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Effects of dual sofosbuvir/daclatasvir therapy on, chronic hepatitis C infected, survivors of childhood malignancy

World Journal of Clinical Cases 2019年第16期7卷 2247-2255页

作者： Mortada HF El-Shabrawi Laila M Sherief Mostafa Yakoot Naglaa M Kamal Mohamed A Almalky Manal M AbdElgawad Aml A Mahfouz Sherine Helmy enas M Kamal Dina Attia Hisham R El-Khayat Paediatric Hepatology Department Cairo Faculty of MedicineCairo 11559Egypt Paediatric Hematology-Oncology Department Zagazig Faculty of MedicineZagazig 21121Egypt Internal medicine Pediatrics and HepatologyGreen Clinic and Research CenterAlexandria UniversityAlexandria 21121Egypt Paediatric Hepatology Department Alexandria Faculty of medicineAlexandria 21121Egypt Innovations & Research Pharco CorporationAlexandria 21121Egypt Endemic medicine and Hepatology Department Minia UniversityMinia 22233Egypt Endemic medicine and Hepatology Department Beni-suef UniversityBeni-suef 62511Egypt Gastroenterology and Endemic Medicine Department Theodore Research InstituteCairo 23323Egypt

BACKGROUND Childhood cancer survivors are potentially at a higher risk of infection with hepatitis C virus (HCV).The effects of all-oral direct-acting antiviral therapy (DAA) on both the HCV infection as well as the state of cancer remission have not been well investigated in this *** To test the effects of dual sofosbuvir/daclatasvir (SOF/DCV) therapy in the treatment of chronic HCV in survivors of hematologic malignancy in pediatric age *** We conducted a prospective,uncontrolled,open-label multicenter study.A total of 20 eligible,chronic HCV,genotype-4,infected children who had been in continuous complete remission from hematologic cancer (leukemia/lymphoma) for at least one year were included in the *** patients were treated with combined SOF/DCV for 12 *** were monitored throughout the study till 12 wk after end of treatment for safety and efficacy outcomes including the sustained virologic response 12 (SVR12) rate,hematological indices,liver and kidney *** The intent-to-treat SVR12 rate was 20 of 20 (100%;95%CI: 84%-100%).All patients showed normalized liver enzymes from *** hematological indices,liver and kidney functions were kept normal throughout the *** fatalities or treatment-emergent serious or severe adverse events were reported throughout the *** SOF/DCV combined therapy could be used safely and effectively in the treatment of chronic HCV genotype-4 infection in leukemia/lymphoma treated *** relapses were detected during treatment and throughout the follow up period for either the original malignant disease or the HCV infection.

关键词： Chronic hepatitis C Survivors of childhood cancer Sofosbuvir Daclatasvir Efficacy

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The Relationship between Circulating Levels of Osteopontin with Carotid Intima-Media Thickness in Children on Regular Hemodialysis

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Open Journal of Nephrology 2021年第4期11卷 467-476页

作者： Raghda Mohamed enas Tawfeek Manal Abdel-Salam Niveen Mohamed Ghoraba Hala Maghraby Pediatric Department Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt Clinical Pathology Department Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt Radiology Department Faculty of Medicine (for Girls) Al-Azhar University Cairo Egypt

Background: Chronic kidney disease (CKD) is associated with cardiovascular morbidity and mortality. Osteopontin (OPN) is a critical factor in developing atherosclerosis and increases the risk for a major adverse cardiovascular event. Aim: To investigate osteopontin serum levels in hemodialysis children and detect the association between the main arteries’ intimal medial thickness (IMT) and peak systolic velocity. Material and Methods: This case-control study included 30 children on regular hemodialysis and 30 children age and sex-matched as controls their age range from 4 to 18 years;we investigated osteopontin serum level in addition to the Doppler ultrasound assessment of intimal medial thickness and peak systolic velocity (PSV) of the main arteries in the same line with the traditional markers of the routine investigations of children on regular hemodialysis. Results: Significantly high osteopontin level in hemodialysis children than the controls was (0.85 ± 0.21 ng/ml) (0.69 ± 0.26 ng/ml), respectively (p = 0.026). A significant increase in the (IMT) of the main arteries, including the carotid and femoral arteries, in the patient’s group than the controls, was (0.51 ± 0.01 mm) (0. 69. ± 0.01 mm) (0.32 ± 0.036 mm) (0.55 ± 0.01), respectively (p = 0.001). There is a strong correlation between (OPN) with the (IMT) of carotid and femoral arteries, a significant positive correlation between (OPN) with urea, creatinine, triglyceride, PTH, ferritin, CRP, and ESR, and a negative correlation with RBCs count and carotid PSV. Conclusion: High osteopontin level is consistent with the increased IMT of the main arteries in hemodialysis children that seem to play a significant role in developing and propagating atherosclerosis in hemodialysis children, evidenced by significant association with inflammatory markers and uremic toxins.

