检索结果-南通市图书馆

Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第21期20卷 6560-6572页

作者： Jennifer Raisch emmanuel buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud Clermont Université UMR1071 Inserm/Ud’Auvergne and INRA USC201863000 Clermont-FerrandFrance Centre Hospitalier Universitaire 63000 Clermont-FerrandFrance

AIM: To provide further insight into the characterization of mucosa-associated Escherichia coli (E. coli) isolated from the colonic mucosa of cancer patients.

关键词： B2 Escherichia coli Carcinoembryonic antigen-related cell adhesion molecule 6 Cell proliferation Colon cancer Polyketide synthase genomic island

Massive hepatic necrosis with toxic liver syndrome following portal vein ligation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第18期19卷 2826-2829页

作者： Aurélien Dupré Johan Gagnière Lucie Tixier David Da Ines Sébastien Perbet Denis Pezet emmanuel buc Department of Digestive and Hepatobiliary Surgery CHU Estaing 1 place Lucie et Raymond Aubrac 63003 Clermont Ferrand France Department of Pathology CHU Estaing 1 place Lucie et Raymond Aubrac 63003 Clermont-Ferrand France Department of Radiology CHU Estaing 1 place Lucie et Raymond Aubrac 63003 Clermont-Ferrand France Department of Anesthesia CHU Estaing 1 place Lucie et Raymond Aubrac 63003 Clermont-Ferrand France

Right portal vein ligation (PVL) is a safe and widespread procedure to induce controlateral liver hypertrophy for the treatment of bilobar colorectal liver metastases. We report a case of a 60-year-old man treated by both right PVL and ligation of the glissonian branches of segment 4 for colorectal liver metastases surrounding the right and median hepatic veins. After surgery, the patient developed massive hepatic necrosis with secondary pulmonary and renal insufficiency requiring transfer to the intensive care unit. This so-called toxic liver syndrome finally regressed after hemofiltration and positive oxygen therapy. Diagnosis of acute congestion of the ligated lobe was suspected. The mechanism suspected was an increase in arterial inflow secondary to portal vein ligation concomitant with a decrease in venous outflow due to liver metastases encircling the right and median hepatic vein. This is the first documented case of toxic liver syndrome in a non-cirrhotic patient with favorable issue, and a rare complication of PVL.

关键词： Colorectal liver metastases Portal vein ligation Liver failure Toxic liver syndrome Hemofiltration

Gut microbiota imbalance and colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第2期22卷 501-518页

作者： Johan Gagnière Jennifer Raisch Julie Veziant Nicolas Barnich Richard Bonnet emmanuel buc Marie-Agnès Bringer Denis Pezet Mathilde Bonnet Clermont Université UMR 1071 Inserm/Universitéd’Auvergne63000 Clermont-FerrandFrance INRA USC-201863000 Clermont-FerrandFrance Chirurgie Digestive Centre Hospitalier Universitaire63000 Clermont-FerrandFrance Bactériologie Centre Hospitalier Universitaire63000 Clermont-FerrandFrance Laboratoire d’Immunologie Institut Armand FrappierLaval H7V 1B7Canada INRA UMR 1324 CNRS UMR 6265Universitéde BourgogneCentre des Sciences du Goût et de l’AlimentationEye Nutrition and Signalling Research Group21000 DijonFrance

