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Journal of Genetics and Genomics 2015年第9期42卷 507-510页

作者： Zhou Tan Zhongkai Hu emily y.cai Cantas Alev Ting yang Zhen Li Joyce Sung yasser yehia El-Sayed Gary M.Shaw David K.Stevenson Atul J.Butte Guojun Sheng Karl G.Sylvester Harvey J.Cohen Xuefeng B.Ling Institute of Developmental and Regenerative Biology Hangzhou Normal University Department of Surgery Stanford University Lab for Early Embryogenesis RIKEN Center for Developmental Biology Department of Obstetrics and Gynecology Stanford University Department of Pediatrics Stanford University Stanford

Over 11% of all pregnancies in the US result in preterm birth, greatly contributing to perinatal morbidity and mortality （Goldenberg and Rouse, 1998）. Preterm birth etiologies remain largely unknown, and effective prevention methods have yet to be developed. The use of biofluid （e.g., serum or urine） for the analysis of the naturally occurring peptidome （MW 〈 4000） as a source of biomarkers has been reported for different diseases （Villanueva et al., 2006; Ling et al., 2010a, 2010b, 2010c, 2011）. Mass spectrometry-based profiling of naturally occurring peptides can provide an extensive in- ventory of serum peptides derived from either high-abundant endogenous circulating proteins or cell and tissue proteins （Liotta and Petricoin, 2006）.

关键词： Serological Targeted Analysis of an ITIH4 Peptide Isoform A Preterm Birth Biomarker and Its Associated SNP Implications SNP

Electron kinetic effects in back-stimulated Raman scattering bursts driven by broadband laser pulses

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Matter and Radiation at Extremes 2024年第4期9卷 54-67页

作者： Q.K.Liu L.Deng Q.Wang X.Zhang F.Q.Meng y.P.Wang y.Q.Gao H.B.cai S.P.Zhu Graduate School China Academy of Engineering PhysicsBeijing 100088China Institute of Applied Physics and Computational Mathematics Beijing 100094China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China Shanghai Institute of Laser Plasma Shanghai 201800China HEDPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100871China School of Physics Zhejiang UniversityHangzhou 310027China

We examine electron kinetic effects in broadband-laser-driven back-stimulated Raman scattering(BSRS)bursts using particle-in-cell *** bursts occur during the nonlinear stage,causing reflectivity spikes and generating large numbers of hot ***-duration simulations are performed to observe burst events,and a simplified model is developed to eliminate the interference of the broadband laser’s random intensity *** the simplified model,we isolate and characterize the spectrum of electron plasma *** spectrum changes from a sideband structure to a turbulence-like structure during the burst.A significant asymmetry in the spectrum is *** asymmetry is amplified and transferred to electron phase space by high-intensity broadband laser pulses,leading to violent vortex-merging and generation of hot *** proportion of hot electrons increases from 6.76%to 14.7%during a single violent burst *** demonstrate that kinetic effects profoundly influence the BSRS evolution driven by broadband lasers.

关键词： scattering kinetic simplified

Induced pluripotent stem cells(iPSCs):molecular mechanisms of induction and applications

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2065-2090页

作者： Jonas Cerneckis Hongxia cai yanhong Shi Department of Neurodegenerative Diseases Beckman Research Institute of City of HopeDuarteCA 91010USA Irell&Manella Graduate School of Biological Sciences Beckman Research Institute of City of HopeDuarteCA 91010USA

The induced pluripotent stem cell(iPSC)technology has transformed in vitro research and holds great promise to advance regenerative *** have the capacity for an almost unlimited expansion,are amenable to genetic engineering,and can be differentiated into most somatic cell *** have been widely applied to model human development and diseases,perform drug screening,and develop cell *** this review,we outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic *** begin by discussing the pivotal discoveries that revealed the potential of a somatic cell nucleus for reprogramming and led to successful generation of *** consider the molecular mechanisms and dynamics of somatic cell reprogramming as well as the numerous methods available to induce ***,we discuss various iPSC-based cellular models,from mono-cultures of a single cell type to complex three-dimensional organoids,and how these models can be applied to elucidate the mechanisms of human development and *** use examples of neurological disorders,coronavirus disease 2019(COVID-19),and cancer to highlight the diversity of disease-specific phenotypes that can be modeled using iPSC-derived *** also consider how iPSC-derived cellular models can be used in high-throughput drug screening and drug toxicity ***,we discuss the process of developing autologous and allogeneic iPSC-based cell therapies and their potential to alleviate human diseases.