关键词： Children Hemodialysis Osteopontin

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Preparation and Spectroscopic of Vanadyl（Ⅱ） Vitamin D3 Amino Acid Mixed Complexes as Insulin Mimetic Drug

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光谱学与光谱分析 2019年第7期39卷 2316-2324页

作者： enas Aljuhani Amnah M.A.Alsuhaibani A.M.El-Di damony N.Hassan Sameh Abo Taleb Moamen S.Refat Department of Chemistry Faculty of Applied ScienceUmm Al-Qura UniversityMakkahP.O.9168 Zip Code 21955Saudi Arabia Nutrition and Food Sciences Dept. Home Economic CollegePrincess Nourah Bint Abdulrahman UniversityRiyadhSaudi Arabia Department of Chemistry Faculty of ScienceZagazig UniversityEgypt Department of Chemistry Faculty of SciencePort SaidPort Said UniversityEgypt Chemistry Department Faculty of ScienceTaif UniversityP.O.Box 888Al-HawiahTaif 21974Saudi Arabia

A new six intraperitoneal injection insulin-mimetic vanadyl(Ⅱ) compounds [(VD3^-1)(VO^+2)(AAn^-1)](where(n=1~6);AA1=isoleucine, AA2=threonine, AA3=proline, AA4=phenylalanine, AA5=lysine and AA6=glutamine) were synthesized by the chemical reactions between vitamin D3(VD3), VOSO4 and amino acids(AAn) with equal molar ratio 1∶1∶1 in neutralized media. The structures of these complexes were elucidated by spectroscopic methods like, infrared and solid reflectance spectroscopes. Magnetic moments and electronic spectra reveal square pyramid geometrical structure of the complexes. The infrared spectra assignments of these complexes revealed that the chelation towards vanadyl(Ⅳ) ions existed via deprotonation of the hydroxyl group of VD3 drug ligand and so amino acids act as bidentate ligand via N-amino and O-carboxylate groups. The anti-diabetic efficiency of these complexes were evaluated against streptozotocin induced diabetic male albino rats.

关键词： Insulin alternative Diabetes Drug VO^2+ ion Vitamin D3 Amino acid Spectroscopic

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Study of Prevalence of Abnormal Cervical Cytology in Al-Shatby Maternity University Hospital

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Open Journal of Obstetrics and Gynecology 2021年第4期11卷 434-449页

作者： Ahmed Essmat Mahmoud Meleis Hossam Elsokkary Sanna Shawky Ahmed enas El-Soody Department of Obstetrics and Gynecology Faculty of Medicine Alexandria University Alexandria Egypt Department of Pathology Medical Research Institute Alexandria University Alexandria Egypt

