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A new approach for development of vaccine against visceral leishmaniasis: Lipophosphoglycan and polyacrylic acid conjugates

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 877-886页

作者： Adil M.Allahverdiyev Rabia Cakir Koc Melahat Bagirova Serhat Elcicek Serap Yesilkir Baydar Olga Nehir Oztel emrah Sefik Abamor Sezen Canim Ates Murat Topuzogullari Sevil Isoglu Dincer Zeynep Akdeste Yildiz Technical University Department of Bioengineering Firat University Department of Bioengineering Yeni Yuzyil University Biomedical Engineering Abdullah Gul University Material Science and Nanotechnology Department

Objective: To determine the antileishmanial vaccine effectiveness of lipophosphoglycan(LPG) and polyacrylic acids(PAA) conjugates on in vivo mice ***: LPG molecule was isolated and purified from large-scale Leishmania donovani parasite culture. Protection efficacies of LPG alone, in combination with Freund's adjuvant, in a physical mixture and in conjugate(consisting of various LPG concentrations) with PAA, were comparatively determined by various techniques, such as cultivation with the micro-culture method, assessment of in vitro infection rates of peritoneal macrophages, determination of parasite load in liver with Leishman-Donovan Units, and detection of cytokine ***: Obtained results demonstrated that the highest vaccine-mediated immune protection was provided by LPG-PAA conjugate due to all parameters investigated. According to the Leishman-Donovan Units results, the sharpest decline in parasite load was seen with a ratio of 81.17% when 35 mg LPG containing conjugate was applied. This value was 44.93% for the control group immunized only with LPG. Moreover, decreases in parasite load were 53.37%, 55.2% and 65.8% for the groups immunized with 10 mg LPG containing LPG-PAA conjugate, a physical mixture of the LPG–PAA, and a mixture of LPG + Freund's adjuvant, respectively. Furthermore, cytokine results supported that Th1 mediated protection occurred when mice were immunized with LPG-PAA ***: It has been demonstrated in this study that conjugate of LPG and PAA has an antileishmanial vaccine effect against visceral leishmaniasis. In this respect, the present study may lead to new vaccine approaches based on high immunogenic LPG molecule and adjuvant polymers in fighting against Leishmania infection.

关键词：利什曼原虫 Lipophosphoglycan 疫苗聚合物 Polyacrylic 酸

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Early endoscopic retrograde cholangiopancreatography after laparoscopic cholecystectomy can strain the occurrence of trocar site hernia

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World Journal of Gastrointestinal Endoscopy 2014年第11期6卷 568-570页

作者： Fatih Sumer Cuneyt Kayaalp Mehmet Ali Yagci emrah Otan Huseyin Kocaaslan Department of Surgery Inonu Uni-versity Malatya 44315 Turkey

This study reports a 69-year-old, obese, female patientpresenting with a biliary leakage after laparoscopiccholecystectomy for cholelithiasis. Closure of the um-bilical trocar site had been neglected during the lapa-roscopic cholecystectomy. Early, on postoperative dayfive, endoscopic retrograde cholangiopancreatography(ERCP) requirement after laparoscopic cholecystectomyresolved the biliary leakage problem but resulted with amore complicated clinical picture with an intestinal ob-struction and severe abdominal pain. Computed tomog-raphy revealed a strangulated hernia from the umbilicaltrocar site. Increased abdominal pressure during ERCPhad strained the weak umbilical trocar site. Emergencysurgical intervention through the umbilicus revealed anischemic small bowel segment which was treated withresection and anastomosis. This report demonstratesthat negligence of trocar site closure can result in veryearly herniation, particularly if an endoscopic interven-tion is required in the early postoperative period.

