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Signaling pathways downstream to receptor tyrosine kinases:targets for cancer treatment

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 556-574页

作者： emma cordover Audrey Minden Susan Lehman Cullman Laboratory for Cancer Research Department of Chemical BiologyErnest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNJ 08854USA

Mammalian cells have the ability to respond to a myriad of diverse extracellular stimuli that modulate cell *** often involves ligands binding to cell surface receptors and subsequent activation of intracellular signaling *** pathways can lead to changes in gene expression patterns that in turn regulate cell growth,differentiation,migration,and *** important type of cell surface receptor is the receptor tyrosine kinase(RTK).In response to in response to ligand binding,RTKs dimerize,then trans-phosphorylate each other,leading to activation of downstream *** the signaling proteins in these pathways are important for normal cell growth control,when improperly regulated they can lead to uncontrolled growth and sometimes *** this reason,they are often considered to be good candidates for drug targets for chemotherapeutic *** can activate multiple different signaling *** of the signaling proteins in these pathways can have crosstalk with other RTK activated pathways,and some of them can be activated by multiple mechanisms in addition to activation by *** there is a wide array of different signaling proteins and pathways activated by RTKs,in this review we will discuss components of several key pathways including the MAPK pathway,the Her2/Neu pathway,mTOR,and Pak *** provide an overview of the roles for these pathways in cell signaling and discuss how different components of these pathways are being considered as targets for cancer treatment.

关键词： Receptor tyrosine kinases signaling pathways targeted cancer therapeutics oncogenes cell signaling

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