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Synergistic Effect of a Selective Serotonin Reuptake Inhibitor and a Selective Cyclo-Oxygenase-2 Inhibitor on Post Spinal Anesthesia Headache

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Pharmacology & Pharmacy 2020年第8期11卷 196-208页

作者： Rivain Fefe Iteke David Mwembo Mutombo Franck Namegabe Zirhumana Olivier Kabiriko Mukuku emmanuel kiyana muyumba Tinsley Mukakala Kibonge Jean Francois Brichant Adolphe Manzanza Kilembe Yapo Brouh Jean Baptiste Zambeze Sakatolo Kakoma Provincial Hospital of Lubumbashi Lubumbashi Congo Official University of Lubumbashi Lubumbashi Congo University of Lubumbashi Lubumbashi Congo University of Liège Liège Belgium University of Kinshasa Kinshasa Congo Alassane Ouattara University Abidjan Cote d’Ivoire

Objective: To evaluate the synergistic effect of a Selective Serotonin Reuptake Inhibitor (SSRI) and a Selective Cyclooxygenase 2 Inhibitor (ISCOx-2) in the management of After Rachianesthesia Headache in Obstetric Care. Patients and Methods: This was an experimental double-blind, randomized, multi-center clinical trial of non-inferiority clinical trials over a 12-month period (May 1, 2018 to April 30, 2019) in six hospitals in southeastern DR Congo, including all patients undergoing surgery or analgesia on spinal anesthesia for obstetrical indication and with headache characteristic of a dural breccia, with no known causes, contraindications to experimental products and informed consent to been obtained. The patients were divided into four different groups depending on the protocol used, namely: Group A = Rehydration + Paracetamol, Group B = Rehydration + Celecoxib, Group C = Rehydration + Nefopam and Group 4 = Rehydration + Celecoxib + Nefopam (Study Group). Using the Statview II software, the statistical analyzes of data obtained from the different tests were made using the ANOVA test for comparing the averages of different samples using the Fisher test. Verification of the normality of the samples was made by the Kurtosis and Skewness flattening and asymmetry test. Results: The protocol associat

关键词： Nefopam Celecoxib Headache Rachianesthesia Obstetrics

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Transient cortical blindness in fat embolism syndrome—a diagnostic enigma

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Chinese Journal of Traumatology 2021年第2期24卷 79-82页

作者： kiyana Mirza Prashant Upendra Acharya Jose Austine Department of Orthopaedic Surgery Father Muller Medical College HospitalMangalore575002India Department of Orthopaedic Surgery Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherry605006India

Fat embolism syndrome(FES)is a serious life-threatening manifestation of the fat embolism phenomenon characterized by Bergman’s triad of dyspnea,petechiae and mental *** fat embolization into systemic circulation is common,FES occurs in a meagre 0.05%e3%of patients having isolated long bone *** visual symptoms are commonly attributed to fat embolism retinopathy and is a later occurrence,it may not always be the *** blindness has been seldom reported in association with FES,and less so as a presenting ***,no previous literature has described the same in context of an isolated tibia *** report a 20-year-old gentleman with an isolated right tibia shaft fracture who developed sudden onset diminution of vision in both eyes less than 24 h following trauma with no other *** of any remarkable ophthalmoscopic findings or other symptoms left us with a diagnostic *** later went on to develop altered mentation,hypoxia and generalized tonic-clonic seizures with subsequent MRI revealing multiple cerebral fat emboli also involving both occipital *** measures were instituted and his general condition as well as vision gradually improved following which he underwent plate fixation of the fracture under spinal *** perioperative period was uneventful and he was discharged following staple *** one month of follow-up,the patient had no residual visual field defects or neurological *** FES is rare among isolated tibia fractures,this clinical catastrophe may strike in any unsuspected setting thereby warranting a high index of suspicion to ensure early diagnosis and improved patient outcomes.

关键词： Fat embolism Cortical blindness Bone fractures

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Clinical and laboratory profile in confirmed vs. suspected septic arthritis patients and its relevance in decision making: A comparative cross-sectional study

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Chinese Journal of Traumatology 2021年第2期24卷 94-99页

作者： Sandeep KNema Suman Kumar Basel Jose Austine kiyana Mirza Department of Orthopaedic Surgery Jawaharlal Institute of Post Graduate Medical Education and ResearchPondicherry605006India Department of Orthopaedic Surgery Father Muller Medical CollegeMangalore575002India

Purpose:There were 10%e30%of patients with adult-onset septic arthritis(SA)exhibiting sterile synovial fluid(SF),and the uncertainty in the determining diagnosis of these patients posed a challenge in *** purpose of this study was to investigate the differences between confirmed(Newman A)and suspected(Newman B&C)SA in ***:This was a descriptive study with a cross-sectional study design conducted at a tertiary referral centre from July 2016 to February *** aged over 18 years presented to the emergency department with clinical features suggestive of SA and were scheduled to undergo arthrotomy and joint lavage by the treating surgeon were included in the *** with prosthetic joint infections and open joint injuries were ***’demographic data,clinical features and laboratory parameters were *** clinical and laboratory profile(blood and SF)of the adult patients presenting with features suggestive of SA based on Newman criteria was statistically analyzed by SPSS version 20 software and Microsoft *** categorical variables were expressed as proportions while the continuous variables were expressed as mean(SD)or median(IQR)depending upon the normality of *** difference between the two groups for categorical variables was assessed using the Chisquare test and the difference for continuous variables was assessed using the unpaired t-test and the Mann-Whitney test depending upon normality.A p value<0.05 was considered ***:Thirty-six patients were divided into confirmed(n¼19)or suspected(n¼17)SA for assessment based on SF *** median(IQR)age of the patients was 50 years(37e60 years).There was no significant difference in demographic,clinical and laboratory parameters between the concerned *** patients presented with *** the confirmed SA cases,8 were negative for C-reactive protein and 6 had synovial white blood cell count<50,*** species were

关键词： Synovial fluid Immunosuppressive agents Arthritis Infectious

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