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Incidence of Acute Disseminated Encephalomyelitis in China: First National Survey

2005年

作者： Richard Lescure emmanuelle Gadet.

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Neuroscience Bulletin 2021年第6期37卷 761-762页

作者： emmanuelle Waubant Department of Neurology University of California at San FranciscoSan FranciscoCAUSA

In this issue,the publication of Xiu et al.[1]provides novel and important information on the incidence and outcomes of acute disseminated encephalomyelitis(ADEM)nationwide in *** study analyzed information from 2,976 cases of ADEM that occurred over a 3-year period,and confirms ADEM is much less common than diseases such as multiple sclerosis(MS)and neuromyelitis optica spectrum disorders.

关键词： myelitis al. acute

Characterisation of the granular dynamics at the interface between a pipe and a granular flow in a rotating drum

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Particuology 2024年第3期86卷 117-125页

作者： Francois Rioual Paule emmanuelle Eva Gbehe Research Unit FRISE National Research Institute for Agriculture Food and the Environment1 Rue Pierre Gilles De Gennes92160AntonyFrance

A new mobile bed heat exchanger is presented in this work which is composed of a flowing granular material in a rotating drum and a cylindrical pipe with potential interest in different energy applications as cooling,heating or heat recovery *** optimal design of the device requires a characterisation of the phenomena involved at the interface between the granular flow and the *** process is modelled by the discrete element method and a global classification of the flow patterns around the pipe is presented with respect to the three main control parameters of the problem:the Froude number,the diameter ratio and the relative filling height of the *** second part is devoted to the characterisation of the structure of the flow at the interface(velocity field,density field)in particular in a so-called Biflow regime where granular motion occurs above as well as below the pipe which is favourable to transfer by convection.A typical behavior at the interface with the pipe consists of a zone I with high velocities of particles at the top of the pipe,a second zone with quasistatic particles or low velocity particles at the front and at the bottom of the pipe and a last zone ll of depletion of particles at the back of the *** Froude number has a limited effect on the features of this structure on the first layer in the range of Froude numbers considered whereas the relative height is a more determinant parameter to control the relative magnitude of velocities in zone I and zone Il as well as the extent of the depletion *** first hydrodynamical characterisation can shed light on the dynamical regimes with improved transfer between the particles and the pipe boundary.

关键词： Granular flow Transfer Heat exchange Mobile bed Boundary condition

Preface for advances in pharmaceutical analysis 2018

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Journal of Pharmaceutical Analysis 2019年第4期9卷 I0002-I0003页

作者： emmanuelle Lipka Zilin Chen School of Pharmaceutical Sciences Lille University School of Pharmaceutical Sciences Wuhan University

The first International Symposium on Advances in Pharmaceutical Analysis (APA 2017) was started and held successfully in Wuhan University, China from November 17 to 19, 2017. The organization of the 2nd International Symposium on Advances in Pharmaceutical Analysis in the capital city of Flanders, Lille, was both an exciting and challenging project because the idea of an annual meeting between our two long cooperating Schools of Pharmaceutical Sciences of Wuhan and Lille, stood to reason.

关键词： pharmaceutical analysis

Impact of past mining on public safety:seismicity in area of flooded abandoned coal Gardanne mine,France

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International Journal of Coal Science & Technology 2022年第6期9卷 101-111页

作者： Dalija Namjesnik Jannes Kinscher Isabelle Contrucci emmanuelle Klein Institut National de l'Environnement Industriel et Des Risques Direction Sites Et TerritoiresNancyFrance

This paper focuses on the impact of past mining on public *** emphasizes the need to understand the induced seismic hazard and consequently improve the post-mining management procedures and legislations,as many mining sites are located in proximity to populated *** to many challenges and complexity of the post-mining environments,induced seismic hazard nowadays remains largely ***,the return experience of several post-mining sites in recent decades have shown us that the mine flooding and/or degradation of mining works can lead to the stress perturbations,inducing the seismicity and the reactivation of the surrounding geological ***,it is important to advance the seismic monitor-ing and research of seismicity in flooded post-mining *** the number of mine closures worldwide is rising,it can be expected that flooding induced reactivation of the surrounding faults becomes a more often observed *** present in this paper the experience of the abandoned flooded coal mine of Gardanne in France,which has been experiencing post-mining seismicity problems since its closure in *** show the results of a recent study of seismic multiplets and clustering of seismic events,as well as their spatio-temporal activity compared to meteorological *** results provide us new insights as well as lead to raising new questions on seismic sources and triggering mechanisms.

