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Adolescents’ perspectives on a school-based physical activity intervention:A mixed method study

Journal of Sport and Health Science 2020年第1期9卷 28-40,F0003页

作者： Stephanie T.Jong Caroline H.D.Croxson Cornelia Guell emma R.Lawlor Campbell Foubister Helen E.Brown emma k.wells Paul Wilkinson Anna Vignoles Esther M.F.van Sluijs kirsten Corder MRC Epidemiology Unit and UkCRC Centre for Diet and Activity Research(CEDAR) University of Cambridge School of Clinical MedicineCambridgeCB2 OQQUK Nuffield Department of Primary Care Health Sciences University of OxfordOxfordOX26GGU European Centre for Environment and Human Health University of Exeter Medical SchoolKnowledge SpaRoyal Cornwall HospitalTruroTRI 3HDUK Department of Psychiatry University of Cambridge and Cambridgeshire and Peterborough NHS Foundation TrustCambridgeCB215EFUK Faculty of Education University of CambridgeCambridgeCB28PQUK

Purpose'. To examine adolescent experiences and perspectives of the GoActive intervention (ISRCTN31583496) using mixed methods processevaluation to determine satisfaction with intervention components and interpret a*dolescents experiences of the intervention process in order toprovide insights for future intervention ***'. Participants (n = 1542;13.2 土 0.4 years, mean 土 SD) provided questionnaire data at baseline (shyness, activity level) and post-intervention(intervention acceptability, satisfaction with components). Between-group differences (boys vs. girls and shy/inactive vs. others) weretested with linear regression models, accounting for school clustering. Data from 16 individual interviews (shy/inactive) and 11 focus groupswith 48 participants (mean = 4;range 2—7) were thematically coded. Qualitative and quantitative data were merged in an integrative mixedmethods convergence matrix, which denoted convergence and dissonance across ***'. Effect sizes for quantitative results were small and may not represent substantial between-group differences. Boys (vs. girls) preferredclass-based sessions (0 = 0.2, 95% confidence interval (CI): 0.1—0.3);qualitative data suggested that this was because boys preferred competition,which was supported quantitatively (0 = 0.2, 95%CI: 0.1-0.3). Shy/inactive students did not enjoy the competition (0 = -0.3, 95%CI:—0.5 to —0.1). Boys enjoyed trying new activities more (0 = 0.1, 95%CI: 0.1 -0.2);qualitative data indicated a desire to try new activities acrossall subgroups but identified barriers to choosing unfamiliar activities with self-imposed choice restriction leading to boredom. Qualitative datahighlighted critique of mentorship;adolescents liked the idea, but older mentors did not meet ***. We interpreted adolescent perspectives of intervention components and implementation to provide insights into future complexinterventions aimed at increasing young people's physical activity in s

关键词： Adolescent Intervention Mixed methods Physical activity Process evaluation

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In vivo analysis of hybrid hydrogels containing dual growth factor combinations,and skeletal stem cells under mechanical stimulation for bone repair

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Mechanobiology in Medicine 2024年第4期2卷 97-109页