Introduction: Cervical cancer is the most common cause of preventable cancer related deaths;cervical cancer has a long pervasive phase (cervical dysplasia);the prevalence of cervical dysplasia varies according to the socioeconomic characteristics and geographic areas of the population studied. Low-grade lesions regress spontaneously in a significant number of patients, while high grade lesions will progress to an invasive cancer if left untreated. Cervical cancer screening is an important component of the World Health Organization (WHO) strategy for combating cervical cancer. The incidence and prevalence of cervical cancer has reduced remarkably over the last three decades in developed countries where there are effective, well-coordinated screening programs, and treatment of cervical dysplasia, while in developing countries it has been increasing and has constituted major health problems among women where there are no well-coordinated and effective screening programs, also resources are very low and no insurance can cover this programs. Aim of the work: The aim is to assess the prevalence of abnormal cervical cytology in Al Shatby Maternity University Hospital patients using Pap smear. Materials and methods: Inclusion criteria: 1) Married woman from 3 years or more;2) Women age from 21 to age 65 years. Exclusion criteria: 1) Previously known cervical cancer patient;2) Virgin females;3) Woman with active vaginal bleeding. Results: 83% of patients were -ve intraepithelial neoplasia {37.7% was normal cytology and 45.3% was inflammatory}. 17% was +ve intraepithelial neoplasia (abnormal cytology), {11.1% ASCUS, 2.9% LSIL, 1.3% HSIL, 1.1% ASC-H, 0.3% AGS

关键词： Abnormal Cervical Cytology Bethesda System Cervical Cancer Screening Pap Smear Preinvasive Cervical Cancer

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Association of Human Herpesvirus 6 and 8 in Relapsing Remitting Multiple Sclerosis Type during Exacerbation

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Neuroscience & Medicine 2010年第1期1卷 33-37页

作者： Hassan Salama Mohamed El-Khateeb Rawya Bader Mohamed Saleh enas Hamad 不详

Multiple Sclerosis (MS) is a chronic demyelinating disease of the CNS with assumed autoimmune etiology. Human herpes viruses have probable effects on relapsing-remitting MS pathogenesis presumably through molecular mimicry and/or bystander mechanisms. In this study we probed the possible contribution of the two herpes viruses, human herpesvirus 6 (HHV-6) and human herpesvirus 8 (HHV-8), in clinically definite multiple sclerosis (CDMS) pa-tients-relapsing remitting type (RRMS) during clinical exacerbations. All patients had no history of immune modulating or suppressing drugs intake in the last 6 months. The peripheral blood samples, from CDMS patients (n = 20) (13F/7M, age (y) = 30.3 ± 3.21) and other immune mediated neurological disorders (OIND) (11F/9M, age = 25.2 ± 12.1), (My-asthenia Gravis, Guillain Barré Syndrome, ischemic stroke in adolescent and young adult with no clear risk factors), as a control group, had been enrolled within 15 months (January-2007-- March -2008). We investigated the existence of specific deoxyribonucleic acid (DNA) sequences belonging to HHV-6 and HHV-8, using polymerase chain reaction (PCR) in the isolated peripheral blood mononuclear cells (PBMCs) and in plasma. PCR demonstrated HHV-6 DNA in 7 cases (35%), HHV-8 sequences in only one cases (5%) in PBMCs from 20 relapsed CDMS patients;all HHV-6 posi-tive cases showed positive plasma results, while the blood samples from 20 OIND patients showed negative results ex-cept one case (5%) out of 9 cases of GBS was positive for HHV-8 in PBMCs. We consequently concluded that there is considerable evidence in this study that proposed the roles of HHV-6 and HHV-8 in MS pathogenesis and clinical ex-acerbation.

关键词： Multiple Sclerosis HHV6 HHV8 Antiviral Drugs

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Indoor Surveillance of Airborne Fungi Contaminating Intensive Care Units and Operation Rooms in Assiut University Hospitals, Egypt

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Journal of Health Science 2014年第1期2卷 20-27页

作者： M. Bassam Aboul-Nasr Abdel-Naser A. Zohri enas Mahmoud Amer Faculty of Science Department of Botany University of Sohag Sohag 82524 Egypt Faculty of Science Department of Botany and Microbiology University of Assiut Assiut 71515 Egypt

