Emek Medical CenterAfula 18134Israel Department of Pathology Emek Medical CenterAfula 18134Israel Department of Medicine D Emek Medical CenterAfula 18134Israel

BACKGROUND Ectopic Cushing syndrome(ECs)is a rare condition commonly associated with neuroendocrine tumors(NET),mainly bronchial *** association of paraneoplastic syndrome with Merkle cell carcinoma(MCC)is limited to individual case *** sUMMARY In this article we report an unusual and striking presentation of ECs in a patient with known metastatic *** elderly patient presented with new onset severe hypertension,hyperglycemia and hypokalemia,muscle wasting,and peripheral edema.A diagnosis of adrenocorticotropic hormone dependent,non-pituitary,Cushing syndrome was *** therapy inhibiting adrenal function was promptly started but unfortunately the patient survived only a few days after *** The occurrence of an aggressive form of ECs in patients with NET should be recognized as an ominous *** our knowledge,the association of this complication in a patient with MCC had not been reported.

关键词： Merkle cell carcinoma Paraneoplastic syndrome Ectopic Cushing's syndrome Neuroendocrine tumor Hypercortisolism skin cancer Case report

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