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Reveal more mechanisms of precondition mesenchymal stem cells inhibiting inflammation

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World Journal of Stem Cells 2024年第4期16卷 459-461页

作者： Yi Li Qian-Qian Chen en-qiang linghu Department of Gastroenterology First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology and Hepatology First Medical Center of Chinese PLA General HospitalBeijing 100853China

Hypoxia can get more ability to inhibit *** how it impact on survival time of mesenchymal stem cells(MSCs)is confusing and how preconditioned MSCs inhibiting inflammation are partially *** issues decided the value of ... 详细信息

关键词： Mesenchymal stem cell Hypoxia-inducible factor 1α Hypoxia Inflammation Macrophage

Autophagy and its role in gastrointestinal diseases

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World Journal of Gastroenterology 2024年第36期30卷 4014-4020页

作者： Bo-Zong Shao Wen-Gang Zhang Zhen-Yu Liu en-qiang linghu Department of Gastroenterology First Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100853China

Gastrointestinal disorders encompass a spectrum of conditions affecting various organs within the digestive system,such as the esophagus,stomach,colon,rectum,pancreas,liver,small intestine,and bile *** role of autophagy in the etiology and progression of gastrointestinal diseases has garnered significant *** paper seeks to evaluate the impact and mechanisms of autophagy in gastrointestinal disorders by synthesizing recent research ***,we delve into inflammation-related gastrointestinal conditions,including ulcerative colitis,Crohn’s disease,and pancreatitis,as well as gastrointestinal cancers such as esophageal,gastric,and colorectal ***,we provide commentary on a recent publication by Chang et al in the World Journal of *** objective is to offer fresh perspectives on the mechanisms and therapeutic approaches for these gastrointestinal *** review aims to offer new perspectives on the mechanisms and therapeutic strategies for gastrointestinal disorders by critically analyzing relevant *** discussed,the role of autophagy in gastrointestinal diseases is complex and,at times,*** harness the full therapeutic potential of autophagy in treating these conditions,more in-depth research is imperative.

关键词： Autophagy Inflammation Cancer Inflammatory bowel disease Pancreatitis

Transcriptome analysis suggests broad jejunal alterations in linghu’s obesity-diarrhea syndrome:A pilot study

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World Journal of Gastroenterology 2024年第21期30卷 2777-2792页

作者： Xiao-Tong Niu Xiang-Yao Wang Yan Wang Ke Han Nan Ru Jing-Yuan Xiang en-qiang linghu Medical School of Chinese PLA Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology The First Medical Center of Chinese PLA General HospitalBeijing 100853China School of Medicine Nankai UniversityTianjin 300071China

BACKGROUND Obesity is associated with a significantly increased risk for chronic diarrhea,which has been proposed as linghu’s obesity-diarrhea syndrome(ODS);however,its molecular mechanisms are largely *** To reveal the transcriptomic changes in the jejunum involved in *** In a cohort of 6 ODS patients(JOD group),6 obese people without diarrhea(JO group),and 6 healthy controls(JC group),high-throughput sequencing and bioinformatics analyses were performed to identify jejunal mucosal mRNA expression alterations and dysfunctional biological *** another cohort of 16 ODS patients(SOD group),16 obese people without diarrhea(SO group),and 16 healthy controls(SC group),serum diamine oxidase(DAO)and D-lactate(DLA)concentrations were detected to assess changes in intestinal barrier *** The gene expression profiles of jejunal mucosa in the JO and JC groups were similar,with only 1 differentially expressed gene(DEG).The gene expression profile of the JOD group was significantly changed,with 411 DEGs compared with the JO group and 211 DEGs compared with the JC group,129 of which *** enrichment analysis of these DEGs showed that the biological processes such as digestion,absorption,and transport of nutrients(especially lipids)tended to be up-regulated in the JOD group,while the biological processes such as rRNA processing,mitochondrial translation,antimicrobial humoral response,DNA replication,and DNA repair tended to be down-regulated in the JOD *** DEGs(CDT1,NHP2,EXOSC5,EPN3,NME1,REG3A,PLA2G2A,and PRSS2)may play a key regulatory role in the pathological process of ODS,and their expression levels were significantly decreased in ODS patients(P<0.001).In the second cohort,compared with healthy controls,the levels of serum intestinal barrier function markers(DAO and D-LA)were significantly increased in all obese individuals(P<0.01),but were higher in the SOD group than in the SO group(P<0.001).CONCLUSION Compared with health

关键词： Obesity Chronic diarrhea Jejunum Transcriptome Intestinal barrier

New classifications of intraoperative bleeding and muscularis propria injury in endoscopic resection

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Chinese Medical Journal 2019年第15期132卷 1856-1858页

作者： en-qiang linghu Department of Gastroenterology and Hepatology Chinese PLA General Hospital Beijing 100853 China

