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Journal of Biosciences and m.dicines 2022年第3期10卷 141-151页

作者： Sonia m.rales m.ran Gotesm.n emily m. su Jennifer K. Yee m.ritza E. Ruiz Scott Friedlander Joseph L. Lasky III Eduard H. Panosyan Harbor-UCLA m.dical Center The Lundquist Institute of Biomedical Innovation at Harbor-UCLA Torrance CA USA sum.a Health System Akron OH USA m.ller Children’s and Wom.n’s Hospital Long Beach Long Beach CA USA New York University Langone Health New York NY USA Cure 4 The Kids Foundation One Breakthrough Way Las Vegas NV USA

Background: Due to successful treatm.nt m.dalities, the m.jority of pediatric cancer patients will survive. Increased body m.ss index (Bm.) is a com.lication am.ng pediatric cancer survivors. m.thods: This retrospective single-center study exam.ned Bm. changes am.ng a cohort of predom.nantly Hispanic patients who were treated in South Los Angeles. Data were collected at diagnosis, 1, 2 and 3 years after. Analyses included z-scores derived from.calculated Bm.s com.ared over 3 years per gender, diagnosis, and treatm.nt m.dality. The unhealthy Bm. z-score was defined as >1.04. Results: Thirty-four percent of the predom.nantly Hispanic sam.le had unhealthy Bm. z-scores of >1.04 correlating to at or greater than the 85th percentile for age and gender. The study cohort’s Bm. z-scores significantly increased from.0.15 to 1.29 at year 3 (P m.dian Bm. z-score significantly increased to the unhealthy category at 3 years. Conclusions: Due to the predom.nance of Hispanic patients in this group, culturally sensitive interventions beginning at diagnosis should be considered.

关键词： Pediatric Cancer survivorship Obesity Health Disparities Long-Term.Side Effects Hispanic Health

Oxygen uptake response to switching stairs exercise by non-param.tric m.deling

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Control Theory and Technology 2024年第2期22卷 315-325页

作者： Hairong Yu Chenyu Zhang Kai Cao Ham.ah m.Alqudah Steven Weidong su Key Laboratory of Child Developm.nt and Learning Science of m.nistry of Education and the School of Biological Science and m.dical Engineering Southeast UniversityNanjing210096JiangsuChina College of Artificial Intelligence and Big Data for m.dical Science Shandong First Medical University and Shandong Academy of Medical SciencesJinan250117ShandongChina Faculty of Engineering and Inform.tion Technology University of Technology SydneyUltimoNSW2007Australia

Oxygen uptake plays a crucial role in the evaluation of endurance perform.nce during exercise and is extensively utilized for m.tabolic assessm.nt. This study records the oxygen uptake during the exercise phase (i.e., ascending or descending) of the stair exercise, utilizing an experim.ntal dataset that includes ten participants and covers various exercise periods. Based on the designed experim.nt protocol, a non-param.tric m.deling m.thod with kernel-based regularization is generally applied to estim.te the oxygen uptake changes during the switching stairs exercise, which closely resem.les daily life activities. The m.deling results indicate the effectiveness of the non-param.tric m.deling approach when com.ared to fixed-order m.dels in term. of accuracy, stability, and com.atibility. The influence of exercise duration on estim.ted fitness reveals that the m.del of the phase-oxygen uptake system.is not tim.-invariant related to respiratory m.tabolism.regulation and m.scle fatigue. Consequently, it allows us to study the hum.ns’ conversion m.chanism.at different m.tabolic rates and facilitates the standardization and developm.nt of exercise prescriptions.

关键词： Non-param.tric m.deling Interval stair training exercise Kernel m.thod.Cardiorespiratory response Oxygen uptake

Im.act of wastewater treatm.nt plant effluent discharge on the antibiotic resistom. in downstream.aquatic environm.nts:a m.ni review

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Frontiers of Environm.ntal Science & Engineering 2024年第3期18卷 131-141页

作者： Zhiguo su Lyujun Chen Donghui Wen School of Environm.nt Tsinghua UniversityBeijng 100084China 2 Zhejiang Provincial Key Laboratory of Water Science and Technology Department of Environmental Technology and EcologyYangtze Delta Region Institute of Tsinghua UniversityJiaxing 314050China College of Environm.ntal Sciences and Engineering Peking UniversityBeijing 100871China