关键词： Laparoscopic cholecystectomy Trocar site hernia Endoscopic retrograde cholangiopancreatogra-phy Postoperative complications

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新光线下的艺术--谈博物馆与美术馆照明

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中国博物馆 2014年第4期 92-99页

作者： emrah Baki Ulas Mirjam Roos 国际照明设计师协会

博物馆和美术馆的照明是影响观众展览体验的重要因素。在使用LED等节能灯具的同时,合理有效的利用日光是当代博物馆照明的重要趋势,尽管日光的动态变化能给观众连接外部世界的体验并增加舒适度,但博物馆中日光的使用一直是充满挑战的任... 详细信息

博物馆和美术馆的照明是影响观众展览体验的重要因素。在使用LED等节能灯具的同时,合理有效的利用日光是当代博物馆照明的重要趋势,尽管日光的动态变化能给观众连接外部世界的体验并增加舒适度,但博物馆中日光的使用一直是充满挑战的任务,要关注照明节能,要提高观众的体验,同时保护展品免受光损伤。

关键词：照明博物馆美术馆展览日光文物保护

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Cytoprotective effects of amifostine,ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

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World Journal of Gastroenterology 2014年第29期20卷 10158-10165页

作者： Sami Akbulut Hulya Elbe Cengiz Eris Zumrut Dogan Gulten Toprak emrah Otan Erman Erdemli Yusuf Turkoz Liver Transplant Institute Inonu University Faculty of Medicine Department of Histology and Embriology Inonu University Faculty of Medicine Department of Anatomy Adiyaman University Faculty of Medicine Department of Biochemistry Dicle University Faculty of Medicine Department of Biochemistry Inonu University Faculty of Medicine

AIM:To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine(NAC),amifostine(AMF)and ascorbic acid(ASC)in methotrexate(MTX)-induced ***:An MTX-induced hepatotoxicity model was established in 44 male Sprague Dawley rats by administration of a single intraperitoneal injection of20 mg/kg *** of the rats were left untreated(Model group;n=11),and the remaining rats were treated with a 7-d course of 50 mg/kg per day NAC (MTX+NAC group;n=11),50 mg/kg per single dose AMF(MTX+AMF group;n=11),or 10 mg/kg per day ASC(MTX+ASC group;n=11).Eleven rats that received no MTX and no treatments served as the negative control *** and functional changes related to MTX-and the various treatments were assessed by histopathological analysis of liver tissues and biochemical assays of malondialdehyde(MDA),superoxide dismutase(SOD),catalase,glutathione(GSH)and xanthine oxidase activities and of serum levels of aspartate aminotransferase,alanine aminotransferase,alkaline phosphatase and total ***:Exposure to MTX caused structural and functional hepatotoxicity,as evidenced by significantly worse histopathological scores[median(range)injury score:control group:1(0-3)vs 7(6-9),P=0.001]and significantly higher MDA activity[409(352-466)nmol/g vs 455.5(419-516)nmol/g,P<0.05].The extent of MTX-induced perturbation of both parameters was reduced by all three cytoprotective agents,but only the reduction in hepatotoxicity scores reached statistical significance[4(3-6)for NAC,4.5(3-5)for AMF and 6(5-6)for ASC;P=0.001,P=0.001 and P<0.005vs model group respectively].Exposure to MTX also caused a significant reduction in the activities of GSH and SOD antioxidants in liver tissues[control group:3.02(2.85-3.43)μmol/g and 71.78(61.88-97.81)U/g vs model group:2.52(2.07-3.34)μmol/g and 61.46(58.27-67.75)U/g,P<0.05];however,only the NAC treatment provided significant increases in these antioxidant enzyme ac

关键词： Methotrexate Amifostine N-acetyl cysteine Ascorbic

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土耳其伊兹密尔歌剧院

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现代装饰 2015年第4期 120-123页

作者： emrah Cetinkaya 姜敏华 Nuvist建筑设计事务所

本案是来自伊斯坦布尔Nuvist建筑设计事务所设计的伊兹密尔地标式建筑——伊兹密尔歌剧院的竞标方案。从地点来看,伊兹密尔坐落在爱琴海边,是土耳其第三大城市,重要的工业、商业、外贸、海运枢纽中心,同时也是历史文化名城、旅游胜地和... 详细信息

本案是来自伊斯坦布尔Nuvist建筑设计事务所设计的伊兹密尔地标式建筑——伊兹密尔歌剧院的竞标方案。从地点来看,伊兹密尔坐落在爱琴海边,是土耳其第三大城市,重要的工业、商业、外贸、海运枢纽中心,同时也是历史文化名城、旅游胜地和军事要塞。而艺术,对于展示人类生活的发展有着巨大的作用。如果说灵魂、智慧与情感是一个社区的反映,

