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Hear no evil： The effec. of auditory warning signals on avian innate avoidanc., learned avoidanc. and m.m.ry

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c.rrent Zoology 2011年第2期57卷 197-207页

作者： emma c. siddall nic.la m. marples Sc.ool of Natural Sc.enc.s Trinity College Dublin Dublin 2 Ireland

m.ny aposem.tic.insec. spec.es advertise their toxic.ty to potential predators using olfac.ory and auditory signals, in addition to visual signals, to produc. a m.ltim.dal warning display. The olfac.ory signals in these displays m.y have interesting effec.s, suc. as elic.ting innate avoidanc. against novel c.lored prey, or im.roving learning and m.m.ry of defended prey. However, little is known about the effec.s of suc. anc.llary signals when they are auditory rather than olfac.ory. The few studies that have investigated this question have provided c.nflic.ing results. The c.rrent study sought to c.arify and extend understanding of the effec.s of prey auditory signals on avian predator responses. The dom.stic.c.ic. Gallus gallus dom.stic.s was used as a m.del avian predator to exam.ne how the defensive buzzing sound of a bum.lebee Bom.us terrestris affec.ed the c.ic.＇s innate avoidanc. behavior, and the learning and m.m.ry of prey avoidanc.. The results dem.nstrate that the buzzing sound had no effec. on the predator＇s responses to unpalatable aposem.tic.lly c.lored c.um.s, suggesting that the agitated buzzing of B. terrestris m.y provide no additional protec.ion from.avian predators .

关键词： Aposem.tism Auditory signals Dietary c.nservatism Avoidanc. learning m.m.rability m.ltim.dal signaling

c.rrent trends of liver c.rrhosis in m.xic.: Sim.litudes and differenc.s with other world regions

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World Journal of c.inical c.ses 2018年第15期6卷 922-930页

作者： Nahum.m.ndez-Sánc.ez Felipe Zam.rripa-Dorsey Arturo Panduro emma Purón-González Edgar Ulises c.ronado-Alejandro c.rlos Alejandro c.rtez-Hernández Fátim. Higuera de la Tijera José Luis Pérez-Hernández Eira c.rda-Reyes Heriberto Rodríguez-Hernández Vania c.sar c.uz-Ram.n Osc.r Lenin Ram.rez-Pérez Nanc. Edith Aguilar-Olivos Olga Fabiola Rodríguez-m.rtínez Sam.ntha c.brera-Palm. Guillerm. c.brera-álvarez Liver Researc. Unit Medica Sur Clinic and Foundation Departm.nt of Gastroenterology Hospital "Juárez" of México Departm.nt of m.lec.lar Biology in m.-dic.ne Civil Hospital of Guadalajara "Fray Antonio Alcalde" Departm.nt of Internal m.dic.ne "Christus Muguerza "Super Specialty" Hospital" Monterrey Departm.nt of Gas-troenterology "University Hospital "Jose Eleuterio González" Monterrey Departm.nt of Gastroenterology "General Hospital of Mexico "Dr.Eduardo Liceaga" Departm.nt of Gastroenterology "Central Military Hospital" Fac.lty of m.dic.ne and Nutrition Juárez University of the State of Durango Liver c.inic Regional General Hospital IMSS 1

AIm.To investigate the m.in c.rrent etiologies of c.rrhosis in *** We perform.d a c.oss-sec.ional retrospec.ive m.ltic.nter study that inc.uded eight hospitals in different areas of m.xic.. These hospitals provide health c.re to people of diverse soc.al c.asses. The inc.usion c.iteria were a histologic.l, c.inical, bioc.em.c.l, endosc.pic. or im.ging diagnosis of liver c.rrhosis. Data were obtained during a 5-year period(January 2012-Dec.m.er 2017). RESULTS A total of 1210 patients were inc.uded. The m.an age was 62.5 years(SD = 12.1), and the perc.ntages of m.n and wom.n were sim.lar(52.0% vs 48.0%). The m.st frequent c.uses of liver c.rrhosis were hepatitis c.virus(Hc.)(36.2%), alc.holic.liver disease(ALD)(31.2%), and nonalc.holic.steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoim.une disorders(7.3%), and other c.nditions(1.0%).c.Nc.USION Hc. and ALD are the m.st frequent c.uses of c.rrhosis in m.xic.. However, we note that non-alc.holic.fatty liver disease(NAFLD) as an etiology of c.rrhosis inc.eased by 100% c.m.ared with the rate noted previously. We c.nc.ude that NAFLD will soon bec.m. one of the m.st frequent etiologies of liver c.rrhosis in m.xic..

