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Climate-driven variations in productivity reveal adaptive strategies in Iberian cork oak agroforestry systems

Forest Ecosystems 2022年第1期9卷 83-93页

作者： José Carlos Pérez-Girón emilio Rafael Díaz-Varela Pedro Álvarez-Álvarez Department of Organisms and Systems Biology Polytechnic School of MieresUniversity of OviedoE-33600MieresAsturiasSpain Research Group on Planning and Management in Complex Adaptive Socio-Ecological Systems(COMPASSES).School of Engineering University of Santiago de CompostelaE-27002LugoSpain

Background:Cork oak agroforestry systems(AFS)have been managed for centuries by humans to produce cork and other goods and services and have recently been recognised as an important reservoir for biodiversity improvement and ***,despite having recently been included as a natural habitat of community-wide interest within the EU Habitats Directive,these systems are in a critical situation of *** other factors,they are strongly threatened by climate change,the effects of which are also expected to be particularly severe in the Mediterranean *** this study,we aimed to evaluate the influence of climate variability by examining primary production indicators and also to analyse whether the geographical location may have a role in the incidence of the adverse effects of ***:Cork oak AFS were identified in the Forest Map of Spain and the Land use map of Portugal and categorized on the basis of canopy *** climate data from 2001 to 2020 were used to model relationships with climate predictors and proximity to the *** analysis was conducted to identify significant spatial clusters of high-and low-efficiency ***:The responses to the influence of climatic conditions differed among the various cork oak AFS categories,particularly in the forest category,which was less dependent on climate *** humidity and water availability were the main drivers of net primary production(NPP).Carbon use efficiency(CUE)was limited by relative humidity and spring temperature in open *** to the coast proved beneficial,especially in years with adverse weather conditions,but was not a limiting factor for survival of the ***,the results of the hotspot analysis supported the other findings,highlighting high-efficiency areas close to the coast and cold spots grouped in specific areas or dispersed ***:Canopy plays a key role in the influence of climatic conditions,particu

关键词： Net primary production Carbon use efficiency Climate Quercus suber Agroforestry system

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Simulation Architecture for Modelling Interaction Between User and Elbow-articulated Exoskeleton

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Journal of Bionic Engineering 2017年第4期14卷 706-715页

作者： Bas J. de Kruif emilio Schmidhauser Konrad S. Stadler Leonard W. O'Sullivan School of Design & Health Research Institute University of Limerick Limerick Ireland Netherlands Organisation for Applied Scientific Research Equipment for Additive Manufacturing 5600 HE Eindhoven The Netherlands Zurich University of Applied Sciences School of Engineering 8401 CH Winterthur Switzerland

The aim of our work is to improve the existing user-exoskeleton models by introducing a simulation architecture that can simulate its dynamic interaction, thereby altering the initial motion of the user. A simulation architecture is developed that uses the musculoskeletal models from OpenSim, and that implements an exoskeleton control algorithm and human response model in Matlab. The musculoskeletal models need to be extended with the response of a user to external forces to simulate the dy- namic interaction. A set of experiments was performed to fit this response model. A validation test showed that more than 80% of the variance of the motion could be explained. With the human response model in the combined simulation architecture, a simulation in which an object connects with the exoskeleton or with the human is performed. The effect of the exoskeleton on, among others, muscle excitation and altered motion can be assessed with this architecture. Our work can be used to better predict the effect an exoskeleton has on the user.

关键词： human-exoskeleton modelling human response modelling exoskeleton musculoskeletal system exoskeletondesign

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Sex and season explain spleen weight variation in the Egyptian mongoose

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Current Zoology 2019年第1期65卷 11-20页

作者： Victor BANDEIRA emilio Virgos Alexandre AZEVEDO Joao Carvalho Monica V. CUNHA Carlos Fonseca Dartment of Biology Centro de Estudos do Ambiente e do Mar (CESAM) University of Aveiro Campus Universitario de Santiago Aveiro 3810-193 Portugal Departamento de Biologia Geologia Fisica y Qufmica Inorganica Area Biodiversidad y Conservacion Escuela Superior de Ciencias Experimentales y Tecnologia (ESCET) Universidad Rey Juan Carlos c/Tulipan s/n Mostoles Madrid E-28933 Spain Leibniz Institute for Zoo and Wildlife Research Alfred-Kowalke-Straβe 17 Berlin 10315 Germany Instituto de Ciencias Biomedicas Abel Salazar R. Jorge de Viterbo Ferreira 228 Porto 4050-313 Portugal Instituto Nacional de Investigaqao Agraria e Veterinaria (INIAV) IP-National Institute for Agrarian and Veterinary Research Rua dos Lagidos Lugar da Madalena Vairao 4485-655 Portugal cE3c-Centre for Ecology Evolution and Environmental Changes Faculdade de Ciencias Universidade de Lisboa Lisboa 1749-016 Portugal BiolSI-Biosystems & Integrative Sciences Institute Faculdade de Ciencias Universidade de Lisboa Lisboa 1749-016 Portugal Wildlife Ecology & Health group (WE&H) and Servei d'Ecopatologia de Fauna Salvatge (SEFaS) Departament de Medicina i Cirurgia Animals Universitat Autonoma de Barcelona 08193-Bellaterra Barcelona Spain

