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Pre-implantation exogenous progesterone and pregnancy in sheep:***,nutrient transport,and progestamedins

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Journal of Animal Science and Biotechnology 2021年第3期12卷 935-951页

作者： emily C.Hoskins Katherine m.Halloran Claire Stenhouse Robyn m.moses Kathrin A.Dunlap michael C.Satterfield Heewon Seo Gregory A.Johnson Guoyao Wu Fuller W.Bazer Departments of Animal Science Texas A&M UniversityCollege StationTX 77843-2471USA Veterinary Integrative Biosciences Texas A&M UniversityCollege StationTX 77843USA

Background:Administration of exogenous progesterone(P4)to ewes during the pre-implantation period advances conceptus development and *** study determined effects of exogenous P4 on transport of select nutrients and pathways that enhance conceptus *** ewes(n=38)were treated with either 25 mg P4 in 1 mL corn oil(P4,n=18)or 1mL corn oil alone(CO,n=20)from day 1.5 through day 8 of pregnancy and hysterectomized on either day 9 or day 12 of *** expression of genes encoding enzymes for synthesis of polyamines,transporters of glucose,arginine,and glycine,as well as progestamedins was determined by ***:On day 12 of pregnancy,conceptuses from P4-treated ewes had elongated while those from CO-treated ewes were *** mRNA expression of AZIN2,an arginine decarboxylase,was lower in endometria of P4-treated than CO-treated ewes on day 9 of *** of FGF10,a progestamedin,was greater in endometria of CO and P4-treated ewes on day 12 of gestation in addition to P4-treated ewes necropsied on day 9 of *** with P4 down-regulated endometrial expression of amino acid transporter SLC1A4 on day 12 of ***:Results indicated that administration of exogenous P4 during the pre-implantation period advanced the expression of FGF10,which may accelerate proliferation of trophectoderm cells,but also was correlated with decreased expression of glycine and serine transporters and polyamine synthesis enzyme *** research with increased sample sizes may determine how differential expression affects endometrial functions and potentially embryonic loss.

关键词： Amino acid Endometrium Gene expression Polyamine Progesterone

Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease

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作者： emily Jane Fox.

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 139-144页

作者： Rui Guo emily C Liong Kwok Fai So man-Lung Fung George L Tipoe Departments of Anatomy Li Ka Shing Faculty of medicine The University of Hong Kong Physiology Li Ka Shing Faculty of MedicineThe University of Hong Kong

BACKGROUND：Non-alcoholic fatty liver disease（NAFLD）refers to any fatty liver disease that is not due to excessive use of *** probably results from abnormal hepatic lipid metabolism and insulin *** exercise is shown to improve *** review aimed to evaluate the molecular mechanisms involved in the beneficial effects of aerobic exercise on *** SOURCE：We searched articles in English on the role of aerobic exercise in NAFLD therapy in Pub ***： The mechanisms of chronic aerobic exercise in regulating the outcome of NAFLD include：（i） reducing in- trahepatic fat content by down-regulating sterol regulatory element-binding protein-lc and up-regulating peroxisome proliferator-activated receptor y expression levels; （ii） decreas- ing hepatic oxidative stress through modulating the reactive oxygen species, and enhancing antioxidant enzymes such as catalase and glutathione peroxidase; （iii） ameliorating hepatic inflammation via the inhibition of pro-inflammatory media- tors such as tumor necrosis factor-alpha and interleukin-1 beta; （iv） attenuating mitochondrial dependent apoptosis by reducing cytochrome C released from the mitochondria to the cytosol; and （v） inducing hepato-protective autophagy. CONCLUSION： Aerobic exercise, via different mechanisms, significantly decreases the fat content of the liver and improves the outcomes of patients with NAFLD.

关键词： non-alcoholic fatty liver disease chronic aerobic exercise oxidative stress inflammation apoptosis autophagy

Efficient Gene Targeting in maize Using Inducible CRISPR-Cas9 and marker-free Donor Template

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molecular Plant 2020年第8期13卷 1219-1227页

作者： Pierluigi Barone emily Wu Brian Lenderts Ajith Anand William Gordon-Kamm Sergei Svitashev Sandeep Kumar Corteva AgriscienceTm JohnstonIA 50131USA