With the development of endoscopic techniques and equipment,endoscopic surgery has been widely performed to treat many diseases,such as early gastrointestinal cancer,submucosal tumors,and *** surgery can be classified as digestive endoscopic tunnel technique (DETT) and non-tunnel *** non-tunnel technique includes endoscopic mucosal resection,endoscopic piecemeal mucosal resection,endoscopic submucosal dissection (ESD),multi-band mucosectomy,endoscopic submucosal excavation,and endoscopic full-thickness resection.[1] endoscopic submucosal tunnel dissection (ESTD),peroral endoscopic myotomy (POEM),and submucosal tunneling endoscopic resection (STER) are considered types of *** resection is safer and more minimally invasive than open surgery and video-assisted surge ry.[2,3] The complication rate of resection is regarded as the main standard to evaluate the safety of endoscopic surgery,while bleeding and “perforation” are reported to be the most common intraoperative complications.[4,5]

关键词： endoscopic resection intraoperative bleeding muscularis propria injury

Fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy: A retrospective study at a single center

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World Journal of Gastroenterology 2017年第9期23卷 1637-1644页

作者： Wen-Gang Zhang en-qiang linghu Hui-Kai Li Departmen of Gastroenterology Chinese PLA General HospitalBeijing 100853China

AIM To assess the efficacy and safety of fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy(POEM).METHODS Twenty-four patients who underwent POEM and experienced mucosal injury of the cardia during the procedure were retrospectively identified. Of the 24 patients, 21 had mucosal penetration and 3 had only slight mucosal damage without penetration. The 21 patients with mucosal penetration received fibrin sealant for closure at the site of penetration. Penetration-related characteristics, treatment, and recovery were reviewed for all 21 patients to assess the efficacy and safety of fibrin sealant for closure of mucosal penetration at the cardia. Clinical data, including general characteristics, procedure-related parameters, Eckardt scores, lower esophageal sphincter pressures (LESP), and esophagogastroduodenoscopy(EGD) results, were analyzed to determine their influence on treatment success after mucosal penetration during *** All 21 patients had a solitary mucosal penetration in the cardia (12 in esophageal region of the cardia, 9 in the stomach region of the cardia, and 1 in both the esophageal and stomach regions). Twelve had ahole-like penetration and 9 had a linear penetration. For those with a hole-like penetration, the mean size was 0.14 cm2 (0.02-0.32 cm2). For those with a linear penetration, the median size was 0.37 cm (0.10-1.00 cm). Closure of the mucosal penetration using fibrin sealant was performed successfully in all 21 patients(two patients required 5 m L fibrin sealant, and the remaining 19 patients required 2.5 mL). Two patients had a nasogastric tube placed for five days after POEM; the remaining 19 patients were kept fasting for 3 d. All 21 patients were discharged after a median of 5 d(range: 5-7 d) postoperatively. During a median 42 mo (range: 9-62 mo) follow-up, all 21 patients with a mucosal penetration successfully healed without the occurrence of infection, ulcer, or esophagitis. Furth

关键词： Fibrin sealant Mucosal penetration Peroral endoscopic myotomy Efficacy Safety

Ling classification describes endoscopic progressive process of achalasia and successful peroral endoscopy myotomy prevents endoscopic progression of achalasia

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World Journal of Gastroenterology 2017年第18期23卷 3309-3314页

作者： wen-gang zhang en-qiang linghu ning-li chai hui-kai li Department of Gastroenterology Chinese PLA General Hospital

AIM To verify the hypothesis that the Ling classification describes the endoscopic progressive process of achalasia and determine the ability of successful peroral endoscopic myotomy (POEM) to prevent endoscopic progression of achalasia. METHODS We retrospectively reviewed the endoscopic findings, symptom duration, and manometric data in patients with achalasia. A total of 359 patients (197 women, 162 men) with a mean age of 42.1 years (range, 12-75 years) were evaluated. Symptom duration ranged from 2 to 360 mo, with a median of 36 mo. Patients were classified with Ling type I (n = 119), II a (n = 106),II b (n = 60),II c (n = 60), or III (n = 14), according to the Ling classification. Of the 359 patients, 349 underwent POEM, among whom 21 had an endoscopic follow-up for more than 2 years. Pre-treatment and post-treatment Ling classifications of these 21 patients were compared. RESULTS Symptom duration increased significantly with increasing Ling classification (from I to III) (p ence in sex ratio or onset age among the Ling types, although the age at time of diagnosis was higher in Ling types I c and III than in Ling types I, IIa, and I b. Of the 21 patients, 19 underwent high-resolution manometry both before and after treatment. The mean preoperative and postoperative lower esophageal sphincter pressure were 34.6 mmHg (range, 15.3-59.4 mmHg) and 15.0 mmHg (range, 2.1-21.6 mmHg), respectively, indicating a statistically significant decrease after POEM. All of the 21 patients were treated successfully by POEM (postoperative Eckardt score ents the endoscopic progressive process of achalasia and may be able to serve as an endoscopic assessment criterion for achalasia. Successful POEM (Eckardt sco

关键词： Ling classification Achalasia Progression Peroral endoscopic myotomy endoscopy

Characteristics of metachronous gastric neoplasms after curative endoscopic submucosal dissection for early gastric neoplasms

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Chinese Medical Journal 2021年第21期134卷 2603-2610页

作者： Shan-Shan Xu Ning-Li Chai Xiao-Wei Tang en-qiang linghu Sha-Sha Wang Bao Li Nankai University School of Medicine Nankai UniversityTianjin 300071China department of Gastroenterology and Hepatology The First Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100853China

Background:With the wide application of endoscopic submucosal dissection(ESD)for early gastric neoplasms,metachronous gastric neoplasms(MGN)have gradually become a *** study aimed to analyze the characteristics of MGN and evaluate the treatment and follow-up outcomes of MGN ***:A total of 814 patients were retrospectively *** these patients were treated by ESD for early gastric cancer or gastric dysplasia between November 2006 and September 2019 at The First Medical Center of Chinese People’s Liberation Army General *** risk factors for MGN were analyzed using Cox hazard proportional ***,the cumulative incidence,the correlation of initial lesions and MGN lesions,and the treatment and follow-up outcomes of MGN patients were ***:A total of 4.5%(37/814)of patients had MGN after curative *** 3-,5-,and 7-year cumulative incidences of MGN were 3.5%,5.1%,and 6.9%,respectively,and ultimately reaching a plateau of 11.3%at 99 months after *** was no significant correlation between initial lesions and MGN lesions in terms of gross type(P=0.178),location(long axis:P=0.470;short axis:P=0.125),and histological type(P=0.832).Cox multivariable analysis found that initial multiplicity was the only independent risk factor of MGN(hazard ratio:4.3,95%confidence interval:2.0-9.4,Penty-three percent of patients with MGN were treated by endoscopic *** follow-up,two patients with MGN died of gastric cancer with lymph node *** disease-specific survival rate was significantly lower in patients with MGN than that in patients without MGN(94.6%vs.99.6%,P=0.006).Conclusions:The MGN rate gradually increased with follow-up time within 99 months after curative gastric ***,regular and long-term surveillance endoscopy may be helpful,especially for patients with initial multiple neoplasms.

关键词： Metachronous gastric neoplasms Early gastric cancer endoscopic submucosal dissection Characteristics Follow-up

endoscopic ultrasound-guided injective ablative treatment of pancreatic cystic neoplasms

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World Journal of Gastroenterology 2020年第23期26卷 3213-3224页

作者： Chen Du Ning-Li Chai en-qiang linghu Hui-Kai Li Xiu-Xue Feng Department of Gastroenterology and Hepatology Chinese PLA General HospitalBeijing 100853China

With the development of cross-sectional imaging modalities and the increasing attention being paid to physical examinations, the prevalence of pancreatic cystic neoplasms(PCNs) has increased. PCNs comprise a broad differential spectrum with some PCNs having low or no malignant potential and others having high malignant potential. The morbidity and mortality rates related to major pancreatic surgical resection are high. Long-term surveillance may not only increase the financial burden and psychological stress for patients but also result in a missed malignancy. Minimally invasive endoscopic ultrasound(EUS)-guided ethanol ablation was first reported in 2005. Several other agents, such as paclitaxel, lauromacrogol, and gemcitabine, were reported to be effective and safe for the treatment of PCNs. These ablative agents are injected through a needle inserted into the cyst via transgastric or transduodenal puncture. This treatment method has been substantially developed in the last 15 years and is regarded as a promising treatment to replace surgical resection for PCNs. While several reviews of EUS-guided ablation have been published, no systematic review has evaluated this method from patient preparation to follow-up in detail. In the present review, we systematically describe EUS-guided injective ablation with regard to the indications, contraindications, preoperative treatment, endoscopic procedure, postoperative care and follow-up, evaluation method, treatment efficiency, safety profile, tips and tricks, and current controversies and perspectives.

关键词： endoscopic ultrasound-guided ablation Pancreatic cystic neoplasm Ethanol Paclitaxel Lauromacrogol Gemcitabine

Long-term outcomes of peroral endoscopic myotomy in achalasia patients with a minimum follow-up of 7 years

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Chinese Medical Journal 2020年第8期133卷 996-998页

作者： Wen-Gang Zhang Ning-Li Chai Ya-Qi Zhai en-qiang linghu Hui-Kai Li Department of Gastroenterology Chinese People's Liberation Army General HospitalBeijing 100853China.

There was an enormous increase in reports confirming the safety and efficacy of using peroral endoscopic myotomy(POEM)to treat achalasia since the pioneering of the technique in 2010.[1]However,the reports focused on short to medium-term follow-ups,and data on long-term outcomes of POEM for achalasia were very *** still remains unknown whether the satisfactory short-term outcomes are long ***,some achalasia patients receiving POEM noted that they could benefit from post-operative dietary recommendations that would be helpful for symptom ***,this study aimed to determine the long-term treatment outcomes of using POEM to treat achalasia,and to assess postoperative Eckardt scores over this *** also crafted a set of post-POEM dietary recommendations according to the feedback from achalasia patients who underwent this treatment to achieve better symptom remission for post-POEM patients.

关键词： patients operative treatment