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Comparison of total/active ghrelin levels in primary open angle glaucoma,pseudoexfoliation glaucoma and pseudoexfoliation syndrome

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International Journal of Ophthalmology(English edition) 2018年第5期11卷 823-827页

作者： Numan Eraslan Ufuk Elgin emine sen Aytul Kilic Pelin Yilmazbas Ulucanlar Eye Research Hospital Ankara 06250 Turkey Department of Biochemistry Ankara Training and Research Hospital Ankara 06250 Turkey

AIM：To investigate the levels of ghrelin（Gh）,acylated ghrelin（AGh） and AGh/Gh ratio in the humor aqueous（HA） of cases with pseudoexfoliation syndrome（PXS）,pseudoexfoliation glaucoma（PXG）,primary open angle glaucoma（POAG） and to compare these with control subjects.METHODS：A prospective examination was made of the total Gh,and AGh levels in HA of 67 patients undergoing cataract surgery.Patients were divided into 4 groups.HA samples were aspirated at the beginning of the surgery,stored at -70℃.Gh and AGh quantification was performed with ELISA kits and the AGh/total-Gh ratios were calculated.ANOVA,Kruskal-Wallis,Chi-square and post-hoc tests were used for statistical analysis.RESULTS：Total Gh levels in HA were 189.2±45.6 pg/mL in the control group,199.2±32.9 pg/mL in PXS,180.6±20.9 pg/mL in PXG and 176.8±21.4 pg/mL in POAG groups（P〉0.05）.AGh levels in HA were 23.09±5.01 pg/mL in the control group,24.13±5.22 pg/mL in PXS,22.29±1.55 pg/m L in PXG and 19.69±2.93 pg/mL in POAG groups（P〉0.05）.The ratio of AGh/Gh was 10.3%±2.34% in the control group,13.03%±2.58% in PXS,12.3%±1.54% in PXG and 11.79%±1.41% in POAG groups（P=0.044）.The difference between the PXS and control groups was significant（P=0.03）.CONCLUSION：In spite of statistically insignificant results,the HA total Gh levels were lower than those of the control subjects but not parallel with the AGh levels in glaucoma patients.The relative increase in the AGh/Gh ratio in glaucoma cases supports the view that proportional increases of AGh might play a role in the pathogenesis of glaucoma.

关键词： ghrelin acylated ghrelin humour aqueous pseudoexfoliation syndrome pseudoexfoliation glaucoma primary open angle glaucoma

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Comparison of aerobic conjunctival bacterial flora in pregnant, reproductive-aged and postmenopausal women

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 731-736页

作者： Melike Balikoglu-Yilmaz emine sen Osman Sevket Yusuf Polat Aysun Karabulut Omer Uysal Department of Ophthalmology Denizli State Hospital Ulucanlar Eye Education and Research Hospital Department of Obstetrics and Gynecology Denizli State Hospital Department of Microbiology and Clinic Microbiology Denizli State Hospital Department of Biostatistics and Medical Informatics Bezmi Alem Vakif University

AIM: To evaluate the effect of hormonal status on aerobic conjunctival flora in women. METHODS: One hundred fifty-eight women [reproductive-aged (n=55), pregnant (n=51), and postmenopausal (n=52)] who admitted to outpatient clinic of Obstetrics and Gynecology Department of Denizli State Hospital were enrolled. Age, body-mass index (BMI), obstetric history, cigarette smoking, drug usage, presence of systemic disease, and intraocular pressure (IOP) were recorded for each patient. The samples were taken from the lower fornix with two culture swabs and directly incubated in culture containing 5% sheep blood, eosin-methylene blue and chocolate agar. The other swab specimen was Gram stained. All growths and microscopic results were analyzed. RESULTS: The coagulase-negative Staphylococcus was the predominant organism isolated in the conjunctival samples in both three groups. The aerobic microorganism growth rate for all isolated aerobic organisms revealed no significant change in the three groups (P>0.05). The conjunctival culture positivity rates were similar in the three groups (49% in reproductive-aged, 57% in pregnant and 58% in postmenopausal women) (P>0.05). Age, IOP, BMI, gravidity, parity, cigarette smoking, drug usage, and presence of systemic diseases did not have an effect on culture positivity in three groups. CONCLUSION: Results of this study showed that conjunctival aerobic flora and bacterial colonization did not differ between reproductive-aged, pregnant and postmenopausal women.