The gut microbiota acts as a real organ. The symbiotic interactions between resident micro-organisms and the digestive tract highly contribute to maintain the gut homeostasis. However, alterations to the microbiome caused by environmental changes(e.g., infection, diet and/or lifestyle) can disturb this symbiotic relationship and promote disease, such as inflammatory bowel diseases and cancer. Colorectal cancer is a complex association of tumoral cells, non-neoplastic cells and a large amount of micro-organisms, and the involvement of the microbiota in colorectal carcinogenesis is becoming increasingly clear. Indeed, many changes in the bacterial composition of the gut microbiota have been reported in colorectal cancer, suggesting a major role of dysbiosis in colorectal carcinogenesis. Some bacterial species have been identified and suspected to play a role in colorectal carcinogenesis, such as Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis, Enterococcus faecalis, Clostridium septicum, Fusobacterium spp. and Escherichia coli. The potential pro-carcinogenic effects of these bacteria are now better understood. In this review, we discuss the possible links between the bacterial microbiota and colorectal carcinogenesis, focusing on dysbiosis and the potential pro-carcinogenic properties of bacteria, such as genotoxicity and other virulence factors, inflammation, host defenses modulation, bacterial derived metabolism, oxidative stress and anti-oxidative defenses modulation. We lastly describe how bacterial microbiota modifications could represent novel prognosis markers and/or targets for innovative therapeutic strategies.

关键词： Colorectal cancer Gut microbiota Dysbiosis Cyclomodulin Oxidative stress

Long-wave instabilities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2024年第8期67卷 1761-1776页

作者： Dongfen Bian emmanuel Grenier School of Mathematics and Statistics Beijing Institute of TechnologyBeijing 100081China Unité de Mathématiques Pures et Appliquées CNRS UMR 5669Ecole Normale Supérieure de LyonLyon 69007France

This paper aims to give a detailed presentation of long-wave instabilities of shear layers for NavierStokes equations,and in particular to give a simple and easy-to-read presentation of the study of the OrrSommerfeld equation and to detail the analysis of its *** these analyses,we prove the existence of long-wave instabilities in the cases of slowly rotating fuids,slightly compressible fuids,or fuids with Navier boundary conditions,under smallness conditions.

关键词： Navier-Stokes equations boundary layers Prandtl equations

Exploring factors of disaster preparedness in UNESCO-designated heritage sites

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Geography and Sustainability 2024年第3期5卷 392-404页

作者： emmanuel Eze Alexander Siegmund Institute of Geography&Heidelberg Center for the Environment(HCE) University of HeidelbergHeidelbergGermany Department of Geography-Research Group for Earth Observation(r geo) UNESCO Chair on Observation and Education of World Heritage&Biosphere ReserveHeidelberg University of EducationHeidelbergGermany Geographical and Environmental Education Unit Department of Social Science EducationUniversity of NigeriaNsukkaNigeria

Increased hazards threatening the United Nations Educational,Scientific and Cultural Organization(UNESCO)-designated sites and endangering cultural heritage and community well-being require attention and ***-sidering the pivotal role of UNESCO sites in conservation and development,this study assessed their levels of disaster *** absence of studies assessing disaster awareness,risk perception,and preparedness among UNESCO site actors,as well as the pivotal place of preparedness within the Disaster Risk Management(DRM)cycle justifies this *** the tenets of the Person-Relative-to-Event framework,we hypothe-sized that a strong positive correlation exists between perceived risks,resources,and disaster *** collect pertinent data,we employed an embedded mixed-method design and conducted an online questionnaire survey yielding 141 responses from 59 *** the results of relevant analyses,wildfires,floods,and droughts are top hazards occurring frequently in UNESCO sites,with significant concerns about pollution and habitat loss during future *** emerged as the most available crucial DRM resource,with higher availability of DRM resources correlating positively and significantly with sites’*** findings con-tribute valuable insights to address missing links for disaster-ready and resilient UNESCO sites,promoting their preservation for future generations.

关键词： Biosphere reserves Disaster risk management(DRM) Global geoparks Person-relative-to-event(PRE)framework Sustainability World heritage sites

Community-led total sanitation(CLTS)implementation in West Mamprusi Municipal Assembly in *** do communities think eleven years on?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Health Journal 2024年第2期8卷 67-73页

作者： Elijah Adam emmanuel Badu School of Media Creative and Social InquiryCurtin UniversityBentleyWestern AustraliaAustralia School of Population Health Curtin UniversityBentleyWestern AustraliaAustralia

