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Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting liu Shiqi Huang Xiangliang Chen Shen liu Junshan Zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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A nonlinear constitutive model for magnetostrictive materials

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Acta Mechanica Sinica 2005年第3期21卷 278-285页

作者： Xin'en liu Xiaojing Zheng Department of Mechanics Lanzhou University Lanzhou 730000 China

A general nonlinear constitutive model is proposed for magnetostrictive materials, based on the important physical fact that a nonlinear part of the elastic strain produced by a pre-stress is related to the magnetic domain rotation or movement and is responsible for the change of the maximum magnetostrictive strain with the pre-stress. To avoid the complicity of determining the tensor function describing the nonlinear elastic strain part, this paper proposes a simplified model by means of linearizing the nonlinear function. For the convenience of engineering applications, the expressions of the 3-D （bulk）, 2-D （film） and 1-D （rod） models are, respectively, given for an isotropic material and their applicable ranges are also discussed. By comparison with the experimental data of a Terfenol-D rod, it is found that the proposed model can accurately predict the magnetostrictive strain curves in low, moderate and high magnetic field regions for various compressive pre-stress levels. The numerical simulation further illustrates that, for either magnetostrictive rods or thin films, the proposed model can effectively describe the effects of the pre-stress or residual stress on the magnetization and magnetostrictive strain curves, while none of the known models can capture all of them. Therefore, the proposed model enjoys higher precision and wider applicability than the previous models, especially in the region of the high field.

关键词： Magnetostrictive materials Constitutive relations Terfenol-D rods Magnetostrictive thin films Microactuators

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Ru doping triggering reconstruction of cobalt phosphide for coupling glycerol electrooxidation with seawater electrolysis

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Journal of energy Chemistry 2025年第1期100卷 317-326页

作者： binglu Deng Jie Shen Jinxing Lu Chuqiang Huang Zhuoyuan Chen Feng Peng Yunpeng liu School of Materials Science and Hydrogen energy Foshan University School of Chemistry and Chemical engineering Guangzhou University Guangdong Key Laboratory for Hydrogen energy Technologies

Seawater electrolysis is a promising approach for sustainable energy without relying on precious ***,the large-scale seawater electrolysis is hindered by low catalytic efficiency and severe anode corrosion caused by the harmful *** contrast to the oxygen evolution reaction （OER）and chlorin ion oxidation reaction （ClOR）,glycerol oxidation reaction （GOR） is more thermodynamically and kinetically favorable ***,a Ru doping cobalt phosphide （Ru-CoP2） is proposed as a robust bifunctional electrocatalyst for seawater electrolysis and GOR,for the concurrent productions of hydrogen and value-added *** in situ and ex situ characterization analyses demonstrated that Ru doping featured in the dynamic reconstruction process from Ru-CoP2to Ru-CoOOH,accounting for the superior GOR *** coupling GOR with hydrogen evolution was realized by employing Ru-CoP2as both anode and cathode,requiring only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower than that in alkaline *** work guides the design of bifunctional electrocatalysts for energy-efficient seawater electrolysis coupled with biomass resource upcycling.

关键词： Glycerol electrooxidation Hydrogen evolution Ru doping Cobalt phosphide Bifunctional electrocatalysts

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Novel design of photoelectrochemical device by dual BiVO4 photoelectrode with abundant oxygen vacancy

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Science Bulletin 2018年第16期63卷 1027-1028页

作者： Dong liu bin liu School of Chemical and Biomedical engineering Nanyang Technological University Singapore 637459 Singapore

Solar-driven catalysis represents a promising strategy and an important approach to provide clean energy and renewable *** decades of research on solar-driven catalysis,scientists are now focusing on module design,mec... 详细信息

关键词：氧化还原作用模块设计催化作用设备高生产率催化剂设计变换效率工作机制

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Vibration absorption of parallel-coupled nonlinear energy sink under shock and harmonic excitations

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Applied Mathematics and Mechanics(english Edition) 2021年第8期42卷 1135-1154页