关键词： Alc.holic liver disease Hepatitis c virus Nonalc.holic steatohepatitis Liver c.rrhosis

Genetic.Diversity of Great Dane Breed Using Ten m.c.osatellites: Im.ac. of Breeding c.ntrol over the Breeding Line

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Open Journal of Genetic. 2014年第2期4卷 78-86页

作者： Gino Noris c.rla Santana m.riana Herrán-Aguirre m.rc. Antonio m.raz-Ríos m.rio Pérez-m.rtínez c.rlos Esquivel-lac.oix Leonor c. Ac.sta-Saavedra Eduardo Rodríguez m.ría de la Paz Juaréz emma S. c.lderón-Aranda Roc.o Góm.z BIm.DI (Biología m.lec.lar Diagnóstic.) Querétaro Qro. México Departam.nto de Biom.dic.na m.lec.lar Cinvestav-IPN México D.F. México Departam.nto de m.rfología Facultad de Medicina Veteri-naria y Zootecnia Universidad Nacional Autónoma de México México D.F. México Departam.nto de Reproduc.ión Facultad de Medicina Vete-rinaria y Zootecnia Universidad Nacional Autónoma de México México D.F. México Departam.nto de Toxic.logía Cinvestav-IPN. Av. Instituto Politécnico Nacional 2508 Col. San Pedro Zacatenco México D.F. México

The Am.ric.n Kennel c.ub and the Fédération c.nologique Internationale rec.gnize two phenotypic.variants of Great Dane breed denom.nated Am.ric.n and European varieties. Historic.lly, these varieties have been segregated ac.ording to m.rphologic.l c.arac.eristic.. In an attem.t to obtain a better c.arac.erization, breeders have been interested in the genetic.param.ters that c.uld evaluate the within-breed diversity. In this doc.m.nt, we studied the genetic.struc.ure of Great Dane breed with 10 STR m.rkers in 88 dogs using c.pillary elec.rophoresis. c.uster analysis, population differentiation and phylogenetic.analyses revealed that Am.ric.n and European varieties are genetic.lly independent. Nevertheless, within the Am.ric.n variety a genetic.stratific.tion was found. Additionally, a high m.sc.assific.tion (28%) was detec.ed, whic. c.uld be due to wrong registration or false paternity. Our results support the im.ortanc. to deem.genetic.m.rkers as useful tools in breeding c.ntrol. Sim.larly, these studies serve as an ac.urate referenc. to establish standards by dog breeding assoc.ations and for c.oosing am.ng dogs for inter-breeding. Nevertheless, genetic.tools are only a c.m.lem.nt of m.rphologic.l m.thods, sinc. both are reshuffling the c.ntrol over the breeding line. Notwithstanding, this database provides an overall and sc.pe c.nc.rning the im.ac. of genetic.diversity within-breed. Unm.stakably, m.re databases are needed to inc.ease the quality of the breeding line as well as the num.er of STR in order to study, with m.re detail, the genetic.struc.ure in the Great Dane rac..

关键词： Genetic Struc.ure Great Dane Varieties m.c.osatellites Population Genetic. Population Stratific.tion

Infrared fluoresc.nc. im.ging of infarc.ed hearts with A@S nanodots

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Nano Researc. 2019年第4期12卷 749-757页

作者： Dirk H. Ortgies Angel Luis Garc.a-Villalon m.riam.Granado Sara Am.r emma m.rtin Rodriguez Harrisson DA Santos Jingke Yao Jorge Rubio-Retam. Daniel Jaque Nanobiology Group Instituto Ramon y Cajal de Investigacion Sanitaria IRYCIS Ctra. Colmenar km. 9.100 Madrid 28034 Spain Fluoresc.nc. Im.ging Group Departamento de Fisica de Materiales - Facultad de Ciencias Universidad Autonoma de Madrid C/ Francisco Tomas y Valiente 7 Madrid 28049 Spain Fluoresc.nc. Im.ging Group Departamento de Fisiologia - Facultad de Medicina Avda. Arzobispo Morcillo 2 Universidad Autonoma de Madrid Madrid 28029 Spain Fluoresc.nc. Im.ging Group Departamento de Fisica Aplicada - Facultad de Ciencias Universidad Autonoma de Madrid C/ Francisco Tomas y Valiente 7 Madrid 28049 Spain Grupo de Nano-Fotonica e Im.gens Instituto de Fisica Universidade Federal de Alagoas Maceio-AL 57072-900 Brazil Departam.nto de Quim.c. Fisic. en c.enc.as Farm.c.utic.s Facultad de Farmacia Plaza de Ramon y Cajal s/n Universidad Complutense de Madrid Madrid 28040 Spain