Objective Access to improved sanitation is a fundamental human right and an important aspect of Public ***,an estimated thousands of people in Ghana especially,the West Mamprusi Municipal Assembly(WMMA)still have no access to adequate toilet *** has brought untold health repercussions to the inhabitants,the community,and the environment at *** address this menace,the community-led total sanitation(CLTS)was *** study aimed to assess communities’perspectives on the implementation of CLTS and to understand the factors influencing its success and *** A mixed-method approach involving sequential qualitative and quantitative methods was employed in this *** for the quantitative study were randomly selected and surveyed using *** qualitative study employed focus group discussion involving purposively sampled participants including assembly members,opinion leaders,and assembly *** The CLTS program in WMMA realized an apparent use of construction and proper use of household latrines leading to a reduction of open defecation free(ODF)and two communities achieving sanitized status in the history of the study area,enabling the training of latrine artisans and natural leaders to facilitate the CLTS expansion and sustainability,improved sanitation and hygiene,strengthened the enforcement of community rules and regulations and many *** The CLTS program has received more widespread acceptance in the study area than the previous government policy of constructing public toilets,which was greeted with massive failures due to poor *** ensure that gains achieved through CLTS implementation are sustained longer,it is recommended that chiefs and opinion leaders should be involved in the CLTS programs to ensure checks and *** entrenchment of bylaws and more education to address enduring myths and misconceptions will sustain the *** in the form

关键词： Community-led total sanitation(CLTS) Community development Ghana Sanitation

Portal hypertension in patients with nonalcoholic fatty liver disease:Current knowledge and challenges

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第4期30卷 290-307页

作者： Anita Madir Ivica Grgurevic emmanuel A Tsochatzis Massimo Pinzani Department of Gastroenterology Hepatology and Clinical NutritionUniversity Hospital DubravaZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia UCL Institute for Liver and Digestive Health Royal Free Hospital and University College LondonLondon NW32PFUnited Kingdom

Portal hypertension(PH)has traditionally been observed as a consequence of significant fibrosis and cirrhosis in advanced non-alcoholic fatty liver disease(NAFLD).However,recent studies have provided evidence that PH may develop in earlier stages of NAFLD,suggesting that there are additional pathogenetic mechanisms at work in addition to liver *** early development of PH in NAFLD is associated with hepatocellular lipid accumulation and ballooning,leading to the compression of liver *** compression and intraluminal obstacles cause mechanical forces such as strain,shear stress and elevated hydrostatic pressure that in turn activate mechanotransduction pathways,resulting in endothelial dysfunction and the development of *** spatial distribution of histological and functional changes in the periportal and perisinusoidal areas of the liver lobule are considered responsible for the pre-sinusoidal component of PH in patients with ***,current diagnostic methods such as hepatic venous pressure gradient(HVPG)measurement tend to underestimate portal pressure(PP)in NAFLD patients,who might decompensate below the HVPG threshold of 10 mmHg,which is traditionally considered the most relevant indicator of clinically significant portal hypertension(CSPH).This creates further challenges in finding a reliable diagnostic method to stratify the prognostic risk in this population of *** theory,the measurement of the portal pressure gradient guided by endoscopic ultrasound might overcome the limitations of HVPG measurement by avoiding the influence of the pre-sinusoidal component,but more investigations are needed to test its clinical utility for this *** and spleen stiffness measurement in combination with platelet count is currently the best-validated non-invasive approach for diagnosing CSPH and varices needing *** change remains the cornerstone of the treatment of PH in NAFLD,together with correcting the comp

关键词： Non-alcoholic fatty liver disease Portal hypertension Mechanotransduction Endothelial dysfunction Hepatic venous pressure gradient

Bulk geochemistry,Rb-Sr,Sm-Nd,and stable O-H isotope systematics of the Metzimevin high-grade iron ore deposit,Mbalam iron ore district,southern Cameroon

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geochimica 2024年第4期43卷 677-706页