CRISPR-Cas9 is a powerful tool for generating targeted mutations and genomic ***,precise gene insertion or sequence replacement remains a major hurdle before application of CRISPR-Cas9 technology is fully realized in plant ***,we report high-frequency,selectable marker-free intra-genomic gene targeting(GT)in *** shock-inducible Cas9 was used for generating targeted double-strand breaks and simultaneous mobilization of the donor template from pre-integratad *** construct was designed such that release of the donor template and subsequent DNA repair activated expression of the selectable marker gene within the donor *** approach generated up to 4.7%targeted insertion of the donor sequence into the target locus in TO plants,with up to 86%detected donor template release and 99%mutation rate being observed at the donor loci and the genomic target site,*** previous in planta or intra-genomic homologous recombination reports in which the original chimeric GT plants required extensive progeny screening in the next generation to identify non-chimeric GT individuals,our method provides non-chimeric heritable GT in one generation.

关键词： donor template insertion

Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta

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Bone Research 2015年第1期3卷 40-45页

作者： Douglas J DiGirolamo Vandana Singhal Xiaoli Chang Se-Jin Lee emily L Germain-Lee Department of Orthopaedic Surgery Johns Hopkins University School of Medicine Bone & Osteogenesis Imperfecta Department Kennedy Krieger Institute Department of molecular Biology and Genetics Johns Hopkins University School of Medicine Department of Pediatrics Johns Hopkins University School of Medicine

Osteogenesis imperfecta（OI） comprises a group of heritable connective tissue disorders generally defined by recurrent fractures, low bone mass, short stature and skeletal fragility. Beyond the skeletal complications of OI,many patients also report intolerance to physical activity, fatigue and muscle weakness. Indeed, recent studies have demonstrated that skeletal muscle is also negatively affected by OI, both directly and indirectly. Given the well-established interdependence of bone and skeletal muscle in both physiology and pathophysiology and the observations of skeletal muscle pathology in patients with OI, we investigated the therapeutic potential of simultaneous anabolic targeting of both bone and skeletal muscle using a soluble activin receptor 2B（ACVR2B） in a mouse model of type Ⅲ OI（oim）. Treatment of 12-week-old oim mice with ACVR2 B for 4 weeks resulted in significant increases in both bone and muscle that were similar to those observed in healthy,wild-type littermates. This proof of concept study provides encouraging evidence for a holistic approach to treating the deleterious consequences of OI in the musculoskeletal system.

关键词： bone Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta

Health Emergency and Disaster Risk management (Health-EDRm) in Remote Ethnic minority Areas of Rural China:The Case of a Flood-Prone Village in Sichuan

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International Journal of Disaster Risk Science 2017年第2期8卷 156-163页

作者： emily Ying Yang Chan Chunlan Guo Poyi Lee Sida Liu Carman Ka man mark Collaborating Centre for Oxford University and CUHK for Disaster and medical Humanitarian Response (CCOUC) The Jockey Club School of Public Health and Primary CareThe Chinese University of Hong Kong Nuffield Department of medicine University of Oxford FXB Centre of Health and Human Rights Harvard University

Remote,rural ethnic-minority communities face greater disaster-related public health risks due to their lack of resources and limited access to health *** Ethnic minority Health Project(EmHP) was initiated in 2009 to work with remote,disaster-prone ethnic-minority villages that live in extreme *** of the project's aims is to develop and evaluate bottom-up health risk reduction efforts in emergency and disaster risk management(HealthEDRm).This article shares project updates and describes field intervention results from the Yi ethnic community of Hongyan village in China's Sichuan Province,an area that experiences recurrent *** was found that 64% of the village respondents had never considered any form of disaster preparation,even with the recurrent flood *** intervention participants showed sustained knowledge retention and were nine times more likely to know the correct composition of oral rehydration solution(ORS) after the *** also retained the improved knowledge on ORS and disaster preparedness kit ownership12 months after the intervention.

关键词： Disaster preparedness kit Disaster risk reduction Ethnic minority Health emergency and disaster risk management (Health-EDRm) Oral rehydration solution Recurrent floods Rural China

Pregnancy in Patients with Shone Complex: A Single-Center Case Series

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Congenital Heart Disease 2022年第2期17卷 147-160页

作者： Rachel Gardner emily Durbak Rachael Baird Katherine Singh Jeff Chapa David majdalany Department of Cardiology Cleveland ClinicCleveland44195USA Department of Obstetrics Cleveland ClinicCleveland44195USA Department of Cardiology Mayo ClinicPhoenix85054USA

