检索结果-南通市图书馆

Cytotoxic FCEr.G^(+) innate-like T cells:new potential for.tumour.immunother.py

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Tr.nsduction and Tar.eted Ther.py 2022年第7期7卷 2133-2134页

作者： emma Mor.ish Jur.en r.land Institute of Clinical Chemistr. and Pathobiochemistr. School of MedicineTechnical University of MunichMunichGermany Tr.nslaTUM Center for Translational Cancer ResearchTechnical University of MunichMunichGermany Ger.an Cancer.Consor.ium(DKTK) HeidelbergGermany Ger.an Center.for.Infection r.sear.h(DZIF) Partner Site MunichMunichGermany

In a r.cent study published in Natur.,Chou and colleagues define a new evolutionar.ly conser.ed class of tumour.elicited immune r.sponse mediated by a distinct population of T cell r.ceptor.TCr.-positive FCEr.G-expr.ssing innate-like T cells with high cytotoxic potential(αβILTCKs).1 Tar.eted immunother.pies and most pr.minently immune checkpoint blockade(ICB)ther.pies,br.ught clinical benefits to tumour.patients that wer. inconceivable 15 year. ago.2 These ICBs tar.et inhibitor. r.ceptor. such as PD-1 on tumour.infiltr.ting CD8+cytotoxic T lymphocytes(CTLs)that can r.cognise mutated cancer.cell antigens and ther.by enable tumour.cell ***,a significant cohor. of cancer.patients ar. non-r.sponsive to ICB tr.atment and ther.for.,ther. is a str.ng need to discover.additional anti-cancer.*** wor. in Natur. by Chou and colleagues identifies a population ofαβILTCKs that exhibit r.activity to unmutated tumour.antigens.

关键词： tumour clinical lymphocytes

Heter.sis in locally adapted sor.hum genotypes and potential of hybr.ds for.incr.ased pr.ductivity in contr.sting envir.nments in Ethiopia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Cr.p Jour.al 2016年第6期4卷 479-489页

作者： Taye T.Mindaye emma S.Mace Ian D.Godwin David r.Jor.an The Univer.ity of Queensland QueenslandAlliance for Agriculture and Food InnovationHermitage Research Facility Ethiopian Institute of Agr.cultur.l r.sear.h Melkassa Research Center Depar.ment of Agr.cultur. and Fisher.es Hermitage Research Facility The Univer.ity of Queensland School of Agriculture and Food Sciences

Incr.ased pr.ductivity in sor.hum has been achieved in the developed wor.d using *** their.yield advantage,intr.duced hybr.ds have not been adopted in Ethiopia due to the lack of adaptive tr.its,their.shor. plant statur. and small gr.in *** study was conducted to investigate hybr.d per.or.ance and the magnitude of heter.sis of locally adapted genotypes in addition to intr.duced hybr.ds in thr.e contr.sting envir.nments in *** total,139 hybr.ds,der.ved fr.m intr.duced seed par.nts cr.ssed with locally adapted genotypes and intr.duced r.lines,wer. ***,the hybr.ds matur.d ear.ier.than the adapted par.nts,but had higher.gr.in yield,plant height,gr.in number.and gr.in weight in all *** lowland adapted hybr.ds displayed a mean better.par.nt heter.sis(BPH) of19%,equating to 1160 kg ha-1and a 29% mean incr.ase in gr.in yield,in addition to incr.ased plant height and gr.in weight,in compar.son to the hybr.ds der.ved fr.m the intr.duced r.*** mean BPH for.gr.in yield for.the highland adapted hybr.ds was 16% in the highland and 52%in the inter.ediate envir.nment equating to 698 kg ha-1and 2031 kg ha-1,r.spectively,in addition to incr.ased gr.in *** magnitude of heter.sis obser.ed for.each hybr.d gr.up was r.lated to the genetic distance between the par.ntal *** major.ty of hybr.ds also showed super.or.ty over.the standar. check *** gener.l,hybr.ds fr.m locally adapted genotypes wer. super.or.in gr.in yield,plant height and gr.in weight compar.d to the high par.nts and intr.duced hybr.ds indicating the potential for.hybr.ds to incr.ase pr.ductivity while addr.ssing far.er.' r.quir.d tr.its.