关键词：伊兹密尔建筑设计事务所海运枢纽地标建筑军事要塞大城市社会价值功能连接露天剧场娱乐文化

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Negative Polarity in Turkish： from negation to nonveridicality

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宏观语言学 2017年第2期5卷 51-69页

作者： emrah Gorgulu Istanbul Sabahattin Zaim University Turkey

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插电式混合电动汽车动力系结构的非线性约束优化(英文)

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汽车安全与节能学报 2012年第1期3卷 64-70页

作者： emrah T.YILDIZ Quazi FAROOQI Sohel ANWAR Yaobin CHEN Afshin IZADIAN 康明斯公司哥伦布市印地安纳州IN47201美国印第安纳大学与普度大学印第安纳波里斯联合分校IUPUI机械工程系印第安纳波里斯IN46202美国 IUPUI电子与计算机工程系 IN46202美国 IUPUI工程技术系 IN46202美国

为了优化插电式混合电动汽车(PHEV)动力系(例如发动机功率、电动机功率、相关经济效率)构件尺寸,使用了"粒子群优化"(PSO)方法。对于非线性约束优化问题,PSO方法比常规优化方法更有效、经济。用动力系反洗工具箱(PSAT)方法,构建了新的... 详细信息

为了优化插电式混合电动汽车(PHEV)动力系(例如发动机功率、电动机功率、相关经济效率)构件尺寸,使用了"粒子群优化"(PSO)方法。对于非线性约束优化问题,PSO方法比常规优化方法更有效、经济。用动力系反洗工具箱(PSAT)方法,构建了新的带有优化配置的PHEV动力系的模型系。仿真计算结果表明:运用PSO优化构件的汽车,具有同等的驾驶性能,在燃料消耗上达30%的改进。

关键词：插电式混合电动汽车(PHEV) 动力系最佳化构件尺寸 “粒子群优化”(PSO)方法动力系反洗工具箱(PSAT)

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Pancreatic extragastrointestinal stromal tumor:A case report and comprehensive literature review

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World Journal of Gastrointestinal Surgery 2014年第9期6卷 175-182页

作者： Sami Akbulut Rdvan Yavuz emrah Otan Sinan Hatipoglu Department of Surgery Diyarbakir Education and Research HospitalUckuyular Mevki Department of Surgery and Liver Transplant Institute Inonu University Faculty of MedicineTurgut Ozal Medical Center Department of Surgery Inonu University Faculty of Medicine Department of Surgery Adiyaman University Faculty of Medicine

AIM: To provide an overview of the literature on pan-creatic extragastrointestinal stromal tumors(EGISTs).METHODS: We report a case of pancreatic EGIST and review published studies on pancreatic EGIST ac-cessed via the PubMed, MEDlInE, Google Scholar, and Google databases. The keywords used were "pancreas and GIST", "pancreas and extra GIST", "pancreas and gastrointestinal stromal tumor", and "pancreas and ex-tragastrointestinal stromal tumor". literature reviews and/or duplicate studies were excluded. The search included articles published in the English language be-tween January 1, 2000 and May 15, ***: From our literature survey, 30 manuscripts on pancreatic EGISTs were considered, of which 27met the search criteria and three were excluded. The studies involved 30 patients(15 men, 15 women) with a mean age of 55.3 ± 14.3 years(range 30-84 years). The mean age of the male patients was 50.8 ± 13.7 years(range 30-84 years); that of the female patients was 59.9 ± 13.3 years(range 38-81 years). Tumor dimensions were obtained for 28 cases(mean 114.4 ± 78.6 mm; range 20-350 mm). Tumors were diagnosed incidentally in 23.3% of patients; abdominal discomfort and weight loss were the major complaints in symp-tomatic patients. Risk of aggressive behavior according to Fletcher criteria was determined in 25 of 30 patients(68%: high risk, 28%: intermediate risk, 4%: low risk). Histopathological examination revealed the presence of spindle cells in 96.1% of cases; CD117 and CD34 were present immunohistochemically in 96.6% and 84% of patients, respectively. The most common surgical pro-cedures were distal pancreatectomy with splenectomy(n = 9) and pancreaticoduodenectomy(n = 7). The to-tal follow-up period for the 28 patients ranged from 3-66 mo, during which locoregional or distant metastases were diagnosed in six patients and two patients ***: Studies on EGISTs have only been published in the last decade. The lack of studies with large patient cohorts and l