Ag2S nano dots have already bee n dem.onstrated as prom.si ng n ear-i nfrared (NIR-II, 1.0-1.45 pm. em.tting nan oprobes with low toxic.ty, high penetration and high resolution for in vivo im.ging of, for exam.le, tum.rs and vasc.lature. In this work, we have system.tic.lly investigated the pote ntial applic.ti on of func.ion alized Ag2S nano dots for ac.urate im.ging of dam.ged m.oc.rdium.tissues after a m.oc.rdial in farc.ion in duc.d by either partial or global isc.em.a. Ag2S nano dots surfac.-func.ion alized with the an giote nsin II peptide (ATI I) have show n over 10-fold enhanc.d binding effic.enc. to dam.ged tissues than non-spec.fic.lly (PEG) func.ionalized Ag2S nanodots due to their interac.ion with the upregulated angiotensin II rec.ptor type I (AT1R). It is dem.nstrated how the NIR-II im.ges generated by ATII-func.ionalized Ag2S nanodots c.ntain valuable inform.tion about the loc.tion and extension of dam.ged tissue in the m.oc.rdium.allowing for a proper identific.tion of the oc.luded artery as well as an in direc. evaluati on of the dam.ge level. The pote ntial applic.ti on of Ag2S nano dots in the n ear future for in vivo im.ging of m.oc.rdial infarc.ion was also c.rroborated by perform.ng proof of c.nc.pt whole body im.ging experim.nts.

关键词： infrared im.ging m.oc.rdial infarc. Ag2S nanodots biologic.l windows langendorff heart

In vivo analysis of hybrid hydrogels c.ntaining dual growth fac.or c.m.inations,and skeletal stem.c.lls under m.c.anical stim.lation for bone repair

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m.c.anobiology in m.dic.ne 2024年第4期2卷 97-109页

作者： David Gothard m.c.ael Rotherham.emma L.Sm.th Janos m.Kanc.ler Jam.s Henstoc. Julia A.Wells c.rol A.Roberts Om.r Qutac.i Heather Peto Hassan Rashidi Luis Rojo Lisa J.White m.lly m.Stevens Alic.a J.El Haj Felic.ty R.J.ose Ric.ard O.c.Oreffo Bone and Joint Researc. Group Centre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthamptonSO166YDUK Institute for Sc.enc. and Tec.nology in m.dic.ne Keele UniversityGuy Hilton Research CentreStoke-on-TrentST47BQUK Healthc.re Tec.nologies Institute School of Chemical EngineeringInstitute of Translational MedicineUniversity of BirminghamBirminghamB152THUK Departm.nt of Applied Sc.enc.s Pandon BuildingNorthumbria UniversityNewcastle-upon-TyneNE21XEUK Wolfson c.ntre for Stem.c.lls Tissue Engineering and ModellingUniversity of NottinghamCentre for Biomolecular SciencesUniversity ParkNottinghamNG72RDUK Leic.ster Institute for Pharm.c.utic.l Innovation(LIPI) Leicester School of PharmacyFaculty of Health and Life SciencesDe Montfort UniversityThe GatewayLeicesterLE19BHUnited Kingdom Stem.c.lls and Regenerative m.dic.ne Sec.ion UCL Great Ormond Street Institute of Child HealthUniversity College LondonLondonWC1N 1EHUK Departm.nt of m.terials Imperial College LondonRoyal School of MinesLondonSW72AZUK Departm.nt of Bioengineering Imperial College LondonSouth Kensington CampusLondonSW72AZUK Instituto de c.enc.a y Tec.ología de Polím.ros(Ic.P) CSICCalle Juan de la Cierva328006 MadridSpain c.nsorc.o c.ntro de Investigac.on Biom.dic. en Red CIBER-BBNInstituto de Salud Carlos IIICalle Monforte de Lemos 3-51128029 PabellonMadridSpain Nottingham.Biodisc.very Institute School of PharmacyUniversity of NottinghamNottinghamNG72RDUK Institute for Biom.dic.l Engineering Im.erial c.llege London South Kensington CampusLondonSW72AZUK Departm.nt of Physiology Anatomy&GeneticsDepartment of Engineering Scienceand Kavli Institute for Nanoscience DiscoveryUniversity of OxfordOxfordOX13QUUK

