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Driving Skills in HIV-Infected Patients Well Controlled with Antiretroviral Therapy

World Journal of AIDS 2012年第3期2卷 122-125页

作者： Carlos Tornero Inmaculada Poquet Marine bourguet Fernando Gomis-Pajares Ana Ventura Maricarmen MafeInternal Medicine DepartmentHospital Francisco de BorjaGandiaEspana Preventive Service Hospital Francisco de BorjaGandiaEspana

A study was made to determine whether HIV-infected patients with prolonged virological control suffer subclinical neurocognitive problems capable of interfering with driving skills, compared with the general population, and to explore the possible existence of differences between those treated with and without efavirenz. Material and Methods: We included 40 patients without history of neoplasm, psychiatric disorders or infections of the central nervous system associated or not to HIV, with stable and effective antiretroviral therapy during at least 48 months. Use was made of the ASDE DRIVER TEST N-845 standardized by the Spanish traffic authorities, and for which data corresponding to the Spanish general population were obtained from the manufacturer of the test battery. The Student t-test was used to compare the different variables with the population standards, and the comparison of proportions Z-statistic was used to determine the proportion of subjects above the accepted limit of normality cutoff point. These analyses were replicated for the two sub-samples (with or without efavirenz therapy), with a 95% confidence level. The SPSS version 15 statistical package and Epidat 3.1 program were used. Results: The scores obtained in the HIV group were significantly poorer in the anticipation speed tests and in one of the multiple reactions test, though better results were obtained in the bimanual visual-motor coordination test. There were no differences in the percentages of patients with scores below the recommended limits. On comparing the treatment subgroups (efavirenz versus protease inhibitor), no differences were recorded in any of the study variables, and the differences with respect to the general population were the same as those described for the global group. Conclusions: Little differences were observed in driving skills in HIV well controlled HIV patients of minor clinical significance, and no differences were found in driving skills between the patients a

关键词： Driving Skills Efavirenz Neurocognitive Disorders

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氢化脱氢钛粉末颗粒的整形及其机理研究

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稀有金属材料与工程 2009年第A3期38卷 264-266页

作者：郝向阳盖国胜邹欣吴运新张以河 emmanuelle Reynaud 中国地质大学北京100083 清华大学北京100084 University of Massachusetts-Lowell MA 01854 USA

HDH(氢化脱氢)钛粉末颗粒形状不规则、流动性较差,不利于注射成形和提高其制品性能。本研究利用PCS系统对HDH钛粉末颗粒进行整形,考察了处理工艺,用扫描电镜和粒度分析表征处理结果,推测PCS的整形机理不是传统的粉碎过程,而是钛粉末颗... 详细信息

HDH(氢化脱氢)钛粉末颗粒形状不规则、流动性较差,不利于注射成形和提高其制品性能。本研究利用PCS系统对HDH钛粉末颗粒进行整形,考察了处理工艺,用扫描电镜和粒度分析表征处理结果,推测PCS的整形机理不是传统的粉碎过程,而是钛粉末颗粒的棱角被打磨掉再与大颗粒吸附嵌入,较好地解释了粒度分布等测试结果。整形后的HDH钛粉末颗粒尖锐的棱角被钝化,变为近球形,粉末的流动性显著提高。

关键词：整形球形化氢化脱氢(HDH)钛粉粒度

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Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers

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World Journal of Gastroenterology 2008年第7期14卷 1053-1059页