关键词： mechanisms programming holds

Graphitic carbon nitride nanosheets mitigate cadmium toxicity in Glycine max *** promoting cadmium retention in root and improving photosynthetic performance

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Journal of Environmental Sciences 2024年第5期139卷 543-555页

作者： Kai Xu yunyu Guo Chenghua Xing Ronglong Fu Bin Zou Rongchuan Liu Luyi cai Jianfang yan Xi-Lin Wu Miaozhen cai College of Geography and Environmental Sciences Zhejiang Normal UniversityJinhua 321004China College of Agriculture Jinhua PolytechnicJinhua 321007China

Cadmium(Cd)pollution poses a serious threat to plant growth and *** have shown great application potential for alleviation of Cd toxicity to *** this study,we applied graphitic carbon nitride nanosheets(g-C_(3)N_(4)NSs)for alleviation of Cd-toxicity to soybean(Glycine max L.).The g-C_(3)N_(4)NSs supplementation significantly improved plant growth and reduced oxidative damage in the Cd-toxicated soybean seedlings through hydroponic ***,the g-C_(3)N_(4)NSs dynamically regulated the root cell wall(RCW)components by increasing pectin content and modifying its demethylation via enhancing pectin methylesterase(PME)activity,therefore greatly enhanced stronger RCW-Cd retention(up to 82.8%)and reduced Cd migration to the ***,the g-C_(3)N_(4)NSs reversed the Cd-induced chlorosis,increased photosynthetic efficiency because of enhancement in F_v/F_mration,y(Ⅱ)and sugars *** results provide new insights into the alleviation of Cd toxicity to plants by g-C_(3)N_(4)NSs,and shed light on the application of low-cost and environmental-friendly carbon-based NMs for alleviating heavy metal toxicity to plants.

关键词： Cadmium Carbon nitride nanosheets Cell wall Pectin Pectin methylesterase Soybean

Co_(3)O_(4)as an efficient passive NO_(x) adsorber for emission control during cold-start of diesel engines

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Chinese Journal of Chemical Engineering 2024年第2期66卷 1-7页

作者： Jinhuang cai Shijie Hao yun Zhang Xiaomin Wu Zhenguo Li Huawang Zhao Department of Environmental Science&Engineering College of Chemical EngineeringHuaqiao UniversityXiamen 361021China Wuxi Weifu Environmental Catalysts Co. LtdWuxi 214000China National Engineering Laboratory for Mobile Source Emission Control Technology China Automotive Technology&Research Center Co.Ltd.Tianjin 300300China

The Co_(3)O_(4)nanoparticles,dominated by a catalytically active(110)lattice plane,were synthesized as a low-temperature NO_(x) adsorbent to control the cold start emissions from *** nanoparticles boast a substantial quantity of active chemisorbed oxygen and lattice oxygen,which exhibited a NO_(x) uptake capacity commensurate with Pd/SSZ-13 at 100℃.The primary NO_(x) release temperature falls within a temperature range of 200-350℃,making it perfectly suitable for diesel *** characterization results demonstrate that chemisorbed oxygen facilitate nitro/nitrites intermediates formation,contributing to the NO_(x) storage at 100℃,while the nitrites begin to decompose within the 150-200℃***,lattice oxygen likely becomes involved in the activation of nitrites into more stable nitrate within this particular temperature *** concurrent processes of nitrites decomposition and its conversion to nitrates results in a minimal NO_(x) release between the temperatures of 150-200℃.The nitrate formed via lattice oxygen mainly induces the NO_(x) to be released as NO_(2) within a temperature range of 200-350℃,which is advantageous in enhancing the NO_(x) activity of downstream NH_(3)-SCR catalysts,by boosting the fast SCR reaction *** to its low cost,considerable NO_(x) absorption capacity,and optimal release temperature,Co_(3)O_(4)demonstrates potential as an effective material for passive NO_(x) adsorber applications.