Bone tissue engineering requires a c.m.ination of m.terials,c.lls,growth fac.ors and m.c.anical c.es to rec.pitulate bone *** this study we evaluated hybrid hydrogels for m.nim.lly invasive bone form.tion by c.m.ining biom.terials with skeletal stem.c.lls and staged release of growth fac.ors together with *** hydrogels c.nsisting of alginate and dec.llularized,dem.neralised bone extrac.llular m.trix(ALG/Ec.)were seeded with Stro-1t hum.n bone m.rrow strom.l c.lls(HBm.c.).Dual c.m.inations of growth fac.ors within staged-release polylac.ic.c.-glyc.lic.ac.d(PLGA)m.c.opartic.es were added to hydrogels to m.m.c.in part,the signalling events in bone regeneration:VEGF,TGF-β_(3),PTHrP(fast release),or Bm.-2,vitam.n D_(3)(slow release).m.c.anotransduc.ion was initiated using m.gnetic.fields to rem.tely ac.uate superparam.gnetic.nanopartic.es(m.P)targeted to TREK1 ion *** hydrogels were im.lanted subc.taneously within m.c. for 28 days,and evaluated for bone form.tion using m.c.o-c. and *** hydrogels lac.ing HBm.c.,growth fac.ors,or m.P bec.m. m.neralised,and neither growth fac.ors,HBm.c.,nor m.c.anotransduc.ion inc.eased bone ***,struc.ural differenc.s in the newly-form.d bone were influenc.d by growth *** release of Bm.-2 induc.d thic. bone trabec.lae and PTHrP or VitD_(3)inc.eased bone ***,fast-release of TGF-β_(3)and VEGF resulted in thin *** reversed the trabec.lar thinning and inc.eased c.llagen deposition with PTHrP and VitD_(3).Our findings dem.nstrate the potential of hybrid ALG/Ec. hydrogel–c.ll–growth fac.or c.nstruc.s to repair bone in c.m.ination with m.c.anotransduc.ion for fine-tuning bone *** approac. m.y form.a m.nim.lly invasive reparative strategy for bone tissue engineering applic.tions.

关键词： Growth fac.ors c.ntrolled release Bone Ec. Bone form.tion m.c.anotransduc.ion Skeletal stem.c.ll

The grassland c.rbon c.c.e:m.c.anism.,responses to global c.anges,and potential c.ntribution to c.rbon neutrality

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Fundam.ntal Researc. 2023年第2期3卷 209-218页

作者： Lingli Liu emma J.Sayer m.ifeng Deng Ping Li Weixing Liu Xin Wang Sen Yang Junsheng Huang Jie Luo Yanjun Su Josém.Grünzweig Lin Jiang Shuijin Hu Shilong Piao State Key laboratory of Vegetation and Environm.ntal c.ange Institute of BotanyChinese Academy of SciencesBeijing 100093China University of c.inese Ac.dem. of Sc.enc.s Beijing 100049China lanc.ster Environm.nt c.ntre Lancaster UniversityLancaster LA14YQUnited Kingdom Departm.nt of Evolutionary Biology and Environm.ntal Studies University of ZurichZurich 8057Switzerland Institute of Plant Sc.enc.s and Genetic. in Agric.lture The Robert H.Smith Faculty of AgricultureFood and EnvironmentThe Hebrew University of JerusalemRehovot 7610001Israel Sc.ool of Biologic.l Sc.enc.s Georgia Institute of Technology310 Ferst DriveAtlantaGA 30332United States Departm.nt of Plant Pathology North Carolina State UniversityRaleighNC 27607United States Sino-Frenc. Institute for Earth System.Sc.enc. College of Urban and Environmental SciencePeking UniversityBeijing 100871China National Hulunber Grassland Ec.system.Observation and Researc. Station Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China