作者： Samndong Cyril Tufoin Cheo emmanuel Suh Tabod Charles Tabod George Lemewihbwen Ngiamte Department of Geology Mining and Environmental ScienceThe University of BamendaB.P.39BambiliNorth West RegionCameroon Economic Geology Unit Department of GeologyUniversity of BueaP.O.63BueaSouth West RegionCameroon Department of Physics Faculty of ScienceThe University of BamendaB.P.39BambiliNorth West RegionCameroon Department of Geology Pan-African University Life and Earth Sciences Institute(PAULESI)University of IbadanIbadanNigeria

Bulk geochemistry,Sr,Nd,and O-H isotope systematics are reported for the first time on banded iron formation(BIF)-hosted high-grade iron ore at the northwestern segment of Congo Craton(CC).Located in Mbalam iron ore district,Southern Cameroon,Metzimevin iron ore deposit is a hematite-magnetite BIF system,dominated by SiO_(2)+Fe_(2)O_(3)(97.1 to 99.84 wt%),with low concentrations of clastic elements e.g.,Al_(2)O_(3),TiO_(2),and HFSE,depicting a nearly pure chemical *** REE+Y signature of the iron deposit displays strong positive Eu anomaly,strong negative Ce anomaly,and chondritic to superchondritic Y/Ho ratios,suggestive of formation by mixed seawater-high temperature hydrothermal fluids in oxidising ***^(87)Sr/^(86)Sr ratios of the BIF are higher than the maximum^(87)Sr/^(86)Sr evolution curves for all Archean reservoirs(bulk silicate earth,Archean crust and Archean seawater),indicating involvement of continentally-derived components during BIF formation and ***Ɛ_(Nd)(t)(+2.26 to+3.77)and Nd model age indicate that chemical constituents for the BIF were derived from undifferentiated crustal source,between 3.002 and 2.88 *** variable and diverse O and H isotope data(−1.9‰to 17.3‰and−57‰to 136‰respectively)indicate that the Metzimevin iron ore formed initially from magmatic plumes and later enriched by magmatic-metamorphic-modified meteoric *** balance calculations indicate mineralisation by combined leaching and precipitation,with an average iron enrichment factor of>2.67 and SiO_(2)depletion factor of>*** is associated with an overall volume reduction of 28.27%,reflecting net leaching and volume collapse of the BIF protholith.

关键词： Bulk geochemistry Rb-Sr Sm-Nd Mitzimevin High-grade iron ore

Finite domain solution of a KGD hydraulic fracture in the viscosity-dominated regime

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rock Mechanics Bulletin

Rock Mechanics Bulletin 2024年第1期3卷 55-63页

作者： Cexuan Liu emmanuel Detournay Fengshou Zhang Department of Geotechnical Engineering Tongji UniversityShanghai200092China Key Laboratory of Geotechnical&Underground Engineering of Ministry of Education Tongji UniversityShanghai200092China Department of Civil Environmentaland Geo-EngineeringUniversity of MinnesotaMinneapolis55455MNUSA

This paper describes a numerical algorithm for solving the classic problem of a plane strain(KGD)fracture propagating in an impermeable elastic medium with zero *** method,which takes advantage of the self-similar nature of the solution,combines a domain-based scheme to solve the elasticity equations and a finite volume method to solve the nonlinear lubrication *** work represents a first step towards developing a model able to account for pore pressure diffusion in the medium and corresponding poroelastic effects,noting that these processes are more efficiently solved using a domain-based rather than a boundary integral *** enhance the efficiency and accuracy of the numerical scheme,the far-field crack asymptotics is embedded in the discretized elastic relationship between the fluid pressure and the crack opening,while the coupled fluid-solid tip asymptote is enforced in a weak form when solving the nonlinear lubrication *** proposed technique yields results that closely match the analytical solution,even with a coarse *** approach offers potential for addressing more complex hydraulic fracturing problems in the future.

关键词： Hydraulic fracturing Numerical simulation Domain-based method Far-field asymptotic boundary Tip asymptote