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Does the use of recombinant TSH in preparation for I-131 scintigraphy scan affect hearing function?

Journal of Otology 2018年第1期13卷 20-24页

作者： Mehtap Dogan Kasim Durmus Zekiye Hasbek emine elif altuntas Department of Otolaryngology Faculty of Medicine Cumhuriyet University 58140 Sivas Turkey Cumhuriyet Univ. School of Medicine Dept. of Nuclear Medicine Campus 58140 Sivas Turkey

Objective: The objective of this study was to examine the effect of hypothyroidism on hearing function in patients surgically treated for differentiated thyroid cancer and subsequently experienced hypothyroidism during preparation for follow up I-131 scintigraphy scan by either recombinant human thyroid stimulating hormone(rhTSH) treatment or thyroid hormone withdrawal(THW).Methods: A total of 55 patients undergoing I-131 scintigraphy scan following surgeries for differentiated thyroid cancer were included in the study, including 25 patients prepared by administration of recombinant TSH(rhTSH Group) and 30 patients by thyroid hormone withdrawal(THW Group).Results: Air conduction thresholds at 1, 2 and 4 kHz for both ears were higher during hypothyroid period than during euthyroid period for patients in the THW group(p < 0.05) but not for patients in the rhTSH ***: Sensorineural hearing loss was detected, especially at low frequencies, in patients with DTC after surgical treatment whose hormone replacement therapy was withdrawn but not in those receiving rhTSH. It is therefore preferred to use rhTSH when preparing for I-131 scintigraphy scan in patients at risk for hearing loss.

关键词： Hearing loss Recombinant TSH Thyroid hormone withdrawal Radioiodine

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A case of mediastinal mesenchymal tumor resembling hemopericardium

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Journal of Geriatric Cardiology 2021年第7期18卷 591-594页

作者： Aynur Acibuca Mustafa Yilmaz elif Karadeli emine Tuba Canpolat Tansel Erol Department of Cardiology Baskent University School of MedicineDr Turgut Noyan Practice and Research CenterAdanaTurkey Department of Radiology Baskent University School of MedicineDr Turgut Noyan Practice and Research CenterAdanaTurkey Department of Pathology Baskent University School of MedicineDr Turgut Noyan Practice and Research CenterAdanaTurkey

Mediastinal neoplasms are rare in the elderly,and clinical suspicion is the first and most important step of differential *** tumors can be misdiagnosed because their symptoms or signs can overlap with cardiovascular diseases,which have a higher prevalence among the older *** diagnostic process should be managed with multimodality imaging and clinical ***,the case of a 74-year-old male patient,who presented with shortness of breath,is examined.A chest X-ray revealed an increased cardiothoracic ratio,and he was diagnosed with hemopericardium following an emergent chest computed *** the echocardiography,it was suspected that a hyperechogenic area adjacent to the heart might be due to a mass,and further examinations confirmed a mediastinal neoplasm.A surgical biopsy was performed,and it was determined to be a mesenchymal *** conclude,clinicians should keep in mind the possibility of paracardiac neoplasm in the elderly,as well as in other age groups,when encountering mediastinal widening so that the patient can be protected from unnecessary interventions such as pericardiocentesis.

关键词： neoplasms neoplasm media

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Radiotherapy for Gastrointestinal Stromal Tumors

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Chinese Medical Journal 2018年第2期131卷 235-240页

作者： emine elif Ozkan Department of Radiation Oncology Suleyman Demirel University Isparta 32260 Turkey

Objective： Gastrointestinal stromal tumors （GISTs） are rare mesenchymal tumors of the gastrointestinal tract, which fiequently cause intraabdominal metastases. The current standard of care is surgery for localized cases, and adjuvant imatinib is recommended for tumors with a high risk of recurrence. To date. radiotherapy has not been commonly accepted as a part of l-nultimodality treatment approach other than palliation. However, recently published case reports and some small series suggest that radiotherapy is a valuable option for controlling locally progressive, drug-resistant disease. The aim of this review is to provide a viewpoint from a radiation oncologist concerning the management of GISTs, especially rectal GIST, and clarify the role and technical aspects of radiotherapy in the treatment approach. Data Sources： A comprehensive search in PubMed using the keywords ＂＇radiotherapy for rectal GIST＂ and ＂＇rectal GIST＂ was undertaken. The literature search included the related articles after 1995. Study Selection： The main articles including rectal GIST case reports and GIST series containing rectal cases were the primary references. Results： Surgery is tile mainstay of treatment, However, to date, radiotherapy is included in the multidisciplinary treatment strategy of rectal GISTs in some circumstances with palliative, adjuvant, or definitive intent using different treatment doses and fields. Conchlsions： Recently reported Iong-terrn local control rates indicate that GIST is a radiosensitive disease. This makes radiotherapy a valuable alternative in GIST management with curative intent, especially in patients who （ I ） cannot tolerate or are resistant to chemotherapy agents. （2） have an unresectable disease, （3） have a gross or microscopic residual disease after surgery, and （4） have a recurrent disease.

