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Endoscopic push through tragal cartilage tympanoplasty: A 10-year retrospective review of our technique and outcomes

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World Journal of Otorhinolaryngology 2024年第2期11卷 18-24页

作者： K m Abidur Rahman Khalid majeed emma Finnegan Ivan Keogh Ear Noseand Throat/Head and Neck SurgeryGalway University HospitalGalway H91 YR71Ireland Academic Department of Otorhinolaryngology and Head and Neck Surgery University of GalwayGalway H91 TK33Ireland

BACKGROUND Endoscopic ear surgery(EES)provides a magnified,high-definition view of the otological surgical *** allows otologists to avoid surgical incisions and associated postoperative *** is an ideal technique for the perfor-mance and teaching of *** To examine the efficacy of total Endoscopic Push Through Tragal Cartilage Tympanoplasty(EPTTCT),at our institution over a 10-year *** A retrospective analysis of 168 cases of EPTTCT for closure of small to medium tympanic membrane perforations from 2013-2023 was *** sex,age range(pediatric vs adult),etiology of injury,success rate,complications,and postoperative hearing status were *** Graft uptake results indicated success in 94%of patients,with less than a 2%complication *** pure tone audiometry demonstrated hearing status improvement in 69%of *** EPTTCT has been shown to be effective in tympanic membrane perforation closures with minimal *** study further demonstrates the efficacy and safety of these procedures in a single-center review.

关键词： Total endoscopic ear surgery Otology Tympanoplasty Hearing Perforation Tragal cartilage graft

Exercise training improves long-term memory in obese mice

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Life metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey L.Egan Tina L.Robinson Nimna Perera Heidy K.Latchman Lauren V.Terry emma D.mcLennan Carolina Chavez emma L.Burrows John W.Scott Robyn m.murphy Henriette van Praag martin Whitham mark A.Febbraio monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and mental Health University of MelbourneMelbourneVictoria3052Australia Department of Biomedical Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(HFD)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(BDNF)could be mitigated by voluntary exercise training in male C57Bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

Enabling Technologies for Autonomous Robotic Systems in manufacturing

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期41卷 403-431页

作者： ERDŐS Gábor ABAI Kristóf BEREGI Richárd CSEmPESZ János CSERTEG Tamás GODÓGábor HAJÓS mátyás HÁY Borbála HORVÁTH Dániel HORVÁTH Gergely JUNIKIÁdám KEmÉNY Zsolt KOVÁCS András NACSA János PANITI Imre PEDONE Gianfranco TAKÁCS emma TIPARY Bence ZAHORÁN László VÁNCZA József Institute for Computer Science and Control Hungarian Research Network(HUN-REN SZTAKI)BudapestHungary Department of manufacturing Science and Technology Budapest University of Technology and Economics(BME)BudapestHungary EPIC InnoLabs Nonprofit Ltd. BudapestHungary Eötvös Loránd University(ELTE) BudapestHungary

Research of autonomous manufacturing systems is motivated both by the new technical possibilities of cyber-physical systems and by the practical needs of the *** operation in semi-structured industrial environments can now be supported by advanced sensor technologies,digital twins,artificial intelligence and novel communication *** enable real-time monitoring of production processes,situation recognition and prediction,automated and adaptive(re)planning,teamwork and performance improvement by *** paper summarizes the main requirements towards autonomous industrial robotics and suggests a generic workflow for realizing such *** case studies will be presented from recent practice at HUN-REN SZTAKI in a broad range of domains such as assembly,welding,grinding,picking and placing,and *** various solutions have in common that they use a generic digital twin concept as their *** making general recommendations for realizing autonomous robotic solutions in the industry,open issues for future research will be discussed.