关键词： Post-mining seismicity Seismic origin Seismic hazard Multiplets Clusters

Neoadjuvant therapy for gastroesophageal adenocarcinoma

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World Journal of Clinical Oncology 2016年第3期7卷 284-292页

作者： emmanuelle Samalin Marc Ychou Digestive Oncology Department Institut régional du Cancer de Montpellier (ICM)

Gastric and esophageal adenocarcinomas are one of the main causes of cancer-related death worldwide. While the incidence of gastric adenocarcinoma is decreasing, the incidence of gastroesophageal junction adenocarcinoma is rising rapidly in Western countries. Considering that surgical resection is currently the major curative treatment, and that the 5-year survival rate highly depends on the p TNM stage at diagnosis, gastroesophageal adenocarcinoma management is very challenging for oncologists. Several treatment strategies are being evaluated, and among them systemic chemotherapy, to decrease recurrences and improve overall survival. The MAGIC and FNCLCCFFCD trials showed a survival benefit of perioperative chemotherapy in patients with operable gastric and lower esophageal cancer, and these results had an impact on the European clinical practice. New strategies, including induction chemotherapy followed by preoperative chemoradiotherapy, targeted therapies in combination with perioperative chemotherapy and the new cytotoxic regimens, are currently assessed to improve current standards and help developing patienttailored therapeutic interventions.

关键词： Gastric adenocarcinoma Lower esophagus adenocarcinoma Gastroesophageal junction adenocarcinoma Preoperative treatment Neoadjuvant treatment

Performance comparison of chlorinated chiral stationary phases in supercritical fluid chromatography for separation of selected pyrrolidone derivatives

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Journal of Pharmaceutical Analysis 2019年第4期9卷 248-253页

作者： Anca-Elena Dascalu Alina Ghinet Muriel Billamboz emmanuelle Lipka Univ. Lille Inserm U995 - LIRIC - Lille Inflammation Research International Center F-59000 Lille France Ecole des Hautes Etudes d'Ingenieur (HEI) Laboratoire de Pharmacochimie 13 rue de Toul F-59046 Lille France UFR Pharmacie Laboratoire de Chimie Analytique BP 83 F-59006 Lille France 'Alexandru Ioan Cuza’ University of Iasi Faculty of Chemistry Bd. Carol I nr. 11 700506 Iasi Romania

The effects of two chlorinated chiral stationary phases, namely, Lux Cellulose-2 and Lux i-Cellulose-5, flow-rate, percentage of co-solvent and chemical structures of the compounds on retention and resolution were studied within this article. In this work a backpressure of 150 bar, a temperature of 40 ℃ and 10% of methanol as co-solvent were chosen as operating conditions. The optimum flow-rate was 2 mL/min. The percentage of co-solvent was studied between 7.5% and 15%.We have observed that 15% of methanol gave the best results for most of the compounds. For all the derivatives, the Lux Cellulose-2 provided better resolutions going from 1.50 to 3.59 compared with Lux i-Cellulose-5.

关键词： Antibacterial compounds Chirality Enantiomers Flow-rate Particle size

Epithelial-mesenchymal transition transcription factors and mi RNAs: “Plastic surgeons” of breast cancer

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World Journal of Clinical Oncology 2014年第3期5卷 311-322页

作者： Caroline Moyret-Lalle emmanuelle Ruiz Alain Puisieux INSERM UMR-S1052 Centre de Recherche en Cancérologie de Lyon69008 LyonFrance CNRS UMR5286 Centre de Recherche en Cancérologie de Lyon69008 LyonFrance Laboratoire d’EXcellence DEVwe CAN INSERM UMR-S1052CNRS UMR5286 Centre de Recherche en Cancérologie de Lyon69008 LyonFrance INSERM UMR-S1052 CNRS UMR5286Centre de Recherche en Cancérologie de LyonCentre Léon Bérard69008 LyonFrance