Background:There is limited literature written on the course and outcomes for pregnant mothers with Shone ***:We describe a case series of five pregnancies in four women with Shone complex within a multidisciplinary cardio-obstetrics clinic from 2016–***:maternal age ranged from 21–39 *** patients had preserved left ventricular function while one had moderately decreased *** age at presentation ranged from 6–15 *** were three successful pregnancies(mean gestational age=37 weeks,range 35–39 weeks)with one patient accounting for two unsuccessful *** infants were delivered via Cesarean *** infant required a NICU stay,but all other infants delivered were ***:Patients with Shone complex can have successful pregnancies although complications can occur for both the mother and the *** prenatal care,coordinated and consistent management during pregnancy,and tertiary care support can promote positive maternal and fetal outcomes.

关键词： Shone complex pregnancy cardiac disease in pregnancy women’s cardiovascular health

Solid phase microextraction(SPmE) sampling under turbulent conditions and for the simultaneous collecting of tracer gases

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International Journal of mining Science and Technology 2015年第4期25卷 559-563页

作者： Underwood Susanne W. Jong Edmund C. Luxbacher Kray D. Sarver emily A. Ripepi Nino S. mc Nair Harold m. Department of mining and minerals Engineering Virginia Tech Department of Chemistry Virginia Tech

Solid phase microextraction （SPmE） is a solvent-flee method of sample collection. SPmE is an appealing method for sample collection because it is designed for the sampling of trace level analytes with short sampling times in a variety of environments. Additionally, SPmE can be used to directly deliver a sample to a gas chromatograph （GC） for analysis by means of thermal desorption. In this paper, the performance of SPmE under dynamic conditions was investigated. Additionally, the competence of SPmE sampling for the simultaneous analysis of multiple trace analytes was also evaluated. This work is discussed in the context of underground mine ventilation surveys but is applicable to any industry in which ventilation circuits must be evaluated. The results of this paper showed that the performance of the 100 ~m PDmS SPmE fiber was both precise and rapid under dynamic conditions. This SPmE fiber was also able to simultaneously collect sulfur hexafluoride （SF6） and perfluoromethylcyclohexane （PmCH） with adequate sensitivity.

关键词： Solid phase microextraction Sulfur hexafluoride Perfluoromethylcyclohexane Tracer gas mine ventilation Air sampling

Laparoscopic liver resection for colorectal liver metastases—shortand long-term outcomes:A systematic review

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World Journal of Gastrointestinal Oncology 2021年第7期13卷 732-757页

作者： emily Taillieu Celine De meyere Frederiek Nuytens Chris Verslype mathieu D'Hondt Department of Digestive and Hepatobiliary/Pancreatic Surgery AZ GroeningeKortrijk 8500Belgium Department of Gastroenterology and Hepatology KU LeuvenLeuven 3000Belgium

BACKGROUND For well-selected patients and procedures,laparoscopic liver resection(LLR)has become the gold standard for the treatment of colorectal liver metastases(CRLm)when performed in specialized ***,little is currently known concerning patient-related and peri-operative factors that could play a role in survival outcomes associated with LLR for *** To provide an extensive summary of reported outcomes and prognostic factors associated with LLR for *** A systematic search was performed in Pubmed,EmBASE,Web of Science and the Cochrane Library using the keywords“colorectal liver metastases”,“laparoscopy”,“liver resection”,“prognostic factors”,“outcomes”and“survival”.Only publications written in English and published until December 2019 were ***,abstracts of which no accompanying full text was published,reviews,case reports,letters,protocols,comments,surveys and animal studies were *** search results were saved to Endnote Online and imported in Rayyan for systematic *** of interest were extracted from the included publications and tabulated for qualitative *** Out of 1064 articles retrieved by means of a systematic and grey literature search,77 were included for qualitative ***-two research papers provided data concerning outcomes of LLR for *** papers were eligible for extraction of data concerning prognostic factors affecting survival *** analysis of the collected data showed that LLR for CRLm is safe,feasible and provides oncological *** research groups have reported on the short-term advantages of LLR compared to open *** obtained results accounted for minor LLR,as well as major LLR,simultaneous laparoscopic colorectal and liver resection,LLR of posterosuperior segments,twostage hepatectomy and repeat LLR for *** research groups so far have studied prognostic factors affecting long-term outcomes of LLR for ***

关键词： Laparoscopic liver resection Colorectal liver metastases Outcomes Prognostic factors Systematic review