关键词： aerobic conjunctival flora coagulase-negative Staphylococcus menopause pregnancy reproductive-aged

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Comparison of autofluorescence and optical coherence tomography findings in acute and chronic central serous chorioretinopathy

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 350-354页

作者： Mehmet Yasin Teke Ufuk Elgin Pinar Nalcacioglu-Yuksekkaya emine sen Pinar Ozdal Faruk Ozturk Ulucanlar Eye Research Hospital

AIM:To discuss and compare the fundus autofluorescence(FAF)and optical coherence tomography(OCT)in acute or chronic central serous chorioretinopathy(CSCR).METHODS:Medical records of 100 cases of CSCR were reviewed.Acute and chronic cases were evaluated according to the duration of decreased visual acuity,serous retinal detachment(RD)and focal leakage on fluorescein angiography(FA).Chi-square test was used for statistical analysis.RESULTS:Forty cases had acute and 60 cases had chronic CSCR.FAF showed focal hypo-autofluorescence in 34(85%)and iso-autofluorescence in 6(15%)of acute cases and hypo-autofluorescence in 51(85%),hyperautofluorescence in 6(10%)and iso-autofluorescence in3(5%)of chronic cases.OCT showed serous RD with distinct borders correlated with FAF findings(hypoautofluorescence)in all acute CSCR cases.In chronic CSCR group,OCT showed serous RD with indistinct borders correlated with FAF findings.The differences between the OCT and FAF findings of the two groups were significant(P=0.000).CONCLUSION:OCT and FAF findings can support the clinical observations in differential diagnosis of acute and chronic CSCR and help clinicians to evaluate retinal pigment epithelium,outer segments of photoreceptors and the components of serous RD.

关键词： central serous chorioretinopathy fluorescein angiography fundus autofluorescence optical coherence tomography

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Oxidant/antioxidant balance in the aqueous humor of patients with glaucoma

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 249-252页

作者： Esra Ergan Faruk Ozturk Emrullah Beyazyildiz Ufuk Elgin emine sen Ali Bulent Cankaya Tugrul Celik Department of Ophthalmology Amasya UniversitySabuncuoglu Serefeddin Research and Training Hospital Department of Ophthalmology Hacettepe University Department of Ophthalmology Samsun Research and Training Hospital Department of Opthalmology Ulucanlar Eye Research Hospital Department of Biochemistry Turgut Ozal University

AIM： To evaluate total antioxidant status （TAS）, total oxidant status （TOS）, and the oxidative stress index （OSI） of the aqueous humor （AH） in patients with glaucoma. METHODS： The prospective study was composed of a study group （n-31） and a control group （n=31）. Fifteen patients in the study group were diagnosed with primary open angle glaucoma （POAG）, and 16 patients were diagnosed with pseudoexfoliation glaucoma （PEG）. The control group was composed of non-glaucomatous patients with cataracts. AH samples were collected and analyzed for TAS, TOS, and OSI levels. RESULTS： Mean AH TAS level was significantly higher in patients with glaucoma than that in the control group （P〈0.01）. Mean TOS and OSI levels tended to increase in patients with glaucoma. No significant differences in TAS, TOS, or OSI levels were observed between patients with POAG and PEG. CONCLUSION： High levels of TAS were observed in patients with glaucoma, which was likely a response to the increased oxidative stress observed in these patients.

关键词： oxidative stress primary open angleglaucoma pseudoexfoliation glaucoma total antioxidantstatus total oxidant status

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Corneal properties in children with congenital isolated growth hormone deficiency

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 317-320页

作者： Pinar Nalcacioglu-Yuksekkaya emine sen Ufuk Elgin Mumin Hocaoglu Faruk Ozturk Sebahat Agladioglu Yilmaz Havva Nur Kendirci Semra etinkaya Zehra Aycan Department of Pediatric Ophthalmology Dr Sami Ulus Children's Health and Disease Training and Research Hospital Ulucanlar Eye Research Hospital Department of Pediatric Endocrinology Dr Sami Ulus Children's Health and Disease Training and Research Hospital