作者： David Gothard Michael Rotherham emma L.Smith Janos M.kanczler James Henstock Julia A.wells Carol A.Roberts Omar Qutachi Heather Peto Hassan Rashidi Luis Rojo Lisa J.White Molly M.Stevens Alicia J.El Haj Felicity R.J.ose Richard O.C.Oreffo Bone and Joint Research Group Centre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthamptonSO166YDUK Institute for Science and Technology in Medicine Keele UniversityGuy Hilton Research CentreStoke-on-TrentST47BQUK Healthcare Technologies Institute School of Chemical EngineeringInstitute of Translational MedicineUniversity of BirminghamBirminghamB152THUK Department of Applied Sciences Pandon BuildingNorthumbria UniversityNewcastle-upon-TyneNE21XEUK Wolfson Centre for Stem Cells Tissue Engineering and ModellingUniversity of NottinghamCentre for Biomolecular SciencesUniversity ParkNottinghamNG72RDUK Leicester Institute for Pharmaceutical Innovation(LIPI) Leicester School of PharmacyFaculty of Health and Life SciencesDe Montfort UniversityThe GatewayLeicesterLE19BHUnited Kingdom Stem Cells and Regenerative Medicine Section UCL Great Ormond Street Institute of Child HealthUniversity College LondonLondonWC1N 1EHUK Department of Materials Imperial College LondonRoyal School of MinesLondonSW72AZUK Department of Bioengineering Imperial College LondonSouth Kensington CampusLondonSW72AZUK Instituto de Ciencia y Tecnología de Polímeros(ICTP) CSICCalle Juan de la Cierva328006 MadridSpain Consorcio Centro de Investigacion Biomedica en Red CIBER-BBNInstituto de Salud Carlos IIICalle Monforte de Lemos 3-51128029 PabellonMadridSpain Nottingham Biodiscovery Institute School of PharmacyUniversity of NottinghamNottinghamNG72RDUK Institute for Biomedical Engineering Imperial College London South Kensington CampusLondonSW72AZUK Department of Physiology Anatomy&GeneticsDepartment of Engineering Scienceand Kavli Institute for Nanoscience DiscoveryUniversity of OxfordOxfordOX13QUUK

Bone tissue engineering requires a combination of materials,cells,growth factors and mechanical cues to recapitulate bone *** this study we evaluated hybrid hydrogels for minimally invasive bone formation by combining biomaterials with skeletal stem cells and staged release of growth factors together with *** hydrogels consisting of alginate and decellularized,demineralised bone extracellular matrix(ALG/ECM)were seeded with Stro-1t human bone marrow stromal cells(HBMSCs).Dual combinations of growth factors within staged-release polylactic-co-glycolic acid(PLGA)microparticles were added to hydrogels to mimic,in part,the signalling events in bone regeneration:VEGF,TGF-β_(3),PTHrP(fast release),or BMP-2,vitamin D_(3)(slow release).Mechanotransduction was initiated using magnetic fields to remotely actuate superparamagnetic nanoparticles(MNP)targeted to TREk1 ion *** hydrogels were implanted subcutaneously within mice for 28 days,and evaluated for bone formation using micro-CT and *** hydrogels lacking HBMSCs,growth factors,or MNP became mineralised,and neither growth factors,HBMSCs,nor mechanotransduction increased bone ***,structural differences in the newly-formed bone were influenced by growth *** release of BMP-2 induced thick bone trabeculae and PTHrP or VitD_(3)increased bone ***,fast-release of TGF-β_(3)and VEGF resulted in thin *** reversed the trabecular thinning and increased collagen deposition with PTHrP and VitD_(3).Our findings demonstrate the potential of hybrid ALG/ECM hydrogel–cell–growth factor constructs to repair bone in combination with mechanotransduction for fine-tuning bone *** approach may form a minimally invasive reparative strategy for bone tissue engineering applications.

关键词： Growth factors Controlled release Bone ECM Bone formation Mechanotransduction Skeletal stem cell

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护士定期随访与传统医学随访肺癌患者的效果:随机试验

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英国医学杂志中文版 2003年第2期6卷 127-127页

作者： Sally Moore Jessica Corner Jo Haviland Mary wells emma Salmon Charles Normand Mike Brada Mary O'Brien Ian Smith 韩锟

研究目的:评价护士定期随访对管理肺癌患者的效果。设计:随机对照试验。研究地点:英国东南部的一所肿瘤专科医院和三家癌症研究中心。研究对象:203例完成初始治疗并预期存活3个月以上的肺癌患者。干预措施:对非住院患者,护士定期随... 详细信息

研究目的:评价护士定期随访对管理肺癌患者的效果。设计:随机对照试验。研究地点:英国东南部的一所肿瘤专科医院和三家癌症研究中心。研究对象:203例完成初始治疗并预期存活3个月以上的肺癌患者。干预措施:对非住院患者,护士定期随访与传统预后随访进行比较。

关键词：护士定期随访肺癌随机试验预后传统医学

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