检索结果-南通市图书馆

国外医药（抗生素分册） 1989年第5期10卷 348-349页

作者： emmerson am 陈汉源

头孢呋新(ce furoxi me)为注射用第二代头孢菌素。它体外抗菌活性很强,对肠道细菌产的β内酰胺酶稳定性高,且药代动力学特征良好。因为它在生理pH时高度离解,脂溶性差,基本上口服不吸收。头孢呋新酯(Cefuroxime axe(?)l)为头孢呋新前体... 详细信息

头孢呋新(ce furoxi me)为注射用第二代头孢菌素。它体外抗菌活性很强,对肠道细菌产的β内酰胺酶稳定性高,且药代动力学特征良好。因为它在生理pH时高度离解,脂溶性差,基本上口服不吸收。头孢呋新酯(Cefuroxime axe(?)l)为头孢呋新前体药,在头孢呋新C4位羧基上发生酯化,从而提高了亲脂性,增加口服后吸收率。头孢呋新酯吸收后仅3～4分钟内在肠粘膜和门循环中迅速水解,去酯分解为头孢呋新、乙醛和乙酸。血循环中测不到头孢呋新酯原药。制剂由于曾存在一些与药物本身理化特性有关的问题,发展头孢呋新酯花了相当长的时间。

关键词：头孢呋新头孢菌素头孢呋新酯

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse

引用

World Journal of Stem Cells 2016年第5期8卷 202-215页

作者： Stuart J emmerson Caroline E Gargett the Ritchie Centre Hudson Institute of Medical Research Department of Obstetrics and Gynaecology Monash University

Pelvic organ prolapse(POP) occurs when the pelvic organs(bladder, bowel or uterus) herniate into the vagina, causing incontinence, voiding, bowel and sexual dysfunction, negatively impacting upon a woman's quality of life. POP affects 25% of all women and results from childbirth injury. For 19% of all women, surgical reconstructive surgery is required for treatment, often augmented with surgical mesh. The surgical treatment fails in up to 30% of cases or results in adverse effects, such as pain and mesh erosion into the bladder, bowel or vagina. Due to these complications the Food and Drug Administration cautioned against the use of vaginal mesh and several major brands have been recently been withdrawn from market. In this review we will discuss new cell-based approaches being developed for the treatment of POP. Several cell types have been investigated in animal models, including a new source of mesenchymal stem/stromal cells(MSC) derived from human endometrium. The unique characteristics of endometrial MSC, methods for their isolation and purification and steps towards their development for good manufacturing practice production will be described. Animal models that could be used to examine the potential for this approach will also be discussed as will a rodent model showing promise in developing an endometrial MSC-based therapy for POP. The development of a preclinical large animal model for assessing tissue engineering constructs for treating POP will also be mentioned.

关键词： Endometrium Mesenchymal stem cells Endometrial mesenchymal stem cells Pelvic organ prolapse Mesh Tissue engineering Regenerative medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the enhanced properties of composite asphalt via adding surface modified calcium sulfate whisker-SBR

引用

CHINESE JOURNAL OF CHEMICAL ENGINEERING 2024年第12期76卷 187-200页

作者： Cui, Aoqi Hondo, emmerson Ari, Nur Fatihah Tajul Pei, Yanpeng Su, Xuan Chen, Zhonghe Univ Jinan Sch Chem & Chem Engn Jinan 250022 Peoples R China Natl Univ Singapore Dept Chem & Biomol Engn Singapore 119260 Singapore

With the aim of improving the durability and safety, erosion time, and cost-effective of asphalt road, a composite of modified calcium sulfate whisker-styrene butadiene rubber modified asphalt (MCSWSBRMA) was prepared via thermal doping. Firstly, stearic acid and titanate coupling agent (NDZ-201) were used as a modifier to transform calcium sulfate whisker (CSW) into MCSW via wet modification method at 60 degrees C and anhydrous ethanol as a dispersant. What is more, the optimum loading of modifier (a mixture of 25% stearic acid + 75% NDZ-201) was found to be at 2% to prepare MCSW. Subsequently, a composite of MCSW-SBRMA was prepared with different loading of MCSW (i.e. 2% to 8%) to enhance the softening point of asphalt. In this study, it was found that 4% of modifiers was the best composition to improve the MCSW-SBRMA properties as elucidated in the orthogonal experiment table L16(42). The effects of MCSW and SBR addition on several properties of asphalt were studied by multiple routine tests including penetration, segregation test, and so on. The results show that: 2% to 8% MCSW can increase the softening point of SBR modified asphalt (SBRMA) by 7% to 8%. 4% MCSW increased the PG of SBRMA from 64 to 70, which greatly improved the high temperature characteristics of asphalt. The 5 degrees C ductility of MCSW-SBRMA is greater than 100 cm, which greatly improves the low temperature performance of asphalt. Through the application of fluorescence microscopy (FM), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and energy dispersive spectroscopy (SEM-EDS), it has been demonstrated that MCSW-SBR effectively alters asphalt in a highly uniform manner, with some MCSW still retaining large cross sections, thereby facilitating the dispersion of shear stress and enhancing the durability of asphalt. (c) 2024 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights are reserved, including those

