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Data-Driven Upscaling of Orientation Kinematics in Suspensions of Rigid Fibres

Computer Modeling in Engineering & Sciences 2018年第12期117卷 367-386页

作者： Adrien Scheuer Amine Ammar emmanuelle Abisset-Chavanne Elias Cueto Francisco Chinesta Roland Keunings Suresh GAdvani ICTEAM Universitécatholique de LouvainAv.Georges Lemaitre 4Louvain-la-Neuve B-1348Belgium Arts et Métiers ParisTech Boulevard du Ronceray 2BP 9352549035 Angers cedex 01France ICI&ESI GROUP Chair Ecole Centrale de NantesRue de la Noe 1F-44300 NantesFrance Aragon Institute of Engineering Research Universidad de ZaragozaEdificio Betancourt.Maria de Lunas.n.50018 ZaragozaSpain PIMM&ESI GROUP Chair ENSAM ParisTechBoulevard de l’Hopital 151F-75013 ParisFrance Deptartment of Mechanical Engineering University of DelawareNewarkDE 19716United States

Describing the orientation state of the particles is often critical in fibre suspension *** descriptors,the so-called second-order orientation tensor(or moment)leading the way,are often preferred due to their low computational *** problems however arise when evolution equations for the moments are derived from the orientation distribution functions and the impact of the chosen closure is often *** this work,our aim is to provide macroscopic simulations of orientation that are cheap,accurate and *** this end,we propose an innovative data-based approach to the upscaling of orientation kinematics in the context of fibre *** the physics at the microscopic scale can be modelled reasonably enough,the idea is to conduct accurate offline direct numerical simulations at that scale and to extract the corresponding macroscopic descriptors in order to build a database of *** the online stage,the macroscopic descriptors can then be updated quickly by combining adequately the items from the database instead of relying on an imprecise macroscopic *** methodology is presented in the well-known case of dilute fibre suspensions(where it can be compared against closure-based macroscopic models)and in the case of suspensions of confined or electrically-charged fibres,for which state-of-the-art closures proved to be inadequate or simply do not exist.

关键词： Fibre suspensions data-driven upscaling closure approximations

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T-lymphoblastic lymphoma with cutaneous involvement

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World Journal of Clinical Cases 2015年第8期3卷 727-731页

作者： emmanuelle Ginoux Fanny Julia Brigitte Balme Luc Thomas Stéphane Dalle Department of Dermatology Centre Hospitalier Lyon-Sud Hospices Civils de Lyon Université Claude Bernard Lyon 1 Unit of Pathology Centre Hospitalier Lyon-Sud Hospices Civils de Lyon Cancer Research Center of Lyon

To study dermatological manifestation of T-lymphoblastic lymphoma and to help clinicians in the diagnosis, we report here the case of a 75-year-old patient who presented with violaceous nodules acquired during the last 4 wk and affecting the scalp and right arm. The diagnosis of systemic lymphoma was suggested upon the appearance of cutaneous tumors, palpable lymph nodes and general symptoms including asthenia and weight-loss. The pathology features: positive immunostaining for CD3 and terminal deoxynucleotidyl transferase(Td T) and staging, led us to the final diagnosis of T-lymphoblastic lymphoma(T-LBL) with cutaneous involvement. He received a CHOP regimen as first-line treatment. Unfortunately, the patient relapsed and died 8 mo after the treatment initiation. T-LBL may be diagnosed by skin lesions. Additional immunostaining including Td T and experienced histopathologists are needed to correctly classify this aggressive disease and discuss the correct management including bone-marrow transplantation where appropriate.

关键词： Cutaneous lymphoma Lymphoblastic lymphoma Skin

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Endoscopic management of biliary strictures after liver transplantation

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World Journal of Gastroenterology 2009年第30期15卷 3725-3733页

作者： emmanuelle D Williams Peter V Draganov Division of Gastroenterology University of FloridaGainesvilleFL 32610-0214United States

Bile duct strictures remain a major source of morbidity after orthotopic liver transplantation (OLT). Biliary strictures are classifi ed as anastomotic or non-anastomotic strictures according to location and are defi ned by distinct clinical behaviors. Anastomotic strictures are localized and short. The outcome of endoscopic treatment for anastomotic strictures is excellent. Nonanastomotic strictures often result from ischemic and immunological events, occur earlier and are usually multiple and longer. They are characterized by a far less favorable response to endoscopic management, higher recurrence rates, graft loss and need for retransplantation. Living donor OLT patients present a unique set of challenges arising from technical factors, and stricture risk for both recipients and donors. Endoscopic treatment of living donor OLT patients is less promising. Current endoscopic strategies for biliary strictures after OLT include repeated balloon dilations and placement of multiple side-by-side plastic stents. Lifelong surveillance is required in all types of strictures. Despite improvements in incidence and long term outcomes with endoscopic management, and a reduced need for surgical treatment, the impact of strictures on patients after OLT is signifi cant. Future considerations include new endoscopic technologies and improved stents, which could potentially allow for a decreased number of interventions, increased intervals before retreatment, and decreased reliance on percutaneous and surgical modalities. This review focuses on the role of endoscopy in biliary strictures, one of the most common biliary complications after OLT.

