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Gene therapy for Parkinson’s Disease and Ethical Challenges: A Systematic Review

Advances in Parkinson's Disease 2023年第2期12卷 9-28页

作者： Théodora M. Zohoncon Joseph Sawadogo Abdou Azaque Zoure Abdoul Karim Ouattara Marie N. L. Ouedraogo Luc Zongo Paul Ouedraogo Florencia W. Djigma Christelle W. M. Nadembèga Raphael kabore Djénéba Ouermi Dorcas Obiri-Yeboah Jacques Simpore Pietro Annigoni Biomolecular Research Centre (CERBA) Ouagadougou Burkina Faso Faculty of Medicine University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Saint Camille Hospital Ouagadougou (HOSCO) Ouagadougou Burkina Faso Molecular Biology and Genetics Laboratory (LABIOGENE) Joseph KI-ZERBO University Ouagadougou Burkina Faso National Center for Scientific and Technological Research (CNRST/IRSS) Ouagadougou Burkina Faso Norbert Zongo University/Manga University Centre Koudougou Burkina Faso Department of Microbiology and Immunology School of Medical Sciences University of Cape Coast Cape Coast Ghana

Background: Parkinson’s disease (PD) is a complex, multifactorial neurodegenerative disorder with a pathophysiology deriving from the synergy of abnormal aggregation of neuroinflammation, synuclein and dysfunction of lysosomes, mitochondria and synaptic transport difficulties influenced by genetic and idiopathic factors. Worldwide, PD has a prevalence of 2-3% in people over the age of 65. To date, there is no certified, effective treatment for PD. Aim: The aims of this research were: (i) to present, on the basis of recent advances in molecular genetics and epigenetics, the genomic aspects and challenges of gene therapy trials for PD;(ii) to outline the ethical principles applicable to therapeutic trials for PD. Method: A systematic literature review was carried out to identify relevant articles reporting on genomic aspects and gene therapy in PD from 2001 to October 2023. The search was conducted in French and/or English in three databases: PubMed, Google Scholar and Science Direct. PRISMA guidelines were used in this systematic review. Results: A total of thirty-three publications were selected. An inductive thematic analysis revealed that numerous genetic mutations (SNCA, Parkin, PINK1, DJ-1, LRRK2, ATP13A2, VPS35, Parkin/PRKN, PINK1, DJ1/PARK7) and epigenetic events such as the action of certain miRNAs (miR-7, miR-153, miR-133b, miR-124, miR-137) are responsible for the onset of PD, and that genetic therapy for this pathology raises ethical questions that need to be elucidated in the light of the bioethical principles of autonomy, beneficence, non-maleficence and justice. Conclusion: There is no zero risk in biotechnology. Then, it will be necessary to assess all the potential risks of Parkinson disease’s gene therapy to make the right decision. It is therefore essential to pursue research and, with the guidance of ethics, to advance treatment options and meet the challenges of brain manipulation and its impact on human identity. The golden rule of medicine remai

关键词： Neurodegenerative Diseases Parkinson Disease Molecular Mechanism Gene Therapy Gene Therapy Ethics

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Attempts to Answer on the Origin of the High Nitrates Concentrations in Groundwaters of the Sourou Valley in Burkina Faso

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Journal of Water Resource and Protection（水资源与保护） 2012年第8期

作者： Francis Rosillon Boubacar Savadogo Aminata kabore Hortense Bado-Sama Dayeri Dianou

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Presymptomatic Diagnosis and Gene Therapy for Alzheimer’s Disease: Genomic, Therapeutic, and Ethical Aspects—A Systematic Review

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Advances in Alzheimer's Disease 2023年第4期12卷 55-74页

作者： Théodora M. Zohoncon Joseph Sawadogo Abdoul Karim Ouattara Abdou Azaque Zoure Marie N. L. Ouedraogo Paul Ouedraogo Florencia W. Djigma Christelle W. M. Nadembèga Raphael kabore Djénéba Ouermi Dorcas Obiri-Yeboah Jacques Simpore Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Faculty of Medicine University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Laboratoire de Biologie Moléculaire H&#244pital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE) Université Joseph KI-ZERBO Ouaga Burkina Département de Biochimie microbiologie Université Norbert Zongo/Centre Universitaire de Manga Koudougou Burkina Faso Department of Microbiology and Immunology School of Medical Sciences University of Cape Coast Cape Coast Ghana