关键词： industrial robotics autonomy digital twin enabling technology

Hear no evil： The effect of auditory warning signals on avian innate avoidance, learned avoidance and memory

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Current Zoology 2011年第2期57卷 197-207页

作者： emma C. SIDDALL Nicola m. mARPLES School of Natural Sciences Trinity College Dublin Dublin 2 Ireland

many aposematic insect species advertise their toxicity to potential predators using olfactory and auditory signals, in addition to visual signals, to produce a multimodal warning display. The olfactory signals in these displays may have interesting effects, such as eliciting innate avoidance against novel colored prey, or improving learning and memory of defended prey. However, little is known about the effects of such ancillary signals when they are auditory rather than olfactory. The few studies that have investigated this question have provided conflicting results. The current study sought to clarify and extend understanding of the effects of prey auditory signals on avian predator responses. The domestic chick Gallus gallus domesticus was used as a model avian predator to examine how the defensive buzzing sound of a bumblebee Bombus terrestris affected the chick＇s innate avoidance behavior, and the learning and memory of prey avoidance. The results demonstrate that the buzzing sound had no effect on the predator＇s responses to unpalatable aposematically colored crumbs, suggesting that the agitated buzzing of B. terrestris may provide no additional protection from avian predators .

关键词： Aposematism Auditory signals Dietary conservatism Avoidance learning memorability multimodal signaling

The effect of pyrazine odor on avoidance learning and memory in wild robins Erithacus rubecula

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Current Zoology 2011年第2期57卷 208-214页

作者： emma C. SIDDALL Nicola m. mARPLES School of Natural Sciences Trinity College Dublin Dublin 2 Ireland

Toxic insects advertise their defended state to potential predators using warning displays. Frequently these displays use cues through more than one sensory modality, and combine color, smell and sound to produce a multimodal warning display. Signalling through more than one sensory pathway may enhance the rate of avoidance learning, and the memorability of the learned avoidance. A common insect warning odor, pyrazine, has previously been shown to increase the rate of learned avoidance of unpalatable yellow prey by domestic chicks （GaUus gallus domesticus）, and the odor also improved memory of this learned avoidance. However, to date no research has examined this response to pyrazine odor using wild birds under natural conditions. This study used wild robins （Erithacus rubecula） to investigate whether wild birds avoided yellow baits that smelled of pyrazine more strongly than those presented with no odor. The results provide some evidence that pyrazine odor does increase the level of protection an aposematic insect gains from a wild avian predator, but that the effect of pyrazine on learned avoidance was much weaker than was found with domestic chicks .

关键词： Aposematism Learned avoidance memory multimodal warning display Pyrazine Robins

Larger floods reduce soil CO_(2)efflux during the post-flooding phase in seasonally flooded forests of Western Amazonia

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Pedosphere 2021年第2期31卷 342-352页

作者： emma m.DOCHERTY Andrew D.THOmAS Department of Geography and Earth Sciences Aberystwyth UniversityAberystwyth SY233DB(UK) School of Geography University of LeedsLeeds LS29JT(UK)

Seasonally flooded várzea forests of Western Amazonia are one of the most productive and biodiverse wetland forests in the ***,data on their soil CO_(2)emissions,soil organic matter decomposition rates,and soil C stocks are *** is a concern because hydrological changes are predicted to lead to increases in the height,extent,and duration of seasonal floods,which are likely to have a significant effect on soil C stocks and ***,with no empirical data,the impact of altered flood regimes on várzea soil C cycles remains *** study quantified the effects of maximum annual flood height and soil moisture on soil CO_(2)efflux rate(R_(s))and soil organic matter decomposition rate(k)in the várzea forests of Pacaya Samiria National Reserve,*** study was conducted between may and August *** results showed that R_(s)(10.6–182.7 mg C m^(-2)h^(-1))and k(0.016–0.078)varied between and within sites,and were considerably lower than the values reported for other tropical *** addition,R_(s)was negatively affected by flood height(Pmoisture(Pmentioned *** moisture was the dominant factor influencing R_(s),and it was significantly affected by maximum flood height,even after the floods had subsided(Pmain unchanged but with decomposition processes becoming more anaerobic.