关键词： Anastomotic strictures Bile duct diseases Endoscopic retrograde cholangiopancreatography Orthotopic liver transplantation Surgical anastomosis

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Offering Smoking Cessation Support to Cancer Patients:The Role of Associations Providing Supportive Care in *** of the Ligue Contre le Cancer Gironde

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Psycho-Oncologie 2023年第3期17卷 133-145页

作者： Océane Phanatzis Rébecca Ratel Isabelle Barcos Marie Daspas emmanuelle Clairembault François Alla Centre Hospitalier Universitaire(CHU)de Bordeaux INSERMBPHU1219I-prev/PHARESEquipe Labellisée Ligue Contre le CancerCIC 1401BordeauxF-33000France CHU de Bordeaux Service de PréventionBordeauxF-33000France Ligue Contre le Cancer Gironde BordeauxF-33800France

Aims:This article aims to explore the interventional and contextual components of smoking cessation support for cancer patients in the context of supportive care in cancer provided by an association,that is viable and effective in the French context,and to describe the partnership research process in which they were ***:The intervention was developed from a dataset collected during a viability study for the development of a smoking cessation intervention carried out at the Ligue Contre le Cancer Gironde,a scoping review of evidence-based interventions and two narrative reviews on the determinants and ethical issues of smoking cessation in ***:The results confirmed a tangible opportunity to develop smoking cessation services within the relevant case because of the obstacles that can be overcome,the facilitators that can be mobilized,and the gaps existing in this *** addition,they enabled the design of an intervention adapted to the context,guided by a voluntarist,multidisciplinary approach,and focused on patients’***:The associations providing supportive care in cancer can initiate and participate in the process of smoking *** can play a key role in mediating between oncology and addictology.

关键词： Theory-based intervention smoking cessation cancer supportive care associative sector

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The sperm-interacting proteome in the bovine isthmus and ampulla during the periovulatory period

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Journal of Animal Science and Biotechnology 2023年第3期14卷 980-1000页

作者： Coline Mahe Regis Lavigne emmanuelle Com Charles Pineau Aleksandra Maria Zlotkowska Guillaume Tsikis Pascal Mermillod Jennifer Schoen Marie Saint-Dizier CNRS IFCEINRAEUniversite de ToursPRC37380 NouzillyFrance Univ Rennes InsermEHESPIrset(Institut de Recherche en SanteEnvironnement Et Travail)-UMR-S 1085F‑35000 RennesFrance Univ Rennes CNRSInsermBiosit UAR 3480 US_S 018Protim Core Facility35000 RennesFrance Institute of Reproductive Biology Leibniz Institute for Farm Animal BiologyFBNDummerstorfGermany Present Address:Department of Reproduction Biology Leibniz Institute for Zoo and Wildlife Research(IZW)BerlinGermany

Background Spermatozoa interact with oviduct secretions before fertilization in vivo but the molecular players of this dialog and underlying dynamics remain largely *** objectives were to identify an exhaustive list of sperm-interacting proteins(SIPs)in the bovine oviduct fluid and to evaluate the impact of the oviduct anatomical region(isthmus ***)and time relative to ovulation(pre-ovulatory ***-ovulatory)on SIPs number and *** Pools of oviduct fluid(OF)from the pre-ovulatory ampulla,pre-ovulatory isthmus,post-ovulatory ampulla,and post-ovulatory isthmus in the side of ovulation were collected from the ***-thawed bull sperm were incubated with OF or phosphate-buffered saline(control)for 60 min at 38.5℃.After protein extraction and digestion,sperm and OF samples were analyzed by nanoLC-MS/MS and label-free protein *** A quantitative comparison between proteins identified in sperm and OF samples(2333 and 2471 proteins,respectively)allowed for the identification of 245 *** highest number(187)were found in the pre-ovulatory isthmus,i.e.,time and place of the sperm *** total,41 SIPs(17%)were differentially abundant between stages in a given region or between regions at a given stage and 76 SIPs(31%)were identified in only one region×stage *** analysis of SIPs predicted roles in cell response to stress,regulation of cell motility,fertilization,and early embryo *** This study provides a comprehensive list of SIPs in the bovine oviduct and evidences dynamic spatiotemporal changes in sperm-oviduct interactions around ovulation ***,these data provide protein candidates to improve sperm conservation and in vitro fertilization media.