Growing evidence suggests that breast cancer cell plasticity arises due to a partial reactivation of epithelialmesenchymal transition(EMT) programs in order to give cells pluripotency, leading to a stemness-like phenotype. A complete EMT would be a dead end program that would render cells unable to fully metastasize to distant organs. Evoking the EMT-mesenchymal-toepithelial transition(MET) cascade promotes successful colonization of distal target tissues. It is unlikely that direct reprogramming or trans-differentiation without passing through a pluripotent stage would be thepreferred mechanism during tumor progression. This review focuses on key EMT transcriptional regulators, EMT-transcription factors involved in EMT(TFs) and the mi RNA pathway, which are deregulated in breast cancer, and discusses their implications in cancer cell plasticity. Cross-regulation between EMT-TFs and mi RNAs, where mi RNAs act as co-repressors or co-activators, appears to be a pivotal mechanism for breast cancer cells to acquire a stem cell-like state, which is implicated both in breast metastases and tumor recurrence. As a master regulator of mi RNA biogenesis, the ribonuclease type Ⅲ endonuclease Dicer plays a central role in EMTTFs/mi RNAs regulating networks. All these EMT-MET key regulators represent valuable new prognostic and predictive markers for breast cancer as well as promising new targets for drug-resistant breast cancers.

关键词： Embryonic transcription factors Epithelial to mesenchymal transition Breast cancer MicroRNAs Dicer Feedback loop

Identification of an odorant receptor responding to sex pheromones in Spodoptera frugiperda extends the novel type-I PR lineage in moths

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Insect Science 2024年第2期31卷 489-502页

作者： Sai Zhang emmanuelle Jacquin-Joly Nicolas Montagne Fang Liu Yang Liu Guirong Wang College of Horticulture and Plant Protection Yangzhou UniversityYangzhouChina State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBejingChina Institute of Ecology and En vironmental Sciences of Paris INRAESorbonne UniversityCNRSIRDUPECUniversity of ParisVersaillesFrance Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenChina

moths,pheromone receptors(PRs)are crucial for intraspecific sexual communication between males and *** PRs are considered as an ideal model for studying the evolution of insect PRs,and a large number of PRs have been identified and functionally characterized in different moth *** PRs were initially thought to fall into a single monophyletic clade in the odorant receptor(OR)family,but recent studies have shown that ORs in another lineage also bind type-I sex pheromones,which indicates that type-I PRs have multiple independent origins in the *** this study,we investigated whether ORs of the pest moth Spodoptera frugiperda belonging to clades closely related to this novel PR lineage may also have the capacity to bind type-I pheromones and serve as male *** the 7 ORs tested,only 1(SfruOR23)exhibited a male-biased expression ***,in vitro functional characterization showed that SfruOR23 could bind several type-I sex pheromone compounds with Z-9-tetradecenal(Z9-14:Ald),a minor component found in female sex pheromone glands,as the optimal *** addition,SfruOR23 also showed weak responses to plant volatile organic ***,we characterized an *** PR positioned in a lineage closely related to the novel PR clade,indicating that the type-I PR lineage can be extended in moths.

关键词： odorant receptor pheromone receptor lineage sex pheromone Spodoptera frugiperda

Origin of the neuro-sensory system: new and expected insights from sponges

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Integrative Zoology 2009年第3期4卷 294-308页

作者： emmanuelle RENARD Jean VACELET Eve GAZAVE Pascal LAPéBIE Carole BORCHIELLINI Alexander V.ERESKOVSKY Centre d’océanologie de Marseille CNRS–Aix-Marseille UniversitéMarseilleFrance Department of Embryology Saint-Petersburg State UniversitySt.PetersburgRussia

The capacity of all cells to respond to stimuli implies the conduction of information at least over short *** multicellular organisms,more complex systems of integration and coordination of activities are *** most animals,the processing of information is performed by a nervous *** the most basal taxa,sponges are nerveless so that it is traditionally assumed that the integrated neuro-sensory system originated only once in Eumetazoa,a hypothesis not in agreement with some recent phylogenomic *** aim of this review is to show that recent data on sponges might provide clues for understanding the origin of this complex ***,sponges are able to react to external stimuli,and some of them display spontaneous movement *** coordinated behaviors involve nervous system-like mechanisms,such as action potentials and/or ***,genomic analyses show that sponges possess genes orthologous to those involved in the patterning or function-ing of the neuro-sensory system in ***,some of these genes are expressed in specific cells(flask cells,choanocytes).Together with ultrastructural data,this gives rise to challenging hypotheses concerning cell types that might play neuro-sensory-like roles in sponges.

关键词： animal evolution choanocyte flask cells nervous system Porifera signal transduction.