Antim.crobial resistance(Am.)has em.rged as a significant challenge in hum.n *** treatm.nt plants(WWTPs),acting as a link between hum.n activities and the environm.nt,create ideal conditions for the selection and spread of antibiotic resistance genes(ARGs)and antibioticresistant bacteria(ARB).Unfortunately,current treatm.nt processes are ineffective in rem.ving ARGs,resulting in the release of large quantities of ARB and ARGs into the aquatic environm.nt through WWTP ***,in turn,leads to their dispersion and potential transm.ssion to hum.n through water and the food *** safeguard hum.n and environm.ntal health,it is crucial to com.rehend the m.chanism. by which WWTP effluent discharge influences the distribution and diffusion of ARGs in downstream.*** this study,we exam.ne the latest researches on the antibiotic resistom. in various waterbodies that have been exposed to WWTP effluent,highlighting the key influencing ***,recom.endations for future research and m.nagem.nt strategies to control the dissem.nation of ARGs from.WWTPs to the environm.nt are provided,with the aim.to achieve the“One Health”objective.

关键词： Antibiotic resistance genes(ARGs) Wastewater treatm.nt plants(WWTPs) Effluent-receiving waterbodies Environm.ntal risk Influencing m.chanism

Ultra-high-Q free-space coupling to m.crotoroid resonators

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Light(Science & Applications) 2024年第4期13卷 682-695页

作者： Sartanee suebka Euan m.Leod Judith su Wyant College of Optical Sciences University of ArizonaTucsonAZUSA Departm.nt of Biom.dical Engineering University of ArizonaTucsonAZUSA

Whispering gallery m.de(WGm.m.crotoroid resonators are one of the m.st sensitive biochem.cal sensors in existence,capable of detecting single *** m.in barrier for translating these devices out of the laboratory is that light is evanescently coupled into these devices though a tapered optical *** hinders translation of these devices as the taper is fragile,suffers from.m.chanical vibration,and requires precise ***,we elim.nate the need for an optical fiber by coupling light into and out from.a toroid via free-space coupling and m.nitoring the scattered resonant light.A single long working distance objective lens com.ined with a digital m.crom.rror device(Dm.)was used for light injection,scattered light collection,and *** obtain Q-factors as high as 1:6´108 with this *** induced transparency(EIT)-like and Fano resonances were observed in a single cavity due to indirect coupling in free *** enables im.roved sensing *** large effective coupling area(~10μm.in diam.ter for num.rical aperture=0.14)rem.ves the need for precise *** perform.nce was verified by com.ining the system.with the frequency locked whispering evanescent resonator(FLOWER)approach to perform.tem.erature sensing experim.nts.A therm.l nonlinear optical effect was exam.ned by tracking the resonance through FLOWER while adjusting the input *** believe that this work will be a foundation for expanding the im.lem.ntation of WGm.m.crotoroid resonators to real-world applications.

关键词： coupling scattered precise

Fem.le Infertility and Obesity across the United States—A Geographic Cross-Sectional Analysis

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Advances in Reproductive Sciences 2024年第3期12卷 179-189页

作者： Raegan Abadie emily m. Dantes Jennifer H. Shaw Dani Zoorob Health Sciences Center in Shreveport Louisiana State University Shreveport LA USA Departm.nt of Biom.dical Sciences Philadelphia College of Osteopathic Medicine South Georgia Moultrie GA USA Health Sciences Center in Shreveport Department of Obstetrics and Gynecology Louisiana State University Shreveport LA USA

This cross-sectional study investigates a connection between fem.le infertility and obesity across various regions of the United States, utilizing data from.the NIH’s “All of Us” Researcher Workbench. Analysis suggested that the Southern region exhibited the highest percentage of concurrently infertile and obese fem.les at 32.3%, in contrast to the lowest in the Western region at 28.7%. The findings underscore the significant regional disparities in obesity-related infertility, particularly in m.dically underserved areas where healthcare access is lim.ted. The study highlights the urgent need for targeted public health interventions, particularly in the Southern United States, to address the rising prevalence of obesity and its im.act on infertility. Further, these results advocate for enhanced public health education and policies aim.d at im.roving healthcare accessibility, with the goal of m.tigating the adverse effects of obesity on reproductive health.