关键词： Ampulla Fallopian tube Interactome Isthmus Oviduct Ovulation Post-ovulatory Pre-ovulatory Proteomics Spermatozoa

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氢化脱氢钛粉末颗粒的整形及其机理研究

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稀有金属材料与工程 2009年第A03期38卷 264-266页

作者：郝向阳盖国胜邹欣吴运新张以河 emmanuelle Reynaud 中国地质大学北京100083 清华大学北京100084 University of Massachusetts-Lowell MA 01854 USA

HDH(氢化脱氢)钛粉末颗粒形状不规则、流动性较差,不利于注射成形和提高其制品性能。本研究利用PCS系统对HDH钛粉末颗粒进行整形,考察了处理工艺,用扫描电镜和粒度分析表征处理结果,推测PCS的整形机理不是传统的粉碎过程,而是钛粉末颗... 详细信息

HDH(氢化脱氢)钛粉末颗粒形状不规则、流动性较差,不利于注射成形和提高其制品性能。本研究利用PCS系统对HDH钛粉末颗粒进行整形,考察了处理工艺,用扫描电镜和粒度分析表征处理结果,推测PCS的整形机理不是传统的粉碎过程,而是钛粉末颗粒的棱角被打磨掉再与大颗粒吸附嵌入,较好地解释了粒度分布等测试结果。整形后的HDH钛粉末颗粒尖锐的棱角被钝化,变为近球形,粉末的流动性显著提高。

关键词：整形球形化氢化脱氢(HDH)钛粉粒度

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Matched or nonmatched interventions based on the transtheoretical model to promote physical activity.A meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2018年第1期7卷 50-57页

作者： Ahmed Jerome Romain Catherine Bortolon Mathieu Gourlan Marion Carayol emmanuelle Decker Olivier Lareyre Grégory Ninot Julie Boiché Paquito Bernard EA4556 Laboratory Epsylon-Dynamics of Human Abilities and Health Behaviours University of Montpellier Montpellier 34000 France Challenge for the Change of Behaviour (CCB) Group Montpellier 34000 France University of Montreal Hospital Research Centre Montreal Quebec H2X OA9 Canada Unit of Adult Psychiatry La colombiere University Hospital of Montpellier Montpellier 34295 France Prevention Department of institut Regional du Cancer de Montpellier Epidaure Montpellier 34298 France Research Centre of the University Hospital of Quebec Quebec GIR 2J6 Canada Cancer Research Centre University of LavaL Quebec G1R 3S3 Canada School of Psychology University of Laval Quebec G1C OA6 Canada

Purpose: The aim of this study was to examine whether the efficacy of transtheoretical model(TTM)-based interventions on physical activity(PA)varied according to the following criteria:(1) interventions targeted the actual stages of change(SOCs) or did not;(2) participants were selected according to their SOC or were not; and(3) its theoretical constructs(decisional balance, temptation, self-efficacy, processes of change).Methods: Thirty-three randomized controlled trials assessing TTM-based interventions promoting PA in adults were systematically ***: The between-group heterogeneity statistic(Qb) did not reveal any differential efficacy either in interventions targeting the actual SOC compared with those that did not(Qb = 1.48, p = 0.22) or in interventions selecting participants according to their SOC compared with those that did not(Qb = 0.01, p = 0.91). TTM-based interventions enhanced PA behavior whether they targeted the actual SOC(Cohen's d = 0.36; 95%confidence interval(CI): 0.22–0.49) or not(d = 0.23; 95%CI: 0.09–0.38) and whether they selected their participants according to their SOC(d = 0.33; 95%CI: 0.13–0.53) or not(d = 0.32; 95%CI: 0.19–0.44). The moderators of the efficacy of TTM-based interventions were the number of theoretical constructs used to tailor the intervention(Qb = 8.82, p = 0.003), the use of self-efficacy(Qb = 6.09, p = 0.01), and the processes of change(Qb = 3.51, p = 0.06).Conclusion: TTM-based interventions significantly improved PA behavior, and their efficacy was not moderated by SOC but by the TTM theoretical constructs.