关键词： Surface modification Calcium sulfate whisker SBR Modified asphalt High temperature performance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combining spawn egg counts,individual photo-ID and genetic fingerprinting to estimate the population size and sex ratio of an endangered amphibian

引用

Integrative Zoology 2021年第2期16卷 240-254页

作者： Marina REYNE Sarah HELYAR Aurélie AUBRY Mark emmerson Ferdia MARNELL Neil REID School of Biological Sciences Queen’s University BelfastBelfastUK Institute of Global Food Security(IGFS) Queen’s University BelfastBelfastUK Agri-Food&Biosciences Institute(AFBI) HillsboroughUK National Parks&Wildlife Service(NPWS) DublinIreland

According to the International Union for Conservation of Nature Red List,41%of the world’s amphibian species are threatened with extinction,making them more threatened than any other vertebrate group *** the global amphibian crisis,comprehensive understanding of demographics and population trends of declining and threatened species is essential for effective management and conservation *** egg spawns is widely used to assess population abundance in pond breeding ***,it is unknown how such counts translate into robust population size *** monitored the breeding activity of the Natterjack toad(Epidalea calamita),combining egg string counts and individual photo-identification with Capture-Mark-Recapture population size and operational sex ratio *** Natterjack toads were identified by the pattern of natural markings with repeated ID of the same individual confirmed for 10%of the samples using genetic *** identified 647 unique individuals within a closed study population at Caherdaniel,Co *** estimates derived from egg string counts estimated a breeding population of 368 females(95%CI 353–384)and Capture-Mark-Recapture estimated a breeding population of 1698 males(95%CI 1000–2397).The female:male sex ratio was conservatively estimated at 1:5(95%CI 1:3–1:6)where 62%±6%of females were assumed to *** substantially departed from any priori assumption of 1:1 which could have underestimated the breeding population by up to 72%.Where amphibian absolute population size estimation is necessary,methods should include empirical survey data on operational sex ratios and not rely on assumptions or those derived from the literature which may be highly population and/or context-dependent.

关键词： Epidalea calamita genetic fingerprinting Mark-Recapture Natterjack toad photo-identification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of dietary supplementation of one-carbon metabolism on neural recovery

引用

Neural Regeneration Research 2017年第7期12卷 1075-1076页

作者： Joshua T.emmerson Lauren K.Murray Nafisa M.Jadavji Department of Neuroscience Carleton University Ottawa ONCanada

In the cell,one-carbon metabolism modulates nucleotide synthesis,DNA repair,as well as methylation through the reduction of homocysteine（Figure 1）.High levels of plasma homocysteine have been associated with negative health outcomes in humans（Murray et al.,2017）.Folates,B-vitamins,are a major component of one-carbon metabolism and play an important role in brain ***,they are involved in nucleotide synthesis,DNA repair,methylation,second messenger systems,ion channels,protein,

关键词： of et is as Impact of dietary supplementation of one-carbon metabolism on neural recovery into been were that on MTHFR for DHFR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

One-step conversion of syngas to light olefins over bifunctional metal-zeolite catalyst

引用

Chinese Journal of Chemical Engineering 2021年第8期34卷 101-110页

作者： Ce Du Linet Gapu Chizema emmerson Hondo Mingliang Tong Qingxiang Ma Xinhua Gao Ruiqin Yang Peng Lu Noritatsu Tsubaki Zhejiang Provincial Key Lab for Chem.&Bio.Processing Technology of Farm Product School of Biological and Chemical EngineeringZhejiang University of Science and TechnologyHangzhou 310023China Department of Applied Chemistry School of EngineeringUniversity of ToyamaGofuku 3190Toyama 930-8555Japan State Key Laboratory Cultivation Base of Natural Gas Conversion Ningxia UniversityYinchuan 750021China

Light olefins(C_(2)–C_(4))are fundamental building blocks for the manufacture of polymers,chemical intermediates,and *** this work,we realized a composite catalyst,comprising MnxZry oxides and SAPO-34 zeolite,which can convert syngas(CO+H_(2))into light *** oxide catalysts with different Mn/Zr molar ratios were facilely prepared using the coprecipitation method prior to physical mixing with SAPO-34 *** redox properties,surface morphology,electronic state,crystal structure,and chemical elemental composition of the catalysts were examined using H_(2)-TPR,SEM,XPS,XRD,and EDS techniques,*** reactions involved activation of CO and subsequent hydrogenation over the metal oxide catalyst,producing methanol and dimethyl ether as the main reaction intermediates,which then migrated onto SAPO-34 zeolite for light olefins *** of temperature,pressure and reactant gas flow rate on CO conversion and light olefins selectivity were investigated in *** Mn_(1)Zr_(2)/SAPO-34 catalyst(Mn/Zr ratio of 1:2)attained a CO conversion of 10.8%and light olefins selectivity of 60.7%,at an optimized temperature,pressure and GHSV of 380℃,3 MPa and 3000h^(−1) *** findings open avenues to exploit other metal oxides with CO activation capabilities for a more efficient syngas conversion and product selectivity.

关键词： Catalyst C-C coupling CO activation Hydrogenation Light olefins Syngas

来源：

维普期刊数据库

同方期刊数据库评论