AIM:To compare the corneal parameters of children with congenital isolated growth hormone deficiency and healthy subjects.METHODS:In this cross-sectional,prospective study,50 cases with growth hormone(GH)deficiency treated with recombinant GH and 71 healthy children underwent a complete ophthalmic examination.The corneal hysteresis(CH),corneal resistance factor(CRF),Goldmann-correlated intraocular pressure(IOPg)and corneal-compensated intraocular pressure(IOPcc)were measured with the Ocular Response Analyzer(ORA).Central corneal thickness(CCT)was measured by a ultrasonic pachymeter.RESULTS:The mean age was 13.0±3.0 years in the GH deficiency group consisting of 21 females and 29 males and 13.4±2.4 years in the healthy children group consisting of 41 females and 30 males.There was no statistically significant difference between the groups for gender or age(Chi-square test,P=0.09;independent ttest,P=0.28,respectively).The mean duration of recombinant GH therapy was 3.8±2.4y in the study group.The mean CH,CRF,IOPg and IOPcc values were 11.0±2.0,10.9±1.9,15.1±3.3,and 15.1±3.2 mm Hg respectively in the study group.The same values were 10.7±1.7,10.5±1.7,15.2±3.3,and 15.3±3.4 mm Hg respectively in the control group.The mean CCT values were 555.7±40.6,545.1±32.5μm in the study and control groups respectively.There was no statistically significant difference between the two groups for CH,CRF,IOPg,IOPcc measurements or CCT values(independent t-test,P=0.315,0.286,0.145,0.747,0.13 respectively).CONCLUSION:Our study suggests that GH deficiency does not have an effect on the corneal parameters and CCT values.This observation could be because of the duration between the beginning of disease and the diagnosis and beginning of GH therapy.

关键词： child corneal biomechanical parameters central corneal thickness growth hormone deficiency

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白内障手术技巧对术源性散光的影响(英文)

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国际眼科杂志 2015年第12期15卷 2036-2039页

作者： Numan Eraslan Ufuk Elgin emine sen Pelin Yilmazbas Ulucanlar眼科研究医院眼科土耳其安卡拉06240

目的:评估行普通白内障超声乳化术,手术经验对术源性散光(SIA)的影响。方法:选取患者50例53眼,平均年龄64.5±10.8a,随机分为两组,一组23眼,二组30眼。手术方式均采用透明角膜切口白内障超声乳化吸除联合人工晶状体植入术。第一组由白... 详细信息

目的:评估行普通白内障超声乳化术,手术经验对术源性散光(SIA)的影响。方法:选取患者50例53眼,平均年龄64.5±10.8a,随机分为两组,一组23眼,二组30眼。手术方式均采用透明角膜切口白内障超声乳化吸除联合人工晶状体植入术。第一组由白内障专家手术,第二组则由住院医师手术。术前所有患者均接受全面眼科检查,包括角膜曲率和自动屈光检测。SIA应用向量分析程序-Alpins法计算,于术后1d,1mo及2mo重复上述检查并记录结果变化。应用Shapiro Wilk和Mann-Whitney检验判断两组间SIA的统计学差异。结果:两组患者人口资料差异无统计学意义。组间分析显示,一组术后1d,1mo及2mo的SIA分别为0.79±0.41D,0.54±0.41 D及0.47±0.37 D;二组分别为1.27±0.66 D,0.98±0.56 D及0.94±0.54 D。可见一组术后1d(P=0.002),1mo(P=0.004)及2mo(P=0.001)的SIA更小。结论:手术经验是影响SIA的因素之一。住院医师应增加超声乳化术手术量以获取更多手术经验。

关键词：手术经验白内障超声乳化术术源性散光

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原发性开角型青光眼和高眼压患者及正常人群结膜印迹细胞学检查的比较（英文）

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国际眼科杂志 2015年第5期15卷 745-749页

作者： Ufuk Elgin Mehmet Citirik Hulya Haksever emine sen Faruk Ozturk Huseyin Ustun 安卡拉Ulucanlar眼研究医院眼科土耳其安卡拉06240 安卡拉培训与研究医院病理科土耳其安卡拉06340

目的：比较原发性开角型青光眼和高眼压患者及拥有健康眼球表面的正常人群的泪膜功能和印象细胞学检查的数值。方法：此前瞻性研究中纳入了原发性开角型青光眼患者11例11眼（平均年龄：62.7±6.1岁）,高眼压患者12例12眼（平均年龄：6... 详细信息

目的：比较原发性开角型青光眼和高眼压患者及拥有健康眼球表面的正常人群的泪膜功能和印象细胞学检查的数值。方法：此前瞻性研究中纳入了原发性开角型青光眼患者11例11眼（平均年龄：62.7±6.1岁）,高眼压患者12例12眼（平均年龄：62.8±6.4岁）及健康人12例12眼（平均年龄：62.9±6.03岁）。这些患者均是最近被诊断出患有原发性开角型青光眼及高眼压,且之前未接受过抗青光眼方面的治疗。均行结膜印迹细胞学检查、泪膜破裂时间和基础泪液分泌试验。每组印迹细胞学检查的样本根据Nelson分级法分为0-3级。应用Kruskal-Wallis检验和Dunn多重比较检验进行统计分析。结果：原发性开角型青光眼患者,高眼压患者及正常人群平均基础泪液分泌值分别为10.4±1.3,10.9±1.2和11.1±1.1 mm/5min,其差距没有统计学意义（P=0.33）；三组的泪膜破裂时间分别为11.2±1.1,11.3±1.1和11.8±1.2s,其差距没有统计学意义（P=0.35）。原发性开角型青光眼患者中6眼（54.5%）为0级,5眼（45.5%）为1级。高眼压患者中6眼（50%）为0级,6眼（50%）为1级,健康人中6眼（50%）为0级,6只眼（50%）为1级（P=0.97）。结论：氧化应激可能会导致青光眼,眼表疾病,泪腺功能障碍及机体杯状细胞所分泌的黏液减少。原发性开角型青光眼患者,高眼压症患者及健康人群间的印象细胞学检查数值并无显著差异。

