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Normal Variants of the Lower Limbs in Pediatric Orthopedics

International Journal of Clinical Medicine 2013年第7期4卷 12-17页

作者： Stanley Jones Sumukh Khandekar emmanuel tolessa Department of Orthopedics Al Ahli Hospital Doha State of Qatar.

Normal variants of lower limb development such as in-toeing, out-toeing, flat feet, bow-legs and knock knees are a common cause for parental concern and also a common source of referral to pediatric clinics. A thorough history and clinical examination is usually all that is required to make the diagnosis of a normal variant. They also help to exclude pathological conditions that may present in a similar fashion. Radiological and other investigations are not routinely required in children with normal variants of the lower limb except to exclude pathological conditions. Shoe inserts, orthoses and physical therapy are not to be encouraged as they provide no benefit. In the majority of cases the natural history is one of spontaneous resolution of the deformity. Surgery may, however, be required in a small number of patients greater than eight years in whom severe in or out-toeing is present. Parental education and reassurance is an important part of the treatment and must be re-emphasized.

关键词： Normal Variants Pediatric Orthopedics

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Ablation of apoptosis-stimulating of p53 protein 1 protects mice from acute hepatic injury and dysfunction via NF-κB pathway in CCl4-induced hepatotoxicity

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Frigid Zone Medicine 2021年第1期1卷 53-64页

作者： tolessa Muleta Daba Xiang Huang Timur Yagudin Ying Yang Jiangang Wang Xiaoyu Fu Yue Zhao Haiyu Gao Yang Zhou Zhenwei Pan Xiangyu Zhong Department of Pharmacology College of PharmacyHarbin Medical UniversityHarbin150081China Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbin150081China Department of Biology College of Natural and Computational SciencesBule Hora UniversityBule HoraOromiaEthiopiaP.O.Box:144 Research Unit of Noninfectious Chronic Diseases in Frigid Zone Chinese Academy of Medical Sciences2019RU070 Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinChina.

Acute liver injury(ALI)is characterized by apoptosis,inflammation,and oxidative stress,and pathogenic mechanism of ALI is poorly ***-stimulating of p53 protein 1(ASPP1)is involved in environmental responses,tumor growth,and NF-κB activity,which is of critical importance to ***,the role of ASPP1 in ALI remains largely *** current study aimed to determine the role of ASPP1 in ALI induced by CCl4 and the underlying ***1 expression was detected in wild type(WT)mice with ALI induced by *** function of ASPP1 in ALI induced by CCl4 was investigated using conventional knockout ASPP1 ***1 expression significantly increased in ALI mice at 24 hours after CCl4 *** of ASSP1 ameliorated apoptosis,inflammation,and necrosis in ALI relative to WT *** addition,deficiency of ASPP1 improved liver flood flow as well as ALT and AST *** levels of phosphorylated p65 and phosphorylated IκBαwere lower in ASPP1-/-mice than in WT mice with *** results implicate that deletion of ASPP1 may act via inhibition of the NF-кB pathway and protect mice from ALI,which may be a new potential therapeutic target for the treatment of ALI.

关键词： Apoptosis ASPP1 CCl4 Liver injury Inflammation NF-κB

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