关键词： Exercise Interventions Meta-regression Moderators Processes of change Stages of change Theory-based

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Production and stability study of a hospital parenteral nutrition solution for neonates

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Journal of Pharmaceutical Analysis 2019年第2期9卷 83-90页

作者： Anne-Laure Yailian Céline Serre Justine Fayard Marina Faucon Patrick Thomaré Samira Filali Christine Pivot Florence Vételé Fabrice Pirot emmanuelle Olivier Service Pharmaceutique Plateforme FripharmGroupe Hospitalier Centre Edouard HerriotHospices Civils de Lyon Laboratoire de Recherche et Développement de Pharmacie Galénique Industrielle UMR 5305Plateforme FripharmFaculté de PharmacieUniversité Claude Bernard Lyon 18 Service Pharmaceutique Site H?tel-DieuCentre Hospitalo-Universitaire de Nantes1place Alexis Ricordeau Service pharmaceutique Groupement Hospitalier EstHospices Civils de Lyon

Standard parenteral nutrition solutions are mixtures comprising interacting components that may degrade themselves over time. The objective of this study was to investigate the physicochemical and microbiological stability of a hospital preparation for parenteral nutrition in neonatology. The analyses were performed throughout the storage of the preparations at 2–8 °C(up to 4 months). The extent of stability was based on the determination of amino acids dosage, visual and physicochemical properties(glucose and electrolytes concentrations, pH and osmolality measurements, particle counting) and microbiological analysis(sterility test). A thermal degradation of ascorbic acid was conducted to evaluate the antioxidant properties of the parenteral mixture. Physicochemical and microbiological controls were found to comply with the specifications. Amino acids showed a good stability throughout the 4 months storage except for cysteine, which was progressively degraded to cystine, conferring a yellow coloration to parenteral solutions. Parenteral nutrition standards solutions remain stable for 4 months at 2–8 °C,ensuring safe administration in preterm infants.

关键词： Stability-indicating method study Parenteral nutrition Neonatology Amino acids High-performance liquid chromatographic

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Chronic fatigue syndrome: An update for psychiatrists

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Open Journal of Psychiatry 2012年第1期2卷 40-48页

作者： Camila Prochalska Florence Gressier emmanuelle Corruble 不详

Chronic fatigue syndrome (CFS) is a poorly understood condition primarily characterized by debilitateing, persistent or recurrent fatigue, increased physical and mental fatigability, cognitive impairment and widespread musculoskeletal pain. During the past two decades, there have been heated debates about CFS among researchers, practitioners and patients. The existence of the disorder has been questioned, its underlying pathophysiology debated and an effective treatment opposed (such as antidepressants, stimulants or antibiotics). A lot of multidisciplinary literature is found about CFS, but to date, many psychiatrists seem to unknown the existence of this illness or think that it is a purely psychological disorder. However, CFS is sitting on the border between medicine and psychiatry. The aim of this review is to make psychiatrists aware of the existence of CFS and that they will, one day, be confronted with the management of this illness. Thus, this update allows understanding what is CFS, the diversity of physiopathology underlined and its management.

关键词： Fatigue Chronic Fatigue Syndrome Diagnosis Physiopathology Treatment

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A machine vision tool for facilitating the optimization of large-area perovskite photovoltaics

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npj Computational Materials 2021年第1期7卷 1764-1773页

作者： Nina Taherimakhsousi Mathilde Fievez Benjamin P.MacLeod Edward P.Booker emmanuelle Fayard Muriel Matheron Matthieu Manceau Stéphane Cros Solenn Berson Curtis P.Berlinguette Department of Chemistry The University of British Columbia2036 Main MallVancouverBC V6T 1Z1Canada Univ.Grenoble Alpes CEALITENCampus Ines73375 Le Bourget du LacFrance Stewart Blusson Quantum Matter Institute The University of British Columbia2355 East MallVancouverBC V6T 1Z4Canada School of Electrical Engineering and Computer Science University of Ottawa800 King Edward AvenueOttawaON K1N 6N5USA Department of Chemical&Biological Engineering The University of British Columbia2360 East MallVancouverBC V6T 1Z3Canada Canadian Institute for Advanced Research(CIFAR) MaRS Innovation Centre661 University Avenue Suite 505M5G 1M1 TorontoONCanada

We report a fast,reliable and non-destructive method for quantifying the homogeneity of perovskite thin films over large areas using machine *** adapt existing machine vision algorithms to spatially quantify multiple perovskite film properties(substrate coverage,film thickness,defect density)with pixel resolution from pictures of 25 cm2 *** machine vision tool—called PerovskiteVision—can be combined with an optical model to predict photovoltaic cell and module current density from the perovskite film *** use the measured film properties and predicted device current density to identify a posteriori the process conditions that simultaneously maximize the device performance and the manufacturing throughput for large-area perovskite deposition using gas-knife assisted slot-die *** thus facilitates the transfer of a new deposition process to large-scale photovoltaic module *** work shows how machine vision can accelerate slow characterization steps essential for the multi-objective optimization of thin film deposition processes.

关键词： optimization perovskite film

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