关键词： C cycle climate change greenhouse gas soil CO_(2)emissions soil moisture soil organic matter decomposition rate tropical forest

The birth hour of mammals:insights from intra-specific variation in wild blue monkeys

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Current Zoology 2022年第5期68卷 499-506页

作者： marina Cords emma Gometz Department of Ecology Evolution and Environmental BiologyColumbia UniversityNew YorkNY 10027USA New York Consortium in Evolutionary Primatology 695 Park AvenueNew YorkNY 10065USA

While most mammals show birth hour peaks at times of the 24-h cycle when they are less active,there are exceptions to this general *** exceptions have been little explored,but may clarify evolutionary reasons for the diel timing of *** investigated intraspecific variation in birth hour in wild blue monkeys Cercopithecus mitis stuhlmanni,a diurnal primate,to identify factors that differentiated daytime versus nighttime *** and life history data from 14 groups over 14 years revealed that 4%of 484 births occurred during the *** of daytime birth varied with mother’s age,peaking at 15.7 *** whose annual timing deviated most from the population’s peak birth months were 5 times more likely to occur during daytime than those that deviated *** was no evidence that mother’s rank or infant sex influenced birth hour,and mixed evidence that daytime births were more probable in larger *** did not differ significantly for infants born during the day versus ***-aged mothers may be able to handle the consequences of an unusual birth hour more successfully than mothers with less experience or those weakened by *** birth may be more advantageous in the off-season because nights are colder at that time of *** findings are consistent with hypotheses relating birth hour to the risk of losing social protection in group-living animals,but are not consistent with those emphasizing risk of conspecific *** of within-species variation can help in evaluating evolutionary hypotheses for non-random birth hour.

关键词： birth timing Cercopithecus mitis circadian pattern diel cycle guenon parturition

Researching social innovation:is the tail wagging the dog?

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Infectious Diseases of Poverty 2020年第1期9卷 77-81页

作者： emma L.m.Rhule Pascale A.Allotey United Nations University-International Institute for Global Health Kuala LumpurMalaysia

Background:Social Innovation in health initiatives have the potential to address unmet community health *** sustainable change to occur,we need to understand how and why a given intervention is *** together communities,innovators,researchers,and policy makers is a powerful way to address this knowledge gap but differing priorities and epistemological backgrounds can make collaboration *** text:To overcome these barriers,stakeholders will need to design policies and work in ways that provide an enabling environment for innovative products and *** about people,the incorporation of community engagement approaches is necessary for both the development of social innovations and accompanying research *** the'appropriate'level of participation is linked to intended outcomes,researchers have a role to play in better understanding how to harness the power of community engagement and to ensure that community perspectives form part of the evidence base that informs policy and ***:To effectively operate at the intersection between policy,social innovation,and research,all collaborators need to enter the process with the mindset of learners,rather than ***-quantitative and qualitative-must be selected according to research *** fields of implementation research,community-based participatory research,and realist research,amongst others,have much to *** do other sectors,notably education and *** all this,researchers must assume the mantel of responsibility for research and not transfer the onus to communities under the guise of *** leveraging the expertise and knowledge of different ecosystem actors,we can design responsive health systems that integrate innovative approaches in ways that are greater than the sum of their parts.

关键词： Social innovation Health systems mixed methods Participation Community engagement Policymaker Implementation research

A novel homozygous missense variant in ARSK causes mPS X,a new subtype of mucopolysaccharidosis

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Genes & Diseases 2024年第3期11卷 87-90页

作者： miao Sun Cornelia K.Kaminsky Philip Deppe mai-Brittllse Frederic m.Vaz Barbara Plecko Torben Lubke Linda m.Randolph Division of Genomic medicine Department of Pathology and Laboratory MedicineChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Radiology Children's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Department of Chemistry BiochemistryBielefeld UniversityBielefeld 33615Germany Amsterdam UmC Location University of Amsterdam Department of Clinical Chemistry and PediatricsLaboratory Genetic Metabolic DiseasesEmma Children's HospitalMeibergdreef 9Amsterdam 1100 DEthe Netherlands Amsterdam Gastroenterology Endocrinology metabolism Inborn Errors of MetabolismAmsterdam 1105 BKthe Netherlands Core Facility metabolomics Amsterdam UMC Location University of AmsterdamAmsterdam 1100DDthe Netherlands Department of Pediatrics Division of General PediatricsMedical Universityof GrazGraz8036Austria Division of medical Genetics Department of PediatricsChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA

mucopolysaccharidoses(mPS)are a group of rare inborn errors of metabolism caused by defective lysosomal enzymes which prevent cells from degrading and recycling certain carbohydrates and fats,resulting in the storage of glycosaminoglycans in cells throughout the *** leads to multisystem abnormalities involving bone,connective tissues,brain,blood,spinal cord,skin,and other tissues.

关键词： metabolism doses polys