Over the past three decades, genomic and epigenetic sciences have identified more than 70 genes involved in the molecular pathophysiology of Alzheimer’s disease (AD). DNA methylation, abnormal histone and chromatin regulation and the action of various miRNAs induce AD. The identification of mutated genes has paved the way for the development of diagnostic kits and the initiation of gene therapy trials. However, despite major advances in neuroscience research, there is yet no suitable treatment for AD. Therefore, the early diagnosis of this neurodegenerative disease raises several ethical questions, including the balance between the principle of non-maleficence and the principle of beneficence. The aims of this research were to present the genomic and ethical aspects of AD, and to highlight the ethical principles involved in its presymptomatic diagnosis and therapy. A systematic review of the literature in PubMed, Google Scholar and Science Direct was carried out to outline the genomic aspects and ethical principles relating not only to the presymptomatic diagnosis of AD, but also to its gene therapy. A total of 16 publications were selected. AD is a multifactorial disease that can be genetically classified into Sporadic Alzheimer’s Disease and Familial Alzheimer’s Disease based on family history. Gene therapy targeting specific disease-causing genes is a promising therapeutic strategy. Advancements in artificial intelligence applications may enable the prediction of AD onset several years in advance. While early diagnosis of AD may empower patients with full decision competence for early decision-making, it also carries implications for the patient’s family members, who are at risk of developing the disease, potentially becoming a source of confusion or anxiety. AD has a significant impact on the life of individuals at risk and their families. Given the absence of disease modifying therapy, genetic screening and early diagnosis for this condition raise ethical issue

关键词： Neurodegenerative Diseases Alzheimer’s Disease Molecular Mechanism Gene Therapy Presymptomatic Diagnosis Ethics Gene Therapy Ethics

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Agro-Morphological Characterization of a Collection of Fonio [Digitaria exilis (Kippist.)Stapf.] Accessions from Burkina Faso

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American Journal of Plant Sciences（美国植物学期刊） 2023年第6期

作者： Balma Patrice kabore Boukare Kiebre Mariam Kiebre Zakaria Sanou Jacob Bationo Kando Pauline

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华顶山3种生境的云锦杜鹃毛根发育与菌根侵染比较研究

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浙江林业科技 2022年第4期42卷 24-29页

作者：王日华 kabore M.Arthur Fabrice 周午祖轩童璐朗月何育栋孟凡博张艳华孙立夫绍兴文理学院生命科学学院浙江绍兴312000 福建农林大学生命科学学院福建福州350002 绍兴职业技术学院浙江绍兴312000

2020年7—8月,在浙江天台山华顶国家森林公园(简称华顶山)以箬竹Indocalamus tessellatus、茶Camellia sinensis为主要伴生种和无下木为对照的3种生境中,对云锦杜鹃Rhododendron fortunei的毛根发育、菌根侵染和土壤及凋落物的主要营养... 详细信息

2020年7—8月,在浙江天台山华顶国家森林公园(简称华顶山)以箬竹Indocalamus tessellatus、茶Camellia sinensis为主要伴生种和无下木为对照的3种生境中,对云锦杜鹃Rhododendron fortunei的毛根发育、菌根侵染和土壤及凋落物的主要营养元素进行比较分析。结果表明:在箬竹伴生生境,云锦杜鹃的毛根发育不良,但其菌根侵染率显著提高,其土壤中的总C、总N、C/N和N/P都极显著高于其他两种生境(P<0.01),总P则相反,极显著低于其他两种生境(P<0.01);在茶伴生生境与无下木伴生生境没有显著差异,但是箬竹扩张却极显著地影响了云锦杜鹃毛根的发育和菌根的形成。

关键词：云锦杜鹃箬竹茶毛根菌根侵染华顶山

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Impacts of Agricultural Activities on Land Degradation along the Bomboré River in Burkina Faso

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Agricultural Sciences（农业科学） 2023年第2期

作者： Joseph Nomwindé kabore elie Serge Gaëtan Sauret Wennegouda Jean Pierre Sandwidi Raoul Christian Ouedraogo Brahima Sorgho

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Effect of High-Speed Solar Winds Turbulence Upstream of the Earth’s Magnetosphere:Case of the Outer Minima of Solar Cycles 20, 21, 22, 23 and 24

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Open Journal of Applied Sciences（应用科学） 2023年第7期

作者： Inza Gnanou Salfo kabore Aristide Marie Frédéric Gyebre Christian Zoundi Jean-Louis Zerbo FrédéricOuattara

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Evaluation of Clinical and Radiological Tumour Response during Neo-Adjuvant Breast Cancer Chemotherapy at Yalgado Ouedraogo University Hospital

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Advances in Breast Cancer Research（乳腺癌） 2022年第4期

作者： bambara augustin tozoula ouedraogo nina-astrid atenguena okobalemba etienne kabore bernard akanni fayçal sama alice cynthia ousseini diallo

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Factors Associated with Antigen HBs Seroconversion among Blood Donors in Ouagadougou from 2008 to 2017

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Advances in Infectious Diseases（传染病进展） 2021年第3期

作者： Abdoul-Guaniyi Sawadogo T. Isidore Traore Salam Sawadogo Kompingnin Nebie Lucien Désiré Dahourou Juste Some Hervé Kpoda Ahmed kabore Dahourou Honorine Arzouma Paul Yooda Bia Emile Drabo Jean-Etienne Koanda Alain Konseybo eléonore Kafando Nicolas Meda Léon Blaise Savadogo

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Spinal Cord Compression, a Rare Neurofibromatosis Complication

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World Journal of Neuroscience（神经科学国际期刊） 2019年第3期

作者： Habib Abdoul Karim Ouiminga Sylvain D. Zabsonr Aminath Kélani Souleymane Ouattara Assane Drav Raphael Marie kabore Désiré Harouna Sankara Magatte Gaye

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