作者： Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur Centre de RechercheJean-Pierre Aubert-JPARC INSERM U837Equipe Mucinesdifférenciation et cancérogenèseépithélialesLaboratoire deBiochimie et Biologie MoléculaireCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Laboratoire d'Anatomie et CytologiePathologiques CHRU de LilleLilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Service de Chirurgie Digestiveet GénéraleCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Laboratoire d'Anatomie et Cytologie PathologiquesCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837and Laboratoire de Biochimie etBiologie MoléculaireCHRU de LilleLilleFrance Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837Laboratoire de Biochimie et Biologie MoléculaireCHRU de LilleLilleFrance Laboratoire d'Immunologie et GénétiqueTunis-ElManarTunisie Centre de Recherche Jean-Pierre Aubert-JPARC INSERM U837LilleFrance Laboratoire de Biochimie et Biologie Moléculaire CHRU de LilleLilleFrance Centre de RechercheJean-Pierre Aubert-JPARC INSERM U837Equipe Mucinesdifférenciation et cancérogenèseépithélialesLaboratoire de Biochimie et Biologie MoléculaireCHRU de Lilleand Facultéde Médecine H.WarembourgUniversitéde Lille 2LilleFrance present address INSERMU843 Université Paris 7Hpital R.DebréParisFrance

AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal ***:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal *** effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and ***:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal ***:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer.

关键词： Epidermal growth factor receptor Microsatellite instability Allelic imbalance Gene polymorphism Expression Colorectal cancer

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Second-line therapy for gemcitabine-pretreated advanced or metastatic pancreatic cancer

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World Journal of Gastroenterology 2012年第12期18卷 1357-1364页

作者： Romain Altwegg Marc Ychou Vanessa Guillaumon Simon Thezenas Pierre Senesse Nicolas Flori Thibault Mazard Ludovic Caillo Stéphanie Faure emmanuelle Samalin Eric Assenat the Oncology and Digestive Endoscopy Department of the CRLC Val d'Aurelle 34000 MontpellierFrance

AIM： To investigate second-line chemotherapy in gemcitabine-pretreated patients with advanced or metastat- ic pancreatic cancer [（frequency, response, outcome, course of carbohydrate antigen 19-9 （CA 19-9）].METHODS： This retrospective study included all patients with advanced or metastatic pancreatic cancer （adenocarcinoma or carcinoma） treated with secondline chemotherapy in our center between 2000 and 2008. All patients received first-line chemotherapy with gemcitabine, and prior surgery or radiotherapy was permitted. We analyzed each chemotherapy protocol for second-line treatment, the number of cycles and the type of combination used. The primary endpoint was overall survival. Secondary endpoints included progression-free survival, response rate, grade 3-4 toxicity, dosage modifications and CA 19-9 course.a second-line therapy among 206 patients who had initially received first-line treatment with a gemcitabi- ne-based regimen. Median number of cycles was 4 （range： 1-12） and the median duration of treatment was 2.6 mo （range： 0.3-7.4）. The overall disease control rate was 40.0%. The median overall survival and progression-free survival from the start of second-line therapy were 5.8 （95% CI： 4.1-6.6） and 3.4 mo （95% CI： 2.4-4.2）, respectively. Toxicity was generally acceptable. Median overall survival of patients with a CA 19-9 level declining by more than 20% was 10.3 mo （95% CI： 4.5-11.6） vs 5.2 mo （95% CI： 4.0-6.4） for others （P = 0.008）.CONCLUSION： A large proportion of patients could benefit from second-line therapy, and CA 19-9 allows efficient treatment monitoring both in first and secondline chemotherapy.

关键词： Second-line Chemotherapy Pancreatic can-cer Gemcitabine Carbohydrate antigen 19-9

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Matched or nonmatched interventions based on the transtheoretical model to promote physical activity.A meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2018年第1期7卷 50-57页

作者： Ahmed Jerome Romain Catherine Bortolon Mathieu Gourlan Marion Carayol emmanuelle Decker Olivier Lareyre Grégory Ninot Julie Boiché Paquito Bernard EA4556 Laboratory Epsylon-Dynamics of Human Abilities and Health Behaviours University of Montpellier Montpellier 34000 France Challenge for the Change of Behaviour (CCB) Group Montpellier 34000 France University of Montreal Hospital Research Centre Montreal Quebec H2X OA9 Canada Unit of Adult Psychiatry La colombiere University Hospital of Montpellier Montpellier 34295 France Prevention Department of institut Regional du Cancer de Montpellier Epidaure Montpellier 34298 France Research Centre of the University Hospital of Quebec Quebec GIR 2J6 Canada Cancer Research Centre University of LavaL Quebec G1R 3S3 Canada School of Psychology University of Laval Quebec G1C OA6 Canada

