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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-qiang zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

梯子崖-富子岭矿区复杂地层钻探技术问题与对策

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探矿工程（岩土钻掘工程） 2017年第9期44卷 1-6页

作者：祁恩强朱金军西北有色地质勘查局七一七总队陕西宝鸡721004

陕西省凤县梯子崖-富子岭铅锌多金属矿区,其地层主要为产状较陡的千枚岩,局部含方解石或石英脉,断层破碎带发育,井壁稳定性差,施工中孔斜严重,许多钻孔因孔斜而达不到设计目的,防斜、治斜和泥浆护壁为该矿区施工方面的主要技术难题。文... 详细信息

陕西省凤县梯子崖-富子岭铅锌多金属矿区,其地层主要为产状较陡的千枚岩,局部含方解石或石英脉,断层破碎带发育,井壁稳定性差,施工中孔斜严重,许多钻孔因孔斜而达不到设计目的,防斜、治斜和泥浆护壁为该矿区施工方面的主要技术难题。文章从孔斜预防、定向造斜、护壁堵漏等方面介绍了所采取的工艺措施和取得的效果。

关键词：钻孔偏斜定向钻进偏斜器护壁堵漏岩心钻探

A New Fast Matching Algorithm by Trans-Scale Search for Remote Sensing Image

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Chinese Journal of Electronics 2015年第3期24卷 654-660页

作者： QI Youjie zhu en College of Information Science and engineering Southeast University

A new fast matching algorithm for remote sensing images is proposed. The algorithm adopts a coarse to fine matching process. A remote sensing image is decomposed into multi-scale images which form a wavelet image pyramid by the way of DWT(Discrete wavelet transform).Extract a low frequency sub-image from the wavelet image pyramid to carry out a rough matching operation between the sub-image and target image, and then get a rough position after cluster analysis. Get a suitable position with center at the rough position from remote sensing image to accomplish fine matching operation. The algorithm has been analyzed theoretically from the signal processing point of view, and a sufficient condition is given to select wavelet filter. Simulation results testify that proposed algorithm not only distinguishes remote sensing images precisely, but also cuts down matching time greatly. It is only 25.04% of SIFT algorithm, and 35.36% of SURF algorithm for matching time.

关键词： Image matching SIFT DWT Remote sensing

Molecular simulation study of the microstructures and properties of pyridinium ionic liquid[HPy][BF_(4)]mixed with acetonitrile

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原子与分子物理学报 2025年第4期42卷 27-32页

作者： XU Jian-qiang MA Zhao-Peng CHenG Si LIU Zhi-Cong zhu Guang-Lai Department of Physics School of Physics and Electronic InformationAnhui Normal UniversityWuhu 241002China

The microstructures and thermodynamic properties of mixed systems comprising pyridinium ionic liquid[HPy][BF_(4)]and acetonitrile at different mole fractions were studied using molecular dynamics simulation in this *** following properties were determined:density,self-diffusion coefficient,excess molar volume,and radial distribution *** results show that with an increase in the mole fraction of[HPy][BF_(4)],the self-diffusion coefficient ***,the excess molar volume initially decreases,reaches a minimum,and then *** rules of radial distribution functions(RDFs)of characteristic atoms are *** increasing the mole fraction of[HPy][BF_(4)],the first peak of the RDFs of HA1-F decreases,while that of CT6-CT6 rises at first and then *** indicates that the solvent molecules affect the polar and non-polar regions of[HPy][BF_(4)]differently.

关键词： Pyridinium ionic liquids Thermodynamic properties Molecular dynamics simulation Radial distribution functions

Risk of Developing Non-Alcoholic Fatty Liver Disease Over Time in a Cohort of the Elderly in Qingdao,China

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Biomedical and environmental Sciences 2023年第8期36卷 760-767页

作者： LIU Li SHAO Yu Han FenG en qiang SHAO zhu Gang XING Dong Ming Cancer Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao 266071ShandongChina Qingdao Cancer Institute Qingdao 266071ShandongChina Qingdao Municipal Center for Disease Control and Prevention Qingdao 266033ShandongChina Qingdao Institute of Preventive Medicine Qingdao 266033ShandongChina Shandong Muhua Medical Technology Co. LtdQingdao 266109ShandongChina School of Life Sciences Tsinghua UniversityBeijing 100084China

Nonalcoholic fatty liver disease(NAFLD)is characterized by fat accumulation in the liver in the absence of alcohol consumption and comprises a variety of conditions such as simple steatosis,nonalcoholic steatohepatitis,fibrosis,and cirrhosis^([1]).More than one-quarter of the world’s population experience NAFLD^([2]).The prevalence of NAFLD in China increased from 23.8%in 2001 to 32.9%in 2018,indicating that hepatitis B virus is the primary cause of chronic liver disease^([3]).