作者： Jian’en CHen Wei ZHANG Jun liu Wenhua HU Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control School of Mechanical EngineeringTianjin University of TechnologyTianjin 300384China National Demonstration Center for Experimental Mechanical and Electrical engineering Education Tianjin University of TechnologyTianjin 300384China Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures College of Mechanical EngineeringBeijing University of TechnologyBeijing 100124China

Nonlinear energy sink(NES)can passively absorb broadband energy from primary *** multiple NESs connected in parallel exhibit superior performance to single-degree-of-freedom(SDOF)*** this work,a linear coupling spring is installed between two parallel NESs so as to expand the application scope of such vibration *** vibration absorption of the parallel and parallel-coupled NESs and the system response induced by the coupling spring are *** results show that the responses of the system exhibit a significant difference when the heavier cubic oscillators in the NESs have lower stiffness and the lighter cubic oscillators have higher ***,the efficiency of the parallel-coupled NES is higher for medium shocks but lower for small and large shocks than that of the parallel *** parallel-coupled NES also shows superior performance for medium harmonic excitations until higher response branches are *** performance of the parallel-coupled NES and the SDOF NES is *** is found that,regardless of the chosen SDOF NES parameters,the performance of the parallel-coupled NES is similar or superior to that of the SDOF NES in the entire force range.

关键词： coupling influence nonlinear energy sink(NES) vibration absorption

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Co-production of hydrogen, oxygen, and electricity via an integrated solar-driven system with decoupled water electrolyzer and Na-Zn ion battery

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Journal of energy Chemistry 2025年第1期100卷 621-627页

作者： Fei Lv Longjie liu Jiazhe Wu Pengfei Wang Lixia Pan Dengwei Jing Yubin Chen International Research Center for Renewable energy State Key Laboratory of Multiphase Flow in Power Engineering Xi'an Jiaotong University

Combining water electrolysis and rechargeable battery technologies into a single system holds great promise for the co-production of hydrogen （H2） and ***,the design and development of such systems is still in its ***,an integrated hydrogen-oxygen （O2）-electricity co-production system featuring a bipolar membrane-assisted decoupled electrolyzer and a Na-Zn ion battery was established with sodium nickelhexacyanoferrate （NaNiHCF） and Zn2+/Zn as dual redox *** decoupled electrolyzer enables to produce H2and O2in different time and space with almost 100%Faradaic efficiency at 100 mA ***,the charged NaNiHCF and Zn electrodes after the electrolysis processes formed a Na-Zn ion battery,which can generate electricity with an average cell voltage of 1.75 V at 10 m A *** connecting Si photovoltaics with the modular electrochemical device,a well-matched solar driven system was built to convert the intermittent solar energy into hydrogen and electric energy with a solar to hydrogen-electricity efficiency of 16.7%,demonstrating the flexible storage and conversion of renewables.

关键词： Hydrogen Electricity Decoupled water electrolyzer Na-Zn ion battery Solar energy

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Comparison of Three Methods for Determination of Root Hydraulic Conductivity of Maize(Zea mays L.)Root System

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Agricultural Sciences in China 2010年第10期9卷 1438-1447页

作者： LI Qing-ming liu bin-bin State Key Laboratory of Crop Biology Shandong Agricultural University Tai'an 271018 P.R. China Key Laboratory of Horticultural Crop Biology Ministry of Agriculture/Shandong Agricultural University Tai'an 271018 P.R.China

Three techniques of root pressure probe, pressure chamber and high pressure flow meter were used to measure the hydraulic conductivities （Lpr） of whole root systems of young maize （Zea mays L.） seedlings grown hydroponically under either drought or normal water conditions. Compared to normal water conditions, drought stress simulated by polyethylene glycol 6 000 （osmotic potential =-0.2 MPa） reduced Lpr in the root system by over 50%. It indicated that water permeability in the roots decreased significantly when plants suffered from water shortages. Moreover, there was no significant difference （P〈 0.05） on the Lpr values in the root systems developed under a given water stress regime among the three techniques used. Therefore, all three methods are acceptable to study the hydraulic conductivity of maize seedling root systems. We have also highlighted some of the technical limitations of each method. It can be inferred that the root pressure probe is preferable for young maize seedlings because it is subtle and has the additional ability to determine solute transport properties, but the method is time consuming. Other advantages and disadvantages of each technique are discussed in order to acquaint researchers with basic information that could contribute to their choice of an appropriate technique for future studies.