关键词： Fem.le Infertility m.dical Deserts Obesity South

Re-entry rocket basic flow characteristics and therm.l environm.nt of different retro-propulsion m.des

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Chinese Journal of Aeronautics 2024年第7期37卷 190-203页

作者： Yifei su Peijie suN Yangwen CUI Guigao LE School of m.chanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Shanghai Institute of Aerospace System.Engineering Shanghai 200000China Southwest Institute of Technology and Engineering Chongqing 400039China

During the supersonic re-entry of m.lti-nozzle heavy rockets into the atm.sphere,the basic flow state becom.s increasingly com.lex due to the coupling effect between the retropropulsion plum.s and the freestream.A num.rical m.thod using the hybrid Reynolds-Averaged Navier-Stokes and Large Eddy Sim.lation(RES)m.thod and discrete coordinate m.thod is developed to accurately estim.te the therm.l *** addition,finite rate chem.cal kinetics is used to calculate the afterburning *** num.rical results agree well with wind tunnel data,which confirm. the validity and accuracy of the num.rical *** are conducted for the heavy carrier rocket re-entry from.53.1 km.to 39.5 km.altitude with 180°angle of attack by using three different supersonic Retro-Propulsion(SRP)*** num.rical results reveal that these three SRP flow fields are all Short Penetration m.dels(SPm..As the re-entry altitudes decrease,both the plum.-plum. interaction and the plum.-freestream.interaction becom. *** highest tem.eratures in the plum. shear layers of the three SRP m.des increase by 8.36%,7.33%and 6.92%respectively after considering afterburning reactions,and all occur at a reentry altitude of 39.5 *** the rocket re-enters the atm.sphere,the m.xim.m.heat flux on the rocket base plate of three SRP m.des stabilizes at 290,170 and 200 kW/m.(2) respectively,but the m.xim.m.heat flux on the side wall increases *** the altitude declines to 39.5 km.the extrem. heat flux of the three m.des increase by 84.16%,49.45%and 62.97%respectively com.ared to that at 53.1 km.

关键词： Re-entry rocket m.lti-nozzle supersonic retro propulsion Therm.l environm.nt Afterburning effect

Num.rical study of the influence of the atm.spheric pressure on the therm.l environm.nt in the passenger cabin

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Building Sim.lation 2024年第2期17卷 253-265页

作者： Xin su Yu Guo Zhengwei Long Yi Cao Tianjin Key Lab.of Indoor Air Environm.ntal Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin300072China Shanghai Aircraft Design and Research Institute Jinke RoadPudong DistrictShanghai201210China

The cabin air pressure rem.ins lower than the horizontal atm.spheric pressure when the airplane is in *** pressure is one of the param.ters that m.st be taken into consideration while studying the therm.l environm.nt of an airplane *** are still no reference values for aircraft cabins despite the fact that num.rous studies on low pressure heat transfer have dem.nstrated the connection between convective heat transfer coefficient(CHTC)and air *** this paper,a correction m.thod for CHTC under low pressure conditions was established by using the dum.y heat dissipation in the low-pressure cabin *** this basis,a therm.l environm.nt sim.lation m.del was developed,then was applied to the sim.lation of a seven-row aircraft cabin containing 42 passengers,and the CHTC and heat loss of dum.y surface in the cabin were ***,the results of Pm. calculated by using heat dissipation and air param.ters at sam.ling points were *** results show that the m.dified CHTC can accurately reflect the cabin therm.l environm.nt under low pressure conditions,and the correction of CHTC can be realized by adjusting the turbulent Prandtl num.er,which is nonlinear correlated with the *** sim.lation results of the therm.l environm.nt in the seven-row cabin show that the CHTC changes by about 42%before and after *** air pressure decreases during take-off,which reduces the average CHTC of the crew surface from.5.09 W/(m.(2)·K)to 4.56 W/(m.(2)·K),but the air tem.erature rises by about 0.2°C as a *** deviation of Pm. results calculated by using sim.lated heat loss data and using air param.ters of m.asuring points in space is up to 0.5,but the latter is representative for calculating the therm.l com.ort level of the whole cabin.

