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肠道非免疫细胞及其在炎症性肠病中的作用研究进展

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解放军医学杂志 2024年第5期49卷 594-601页

作者：王泽瑞焦艳梅令狐恩强解放军总医院第一医学中心消化内科医学部北京100853 解放军总医院第五医学中心感染病医学部北京100039

炎症性肠病(IBD)是免疫性疾病,虽然免疫细胞及相关的免疫学反应在IBD的发病过程中起主导作用,但是非免疫细胞,如肠道上皮细胞、间质细胞、内皮细胞等也参与了这一过程。近年来研究表明,肠道非免疫细胞在维持肠道上皮稳态、基质重塑、免... 详细信息

炎症性肠病(IBD)是免疫性疾病,虽然免疫细胞及相关的免疫学反应在IBD的发病过程中起主导作用,但是非免疫细胞,如肠道上皮细胞、间质细胞、内皮细胞等也参与了这一过程。近年来研究表明,肠道非免疫细胞在维持肠道上皮稳态、基质重塑、免疫反应及炎症过程中发挥着重要作用。有关肠道非免疫细胞的构成、基因表达特点及细胞功能,以及它们在IBD发生发展过程中的作用成为研究热点,尤其单细胞RNA测序(scRNA-seq)技术初步阐明了肠道细胞不同亚群的基因表达特征及细胞功能,以及这些变化与IBD发生发展的关系。本文针对肠道非免疫细胞在IBD中作用的相关进展进行综述。

关键词：炎症性肠病溃疡性结肠炎克罗恩病单细胞RNA测序上皮细胞间充质细胞

Influence of pier height on the safety of trains running on high-speed railway bridges during earthquakes

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Journal of Central South University 2024年第6期31卷 2102-2115页

作者： NIE Yu-tao GUO Wei JIANG Li-zhong YU Zhi-wu ZenG Chen WANG Yang HE Xu-en Ren Shao-xun HUANG Ren-qiang LIANG Guang-yue LI Chang-qing School of Civil engineering Central South UniversityChangsha 410075China National engineering Research Center of High-speed Railway Construction Technology Central South UniversityChangsha 410075China

Sudden earthquakes pose a threat to the running safety of trains on high-speed railway bridges,and the stiffness of piers is one of the factors affecting the dynamic response of train-track-bridge *** this paper,a experiment of a train running on a high-speed railway bridge is performed based on a dynamic experiment system,and the corresponding numerical model is *** reliability of the numerical model is verified by ***,the experiment and numerical data are analyzed to reveal the pier height effects on the running safety of trains on *** results show that when the pier height changes,the frequency of the bridge below the 30 m pier height changes greater;the increase of pier height causes the transverse fundamental frequency of the bridge close to that of the train,and the shaking angle and lateral displacement of the train are the largest for bridge with 50 m pier,which increases the risk of derailment;with the pier height increases from 8 m to 50 m,the derailment coefficient obtained by numerical simulations increases by 75% on average,and the spectral intensity obtained by experiments increases by 120% on average,two indicators exhibit logarithmic variation.

关键词： pier height high-speed railway bridge running safety numerical model

基于序列注意力和局部相位引导的骨超声图像分割网络

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自动化学报 2024年第5期50卷 970-979页

作者：陈芳张道强廖洪恩赵喆南京航空航天大学计算机科学与技术学院南京211106 清华大学医学院北京100084 清华大学附属北京清华长庚医院骨科与运动医学中心北京102218

在超声辅助的骨科手术导航中,需要从采集的超声图像序列中精确分割出骨结构,并展示给医生,来辅助医生进行术中决策.但是,图像噪声、成像伪影以及模糊的骨边界导致从超声图像序列中精确分割提取骨结构十分困难.为解决该问题,提出一种新... 详细信息

在超声辅助的骨科手术导航中,需要从采集的超声图像序列中精确分割出骨结构,并展示给医生,来辅助医生进行术中决策.但是,图像噪声、成像伪影以及模糊的骨边界导致从超声图像序列中精确分割提取骨结构十分困难.为解决该问题,提出一种新的基于序列注意力与局部相位引导的骨超声图像分割网络.该网络一方面自适应地利用超声序列帧之间的关系即序列注意力来辅助骨结构的语义分割.另一方面,该网络通过引入局部相位引导模块,突出骨边缘信息,进一步提高分割精度.利用包含19050幅图像的骨超声数据集,进行交叉实验、消融实验并与最新的超声骨分割方法进行比较.实验结果表明所提方法对骨结构分割精度高,优于现有的超声骨分割方法.