Mycoflora of atmospheric air and dust samples collected from air conditioning systems in 12 of each I.C.U. （intensive care units） and O.R. （operation rooms） were tested using settle and dilution plate methods on four types of agar media and incubated at 25℃. Forty-five fungal species representing 23 genera were isolated and identified. The most prevalent genera recorded were Cladosporium, Aspergillus, Penicillium and Fusarium. The total colony forming units of airborne fungi recovered in I.C.U. and O.R. ranged between 31.13-49.61 colonies/m3 on the four types of media usedl The fungal total catch of the dust samples collected from the air conditioning system filters in I.C.U. and O.R. were ranged from 65.5-170 colonies/mg dust. Since, the interest to replace synthetic xenobiotics by natural compounds with low environmental persistence and biodegradable to control such airborne fungal contaminants is needed. In this respect, essential oils showed to possess a broad spectrum of antifungal activity. Fungal static ability of six oils was tested on 30 different fungal isolates. Vapors of common thyme oil exhibited the strongest inhibitory effects on the tested isolates, whereas the headspace vapors of blue gum and ginger had no inhibitory effects on the tested fungal isolates. These data revealed that the air conditioning systems may be an important source of contamination in I.C.U. and O.R. of Assiut university hospitals. Thus, patients may be in risk of being exposed to contaminated atmospheric air by opportunistic fungi and the use of essential oils as an alternative option to control hospital wards from fungal contaminants needs further studies.

关键词： Air conditions airborne fungi intensive care units operation rooms and volatile oils.

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Cost Effective Adsorption of Aluminium and Iron from Synthetic and Real Wastewater by Rice Hull Activated Carbon (RHAC)

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American Journal of Analytical Chemistry 2015年第1期6卷 71-83页

作者： Nour T. Abdel-Ghani Ghadir A. El-Chaghaby enas Mohamed Zahran Chemistry Department Faculty of science Cairo University Cairo Egypt RCFF Agricultural Research Center Giza Egypt Holding Company for Water and Wastewater Greater Cairo Water Company Cairo Egypt

The adsorption of aluminium(III) and iron(III) ions from their single and binary systems, by RHAC was investigated in a batch system. The activated carbon prepared from rice hulls was characterized by scanning electron microscopy and Fourier transformation infrared techniques. Batch adsorption experiments were performed under different operating conditions including pH (2 - 5), adsorbent dosage (0.5 - 2.0 g/l), initial ion concentration (5 - 100 mg/l), and contact time (30 - 240 min). The equilibrium time for maximum ions removal was found to be 180 min in single and binary ions systems. The kinetics of adsorption was evaluated using the pseudo-first order, pseudo-second order and Elovich kinetic models. The Langmuir, Freundlich and Temkin equilibrium models were applied to the adsorption experimental data. Real wastewater samples were collected from different locations to investigate the efficiency of rice hull activated carbon in treating real samples. The real wastewater samples were treated with the activated carbon prepared from rice hulls and a commercial activated carbon. The results showed that the activated carbon prepared in the present work was more efficient in the removal of aluminium and iron from real wastewater as compared to the commercial activated carbon which is more advantageous considering both economics and environmental parameters.

关键词： Aluminium Iron Adsorption Rice Hulls Activated Carbon Kinetics Equilibrium

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Formulation and evaluation of anti-asthmatic drug montelukast in mucoadhesive buccal patches

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Journal of Coastal Life Medicine 2014年第11期 907-914页

作者： Magdy Ibrahim Mohamed enas Abd El-Moneim Mohamed Radwan Afify Mary Kamal Gad Mekhael Department of Pharmaceutics Faculty of PharmacyCairo UniversityCairoEgypt National Organization for Drug Control and Research DokyGizaEgypt

Objective: To formulate and evaluate anti-asthmatic drug montelukast in mucoadhesive buccal patches. Methods:Buccal patches were formulated by using different hydrophilic polymers by solvent casting technique. Buccal patches were evaluated by seven physical appearances, in addition toin vitro drug release study. Results: All patches were uniform and translucent, and had smooth surface. In vitro release studies were conducted for montelukast buccal patches proved that release in the range of 75.26%-92.30% in 8 h. Emission of montelukast from all patches simulated zero order and diffusion mechanism. Finally it can be concluded that F3, F15 and F16 are the best formulation. Conclusions: The investigation concluded that patch of 5 mg of montelukast sodium were formulated by using sodium alginate with sodium carboxy methyl cellulose, hydroxy propyl methyl cellulose K100M with sodium carboxy methyl cellulose, and hydroxy propyl methyl cellulose K100M with sodium alginate (F3, F15 and F16 formulations) were the best formulations.

关键词： Montelukast sodium Gelatin Hydroxy propyl methyl cellulose Poly vinyl pyrrolidone Buccal film In-vitro release

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Video recording of neonatal resuscitation:A feasibility study to inform widespread adoption

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World Journal of Clinical Pediatrics 2017年第1期6卷 69-80页

作者： Sandesh Shivananda Jennifer Twiss enas el-Gouhary Salhabel-Helou Connie Williams Prashanth Murthy Gautham Suresh Department of Pediatrics McM aster University Pediatrics-Newborn Baylor College of MedicineHouston

AIM To determine the feasibility of introducing video recording(VR) of neonatal resuscitation(NR) in a perinatal *** This was a prospective cohort quality improvement study on preterm infants and their *** on evidence and experience of other centers using VR intervention,a contextually relevant implementation and evaluation strategy was designed in the planning *** components of intervention were pre-resuscitation team huddle,VR of NR and video debriefing(VD),all occurringon the same *** domains of feasibility and sustainability as well as feasibility criteria were *** for analysis was collected using quantitative and qualitative *** Seventy-one caregivers participated in VD of 14 NRs facilitated by six trained ***-one percent of caregivers perceived enhanced learning and patient safety and,48 issues were identified related to policy,caregiver roles,and latent safety *** percent of caregivers expressed their willingness to participate in VD activity and supported the idea of integrating it into a resuscitation team ***-three percent and 50% of instructors expressed satisfaction with video review software and quality of audio *** issues about maintenance of infant or caregivers' confidentiality and erasure of videos were *** for feasibility were met(refusal rate of 50% of occasions,and < 20% caregivers' perceiving a negative impact on team performance).Necessary adaptations to enhance sustainability were *** VR of NR as a standard of care quality assurance activity to enhance caregivers' learning and create opportunities that improve patient safety is *** its complexity with inherent challenges in implementation,the intervention was acceptable,implementable,and potentially sustainable with adaptations.

关键词： Video recording Neonatal resuscitation Delivery room Feasibility Perinatal centre

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Use of the urinary trypsinogen-2 dipstick test in early diagnosis of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP)

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Open Journal of Gastroenterology 2013年第6期3卷 289-294页

作者： Hasan El-Garem enas Hamdy Sherif Hamdy Mohammad El-Sayed Aisha Elsharkawy Azmi Mohammed Saleh Department of Clinical Pathology Faculty of Medicine Cairo University Cairo Egypt Department of Endemic Medicine and Hepatology Faculty of Medicine Cairo University Cairo Egypt

Background: Acute pancreatitis is one of the most serious complications of ERCP. Early diagnosis of post ERCP pancreatitis helps physicians to provide intensive care and possible medical treatment as early as possible. Trypsinogen-2 in urine is a good diagnostic and prognostic marker of acute pancreatitis. Objectives: To evaluate the diagnostic value of urinary trypsinogen-2 dipstick test for early diagnosis of post ERCP pancreatitis. Methods: A total of 37 patients with obstructive jaundice were tested with the urinary trypsinogen-2 dipstick test and serum levels of amylase and lipase before ERCP and 6 hours after ERCP. Results: Post ERCP pancreatitis was diagnosed in 6 (16%) of 37 patients. The sensitivity, specificity, positive predictive value and negative predictive value of urinary trypsinogen-2 dipstick test at 6 hours after ERCP were 100%, 97%, 86%, 100% respectively. At the cutoff level (130 U/L) for lipase, the positive predictive value and negative predictive value all were (100%), however, the positive predictive value and negative predictive value for amylase levels at cutoff (122 U/L) were 60%, 100% respectively. Serum lipase level was the best test for diagnosing post ERCP pancreatitis followed by the urinary trypsinogen-2 dipstick test. Conclusions: The urinary trypsinogen-2 dipstick test can be used as a rapid and easy test for early diagnosis of post ERCP pancreatitis with high sensitivity and specificity.

关键词： ERCP Pancreatitis Urinary Trypsinogen-2 Dipstick Test

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