关键词： Emission control Cold-start Low-temperature adsorption Co_(3)O_(4) Nitrate formation

GmNF-yC4 delays soybean flowering and maturation by directly repressing GmFT2a and GmFT5a expression

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Journal of Integrative Plant Biology 2024年第7期66卷 1370-1384页

作者： yupeng cai Li Chen Xiaoqian Liu Weiwei yao Wensheng Hou State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Ministry of Agriculture Key Laboratory of Soybean Biology(Beijing) Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Flowering time and growth period are key agronomic traits which directly affect soybean(Glycine max(L.)Merr.)adaptation to diverse latitudes and farming *** FLOWERING LOCUS T(FT)homologs GmFT2a and GmFT5a integrate multiple flowering regulation pathways and significantly advance flowering and maturity in *** the genes responsible for regulating GmFT2a and GmFT5a will improve our understanding of the molecular mechanisms governing growth period in *** this study,we identified the Nuclear Factor y-C(NFy-C)protein GmNF-yC4 as a novel flowering suppressor in soybean under long-day(LD)***-yC4 delays flowering and maturation by directly repressing the expression of GmFT2a and *** addition,we found that a strong selective sweep event occurred in the chromosomal region harboring the GmNF-yC4 gene during soybean *** GmNF-yC4Hap3 allele was mainly found in wild soybean(Glycine soja Siebold&Zucc.)and has been eliminated from *** landraces and improved cultivars,which predominantly contain the GmNF-yC4Hap1 ***,the Gmnf-yc4 mutants displayed notably accelerated flowering and maturation under LD *** alleles may prove to be valuable genetic resources for enhancing soybean adaptability to higher latitudes.

关键词： CRISPR/Cas9 early flowering and maturity GmNF-yC4 regional adaptability soybean

Excess non-COVID-19-related mortality among inflammatory bowel disease decedents during the COVID-19 pandemic

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World Journal of Gastroenterology 2024年第20期30卷 2677-2688页

作者： Sarah Rotondo-Trivette Xin-yuan He Jamil S Samaan Fan Lv emily Truong Michaela Juels Anthony Nguyen Xu Gao Jian Zu yee Hui yeo Fan-Pu Ji Gil y Melmed Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Infectious Disease The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Karsh Division of Gastroenterology and Hepatology Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049Shaanxi ProvinceChina David Geffen School of Medicine University of CaliforniaLos AngelesLos AngelesCA 90095United States Division of Gastroenterology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Key Laboratory of Surgical Critical Care and Life Support(Xi’an Jiaotong University) Ministry of EducationXi’an 710004Shaanxi ProvinceChina

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic disrupted healthcare in the United *** To investigate COVID-19-related and non-COVID-19-related death and characteristics associated with excess death among inflammatory bowel disease(IBD)*** We performed a register-based study using data from the National Vital Statistics System,which reports death data from over 99%of the United States population,from January 1,2006 through December 31,***-related deaths among adults 25 years and older were stratified by age,sex,race/ethnicity,place of death,and primary cause of *** and actual age-standardized mortality rates(ASMRs)per 100000 persons were *** 49782 IBD-related deaths occurred during the study ***-COVID-19-related deaths increased by 13.14%in 2020 and 18.12%in 2021[2020 ASMR:1.55 actual vs 1.37 predicted,95%confidence interval(CI):1.26-1.49;2021 ASMR:1.63 actual vs 1.38 predicted,95%CI:1.26-1.49].In 2020,non-COVID-19-related mortality increased by 17.65%in ulcerative colitis(UC)patients between the ages of 25 and 65 and 36.36%in non-Hispanic black(NHB)Crohn’s disease(CD)*** the pandemic,deaths at home or on arrival and at medical facilities as well as deaths due to neoplasms also *** IBD patients suffered excess non-COVID-19-related death during the *** death was associated with younger age among UC patients,and with NHB race among CD *** death at home or on arrival and due to neoplasms suggests that delayed presentation and difficulty accessing healthcare may have led to increased IBD mortality.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease COVID-19 Excess death Race Sex Disparities

Theoretical understanding of correlation between magnetic phase transition and the superconducting dome in high-Tc cuprates