关键词： Gastrointestinal stromal tumor Extra-gastrointestinal stromal tumor Pancreas Imatinib mesylate CD117

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Isolation and diagnosis of Helicobacter pylori by a new method: Microcapillary culture

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World Journal of Gastroenterology 2015年第9期21卷 2622-2628页

作者： Adil M Allahverdiyev Melahat Bagirova Reyhan Caliskan Hrisi Bahar Tokman Hayat Aliyeva Gokce Unal Olga Nehir Oztel emrah Sefik Abamor Hilal Toptas Pelin Yuksel Fatma Kalayci Mustafa Aslan Yusuf Erzin Kadir Bal Bekir S Kocazeybek Department of Bioengineering Yildiz Technical University34201 IstanbulTurkey Department of Medical Microbiology Cerrahpasa Faculty of MedicineIstanbul University34098 IstanbulTurkey Department of Microbiology and Immunology Azerbaijan Medical UniversityAZ1022 BakuAzerbaijan Department of Gastroenterology Cerrahpasa Faculty of MedicineIstanbul University34098 IstanbulTurkey

AIM:To investigate the performance of the microcapillary culture method(MCM) in Helicobacter pylori(***) isolation and ***:Microcapillary culture(MC),classical culture(CC),rapid urease(CLO) test,and histopathologic examination(HE) were performed with biopsy *** biopsy samples were loaded into capillary tubes and incubated for 48 h at 37 ℃ without providing a microaerophilic ***,three or four loops of the homogenized sample were inoculated in a ready-to-use selective medium(Becton Dickinson,Helicobacter Agar,Modified) specific for the isolation of *** and incubated at 37 ℃ in a microaerophilic atmosphere provided by Campy Gen(Becton Dickinson,Gas Pack).Bacteria reproducing in microcapillary tubes were evaluated in an inverted microscope and also were evaluated after performing a CC with the *** obtained by CC,CLO test,and HE were compared with those of *** diagnostic performances of the methods used in this study were evaluated for specificity,sensitivity,positive predictive value(PPV),negative predictive value(NPV),and ***:*** was found positive by CLO test +HE and/or CC culture in 26 patient antrum and corpus biopsy *** 25(25/26) patient biopsy samples,*** was isolated by MCM,whereas in only 14(14/26) patient biopsy samples,*** was isolatedby *** test and HE were found positive in 17(17/26) patient biopsy *** the results of the isolation of *** by MCM,CC,CLO test,and HE,the sensitivity of the MCM was found as 96%,the specificity as 80%,the PPV as 83%,the NPV as 95%,and the 95%CI as 0.76(χ2 =31.51,P < 0.01) whereas the sensitivity of the CC was found as 54%(χ2 =19.15,P < 0.01),and the sensitivity of the CLO test and HE were found as 65%(χ2 =25.26,P < 0.01).CONCLUSION:This new microcapillary cultivation method for *** has high diagnostic sensitivity compared with CC,HE,and CLO tests.

关键词： Microcapillary culture Classical culture New metho

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Malformations of cortical development:3T magnetic resonance imaging features

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World Journal of Radiology 2015年第10期7卷 329-335页

作者： Bilal Battal Selami Ince Veysel Akgun Murat Kocaoglu emrah Ozcan Mustafa Tasar Department of Radiology Gulhane Military Medical School Department of Radiology Near East UniversityFaculty of Medicine

Malformation of cortical development(MCD) is a term representing an inhomogeneous group of central nervous system abnormalities, referring particularly to embriyological aspect as a consequence of any of the three developmental stages, i.e., cell proliferation, cell migration and cortical organization. These include cotical dysgenesis, microcephaly, polymicrogyria, schizencephaly, lissencephaly, hemimegalencephaly, heterotopia and focal cortical dysplasia. Since magnetic resonance imaging is the modality of choice that best identifies the structural anomalies of the brain cortex, we aimed to provide a mini review of MCD by using 3T magnetic resonance scanner images.

关键词： Cortical development Cortical dysplasia Lissenceph

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