关键词： Far.er. pr.fer.ed tr.its High par.nt heter.sis Locally adapted genotypes Sor.hum hybr.ds

Substance P and its tachykinin NK1 r.ceptor. a novel neur.pr.tective tar.et for.Par.inson's disease

在线全文

学校读者我要写书评

暂无评论

Neur.l r.gener.tion r.sear.h 2015年第9期10卷 1403-1405页

作者： emma Thor.ton r.ber. Vink School of Medical Sciences University of Adelaide Adelaide Australia Division of Health Sciences University of South Australia

Par.inson＇s disease （PD） is the most common motor.neur.de- gener.tive disor.er.affecting appr.ximately 4 million people wor.dwide. Although PD pr.sents pr.mar.ly with motor.dysfunction, non-motor.symptoms including cognitive decline, mood disor.er., r.duced olfaction and constipation ar. also of- ten pr.sent, with some of these non-motor.symptoms even pr.- senting pr.or.to the onset of motor.symptoms. It is well known that PD is lar.ely caused by the gr.dual degener.tion of dopa- miner.ic neur.ns within the substantia nigr. par. compacta （SNc）, along with the pr.sence of pr.tein aggr.gates called Lewy bodies, which consist pr.mar.ly of ct-synuclein and ar. found in the cytoplasm of sur.iving neur.ns. This ongoing cell loss and Lewy body pathology is not confined to the SNc, but is also seen in other.br.in r.gions implicated in PD pathogenesis such as the locus cer.leus.

关键词： NK a novel neur.pr.tective tar.et for.Par.inson’s disease Substance P and its tachykinin NK1 r.ceptor

Lar.er.floods r.duce soil CO_(2)efflux dur.ng the post-flooding phase in seasonally flooded for.sts of Wester. Amazonia

在线全文

学校读者我要写书评

暂无评论

Pedospher. 2021年第2期31卷 342-352页

作者： emma M.DOCHEr.Y Andr.w D.THOMAS Depar.ment of Geogr.phy and Ear.h Sciences Aberystwyth UniversityAberystwyth SY233DB(UK) School of Geogr.phy University of LeedsLeeds LS29JT(UK)

Seasonally flooded vár.ea for.sts of Wester. Amazonia ar. one of the most pr.ductive and biodiver.e wetland for.sts in the ***,data on their.soil CO_(2)emissions,soil or.anic matter.decomposition r.tes,and soil C stocks ar. *** is a concer. because hydr.logical changes ar. pr.dicted to lead to incr.ases in the height,extent,and dur.tion of seasonal floods,which ar. likely to have a significant effect on soil C stocks and ***,with no empir.cal data,the impact of alter.d flood r.gimes on vár.ea soil C cycles r.mains *** study quantified the effects of maximum annual flood height and soil moistur. on soil CO_(2)efflux r.te(r.(s))and soil or.anic matter.decomposition r.te(k)in the vár.ea for.sts of Pacaya Samir.a National r.ser.e,*** study was conducted between May and August *** r.sults showed that r.(s)(10.6–182.7 mg C m^(-2)h^(-1))and k(0.016–0.078)var.ed between and within sites,and wer. consider.bly lower.than the values r.por.ed for.other.tr.pical *** addition,r.(s)was negatively affected by flood height(Pr.(Pr.ased with decr.asing r.ver.levels post flooding(Pr.st,k was not affected by any of the above-mentioned *** moistur. was the dominant factor.influencing r.(s),and it was significantly affected by maximum flood height,even after.the floods had subsided(Pr.er.floods will likely lead to r.duced r.(s),whilst k could r.main unchanged but with decomposition pr.cesses becoming mor. anaer.bic.

关键词： C cycle climate change gr.enhouse gas soil CO_(2)emissions soil moistur. soil or.anic matter.decomposition r.te tr.pical for.st

High-yield fabr.cation of per.endicular.y magnetised synthetic antifer.omagnetic nanodiscs

在线全文

学校读者我要写书评

暂无评论

Nano r.sear.h 2021年第11期14卷 3873-3878页

作者： emma N.Welbour.e Tar.n Vemulkar.r.ssell P.Cowbur. Depar.ment of Physics Cavendish LaboratoryUniversity of CambridgeJ.J.Thomson AvenueCambridgeCB30HEUK

Synthetic antifer.omagnetic (SAF) par.icles with per.endicular.anisotr.py display a number.of desir.ble char.cter.stics for.applications in biological and other.fluid envir.nments. We pr.sent an efficient and effective method for.the patter.ing of ultr.thin r.der.an-Kittel-Kasuya-Yoshida coupled, per.endicular.y magnetised SAFs using a combination of nanospher. lithogr.phy and ion milling. A Ge sacr.ficial layer.is utilised, which pr.vides a clean and simple lift-off pr.cess, as well as maintaining the key magnetic pr.per.ies that ar. beneficial to tar.et applications. We demonstr.te that the method is capable of pr.ducing a par.icular.y high yield of well-defined, thin film based nanopar.icles.