Purpose: The aim of this study was to examine whether the efficacy of transtheoretical model(TTM)-based interventions on physical activity(PA)varied according to the following criteria:(1) interventions targeted the actual stages of change(SOCs) or did not;(2) participants were selected according to their SOC or were not; and(3) its theoretical constructs(decisional balance, temptation, self-efficacy, processes of change).Methods: Thirty-three randomized controlled trials assessing TTM-based interventions promoting PA in adults were systematically ***: The between-group heterogeneity statistic(Qb) did not reveal any differential efficacy either in interventions targeting the actual SOC compared with those that did not(Qb = 1.48, p = 0.22) or in interventions selecting participants according to their SOC compared with those that did not(Qb = 0.01, p = 0.91). TTM-based interventions enhanced PA behavior whether they targeted the actual SOC(Cohen's d = 0.36; 95%confidence interval(CI): 0.22–0.49) or not(d = 0.23; 95%CI: 0.09–0.38) and whether they selected their participants according to their SOC(d = 0.33; 95%CI: 0.13–0.53) or not(d = 0.32; 95%CI: 0.19–0.44). The moderators of the efficacy of TTM-based interventions were the number of theoretical constructs used to tailor the intervention(Qb = 8.82, p = 0.003), the use of self-efficacy(Qb = 6.09, p = 0.01), and the processes of change(Qb = 3.51, p = 0.06).Conclusion: TTM-based interventions significantly improved PA behavior, and their efficacy was not moderated by SOC but by the TTM theoretical constructs.

关键词： Exercise Interventions Meta-regression Moderators Processes of change Stages of change Theory-based

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Production and stability study of a hospital parenteral nutrition solution for neonates

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Journal of Pharmaceutical Analysis 2019年第2期9卷 83-90页

作者： Anne-Laure Yailian Céline Serre Justine Fayard Marina Faucon Patrick Thomaré Samira Filali Christine Pivot Florence Vételé Fabrice Pirot emmanuelle Olivier Service Pharmaceutique Plateforme FripharmGroupe Hospitalier Centre Edouard HerriotHospices Civils de Lyon Laboratoire de Recherche et Développement de Pharmacie Galénique Industrielle UMR 5305Plateforme FripharmFaculté de PharmacieUniversité Claude Bernard Lyon 18 Service Pharmaceutique Site H?tel-DieuCentre Hospitalo-Universitaire de Nantes1place Alexis Ricordeau Service pharmaceutique Groupement Hospitalier EstHospices Civils de Lyon

Standard parenteral nutrition solutions are mixtures comprising interacting components that may degrade themselves over time. The objective of this study was to investigate the physicochemical and microbiological stability of a hospital preparation for parenteral nutrition in neonatology. The analyses were performed throughout the storage of the preparations at 2–8 °C(up to 4 months). The extent of stability was based on the determination of amino acids dosage, visual and physicochemical properties(glucose and electrolytes concentrations, pH and osmolality measurements, particle counting) and microbiological analysis(sterility test). A thermal degradation of ascorbic acid was conducted to evaluate the antioxidant properties of the parenteral mixture. Physicochemical and microbiological controls were found to comply with the specifications. Amino acids showed a good stability throughout the 4 months storage except for cysteine, which was progressively degraded to cystine, conferring a yellow coloration to parenteral solutions. Parenteral nutrition standards solutions remain stable for 4 months at 2–8 °C,ensuring safe administration in preterm infants.