关键词：骨科导航超声图像分割局部相位序列注意力

Consensus on the digestive endoscopic tunnel technique

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World Journal of Gastroenterology 2019年第7期25卷 744-776页

作者： Ning-Li Chai Hui-Kai Li en-qiang linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai Department of Gastroenterology and Hepatology Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Gastroenterology the First Affiliated Hospital of Xi’an Jiao Tong UniversityXi’an 710000Shaanxi ProvinceChina Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of endoscopy Eastern Hepatobiliary Surgical Hospital Affiliated to Naval Medical UniversityShanghai 200438China Department of Gastroenterology the Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Gastroenterology Peking University Third HospitalBeijing 100191China Division of Gastroenterology and Hepatology the Johns Hopkins University School of MedicineBaltimoreMD 21218United States Department of Gastrointestinal endoscopy Prince of Wales Hospitalthe Chinese University of Hong KongHong KongChina Department of Gastroenterology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Gastroenterology Second Xiangya Hospital of Central South UniversityChangsha 410000Hunan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Gastroenterology General Hospital of Chinese People’s Armed Police ForcesBeijing 100039China Division of Gastroenterology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Gastroenterology Sichuan Provincial People’s HospitalChengdu 610072Sichuan ProvinceChina Department of Gastroenterology Xijing HospitalAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Digestion Qinghai Provincial People’s HospitalXining 810007Qinghai ProvinceChina Department of Gastroenterology Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Gastroenterology Peking Univ

With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) *** present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative *** International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations).

关键词： Digestive endoscopic tunnel technique endoscopic submucosal tunnel dissection Per-oral endoscopic myotomy Submucosal tunnelling endoscopic resection Gastrointestinal tract

基于ITS2序列及其二级结构对矩镰荚苜蓿和近缘种的分子鉴定

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西北农业学报 2024年第3期33卷 397-405页

作者：王霞刘艳贾秀秀方强恩甘肃农业大学草业学院草业生态系统教育部重点实验室中-美草地畜牧业可持续发展研究中心兰州730070

为准确鉴定矩镰荚苜蓿(Medicagoarchiducis-nicolai)及其近缘种花苜蓿(***)、阔荚苜蓿(***)和毛荚苜蓿(***),利用DNA条形码技术对4个物种的ITS2序列进行注释、比对、检验,计算种内种间遗传距离,邻接法(neighbor-joining, NJ)构建系统发... 详细信息

为准确鉴定矩镰荚苜蓿(Medicagoarchiducis-nicolai)及其近缘种花苜蓿(***)、阔荚苜蓿(***)和毛荚苜蓿(***),利用DNA条形码技术对4个物种的ITS2序列进行注释、比对、检验,计算种内种间遗传距离,邻接法(neighbor-joining, NJ)构建系统发育树,通过RNAfoldwebserver预测4个近缘种的ITS2二级结构。结果显示,矩镰荚苜蓿及其近缘种的ITS2序列长度为220~221 bp,稳定性好;种间遗传距离(0.004 55~0.022 73)明显大于种内遗传距离(均为0),存在明显的“BarcodingGap”区域;NJ系统发育树显示,毛荚苜蓿聚为一支,矩镰荚苜蓿、花苜蓿和阔荚苜蓿聚为另一支,然后矩镰荚苜蓿与阔荚苜蓿又各自形成单系;在二级结构中,矩镰荚苜蓿与阔荚苜蓿、毛荚苜蓿存在明显差异,但与花苜蓿极为相似,难以区分。分析表明:除花苜蓿外,以ITS2序列作为条形码并辅以二级结构,可以达到对矩镰荚苜蓿、阔荚苜蓿和毛荚苜蓿准确、快速鉴定的目的。

关键词：矩镰荚苜蓿 ITS2序列二级结构分子鉴定

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面向遥感视觉问答的尺度引导融合推理网络

软件学报 2024年第5期35卷 2133-2149页

作者：赵恩源宋宁聂婕王鑫郑程予魏志强中国海洋大学信息科学与工程学部山东青岛266100 清华大学计算机科学与技术系北京100084 青岛海洋科技中心山东青岛266061

遥感视觉问答(remote sensing visual question answering,RSVQA)旨在从遥感图像中抽取科学知识.近年来,为了弥合遥感视觉信息与自然语言之间的语义鸿沟,涌现出许多方法.但目前方法仅考虑多模态信息的对齐和融合,既忽略了对遥感图像目... 详细信息

遥感视觉问答(remote sensing visual question answering,RSVQA)旨在从遥感图像中抽取科学知识.近年来,为了弥合遥感视觉信息与自然语言之间的语义鸿沟,涌现出许多方法.但目前方法仅考虑多模态信息的对齐和融合,既忽略了对遥感图像目标中的多尺度特征及其空间位置信息的深度挖掘,又缺乏对尺度特征的建模和推理的研究,导致答案预测不够全面和准确.针对以上问题,提出一种多尺度引导的融合推理网络(multi-scale guided fusion inference network,MGFIN),旨在增强RSVQA系统的视觉空间推理能力.首先,设计基于Swin Transformer的多尺度视觉表征模块,对嵌入空间位置信息的多尺度视觉特征进行编码;其次,在语言线索的引导下,使用多尺度关系推理模块以尺度空间为线索学习跨多个尺度的高阶群内对象关系,并进行空间层次推理;最后,设计基于推理的融合模块来弥合多模态语义鸿沟,在交叉注意力基础上,通过自监督范式、对比学习方法、图文匹配机制等训练目标来自适应地对齐融合多模态特征,并辅助预测最终答案.实验结果表明,所提模型在两个公共RSVQA数据集上具有显著优势.