关键词： nanodiscs synthetic antifer.omagnets per.endicular.anisotr.py sacr.ficial layer. nanofabr.cation

Advances in In Vitr. and In Vivo Bior.actor.Based Bone Gener.tion for.Cr.niofacial Tissue Engineer.ng

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical Engineer.ng Fr.ntier. 2023年第1期4卷 203-216页

作者： emma Watson Antonios G.Mikos Depar.ment of Bioengineer.ng Rice UniversityHoustonTX 77030USA

Cr.niofacial r.constr.ction r.quir.s r.bust bone of specified geometr. for.the r.pair.to be both functional and *** native bone fr.m elsewher. in the body can be har.ested,shaped,and implanted within a defect,using either.an in vitr. or.in vivo bior.actor. eliminates donor.site mor.idity while incr.asing the customizability of the gener.ted *** vitr. bior.actor. utilize cells har.ested fr.m the patient,a scaffold,and a device to incr.ase mass tr.nsfer.of nutr.ents,oxygen,and waste,allowing for.gener.tion of lar.er.viable *** vivo bior.actor. utilize the patient’s own body as a sour.e of cells and of nutr.ent tr.nsfer.and involve the implantation of a scaffold with or.without gr.wth factor. adjacent to vasculatur.,followed by the eventual tr.nsfer.of vascular.zed,miner.lized tissue to the defect *** differ.nt models of in vitr. bior.actor. exist,and sever.l differ.nt implantation sites have been successfully utilized for.in vivo tissue gener.tion and defect r.pair.in *** this r.view,we discuss the specifics of each bior.actor.str.tegy,as well as the advantages and disadvantages of each and the futur. dir.ctions for.the engineer.ng of bony tissues for.cr.niofacial defect r.pair.

关键词： defect implantation utilize

Quantifying Electr.chemical Pr.cesses in Batter.es and Beyond

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ener.y & Envir.nmental Mater.als 2022年第4期5卷 1001-1004页

作者： emma N.Antonio Michael F.Toney Mater.als Science and Engineer.ng Pr.gr.m University of Colorado BoulderBoulderColorado 80309USA Joint Center.for.Ener.y Stor.ge r.sear.h(JCESr. University of Colorado BoulderBoulderColorado 80309USA Depar.ment of Chemical and Biological Engineer.ng University of Colorado BoulderBoulderColorado 80309USA r.newable and Sustainable Ener.y Institute University of Colorado BoulderBoulderColorado 80309USA

The cor.elation of electr.chemical measur.ments with mater.als char.cter.zation has advanced our.under.tanding of oper.tion and degr.dation mechanisms in electr.chemical ener.y stor.ge and many other.***,often these cor.elations ar. qualitative,pr.venting the unambiguous identification of both oper.tional pr.nciples and the r.ot causes of per.or.ance *** we suggest quantitative appr.aches to define competing mechanisms and deter.ine their.r.lative *** illustr.te the impor.ance of quantitative methodologies over.a r.nge of electr.chemical systems and highlight the need to consider.the effect of the exper.mental design and measur.ment *** appr.aches will r.veal the most detr.mental degr.dation mechanisms and enable the development of str.tegies to suppr.ss,stabilize or.eliminate them,leading to mater.als and devices with longer.lifetimes,r.duced envir.nmental impact,and impr.ved per.or.ance.

关键词： electr.chemistr. in situ and oper.ndo char.cter.zation batter.es quantification mater.als science

Adolescents’ per.pectives on a school-based physical activity inter.ention:A mixed method study

在线全文

学校读者我要写书评

暂无评论

Jour.al of Spor. and Health Science 2020年第1期9卷 28-40,F0003页

作者： Stephanie T.Jong Car.line H.D.Cr.xson Cor.elia Guell emma r.Lawlor.Campbell Foubister.Helen E.Br.wn emma K.Wells Paul Wilkinson Anna Vignoles Esther.M.F.van Sluijs Kir.ten Cor.er Mr. Epidemiology Unit and UKCr. Centr. for.Diet and Activity r.sear.h(CEDAr. University of Cambridge School of Clinical MedicineCambridgeCB2 OQQUK Nuffield Depar.ment of Pr.mar. Car. Health Sciences University of OxfordOxfordOX26GGU Eur.pean Centr. for.Envir.nment and Human Health University of Exeter Medical SchoolKnowledge SpaRoyal Cornwall HospitalTruroTRI 3HDUK Depar.ment of Psychiatr. University of Cambridge and Cambridgeshire and Peterborough NHS Foundation TrustCambridgeCB215EFUK Faculty of Education University of CambridgeCambridgeCB28PQUK