关键词： Stability-indicating method study Parenteral nutrition Neonatology Amino acids High-performance liquid chromatographic

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Chronic fatigue syndrome: An update for psychiatrists

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Open Journal of Psychiatry 2012年第1期2卷 40-48页

作者： Camila Prochalska Florence Gressier emmanuelle Corruble 不详

Chronic fatigue syndrome (CFS) is a poorly understood condition primarily characterized by debilitateing, persistent or recurrent fatigue, increased physical and mental fatigability, cognitive impairment and widespread musculoskeletal pain. During the past two decades, there have been heated debates about CFS among researchers, practitioners and patients. The existence of the disorder has been questioned, its underlying pathophysiology debated and an effective treatment opposed (such as antidepressants, stimulants or antibiotics). A lot of multidisciplinary literature is found about CFS, but to date, many psychiatrists seem to unknown the existence of this illness or think that it is a purely psychological disorder. However, CFS is sitting on the border between medicine and psychiatry. The aim of this review is to make psychiatrists aware of the existence of CFS and that they will, one day, be confronted with the management of this illness. Thus, this update allows understanding what is CFS, the diversity of physiopathology underlined and its management.

关键词： Fatigue Chronic Fatigue Syndrome Diagnosis Physiopathology Treatment

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A machine vision tool for facilitating the optimization of large-area perovskite photovoltaics

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npj Computational Materials 2021年第1期7卷 1764-1773页

作者： Nina Taherimakhsousi Mathilde Fievez Benjamin P.MacLeod Edward P.Booker emmanuelle Fayard Muriel Matheron Matthieu Manceau Stéphane Cros Solenn Berson Curtis P.Berlinguette Department of Chemistry The University of British Columbia2036 Main MallVancouverBC V6T 1Z1Canada Univ.Grenoble Alpes CEALITENCampus Ines73375 Le Bourget du LacFrance Stewart Blusson Quantum Matter Institute The University of British Columbia2355 East MallVancouverBC V6T 1Z4Canada School of Electrical Engineering and Computer Science University of Ottawa800 King Edward AvenueOttawaON K1N 6N5USA Department of Chemical&Biological Engineering The University of British Columbia2360 East MallVancouverBC V6T 1Z3Canada Canadian Institute for Advanced Research(CIFAR) MaRS Innovation Centre661 University Avenue Suite 505M5G 1M1 TorontoONCanada

We report a fast,reliable and non-destructive method for quantifying the homogeneity of perovskite thin films over large areas using machine *** adapt existing machine vision algorithms to spatially quantify multiple perovskite film properties(substrate coverage,film thickness,defect density)with pixel resolution from pictures of 25 cm2 *** machine vision tool—called PerovskiteVision—can be combined with an optical model to predict photovoltaic cell and module current density from the perovskite film *** use the measured film properties and predicted device current density to identify a posteriori the process conditions that simultaneously maximize the device performance and the manufacturing throughput for large-area perovskite deposition using gas-knife assisted slot-die *** thus facilitates the transfer of a new deposition process to large-scale photovoltaic module *** work shows how machine vision can accelerate slow characterization steps essential for the multi-objective optimization of thin film deposition processes.

关键词： optimization perovskite film

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Relationships between mucinous gastric carcinoma, MUC2 expression and survival

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World Journal of Gastroenterology 2006年第21期12卷 3324-3331页

作者： emmanuelle Leteurtre Farid Zerimech Guillaume Piessen Agnès Wacrenier Xavier Leroy Marie-Christine Copin Christophe Mariette Jean-Pierre Aubert Nicole Porchet Marie-Pierre Buisine INSERM U560 59045Lille cedexFrance Service d'Anatomie et Cytologie Pabologiques Pôle Biologie-Pathogie Pac Eurasanté.CHR-U de Lille59037 Lille cedexFrance Service de Biochimie et Biologie Moléculaire CHR-U de Lille59037 Lille cedexFrance Facultéde Médecine H.Warembourg 59045 Lille cedexFrance Service.de Chirurgie Digetive et Générale CAEB CHR-U de Lille59045 Lille cedexFrance