关键词：结膜印迹细胞学原发性开角型青光眼高眼压

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有自发的有斑点的洞的病人的宫底 autofluorescence 成像

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International Journal of Ophthalmology(English edition) 2013年第5期6卷 685-689页

作者： Mehmet Yasin Teke Pinar Cakar-Ozdal emine sen Ufuk Elgin Pinar Nalcacioglu-Yuksekkaya Faruk Ozturk Ulucanlar Eye Research and Training Hospital

AIM:To investigate the role of fundus autofluo rescence(FAF) both in the diagnosis and the preoperative and postoperative evaluation of patients with idiopathic macular hole(MH).METHODS:Forty eyes of 40 patients diagnosed as idiopathic MH between May 2010 and May 2011 were included in this retrospective study.All patients underwent full ophthalmologic examinations and imagings including fluorescein angiography,fundus autofluorescence(FAF) and optical coherence tomography.Thirty of these patients underwent MH surgery.FAF findings were associated with duration of symptoms,visual acuity at presentation,stage of MH,and postoperative anatomical correction.RESULTS:The mean duration of patients’ symptoms was 3.8±2.0(1-9) months.The MH was stage 2 in 4(10%),stage 3 in 24(60%) and stage 4 in 12(30%) eyes.The median preoperative best corrected visual acuity was 20/200(between 20/800 and 20/100).Twenty-eight of cases(70%) showed a stellate appearance with dark radiating striae.Having a visual acuity ≥20/200 was significantly more common in eyes with stellate appearance(Psentation,shorter duration of symptoms,thus more favorable prognosis.

关键词： autofluorescence imaging macular hole prognosis surgery

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A Spleen Tyrosine Kinase’s Sky in Neuronal Degeneration

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Neuroscience Bulletin 2024年第2期40卷 273-276页

作者： Wan-Yun Zhang sen Lin Department of Neurology Xinqiao HospitalThe Second Afliated HospitalArmy Medical UniversityChongqing 400042China Chongqing Institute for Brain and Intelligence Guangyang Bay LaboratoryChongqing 400064China

With the growing elderly population,neurodegenerative disorders like Alzheimer's disease(AD)are emerging as a significant public health concern.It is widely acknowledged in the scientific community that the accumulation of neurotoxic aggregates,such as amyloid beta(Aβ),within the central nervous system is a major factor in the development of these disorders.Furthermore,human genome-wide association studies have identified mutations in microglial receptors that may be linked to a number of neurodegenerative diseases[1].

关键词： Aβ Spleen Alzheimer

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An extended state observer with adjustable bandwidth for measurement noise

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Journal of Systems Engineering and Electronics 2024年第1期35卷 233-241页

作者： ZHANG Shihua QI Xiaohui YANG sen Shijiazhuang Campus Army Engineering University of PLAShijiazhuang 050053China

In this paper,a bandwidth-adjustable extended state observer(ABESO)is proposed for the systems with measurement noise.It is known that increasing the bandwidth of the observer improves the tracking speed but tolerates noise,which conflicts with observation accuracy.Therefore,we introduce a bandwidth scaling factor such that ABESO is formulated to a 2-degree-of-freedom system.The observer gain is determined and the bandwidth scaling factor adjusts the bandwidth according to the tracking error.When the tracking error decreases,the bandwidth decreases to suppress the noise,otherwise the bandwidth does not change.It is proven that the error dynamics are bounded and converge in finite time.The relationship between the upper bound of the estimation error and the scaling factor is given.When the scaling factor is less than 1,the ABESO has higher estimation accuracy than the linear extended state observer(LESO).Simulations of an uncertain nonlinear system with compound disturbances show that the proposed ABESO can successfully estimate the total disturbance in noisy environments.The mean error of total disturbance of ABESO is 15.28% lower than that of LESO.

关键词： extended state observer(ESO) boundedness and convergence adjustable bandwidth measurement noise

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