关键词：遥感视觉问答多模态智能融合多模态推理多尺度表征

Percutaneous ultrasound-guided coaxial core needle biopsy for the diagnosis of multiple splenic lesions: A case report

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 616-621页

作者： Sha-Hong Pu Wu-Yong-Ga Bao Zhen-Peng Jiang Rui Yang qiang Lu Department of Medical Ultrasound West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The overlap of imaging manifestations among distinct splenic lesions gives rise to a diagnostic ***,a definitive diagnosis primarily relies on his-tological *** ultrasound(US)-guided coaxial core needle biopsy(CNB)not only procures sufficient tissue to help clarify the diagnosis,but reduces the incidence of puncture-related *** SUMMARY A 41-year-old female,with a history of pulmonary tuberculosis,was admitted to our hospital with multiple indeterminate splenic ***-scale ultrasono-graphy demonstrated splenomegaly with numerous well-defined hypoechoic *** contrast-enhanced computed tomography(CT)showed an en-larged spleen with multiple irregular-shaped,peripherally enhancing,hypodense *** emission CT revealed numerous abnormal hyperglycemia *** imaging findings strongly indicated the possibility of infectious disease as the primary concern,with neoplastic lesions requiring *** obtain the precise pathological diagnosis,the US-guided coaxial CNB of the spleen was ca-rried *** patient did not express any discomfort during the *** Percutaneous US-guided coaxial CNB is an excellent and safe option for obtaining precise splenic tissue samples,as it significantly enhances sample yield for exact pathological analysis with minimum trauma to the spleen parenchyma and sur-rounding tissue.

关键词： Spleen Splenic disease Ultrasound Biopsy Ultrasound-guided coaxial core needle biopsy Case report

Design and synthesis of polyoxovanadate-based framework for efficient dye degradation

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Tungsten 2024年第2期6卷 447-453页

作者： Qing Lan Su-Juan Jin Zheng Wang Xu-Yang Li Yan Xiong Zhuo-Cheng Wang Shan-Shan Liu Zhi-Ming Zhang qiang Zhao engineering Technology Research Center of Henan Province for Solar Catalysis School of Chemical and Pharmaceutical EngineeringNanyang Normal UniversityNanyang 473061China Institute of New energy Materials&Low Carbon Technology Tianjin University of TechnologyTianjin 300384China

A new polyoxovanadate-based framework material[Cu(en)_(2)]_(4)V_(18)O_(42)(H_(2)O)·6H_(2)O(1)was designed and synthesized by hydrothermal reaction of NaVO_(3),Cu(NO_(3))_(2)·6H_(2)O and 1,2-diaminoethane(en)via carefully adjusting the pH value of the reaction *** structure of the title compound has been determined by single-crystal X-ray diff raction analysis,thermogravimetric analysis,infrared spectra and elemental *** structural analysis demonstrate the three-dimensional(3D)framework structure of compound 1,which was composed of the[V_(18)O_(42)(H_(2)O)]_(8)−({V_(18)O_(42)(H_(2)O)})anions linked by the Cu^(2+)*** 1 represents the fi rst 3D framework based on{V_(18)O_(42)(H_(2)O)}polyoxoanions and copper ***-driven degradation of residual organic pollutants in industrial wastewater is still a major problem for human *** experiments reveal that compound 1 possesses of excellent photocatalytic activity for the degradation of methylene blue and rhodamine B.

关键词： Polyoxovanadate Framework Polyoxovanadate-based framework Photocatalytic Organic pollutants

Observations on pathological and histochemical changes in piglet livers infected with Taenia saginata asiatica

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Frontiers of Medicine 2007年第3期1卷 258-263页

作者： linghu Yan ZHU Wujun BAO Huai’en CHen Yan Department of Parasitology Guiyang Medical CollegeGuiyang 550004China

To study the pathological and histochemical characteristics of lesions in piglet livers infected with Taenia saginata asiatica(*** asiatica)throughout the different stages,piglets were fed with eggs of *** asiatica and raised in isolation in an animal center to establish the *** asiatica infection model with normal piglets as *** pathological changes in the piglet livers were observed after the infection using liver sections stained with hematoxylin and *** methods were used to check the changes in lipid,glycogen and protein content in the *** data collected by image analysis were analyzed statistically with Statistical Package for the Social *** results show that *** asiatica-exposed piglets were indeed *** reactions began on the fourth day and progressed *** cell hyperplasia,hepatic hydropic degeneration and ballooning degeneration were found in the 10th–20th days after *** central veins and hepatic sinusoids were dilated and *** necrosis occurred in some local liver *** the 40th–60th days,granulomatous reactions and mild hepatocirrhosis were the main *** the 70th–80th days,hepatocirrhosis and bile duct proliferation were observed in the *** the different stages,lipid drops were increased while glycogen and protein levels were decreased to some *** was a significant difference in metabolism between the infected group and the control group(P<0.01).It is concluded that pigs are the favorable intermediate host of *** asiatica and its infection can result in serious pathological and histochemical lesions in host organs.

关键词： Taenia saginata liver