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 167-173页

作者： Chen Zhang cai-Xin Zhang Su-Huai Wei Haiqing Lin Hui-Xiong Deng State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Computational Science Research Center Beijing 100193China

Many issues concerning the origin of high-temperature superconductivity(HTS)are still under *** example,how the magnetic order varies with doping and its relationship with the superconducting temperature(Tc);and why Tcalways peaks near the quantum critical *** this paper,taking hole-doped La_(2)CuO_(4)as a classical example,we employ the first-principles band structure and total energy calculations with Monte Carlo simulations to explore how the symmetry-breaking magnetic ground state evolves with hole doping and the origin of a dome-shaped superconductivity region in the phase *** demonstrate that the local antiferromagnetic order and doping play key roles in determining the electron-phonon coupling,thus ***,the La_(2)CuO_(4)possesses a checkerboard local antiferromagnetic ground *** the hole doping increases,Tcincreases with the enhanced electron-phonon coupling *** as the doping increases further,the strength of the antiferromagnetic interaction weakens and spin fluctuation *** the critical doping level,a magnetic phase transition occurs that reduces the local antiferromagnetism-assisted electron-phonon coupling,thus diminishing the *** superconductivity disappears in the heavily overdoped region when the ferromagnetic order *** observations could account for why cuprates have a dome-shaped superconductivity region in the phase *** study,thus,contributes to a fundamental understanding of the correlation between doping,local magnetic order,and superconductivity of HTS.

关键词： high-temperature superconductivity antiferromagnetic order electron-phonon coupling doping effect cuprates

Revealing excited states of rotational Bose-Einstein condensates

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The Innovation 2024年第1期5卷 41-48页

作者： Jianyuan yin Zhen Huang yongyong cai Qiang Du Lei Zhang School of Mathematical Sciences Laboratory of Mathematics and Applied MathematicsPeking UniversityBeijing 100871China Department of Mathematics National University of SingaporeSingapore 119076Singapore Department of Mathematics University of CaliforniaBerkeleyBerkeleyCA 94720USA School of Mathematical Sciences Beijing Normal UniversityBeijing 100875China Department of Applied Physics and Applied Mathematics and Data Science Institute Columbia UniversityNew YorkNY 10027USA Beijing International Center for Mathematical Research Center for Quantitative BiologyCenter for Machine Learning ResearchPeking UniversityBeijing 100871China

Rotational Bose-Einstein condensates can exhibit quantized vortices as topological *** this study,the ground and excited states of the rotational Bose-Einstein condensates are systematically studied by calculating the stationary points of the Gross-Pitaevskii energy *** excited states and their connections at different rotational frequencies are revealed in solution landscapes constructed with the constrained high-index saddle dynamics *** excitation mechanisms are identified:vortex addition,rearrangement,merging,and *** demonstrate changes in the ground state with increasing rotational frequencies and decipher the evolution of the stability of ground states.

关键词： method rotational excited

Sigmatropic rearrangements of B(MIDA)-propargylic alcohols towards the diverse synthesis of α-functionalized organoborons

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Science China Chemistry 2024年第2期67卷 568-575页

作者： Jiasheng Qian Li-cai Liu Zhi-Hao Chen yuan Liu yin Li Qingjiang Li Honggen Wang Guangdong Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou510006China

α-Functionalized organoborons are useful building blocks and key structural elements in functional *** previous synthesis relied on the famous Matteson reaction or the late-stage borylative modification of alkynes or ***,the synthetic transformation of borylated building blocks offers another useful strategy and is currently actively *** report herein that B(MIDA)-propargylic alcohols(BPAs) are a useful type of borylated building *** two complementary functional group handles(alkyne and hydroxyl) in close proximity,the redox-neutral [3,3] and [2,3] sigmatropic rearrangements of BPAs allow the efficient synthesis of several types of α-functionalized boronates,including α,β-unsaturated acylborons,α-S/P-substituted allenylborons,boryl-substituted thiazoles and a borylated α,β-unsaturated hydrazine,some of which are otherwise challenging targets using other synthetic methods.

关键词： organoboron diverse synthesis sigmatropic rearrangement heteroarene amide