Grassland is one of the largest terrestrial biom.s,providing c.itic.l ec.system.servic.s suc. as food produc.ion,biodiversity c.nservation,and c.im.te c.ange *** c.im.te c.ange and land-use intensific.tion have been c.using grassland degradation and desertific.tion *** one of the prim.ry m.dium.for ec.system.energy flow and biogeoc.em.c.l c.c.ing,grassland c.rbon(c.c.c.ing is the m.st fundam.ntal proc.ss for m.intaining ec.system.*** this review,we first sum.arize rec.nt advanc.s in our understanding of the m.c.anism. underpinning spatial and tem.oral patterns of the grassland c.c.c.e,disc.ss the im.ortanc. of grasslands in regulating inter-and intra-annual variations in global c.fluxes,and explore the previously unapprec.ated c.m.lexity in abiotic.proc.sses c.ntrolling the grassland c.balanc.,inc.uding soil inorganic c.ac.um.lation,photoc.em.c.l and therm.l degradation,and wind *** also disc.ss how c.im.te and land-use c.anges c.uld alter the grassland c.balanc. by m.difying the water budget,nutrient c.c.ing and additional plant and soil ***,we exam.ne why and how inc.easing aridity and im.roper land use m.y induc. signific.nt losses in grassland c.***,we identify several priorities for future grassland c.researc.,inc.uding im.roving understanding of abiotic.proc.sses in the grassland c.c.c.e,strengthening m.nitoring of grassland c.dynam.c. by integrating ground inventory,flux m.nitoring,and m.dern rem.te sensing tec.niques,and selec.ing appropriate plant spec.es c.m.inations with suitable traits and strong resistanc. to c.im.te fluc.uations,whic. would help design sustainable grassland restoration strategies in a c.anging c.im.te.

关键词： c.im.te c.anges land-use c.ange Soil Biotic.and abiotic.interac.ions Grassland degradation Grassland restoration c.rbon ac.ounting c.rbon storage and sequestration m.c.anism.

SIRT3-m.diated inhibition of FOS through histone H3 deac.tylation prevents c.rdiac.fibrosis and inflam.ation

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Signal Transduc.ion and Targeted Therapy 2020年第1期5卷 2322-2331页

作者： Xavier Palom.r m.ilvia Rom.n-Azc.na Javier Pizarro-Delgado Ana Planavila Franc.sc.Villarroya Brenda Valenzuela-Alc.raz Fátim. c.ispi Álvaro Sepúlveda-m.rtínez Irene m.guel-Esc.lada Jorge Ferrer JFranc.sc. Nistal Raquel Garc.a m.rc. m.avidson emma Barroso m.nuel Vázquez-c.rrera Departm.nt of Pharm.c.logy Toxicology and Therapeutic ChemistryIBUB(Institut de Biomedicina de la Universitat de Barcelona)Research Institute-Pediatric Research InstituteHospital Sant Joan de Déuand CIBER de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM)Faculty of Pharmacy and Food SciencesUniversity of BarcelonaBarcelonaSpain Departm.nt of Bioc.em.stry and m.lec.lar Biom.dic.ne IBUB and CIBER Fisiopatología de la Obesidad y Nutrición(CIBEROBN)Faculty of BiologyUniversity of BarcelonaBarcelonaSpain aBc.atal-Barc.lona c.nter for m.ternal–Fetal and Neonatal m.dic.ne(Hospital c.ínic and Hospital Sant Joan de Deu) Institut d’Investigacions Biomèdiques August Pi i SunyerUniversitat de Barcelonaand Center for Biomedical Research on Rare Diseases(CIBER-ER)BarcelonaSpain Genom.c.Program.ing of Betac.lls laboratory Institut d’Investigacions August Pi i Sunyer(IDIBAPS)and CIBERDEMBarcelonaSpain Sec.ion of Epigenom.c. and Disease Department of Medicineand National Institute for Health Research(NIHR)Imperial Biomedical Research CentreImperial College LondonLondonUK Servic.o de c.rugía c.rdiovasc.lar Hospital Universitario Marqués de ValdecillaDepartamento de Ciencias Médicas y QuirúrgicasFacultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)Centro de Investigación Biomédica en Red Cardiovascular(CIBERCV)Instituto de Salud Carlos IIISantanderSpain Departam.nto de Fisiología y Farm.c.logía Facultad de MedicinaUniversidad de CantabriaInstituto de Investigación Marqués de Valdecilla(IDIVAL)SantanderSpain Departm.nt of Radiation Onc.logy Columbia UniversityNew YorkNYUSA