关键词： Gastrointestinal Stromal Tumor Radiotherapy: Rectum

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Clinical characteristics and outcomes of nosocomial COVID-19 in Turkey:A retrospective multicenter study

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Asian Pacific Journal of Tropical Medicine 2023年第8期16卷 347-353页

作者： Süleyman Yıldırım Celalettin Yılmaz Gülru Polat Serap Argun Baris İlknur Başyiğit İlknur Kaya Ceyda Anar Mihriban Bozkurt HüsnüBaykal Hulya Dirol Gamzenur Ozbey emine Ozsari Emel Cireli Ali KadriÇırak Dursun Tatar Mine Gayaf Selen Karaoglanoglu Yener Aydin Atilla Eroglu Yıldız Olçar Berna Botan Yıldırım Bengül Gürsoy Deniz Demir Yılmaz elif Yelda Ozgun Niksarlioglu Ramazan Eren Ayşegül Tomruk Erdem Müge Meltem Tor Fusun Fakili MustafaÇolak Merve Erçelik Ali Tabaru Özlem Ediboglu Intensive Care Unit Dr.Suat Seren Chest Disease and Surgery Training and Research HospitalUniversity of Health Sciences TurkeyİzmirTurkey Department of Pulmonology Dr.Suat Seren Chest Disease and Surgery Training and Research HospitalUniversity of Health Sciences TurkeyİzmirTurkey Department of Pulmonary Medicine School of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonology Kütahya Health Sciences UniversityKütahyaTurkey Department of Pulmonology Atatürk Training and Research Hospitalİzmir KatipÇelebi UniversityİzmirTurkey Department of Pulmonology Ankara Atatürk Sanatory Training and Research HospitalUniversity of Health SciencesAnkaraTurkey Department of Pulmonology Faculty of MedicineAkdeniz UniversityAntalyaTurkey Department of Pulmonology Bolu Abantİzzet Baysal University Training and Research HospitalBoluTurkey Department of Pulmonology Ordu University Training and Research HospitalOrduTurkey Department of Thoracic Surgery Medical FacultyErzurumAtaturk UniversityTurkey Department of Infectious Disease and Clinical Microbiology Kastamonu Training and Research HospitalKastamonuTurkey Department of Pulmonology Başkent University Hospital KonyaKonyaTurkey Department of Pulmonology İstanbul SancaktepeŞehit Prof.Dr.İlhan Varank Training and Research HospitalİstanbulTurkey Department of Chest Diseases Yedikule Chest Diseases and Thoracic Surgery Training and Research HospitalHealth Science UniversityİstanbulTurkey Department of Pulmonology Faculty of MedicineZonguldak Bülent Ecevit UniversityZonguldakTurkey Department of Pulmonary Medicine GaziantepFaculty of MedicineŞahinbey Research HospitalGaziantep UniversityTurkey Department of Pulmonology BalıkesirHealth Practice and Research HospitalBalıkesir UniversityTurkey Department of Pulmonology Afyonkarahisar Dinar State HospitalAfyonTurkey Department of Pulmonology Söke Fehime Faik Kocagöz State HospitalAydınTurkey

Objective:To identify the clinical characteristics and outcomes of hospital-acquired SARS-CoV-2 infection during the vaccination period nationwide in ***:COVID-19 patients followed in the pandemic services across Turkey between January 1,2021,and March 31,2022 were investigated *** COVID-19 was defined as a patient neither diagnosed with COVID-19 nor suspected COVID-19 at the hospital admission and was confirmed COVID-19≥5 days after hospital *** primary outcome of this study was in-hospital mortality;demographic features and vaccination status was compared between survivors and ***:During the study period,15573 COVID-19 patients were followed in 18 centers and 543(3.5%)patients were nosocomial *** patients with nosocomial COVID-19(80.4%)were transferred from medical wards.162(29.8%)of the patients with nosocomial COVID-19 admitted to the intensive care unit due to disease severity and 138(25.4%)of the patients died during hospital *** age(≥65 years)and number of comorbid diseases(≥2)was found to be associated with mortality in nosocomial COVID-19(OR 1.74,95%CI 1.11-2.74 and OR 1.60,95%CI 1.02-2.56,respectively).Vaccination was associated with survival in nosocomial COVID-19(OR 0.25,95%CI 0.16-0.38).Conclusions:Patients with nosocomial COVID-19 had increased admission to intensive care units and higher mortality *** can decrease the in-hospital mortality rate.

关键词： COVID-19 Nosocomial infection Vaccination Intensive care unit

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