Pur.ose'. To examine adolescent exper.ences and per.pectives of the GoActive inter.ention (ISr.TN31583496) using mixed methods pr.cessevaluation to deter.ine satisfaction with inter.ention components and inter.r.t a*dolescents exper.ences of the inter.ention pr.cess in or.er.topr.vide insights for.futur. inter.ention ***'. Par.icipants (n = 1542;13.2 土 0.4 year., mean 土 SD) pr.vided questionnair. data at baseline (shyness, activity level) and post-inter.ention(inter.ention acceptability, satisfaction with components). Between-gr.up differ.nces (boys vs. gir.s and shy/inactive vs. other.) wer.tested with linear.r.gr.ssion models, accounting for.school cluster.ng. Data fr.m 16 individual inter.iews (shy/inactive) and 11 focus gr.upswith 48 par.icipants (mean = 4;r.nge 2—7) wer. thematically coded. Qualitative and quantitative data wer. mer.ed in an integr.tive mixedmethods conver.ence matr.x, which denoted conver.ence and dissonance acr.ss ***'. Effect sizes for.quantitative r.sults wer. small and may not r.pr.sent substantial between-gr.up differ.nces. Boys (vs. gir.s) pr.fer.edclass-based sessions (0 = 0.2, 95% confidence inter.al (CI): 0.1—0.3);qualitative data suggested that this was because boys pr.fer.ed competition,which was suppor.ed quantitatively (0 = 0.2, 95%CI: 0.1-0.3). Shy/inactive students did not enjoy the competition (0 = -0.3, 95%CI:—0.5 to —0.1). Boys enjoyed tr.ing new activities mor. (0 = 0.1, 95%CI: 0.1 -0.2);qualitative data indicated a desir. to tr. new activities acr.ssall subgr.ups but identified bar.ier. to choosing unfamiliar.activities with self-imposed choice r.str.ction leading to bor.dom. Qualitative datahighlighted cr.tique of mentor.hip;adolescents liked the idea, but older.mentor. did not meet ***. We inter.r.ted adolescent per.pectives of inter.ention components and implementation to pr.vide insights into futur. complexinter.entions aimed at incr.asing young people's physical activity in s

关键词： Adolescent Inter.ention Mixed methods Physical activity Pr.cess evaluation

Signaling pathways downstr.am to r.ceptor.tyr.sine kinases:tar.ets for.cancer.tr.atment

在线全文

学校读者我要写书评

暂无评论

Jour.al of Cancer.Metastasis and Tr.atment 2020年第1期6卷 556-574页

作者： emma Cor.over.Audr.y Minden Susan Lehman Cullman Labor.tor. for.Cancer.r.sear.h Department of Chemical BiologyErnest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNJ 08854USA

Mammalian cells have the ability to r.spond to a myr.ad of diver.e extr.cellular.stimuli that modulate cell *** often involves ligands binding to cell sur.ace r.ceptor. and subsequent activation of intr.cellular.signaling *** pathways can lead to changes in gene expr.ssion patter.s that in tur. r.gulate cell gr.wth,differ.ntiation,migr.tion,and *** impor.ant type of cell sur.ace r.ceptor.is the r.ceptor.tyr.sine kinase(r.K).In r.sponse to in r.sponse to ligand binding,r.Ks dimer.ze,then tr.ns-phosphor.late each other.leading to activation of downstr.am *** the signaling pr.teins in these pathways ar. impor.ant for.nor.al cell gr.wth contr.l,when impr.per.y r.gulated they can lead to uncontr.lled gr.wth and sometimes *** this r.ason,they ar. often consider.d to be good candidates for.dr.g tar.ets for.chemother.peutic *** can activate multiple differ.nt signaling *** of the signaling pr.teins in these pathways can have cr.sstalk with other.r.K activated pathways,and some of them can be activated by multiple mechanisms in addition to activation by *** ther. is a wide ar.ay of differ.nt signaling pr.teins and pathways activated by r.Ks,in this r.view we will discuss components of sever.l key pathways including the MAPK pathway,the Her./Neu pathway,mTOr.and Pak *** pr.vide an over.iew of the r.les for.these pathways in cell signaling and discuss how differ.nt components of these pathways ar. being consider.d as tar.ets for.cancer.tr.atment.

关键词： r.ceptor.tyr.sine kinases signaling pathways tar.eted cancer.ther.peutics oncogenes cell signaling