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Brain metastasis as exclusion criteria in extensive-stage small cell lung cancer trials:a trend over decades

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 10-16页

作者： Takefumi Komiya Gerard Chaaya Leigh Deshotels emily powell Achuta Kumar Guddati Medical Oncology Parkview Cancer InstituteFort WayneIN 46845USA Section of Hematology/Medical Oncology Tulane University School of MedicineNew OrleansLA 70112USA Department of Internal Medicine Tulane University School of MedicineNew OrleansLA 70112USA Parkview Research Center Mirro Center for Research and InnovationFort WayneIN 46845USA Medical Oncology Augusta UniversityAugustaGA 30901USA

Aim:To investigate the frequencies and trends of brain metastases(BMs)as exclusion criteria in extensive-stage small cell lung cancer(ES-SCLC)***:We conducted a comprehensive search to identify prospective clinical trials in patients with *** searches were conducted with the key words“small cell lung cancer”and“extensive”.The online archives of 20 oncology journals were also *** review articles in ES-SCLC were also investigated for additional *** studies must have enrolled primarily ES-SCLC and been published in *** involving brain/chest radiation and brain metastasis-specific trials were *** were categorized into allowed/undefined,conditional,or complete exclusion of ***:In total,491 published studies were identified by PubMed(240),journal websites(198),and review articles(53).Early publication year(1970-1999)and first-line/maintenance setting were associated with higher incidence of complete exclusion of cases with BMs(P<0.0001 and 0.0233,respectively).Incidence of complete exclusion was 27%in the 1990s,and then decreased to 12%in the 2000s and 8%in the ***:A significant number of ES-SCLC trials continues to exclude patients with *** studies need to ease eligibility regarding BM according to ASCO/Friends recommendations.

关键词： Brain metastasis small cell lung cancer clinical trials

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