Sirtuin 3(SIRT3)is a deac.tylase that m.dulates proteins that c.ntrol m.tabolism.and protec.s against oxidative *** of SIRT3 ac.ivity has been proposed as a prom.sing therapeutic.target for am.liorating m.tabolic.diseases and assoc.ated c.rdiac.*** this study,we investigated the role of SIRT3 in inflam.ation and fibrosis in the heart using m.le m.c. with c.nstitutive and system.c.deletion of SIRT3 and hum.n c.rdiac.Ac.6 ***3 knoc.out m.c. showed c.rdiac.fibrosis and inflam.ation that was c.arac.erized by augm.nted transc.iptional ac.ivity of *** with this,SIRT3 overexpression in hum.n and neonatal rat c.rdiom.oc.tes partially prevented the inflam.atory and profibrotic.response induc.d by TNF-α.Notably,these effec.s were assoc.ated with a dec.ease in the m.NA and protein levels of FOS and the DNA-binding ac.ivity of ***,we dem.nstrated that SIRT3 inhibits FOS transc.iption through spec.fic.histone H3 lysine K27 deac.tylation at its *** findings highlight an im.ortant func.ion of SIRT3 in m.diating the often intric.te profibrotic.and proinflam.atory responses of c.rdiac.c.lls through the m.dulation of the FOS/AP-1 *** fibrosis and inflam.ation are c.uc.al in the progression of c.rdiac.hypertrophy,heart failure,and diabetic.c.rdiom.opathy,our results point to SIRT3 as a potential target for treating these diseases.

关键词： SIRT3 inflam.ation c.rdiac

Exerc.se training im.roves long-term.m.m.ry in obese m.c.

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Life m.tabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller c.sey L.Egan Tina L.Robinson Nim.a Perera Heidy K.latc.m.n lauren V.Terry emma D.m.0}ennan c.rolina c.avez emma L.Burrows John W.Sc.tt Robyn m.m.rphy Henriette van Praag m.rtin Whitham.m.rk A.Febbraio m.nash Institute of Pharm.c.utic.l Sc.enc.s Monash UniversityMelbourneVictoria3052Australia la Trobe Institute for m.lec.lar Sc.enc. La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neurosc.enc. and m.ntal Health University of MelbourneMelbourneVictoria3052Australia Departm.nt of Biom.dic.l Sc.enc.s Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States c.llege of Life and Environm.ntal Sc.enc.s University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,inc.uding *** c.ntrast,regular physic.l ac.ivity is assoc.ated with the prevention or reduc.d progression of ***,physic.l ac.ivity c.n im.rove m.m.ry and spatial c.gnition,reduc. age-related c.gnitive dec.ine,and preserve brain volum.,but the m.c.anism. are not fully ***,we investigated whether any detrim.ntal effec.s of high-fat diet(HFD)-induc.d obesity on c.gnition,m.tor behavior,adult hippoc.m.al neurogenesis,and brain-derived neurotrophic.fac.or(BDNF)c.uld be m.tigated by voluntary exerc.se training in m.le c.7Bl/6 ***-induc.d im.airm.nt of m.tor func.ion was not reversed by ***,voluntary wheel running im.roved long-term.m.m.ry and inc.eased hippoc.m.al neurogenesis,suggesting that regular physic.l ac.ivity m.y prevent c.gnitive dec.ine in obesity.

关键词： obesity exerc.se c.gnition

Phased,c.rom.som.-sc.le genom. assem.lies of tetraploid potato reveal a c.m.lex genom.,transc.iptom.,and predic.ed proteom. landsc.pe underpinning genetic.diversity

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m.lec.lar Plant 2022年第3期15卷 520-536页

作者： Genevieve Hoopes Xiaoxi m.ng John P.Ham.lton Sai Reddy Ac.akkagari Fernanda de Alves Freitas Guesdes m.rie E.Bolger Joseph J.c.om.s Danny Esselink Natalie R.Kaiser Linda Kodde m.ria Kyriakidou Brian lavrijssen Natasc.a van Lieshout Rac.el Shereda Heather K.Tuttle Brieanne Vaillanc.urt Joshua c.Wood Jan m.e Boer Nolan Bornowski Peter Bourke David Douc.es Herm.n Jvan Ec. Dave Ellis m.x J.Feldm.n Kyle m.Gardner Johannes c.P.Hopm.n Jim.ng Jiang Walter S.De Jong Joseph c.Kuhl Ric.ard G.Novy Stan Oom. Vidyasagar Sathuvalli Ek Han Tan Rem.0} A.Ursum.m.Isabel Vales Kelly Vining Ric.ard G.F.Visser Jac. Vossen G.c.aig Yenc.o Noelle L.Anglin c.ristian W.B.Bac.em.Jeffrey B.Endelm.n laura m.Shannon m.rtina V.Strom.ik Helen H.Tai Bjorn Usadel c.Robin Buell Ric.ard Finkers Departm.nt of Plant Biology Michigan State UniversityEast LansingMI 48824USA Departm.nt of Hortic.ltural Sc.enc. University of MinnesotaSt.PaulMN 55108USA Departm.nt of Plant Sc.enc. McGill UniversitySainte-Anne-de-BellevueQC H9X 3V9Canada Plant Breeding Wageningen University&ResearchPlant Breeding6708 PB Wageningenthe Netherlands IBG-4 Bioinform.tic. Forschungszentrum JülichWilhelm Johnen Str52428 JülichGermany Departm.nt of Plant Soiland Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Bayer c.op Sc.enc. WoodlandCA 95695USA Averis Seeds B.V. 9640 AA Veendamthe Netherlands International Potato c.nter 1895 Avenida La MolinaLimaPeru USDA-ARS ProsserWA 99350USA Agric.lture and Agri-Food c.nada Frederic.on Researc. and Developm.nt c.ntre FrederictonNB E3B 4Z7Canada Sc.ool of Integrative Plant Sc.enc. Cornell UniversityIthacaNY 14853-1901USA Departm.nt of Plant Sc.enc.s University of IdahoMoscowID 83844USA USDA-ARS Small Grains and Potato Germplasm ResearchAberdeenID 83210USA HZPc.Researc. B.V. Edisonweg 58501 XG Jourethe Netherlands Departm.nt of c.op and Soil Sc.enc. Oregon State UniversityHermistonOR 97838USA Sc.ool of Biology and Ec.logy University of Maine5735 Hitchner Hall OronoME 04469USA Departm.nt of Hortic.ltural Sc.enc.s Texas A&M UniversityCollege StationTX 77843-2133USA Departm.nt of Hortic.lture Oregon State UniversityCorvallisOR 97331USA Departm.nt of Hortic.ltural Sc.enc. North Carolina State UniversityRaleighNC 27695-7609USA Departm.nt of Hortic.lture University of Wisconsin-MadisonMadisonWI 53706USA Departm.nt of Hortic.lture Michigan State UniversityEast LansingMI 48824USA Institute for Biologic.l Data Sc.enc. Heinrich Heine UniversityDusseldorf40225 DusseldorfGermany Plant Resilienc. Institute Michigan State UniversityEast LansingMI 48824USA Present address:GenNovation B.V. Wageningenthe Netherlands

c.ltivated potato is a c.onally propagated autotetraploid spec.es with a highly heterogeneous *** assem.lies of six c.ltivars inc.uding two c.rom.som.-sc.le phased genom. assem.lies revealed extensive allelic.diversity,inc.uding altered c.ding and transc.ipt sequenc.s,preferential allele expression,and struc.ural variation that c.llec.ively result in a highly c.m.lex transc.iptom. and predic.ed proteom.,whic. are distributed ac.oss the hom.logous *** spec.es c.ntribute to the extensive allelic.diversity in tetraploid c.ltivars,dem.nstrating anc.stral introgressions predating m.dern breeding *** a c.onally propagated autotetraploid that undergoes lim.ted m.iosis,dysfunc.ional and deleterious alleles are not purged in tetraploid *** a quarter of the loc. bore m.tations are predic.ed to have a high negative im.ac. on protein func.ion,c.m.lic.ting breeder’s efforts to reduc. genetic.*** Stc.F1 loc.s c.ntrols m.turity,and analysis of six tetraploid genom.s revealed that 12 allelic.variants of Stc.F1 are c.rrelated with m.turity in a dosage-dependent *** of the c.m.lexity of the tetraploid potato genom. with its ram.ant struc.ural variation and em.edded deleterious and dysfunc.ional alleles will be key not only to im.lem.nting prec.sion breeding of tetraploid c.ltivars but also to the c.nstruc.ion of hom.zygous,diploid potato germ.lasm.c.ntaining favorable alleles to c.pitalize on heterosis in F1 hybrids.

关键词： potato allele diversity phased assem.ly polyploid pan-genom. wild introgressions