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Petroleum Science 2022年第6期19卷 3046-3058页

作者： en-bin liu Yong Peng Shan-Bi Peng bin Yu Qi-Kun Chen Petroleum engineering School Southwest Petroleum UniversityChengdu610500China School of Civil engineering and Geomatics Southwest Petroleum UniversityChengdu610500China China Petroleum Pipeline engineering Corporation Hebei065000China School of engineering Cardiff UniversityCardiffCF243AAUK

In order to reduce the carbon emissions of natural gas pipelines,based on the background of different energy structures,this paper proposes a general low carbon and low consumption operation model of natural gas pipelines,which is used to fine calculate the carbon emissions and energy consumption of natural gas *** this paper,an improved particle swarm optimization(NHPSO-JTVAC)algorithm is used to solve the model and the optimal scheduling scheme is *** a parallel pipeline located in western China as an example,the case is *** results show that after optimization,under the existing energy types,the pipeline system can reduce 31.14%of carbon emissions,and after introducing part of new energy,the pipeline system can reduce 34.02%of carbon emissions,but the energy consumption has increased.

关键词： Natural gas Pipeline optimization NHPSO-JTVAC algorithm Carbon emission New energy

Experiment and numerical simulation of distribution law of waterbased corrosion inhibitor in natural gas gathering and transportation pipeline

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Petroleum Science 2023年第3期20卷 1857-1873页

作者： en-bin liu Hao Tang Yin-Hui Zhang Dang-jian Li Bo Kou Ning liu Mohammadamin Azimi Petroleum engineering School Southwest Petroleum UniversityChengdu610500China Research Institute of Natural Gas Technology Southwest Oil&Gasfield CompanyPetroChinaChengduSichuan610213China National energy Research and Development Center of Sour Gas Exploitation PetroChinaChengduSichuan610213China Sour Gas Exploitation Pilot Test Center PetroChinaChengduSichuan610213China China United Coalbed Methane Corporation LtdTaiyuan030000China Trenchless Technology Center Louisiana Tech UniversityRustonLA71270USA

The transmission medium of natural gas gathering and transportation pipelines usually contains cor-rosive gases,which will cause serious corrosion on the inner wall of the pipelines when they coexist with ***,it is necessary to add corrosion inhibitor to form a protective film to protect the *** distribution of corrosion inhibitors in a gathering and transportation pipeline in Moxi gas field was studied by combining experiment and *** Pearson function was used to calculate the experimental and simulation results,and the correlation was more than 80%,indicating a high degree of *** simulation results show that:①The larger the pipe angle,filling speed and gas flow rate,the smaller the particle size,the better the distribution of corrosion inhibitor particles in the *** filling amount will affect the concentration,but the distribution trend is unchanged;②A method to determine the filling mode based on the loss was proposed,and for this pipeline,the loss of corrosion inhibitor was determined to be 5.31×10^(-3) kg/s,and the flling amount was recommended to be adjusted to 2o L/h,which has certain guiding significance for the actual flling strategy of pipeline corrosion inhibitor.

关键词： Corrosion inhibitor Corrosion Computational fluid dynamics Electrochemistry Droplet distribution

Experimental and numerical simulation study on the erosion behavior of the elbow of gathering pipeline in shale gas field

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Petroleum Science 2024年第2期21卷 1257-1274页

作者： en-bin liu Shen Huang Ding-Chao Tian Lai-Min Shi Shan-Bi Peng He Zheng Petroleum engineering School Southwest Petroleum UniversityChengdu 610500SichuanChina Chongqing Natural Gas Sales Center Natural Gas BranchSinopecChongqing400023China Zhejiang Zheneng Natural Gas Operation Co. Ltd.Hangzhou 310000ZhejiangChina School of Civil engineering and Architecture Southwest Petroleum UniversityChengdu 610500SichuanChina Louisiana Tech Univ Trenchless Technol Ctr599 Dan Reneau DrRustonLA71270USA Southwest Oil and Gas Field Branch Natural Gas Research Institute Chengdu 610213SichuanChina

During the production period of shale gas, proppant particles and rock debris are produced together,which will seriously erode the elbows of gathering pipelines. In response to this problem, this paper takes the elbow of the gathering pipeline in the Changning Shale Gas Field as an example to test the erosion rate and material removal mechanism of the test piece at different angles of the elbow through experiments and compares the four erosion models with the experimental results. Through analysis, it is found that the best prediction model for quartz sand-carbon steel erosion is the Oka model. Based on the Oka model, FLUenT software was used to simulate and analyze the law of erosion of the elbow of the gas gathering pipeline under different gas flow velocities, gas gathering pressure, particle size, length of L1,and bending directions of the elbow. And a spiral pipeline structure is proposed to reduce the erosion rate of the elbow under the same working conditions. The results show that this structure can reduce erosion by 34%.

关键词： Shale gas Gas gathering pipeline Elbow Erosion CFD

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo en Ning Chang liu Yu-Chi liu Tissue engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-en Xu Ming-Lei Wu Ji-Chuan liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui liu Xingxing Fang Liangming Zhang bin liu Limin Rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Unveiling the superior hydrogen evolution reaction activity of 1T-2H MoS_(2)heterointerface by on-chip microdevices

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Nano Research 2025年第1期18卷 149-156页

作者： Bowen liu Junjie Xiong Shuaishuai Xu Xinying Luo Wenyan Yao Shigang liu Yuting Du Qinghua Zhang Yang Gao bin Wang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology(NCNST)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Materials Science and engineering China University of Petroleum(East China)Qingdao 266580China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

The identification and clarification of active sites of MoS_(2)have long been the focus of research efforts in hydrogen evolution reaction(HER).In this study,we constructed phase transition-induced 1T-2H MoS_(2)heterojunction via lithium intercalation and evaluated the HER activity using on-chip electrocatalytic microdevices(OCEMs).The heterojunction achieved an overpotential of only 226 mV at a cathodic current density of 10 mA/cm^(2),outperforming the basal planes of 1T and 2H MoS_(2).Furthermore,density functional theory(DFT)calculations demonstrated that the charge redistribution occurs at the 1T-2H MoS_(2)interface with electrons transferring from 1T to 2H MoS_(2),and the interfacial S atom at the top site of 1T MoS_(2)presents the smallest overpotential of 0.37 ***,the interference from highly active edge sites was avoided by precisely exposing specific active areas,quantitatively revealing the catalytic activity order of different types of in-plane MoS_(2)active *** work enables a systematic investigation of the HER activity of various active sites in MoS_(2),laying the foundation for quantitative analysis of activity in other lowdimensional materials.

关键词： on-chip microdevice phase transition heterojunction MoS_(2) hydrogen evolution reaction(HER)

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang bin liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi liu Fangxia Xu Chengcheng Zhou Kaimei Lu bin Fang Lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： bin Xie Yuanhui Guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong liu Li Ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TenG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TenG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TenG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TenGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TenGs in various scenarios as well as the enhancement of graphene electrodes for TenG performance are *** addition,the future development of graphene electrode-based TenGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TenGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor