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Reproductive Outcome of Transcervical Uterine Incision in Unicornuate Uterus

Chinese Medical Journal 2017年第3期130卷 256-261页

作者： en-lan xia Tin-Chiu Li Sze-Ngar Sylvia Choi Qiao-Yun Zhou Hysteroscopic Center Fu Xing Hospital Capital Medical University Beijing 100038 China Department of Obstetrics and Gynaecology Prince of Wales Hospital Hong Kong 999077 China Department of Obstetrics and Gynaecology United Christian Hospital Hong Kong 999077 China

Background： The pregnancy outcome of the unicornuate uterus is associated with an increased risk of miscarriage, cervical incompetence, and a number of obstetric complications. However, at present, there is no accepted treatment method for women with unicornuate uterus, other than expectant measures. The aim of this study was to evaluate the reproductive outcome of transcervical uterine incision （TCUI） in patients with unicornuate uterus. Methods： Thirty-three patients with unicoruuate uterus presented to our tertiary center tbr infertility or miscarriage. All 33 patients underwent TCUI and were followed up for 10-52 months. The pregnancy outcomes （first-trimester miscarriage, second-trimester miscarriage, preterm, term, intrauterine death, ongoing pregnancy, and live birth） before and after TCUI were compared by t-test. Results： Among 31 patients who attempted to conceive alter TCUI, twenty conceived including one terufination of pregnancy, one second-trimester miscarriage, one ectopic pregnancy, five preterm deliveries, 11 term delivery, and one ongoing pregnancy. There were 16 live births in total. There was significant reduction in the first-trimester miscarriage rate （t = 4.890; P 〈 0.001 ）, increase in term delivery （t = -3.288; P =0.002）, and live birth rates （t = -4.073; P 〈 0.001 ） after TCUI. Conclusion： TCUI appeared to improve the pregnancy outcome in women with unicoruuate uterus presenting with infertility or miscarriage.

关键词： Hysteroscopy Pregnancy Outcome Surgery Transcervical Incision of Uterus Unicornuate Uterus Uterine Anomalies

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Laparoscopic metroplasty for bicorporeal uterus: surgical techniques and outcomes

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Chinese Medical Journal 2021年第9期134卷 1107-1109页

作者： Qiao-Yun Zhou Sotirios Saravelos xiao-Wu Huang Ning Ma Tinchiu Li en-lan xia Department of Hysteroscopic Center Fuxing HospitalCapital Medical UniversityBeijing 100038China IVF Unit Department of Obstetrics&GynaecologyHammersmith HospitalImperial College LondonUK Assisted Reproduction Unit Department of Obstetrics&GynaecologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina

The incidence of congenital uterine anomalies(CUA)appears to be higher than previously thought owing to improved diagnostic imaging modalities.[1]A recent systematic review has estimated the prevalence to be 5.5%in the unselected population,8.0%in infertile women,and 13.3%in those with a history of *** commonest anomaly across all populations appear to be the septate variety(ie,canalization defects)followed by the bicornuate variety(ie,fusion defects).[2]Another meta-analysis has shown that several adverse reproductive outcomes associated with CUA,such as increased miscarriage rates,increased preterm delivery rates,and increased perinatal mortality rates.[3]

关键词： mortality outcome congenital

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宫腔镜Ⅱ度宫腔粘连切除术后放置与不放置球囊预防复粘疗效分析

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中国内镜杂志 2017年第3期23卷 88-90页

作者：郭艳夏恩兰首都医科大学附属复兴医院宫腔镜中心北京100038

目的观察Foley球囊联合芬吗通序贯疗法预防宫腔镜下Ⅱ度宫腔粘连(IUA)切除术后复发的临床效果。方法 60例Ⅱ度IUA患者随机分为两组,行宫腔镜IUA切除术(TCRA)。观察组30例术后口服芬吗通序贯疗法预防IUA复发,对照组30例术后宫腔放置Fole... 详细信息

目的观察Foley球囊联合芬吗通序贯疗法预防宫腔镜下Ⅱ度宫腔粘连(IUA)切除术后复发的临床效果。方法 60例Ⅱ度IUA患者随机分为两组,行宫腔镜IUA切除术(TCRA)。观察组30例术后口服芬吗通序贯疗法预防IUA复发,对照组30例术后宫腔放置Foley球囊5~7 d加口服芬吗通序贯疗法干预1或2个周期,术后随访1或2个月,宫腔镜检查评估两组IUA复发情况。结果观察组术后2个月IUA复发率3.33%,对照组术后2个月复发率3.33%。两组无差异。结论Ⅱ度IUA行TCRA,术后使用Foley球囊联合芬吗通序贯疗法与术后仅使用芬吗通序贯疗法预防IUA,术后IUA复发率无差异。

关键词：宫腔粘连宫腔粘连切除术 Foley球囊序贯疗法

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羊膜宫腔内植入+人工周期治疗中、重度宫腔粘连的安全性及有效性

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生殖与避孕 2012年第12期32卷 857-861页

作者：彭雪冰夏恩兰首都医科大学附属复兴医院宫腔镜中心北京100038

目的:评价人羊膜在宫腔粘连松解术(TCRA)后置入宫腔的安全性及预付再粘连的有效性。方法:回顾性分析34例宫腔中、重度粘连的不孕患者宫腔粘连松解术后宫腔内放置表面被覆羊膜的Foley’s球囊,1周后取出,同时给予雌激素/黄体酮周期治疗。... 详细信息

目的:评价人羊膜在宫腔粘连松解术(TCRA)后置入宫腔的安全性及预付再粘连的有效性。方法:回顾性分析34例宫腔中、重度粘连的不孕患者宫腔粘连松解术后宫腔内放置表面被覆羊膜的Foley’s球囊,1周后取出,同时给予雌激素/黄体酮周期治疗。术后第1、3个月宫腔镜检查。随访观察粘连复发率,月经改善和妊娠结局。结果:12例中度粘连组(A组)和22例重度粘连组(B组)患者手术均顺利且无并发症发生,围手术期均无感染症状。A组中75%的患者和B组中45.5%的患者月经恢复正常或得到明显改善。A组无一例宫腔粘连复发,B组中11例复发。所有患者宫内妊娠率为35.3%(12/34)。结论:人羊膜+雌激素/黄体酮周期治疗安全、有效,并能预防宫腔再次粘连的有效方法。

关键词：宫腔粘连(IUA) 人羊膜宫腔镜下宫腔粘连松解术(TCRA) 雌激素

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77例腹腔镜输卵管积水不同术式与妊娠结局

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中国内镜杂志 2017年第2期23卷 18-20页

作者：郭艳夏恩兰黄晓武首都医科大学附属复兴医院宫腔镜中心北京100038

目的研究腹腔镜输卵管造口术或输卵管切除术治疗输卵管积水术后的妊娠结局。方法 77例经该中心子宫输卵管造影或B超诊断为输卵管积水,除外其他不孕因素的不孕患者,经腹腔镜探查证实诊断后,行单侧、双侧输卵管造口术或单侧、双侧输卵管... 详细信息

目的研究腹腔镜输卵管造口术或输卵管切除术治疗输卵管积水术后的妊娠结局。方法 77例经该中心子宫输卵管造影或B超诊断为输卵管积水,除外其他不孕因素的不孕患者,经腹腔镜探查证实诊断后,行单侧、双侧输卵管造口术或单侧、双侧输卵管切除术,术后随访1~4年。结果 77例因输卵管积水导致不孕患者,经腹腔镜相应手术治疗后,39例妊娠,妊娠率50.65%。其中13例(16.88%)自然受孕,26例(33.77%)经体外受精-胚胎移植(IVF-ET)分娩,已分娩35例,妊娠状态3例,早期流产1例。结论腹腔镜手术是输卵管积水导致不孕患者的有效治疗方法,术后IVF-ET较自然受孕妊娠率高,但差异无统计学意义。

关键词：腹腔镜输卵管积水输卵管造口输卵管切除妊娠不孕症

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陈旧性子宫壁假道临床分析—附33例报道

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中国内镜杂志 2015年第7期21卷 718-722页

作者：宋冬梅夏恩兰 TINCHIU LI 黄晓武肖豫首都医科大学附属复兴医院宫腔镜中心北京100038 香港中文大学妇产科学系香港649490

目的探讨陈旧性子宫壁假道的诊断与预防子宫壁假道的方法。方法 2013年1月-2015年1月该中心行超声联合宫腔镜检查诊断陈旧性子宫壁假道33例,分析其发生原因、超声及宫腔镜下特点。结果 33例患者中子宫壁假道发生在宫颈25例,占75.8%,宫体... 详细信息

目的探讨陈旧性子宫壁假道的诊断与预防子宫壁假道的方法。方法 2013年1月-2015年1月该中心行超声联合宫腔镜检查诊断陈旧性子宫壁假道33例,分析其发生原因、超声及宫腔镜下特点。结果 33例患者中子宫壁假道发生在宫颈25例,占75.8%,宫体8例,其中,子宫过度前屈及后屈84.9%;子宫壁假道长度≤1.5 cm 11例,1.5～3.0 cm 16例,〉3 cm 6例;宫腔完全封闭15例,其中,宫腔镜检查时分离并进入宫腔3例。结论子宫壁假道多发生于宫颈,与子宫体过度屈曲有关,超声引导的宫腔操作可能会减少宫壁假道的发生。

关键词：子宫壁假道宫腔镜检查超声宫腔粘连

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Efficient OpenMP Based Z-curve encoding and Decoding Algorithms

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Computers, Materials & Continua 2025年第1期82卷 1313-1327页

作者： Zicheng Zhou Shaowen Sun Teng Liang Mengjuan Li Fengling xia School of Electronic Science and engineering University of Electronic Science and Technology of ChinaChengdu611731China Faculty of Information engineering and Automation Kunming University of Science and TechnologyKunming650500China School of Communications Information engineering Yunnan Communications Vocational and Technical CollegeKunming650500China Library Yunnan Normal UniversityKunming650500China Faculty of Civil Aviation and Aeronautics Kunming University of Science and TechnologyKunming650500China

Z-curve’s encoding and decoding algorithms are primely important in many Z-curve-based *** bit interleaving algorithm is the current state-of-the-art algorithm for encoding and decoding *** simple,its efficiency is hindered by the step-by-step coordinate shifting and bitwise *** tackle this problem,we first propose the efficient encoding algorithm LTFe and the corresponding decoding algorithm LTFd,which adopt two optimization methods to boost the algorithm’s efficiency:1)we design efficient lookup tables(LT)that convert encoding and decoding operations into table-lookup operations;2)we design a bit detection mechanism that skips partial order of a coordinate or a Z-value with consecutive 0s in the front,avoiding unnecessary iterative *** propose order-parallel and point-parallel OpenMP-based algorithms to exploit the modern multi-core *** results on discrete,skewed,and real datasets indicate that our point-parallel algorithms can be up to 12.6×faster than the existing algorithms.

关键词： Z-curve lookup table OpenMP bit detection mechanism

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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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[Recent progress in mass spectrometry imaging using nanospray desorption electrospray ionization]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 43-49页

作者： Jing-Bo Wang xiao-lan Li Rui-xia Fan Ping Lü Rui-Chuan Yin West China School of Pharmacy Sichuan University Chengdu 610041 China.

Ambient mass spectrometry imaging (MSI) enables hundreds of analytes in tissue sections to be directly mapped at atmospheric pressure with minimal sample preparation. This field is currently experiencing rapid growth, with numerous reported ambient ionization techniques resulting in a "hundred flowers bloom" situation. Nanospray desorption electrospray ionization (nano-DESI), developed by the Laskin group in 2010, is a widely used liquid-extraction-based ambient ionization technique that was first used for mass spectrometry imaging of tissue in 2012. The nano-DESI probe comprises a primary capillary and a nanospray capillary, with the latter efficiently transferring analyte-containing droplets via a tiny liquid bridge formed between the probe and sample surface, thereby enabling nanoelectrospray ionization (nano-ESI) in front of the inlet of a mass spectrometer. The advantages of nano-DESI MSI include minimal sample preparation, high spatial resolution, and high sensitivity. These features are well-suited for imaging various sample types, including frozen tissue sections, microbial communities, and environmental samples. A PubMed-database search using the "nano-DESI" keyword revealed 72 related articles in the 2010-2024 period, with 34 of them published between 2021 and 2024, which indicates that nano-DESI has rapidly developed as an ambient ionization technique over recent years. Herein, we briefly introduce key nano-DESI-MSI research progress reported in the past three years with the aim of better understanding and facilitating the use of this technology. We first discuss advances in ion-source development. Since no commercial nano-DESI source exists, designing and constructing ion sources remain technical challenges that limit its development. Nano-DESI has been successfully coupled with various types of mass spectrometer, including LTQ Orbitrap, quadrupole-Orbitrap (Q Exactive), 6560 IM QTOF, timsTOF Pro2, triple quadrupole, and FTICR. These couplings have signi

关键词： ambient mass spectrometry imaging nanospray desorption electrospray ionization spatial proteomics structural characterization of lipid

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao Hui-Lin Jiang Bao-xia Dong Yun-Lei Teng School of Chemistry and Chemical engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： CO 2 methanation Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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