关键词： NAFLD liver Liver

New direction for surgery:Super minimally invasive surgery

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World Journal of Gastroenterology 2024年第12期30卷 1676-1679页

作者： en-qiang Linghu Department of Gastroenterology First Medical Center of Chinese PLA General HospitalBeijing 100853China

The top goal of modern medicine is treating disease without destroying organ structures and making patients as healthy as they were before their *** invasive surgery(MIS)has dominated the surgical realm because of its lesser ***,changes in anatomical structures of the body and reconstruction of internal organs or different organs are common after traditional surgery or MIS,decreasing the quality of life of patients ***,I propose a new treatment mode,super MIS(SMIS),which is defined as“curing a disease or lesion which used to be treated by MIS while preserving the integrity of the organs”.In this study,I describe the origin,definition,operative channels,advantages,and future perspectives of SMIS.

关键词： Super minimally invasive surgery Minimally invasive surgery Treatment mode Traditional Surgery New direction for surgery

ANALYSIS OF TWO-PHASE FLOW PRESSURE BUILDUP DATA FROM A WELL IN ANINFINITE MULTI WELL RESERVOIR

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Journal of Hydrodynamics 2005年第4期17卷 489-497页

作者： LIN Jia-en YANG Hui-zhu Department of engineering Mechanics Tsinghua University Beijing 100084 China Petroleum engineering Institute Xi＇an Petroleum University Xi＇an 710065China Department of engineering Mechanics Tsinghua UniversityBeijing 100084 China

A general method has been developed for analyzing two-phase flow pressure buildup data from a well located in a system of both production and injection wells completed in an infinite muhiwell reservoir. The analysis technique assumes that the tested well has established its own drainage area before shut-in and a linear reservoir pressure trend dominates the well pressure behavior at the instant of shut-in. And for the two-phase flow problems the horizontal saturation gradients are assumed to be negligible. The entire pressure rcsponse, whether or not conventional semilog straight lines exist, can be analyzed and the Injection-Production Ratio （IPR）, the total fluid （oil/water） mobility, the average drainage-area pressure, and also the skin factor can be calculated much easily. The validity and applicability of the method are demonstrated by a field example. The technique by using the type curves for analyzing the pressure-buildup data is also presented here.

关键词： two-phase flow infinite multiwell reservoir well test analysis typc-curve analysis

Both self-assembly and aggregation-induced emission are photoswitchable

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Science China Chemistry 2018年第10期61卷 1201-1202页

作者： Ming-qiang zhu Wuhan National Laboratory of Optoelectronics(WNLO) Huazhong University of Science and Technology (HUST)

As a classical photochromic candidate, bisthienylethene(BTE) is a thermally irreversible photochromic compound and its photochromic behavior was firstly reported in *** to its thermal irreversibility and high fatigue resistance,its application has been widely studied for opto-electrical devices such as memories and switches. In general, the modification of fluorophore to the side of BTE is a simple method for constructing fluorescent photoswitches.

关键词：组装排放聚集光反应候选人变色混合物不可逆

ANALYSIS OF A MIXED FINITE ELEMenT METHOD FOR A PHASE FIELD BenDING ELASTICITY MODEL OF VESICLE MEMBRANE DEFORMATION

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Journal of Computational Mathematics 2006年第3期24卷 265-280页

作者： qiang Du Liyong zhu Department of Mathematics Pennsylvania State University University Park PA 16802 USA ICMSEC Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100080 China ICMSEC Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China

In this paper, we study numerical approximations of a recently proposed phase field model for the vesicle membrane deformation governed by the variation of the elastic bending energy. To overcome the challenges of high order nonlinear differential systems and the nonlinear constraints associated with the problem, we present the phase field bending elasticity model in a nested saddle point formulation. A mixed finite element method is then employed to compute the equilibrium configuration of a vesicle membrane with prescribed volume and surface area. Coupling the approximation results for a related linearized problem and the general theory of Brezzi-Rappaz-Raviart, optimal order error estimates for the finite element approximations of the phase field model are obtained. Numerical results are provided to substantiate the derived estimates.

关键词： Bio-membrane Elastic bending energy Phase field Finite element Nestedmixed saddle point formulation Optimal error estimates.