关键词： hydraulic conductivity Zea mays L. root pressure probe pressure chamber high pressure flow meter

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New Upper Bounds on Linear Coloring of Planar Graphs

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Acta Mathematica Sinica,english Series 2012年第6期28卷 1187-1196页

作者： bin liu Gui Zhen liu Department of Mathematics Ocean University of China School of Mathematics Shandong University

A proper vertex coloring of a graph G is linear if the graph induced by the vertices of any two color classes is the union of vertex-disjoint paths. The linear chromatic number lc（G） of the graph G is the smallest number of colors in a linear coloring of G. In this paper, it is proved that every planar graph G with girth g and maximum degree A has （1） lc（G） ≤ △ ＋ 21 if △ ≥ 9; （2） lc（G） ≤[△/2]＋ 7 if g≥5; （3） lc（G） ≤ [△/2]＋2ifg≥7and△ ≥7.

关键词： Linear coloring planar graph girth

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Synergistically Toughening Effect of SiC Whiskers and Nanoparticles in Al_2O_3-based Composite Ceramic Cutting Tool Material

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Chinese Journal of Mechanical engineering 2016年第5期29卷 977-982页

作者： liu Xuefei liu Hanlian HUANG Chuanzhen WANG Limei ZOU bin ZHAO bin Centre for Advanced Jet engineering Technologies School of Mechanical EngineeringShandong University School of Mechanical and Electrical engineering Qilu Institute of Technolegy Key Laboratory of High Efficiency and Clean Mechanical Manufacture of Ministry of Education Shandong University

In recent decades, many additives with different characteristics have been applied to strengthen and toughen Al2O3-based ceramic cutting tool materials. Among them, SiC whiskers and SiC nanoparticles showed excellent performance in improving the material properties. While no attempts have been made to add SiC whiskers and SiC nanoparticles together into the ceramic matrix and the synergistically toughening effects of them have not been studied. An Al2O3-SiCw-SiC np advanced ceramic cutting tool material is fabricated by adding both one-dimensional SiC whiskers and zero-dimensional SiC nanoparticles into the Al2O3 matrix with an effective dispersing and mixing process. The composites with 25 vol% SiC whiskers and 25 vol% SiC nanoparticles alone are also investegated for comparison purposes. Results show that the Al2O3-SiCw-SiCnp composite with both 20 vo1% SiC whiskers and 5 vol% SiC nanoparticles additives have much improved mechanical properties. The flexural strength of Al2O3-SiCw-SiCnp is 730＋ 95 MPa and fracture toughness is 5.6 ± 0.6 MPa.m1/2. The toughening and strengthening mechanisms of SiC whiskers and nanoparticles are studied when they are added either individually or in combination. It is indicated that when SiC whiskers and nanoparticles are added together, the grains are further refined and homogenized, so that the microstructure and fracture mode ratio is modified. The SiC nanoparticles are found helpful to enhance the toughening effects of the SiC whiskers. The proposed research helps to enrich the types of ceramic cutting tool and is benefit to expand the application range of ceramic cutting tool.

关键词： Al2O3-based ceramic cutting tool materials SiC whiskers SiC nanoparticles mechanical properties,toughening and strengthening mechanisms

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Cell-surface cascaded landing location for nanotheranostics

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Chinese Chemical Letters 2017年第9期28卷 1799-1800页

作者： en Ren Junqing Wang Gang liu State Key Laboratory of Molecular Vaccinology Molecular Diagnostics Center for Molecular Imaging Translational MedicineSchool of Public Health Xiamen UniversityXiamen 361005 China

Theranostics is an appealing approach in precision medicine and it is still a critical challenge to design smart strategies which can precisely accumulate the functional probes/drugs into targeted disease ***-surface cascaded landing location is an effective strategy to develop functional drug-loading platforms to explore basic physiological processes at the cellular level and to facilitate the development of nanotheranostics for disease treatment.

关键词： Theranostics Molecular imaging Nanomedicine Cell-surface engineering Self-assembliag

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