AIM:To investigate the expression of the four secreted gel-forming mucins(MUC2,MUCSAC,MUCSB and MUC6)in a series of gastric carcinomas,classified according Laurén's,Mulligan's,WHO and Goseki's classifications,with special attention to all the different components(major and minor)present in tumors and to follow up clinical ***:Expression of MUC2,MUC5AC,MUC5B and MUC6 was investigated using immunohistochemistry and in situ ***:Expression of secreted gel-forming mucins in gastric carcinoma was particularly complex,each mucin being not restricted to any histopathological type even considering all components(major and minor)present in a given *** was a worst survival in patients with a higher content of mucus(GosekiⅡorⅣ)and high positive MUC2 ***:Complexity of mucin gene expression patterns in gastric cancer may reflect a precise state of differentiation at the cell level not recognized in used morphologic classification *** expression of MUC2 was nevertheless associated with mucinous subtype of the WHO classification and with groupⅡof Goseki's classification identified by the major component of a particular *** quantity and quality of mucus were related to survival.

关键词： Gastric cancer Secreted gel-forming mucin MUC Immunohistochemistry in situ hybridization Survival

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Pharmacological properties and related constituents of stem bark of Pterocarpus erinaceus Poir.(Fabaceae)

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Asian Pacific Journal of Tropical Medicine 2012年第1期5卷 46-51页

作者： Ouedraogo Noufou Sawadogo Richard Wamtinga Tibiri Andre Bayet Christine Lompo Marius Hay A emmanuelle Koudou Jean Dijoux Marie-Genevieve Guissou Innocent Pierre Departement de medecine-pharmacopee traditionnelle/pharmacie(IRSS/CNRST) 03 BP 7192 Ouagadougou 03 Burkina Faso Laboratoire de pharmacologie et toxicologie UFR/SDSUniversite de Ouagadougou 03 BP 7021 Ouagadougou 03Burkina Faso Universite de Lyon F-69622LyonFrance Universite Lyon I Villeurbanne CNRS UMR 5557Ecologie MicrobienneISPB69373 LyonFrance Laboratoire de chimie des substances naturelles Faculte des SciencesUniversite de Bangui.BP908Bangui.Republique Centrafricaine Departement de medecine-pharmacopee traditionnelle/pharmacie(IRSS/CNRST) 03 BP 7192 Ouagadougou 03 Burkina Faso Laboratoire de pharmacologie et toxicologieUFR/SDSUniversite de Ouagadougou 03 BP 7021 Ouagadougou 03Burkina Faso

Objective:To sereen methanol and dichloromethane extracts of stem bark of Pterocarpus erinaceus for anti-inflammatory,*** vitro antioxidant activities and phytochemical ***:Anti-inflammatory activity was detcrmined by using carrageenan inducededema of mice paw and croton oil-induced edema of mice ear:analgesic effect was evaluated using acetic acid-induced *** screening of extracts was performed by thin layer *** chromatographic fractionation led to the isolation of main active components as *** and *** structures were established hy TLC and nuclear magnetic resonance ***:Both methanol and dichloromethane extracts, *** and epicatechin showed a significant anti—inflammatory effect using croton oil induced—ear ***,the action of dichloroinethane extract was more important. At the doses of 100 and 200 mg/*** methanol extract was able to reduce the carrageeuan induced-hind paw edema,while al the doses of 100.200 and 400 mg/*** showed an important analgesic effect against writhing induced by acetic acid injection of 38.8%.68.0%and 74.3%, *** properties of methanol extract and its dichloromethane and ethyl acetate fractions were assessed by using the 1,1—diphenyl—2—picrylhydrazyl *** methanol extract showed the stronger radical scavenging activity than dichloromethane and ethyl acetate fractions,with an antiradical power of 5.3.5 and 2 *** main components isolated from these extracts as friedelin,lupeol and epicathechin were responsible of these ***:The results suggest that the stem hark extracts of Pterocarpus erinaceus possessed important *** activities and strong antioxidant properties, therefore,they could he used as natural potential ingredients for pharma ceutical industry.

关键词： Pterocarpus erinaceus Phytochemical Anti-inflammatory Analgesic Antioxidant

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