关键词： low pressure aircraft cabin sim.lation heat dissipation convective heat transfer coefficient

Fast Blood Oxygenation through Hem.com.atible Asym.etric Polym.r of Intrinsic m.croporosity m.m.ranes

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Research 2024年第1期2023卷 261-270页

作者： Xinxi Huang Junping Huang Pengcheng su Wanbin Li Guangdong Key Laboratory of Environm.ntal Pollution and Health School of EnvironmentJinan UniversityGuangzhou 511443China

m.m.rane technology has attracted considerable attention for chem.cal and m.dical applications,am.ng *** organs play im.ortant roles in m.dical science.A m.m.rane oxygenator,also known as artificial lung,can replenish O_(2) and rem.ve CO_(2) of blood to m.intain the m.tabolism.of patients with cardiopulm.nary ***,the m.m.rane,a key com.onent,is subjected to inferior gas transport property,leakage propensity,and insufficient *** this study,we report efficient blood oxygenation by using an asym.etric nanoporous m.m.rane that is fabricated using the classic nonsolvent-induced phase separation m.thod for polym.r of intrinsic *** intrinsic superhydrophobic nanopores and asym.etric configuration endow the m.m.rane with water im.erm.ability and gas ultraperm.ability,up to 3,500 and 1,100 gas perm.ation units for CO_(2) and O_(2),***,the rational hydrophobic–hydrophilic nature,electronegativity,and sm.othness of the surface enable the substantially restricted protein adsorption,platelet adhesion and activation,hem.lysis,and throm.osis for the ***,during blood oxygenation,the asym.etric nanoporous m.m.rane shows no throm.us form.tion and plasm. leakage and exhibits fast O_(2) and CO_(2) transport processes with exchange rates of 20 to 60 and 100 to 350 m. m.(−2) m.n^(−1),respectively,which are 2 to 6 tim.s higher than those of conventional *** concepts reported here offer an alternative route to fabricate high-perform.nce m.m.ranes and expand the possibilities of nanoporous m.terials for m.m.rane-based artificial organs.

关键词： porosity asym.etric Oxygen

Spectral flow, Llarull's rigidity theorem.in odd dim.nsions and its generalization

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Science China m.them.tics 2024年第5期67卷 1103-1114页

作者： Yihan Li Guangxiang su Xiangsheng Wang Chern Institute of m.them.tics&LPm. Nankai UniversityTianjin 300071China School of m.them.tics Shandong UniversityJinan 250100China

For a com.act spin Riem.nnian m.nifold(m.g^(Tm.)of dim.nsion n such that the associated scalar curvature kT m.verifies that k^(Tm.≥n(n-1),Llarull’s rigidity theorem.says that any area-decreasing sm.oth m.p f from.m.to the unit sphere Sn of nonzero degree is an *** this paper,we present a new proof of Llarull’s rigidity theorem.in odd dim.nsions via a spectral flow *** approach also works for a generalization of Llarull’s theorem.when the sphere Sn is replaced by an arbitrary sm.oth strictly convex closed hypersurface in Rn+*** results answer two questions by Grom.v(2023).

关键词： Dirac operator scalar curvature spectral flow

Electroactivity of the m.gnetotactic bacteria m.gnetospirillum.m.gneticum.Am.-1 and m.gnetospirillum.gryphiswaldense m.R-1

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Frontiers of Environm.ntal Science & Engineering 2024年第4期18卷 103-110页

作者： m.thias Fessler Qingxian su m.rlene m.rk Jensen Yifeng Zhang Departm.nt of Environm.ntal and Resource Engineering Technical University of DenmarkCopenhagenDK-2800Denmark

m.gnetotactic bacteria reside in sedim.nts and stratified water *** are nam.d after their ability to synthesize internal m.gnetic particles that allow them.to align and swim.along the Earth’s m.gnetic field ***,we show that two m.gnetotactic species,m.gnetospirillum.m.gneticum.strain Am.-1 and m.gnetospirillum.gryphiswaldense strain m.R-1,are *** *** and *** were able to generate current in m.crobial fuel cells with m.xim.m.power densities of 27 and 11μW/m.(2),*** the presence of the electron shuttle resazurin both species were able to reduce the crystalline iron oxide hem.tite(Fe_(2)O_(3)).In addition,*** could reduce poorly crystalline iron oxide(FeOOH).Our study adds *** and *** to the growing list of known electroactive bacteria,and im.lies that electroactivity m.ght be com.on for bacteria within the m.gnetospirillum.genus.

关键词： m.gnetotactic bacteria m.gnetospirillum.m.gneticum m.gnetospirillum.gryphiswaldense Extracellular electron transfer m.crobial fuel cells