The Egyptia n mon goose (Herpestes ichneumon Linn aeus, 1758) is a medium-sized car nivore that experienced remarkable geographic expansion over the last 3 decades in the Iberian Peninsula. In this study, we investigated the association of species-related and abiotic factors with spleen weight (as a proxy for immunocompete nee) in the species. We assessed the relationship of body con dition, sex, age, seas on, and envir onmental conditi ons with splee n weight established for 508 hunted specimens. Our results indicate that the effects of sex and season outweigh those of all other variables, including body condition. Spleen weight is higher in males than in females, and heavier spleens are more likely to be found in spring, coinciding with the highest period of investment in reproduction due to mating, gestation, birth, and lactation. Coupled with the absence of an effect of body condition, our findi ngs suggest that splee n weight variation in this species is mostly influe need by lifehistory traits linked to reproduction, rather than overall energy availability, winter immunoenhancement, or energy partitioning effects, and prompt further research focusing on this topic.

关键词： body condition carnivore Herpestes ichneumon Iberian Peninsula mongoose spleen weight

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Development of an HPLC–UV assay method for the simultaneous quantification of nine antiretroviral agents in the plasma of HIV-infected patients

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Journal of Pharmaceutical Analysis 2016年第6期6卷 396-403页

作者： Nitin Charbe Sara Baldelli Valeria Cozzi Simone Castoldi Dario Cattaneo emilio Clementi Unit of Clinical Pharmacology Department of Biomedical and Clinical Sciences L. Sacco University Hospital Università di Milano 20157 Milan Italy Clinical Pharmacology Unit CNR Institute of Neuroscience Department of Biomedical and Clinical Sciences L. Sacco University Hospital Università di Milano 20157 Milan Italy Scientific Institute IRCCS Eugenio Medea Bosisio Parini Italy

A new method using high-performance liquid chromatography coupled with ultra violet detection(HPLC–UV)was developed and validated for the simultaneous quantification of atazanavir,dolutegravir,darunavir,efavirenz,etravirine lopinavir,raltegravir,rilpivirine and tipranavir in human *** the first time we reported here the development and validation of an HPLC–UV assay to quantify the frequently administered 9antiretroviral compounds including dolutegravir and rilpivirine.A simple solid phase extraction procedure was applied to 500 μL aliquots of *** chromatographic separation of the drugs and internal standard(quinoxaline) was achieved with a gradient of acetonitrile and sodium acetate buffer on a C_(18) reverse-phase analytical column with a 25 min analytical run *** curves were optimised according to the therapeutic range of drug concentrations in patients,and the coefficient of determination(r^2) was higher than0.99 for all *** intraday and interday precisions(RSD) for all compounds were less than 15.0%,and the mean accuracy(% deviation from nominal concentration) was also found to be less than 15.0%.Extraction recovery range was between 80% and 120% for all drugs *** solid phase extraction and HPLC–UV method enable a specific,sensitive,and reliable simultaneous determination of nine antiretroviral agents in *** extraction efficiency and low limit of HPLC–UV quantification make this method suitable for use in clinical trials and therapeutic drug monitoring.

关键词： HPLC–UV Antiretrovirals Bioanalytical method validation

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Eosinophil cationic protein in Henoch-Schönlein purpura

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世界儿科杂志:英文版 2014年第1期10卷 90-91页

作者： Castellazzi Massimo Luca Emanuela Anna Laicini emilio F Fossali Pediatric Emergency Department Foundation IRCCS Ca'Granda Ospedale Maggiore PoliclinicoVia Commenda 9MilanItaly

Henoch-Schönlein purpura,the most common childhood vasculitis,is often a self-limiting condition,with resolution within 2-8 *** 20%-40%of the patients develop a renal involvement.[1]Eosinophil cationic protein is a secretory ribonuclease which has been associated with cytotoxic,neurotoxic,fibrosis promotion and immuneregulatory functions and has been implicated in various disease conditions.[2]This study was undertaken to clarify a possible role of eosinophil cationic protein in Italian children with Henoch-Schönlein purpura.

关键词： eosinophil cationic protein possible role

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Road Pricing Design Based on Game Theory and Multi-agent Consensus

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IEEE/CAA Journal of Automatica Sinica 2014年第1期1卷 31-39页

作者： Nan Xiao Xuehe Wang Lihua Xie Tichakorn Wongpiromsarn emilio Frazzoli Daniela Rus the Singapore-MIT Alliance for Research and Technology Centre the EXQUISITUS Centre for ECity School of Electrical and Electronic Engineering Nanyang Technological University the Ministry of Science and Technology the Massachusetts Institute of Technology

Consensus theory and noncooperative game theory respectively deal with cooperative and noncooperative interactions among multiple players/agents. They provide a natural framework for road pricing design, since each motorist may myopically optimize his or her own utility as a function of road price and collectively communicate with his or her friends and neighbors on traffic situation at the same time. This paper considers the road pricing design by using game theory and consensus theory. For the case where a system supervisor broadcasts information on the overall system to each agent, we present a variant of standard fictitious play called average strategy fictitious play(ASFP) for large-scale repeated congestion *** a weighted running average of all other players actions is assumed to be available to each player. The ASFP reduces the burden of both information gathering and information processing for each player. Compared to the joint strategy fictitious play(JSFP) studied in the literature, the updating process of utility functions for each player is avoided. We prove that there exists at least one pure strategy Nash equilibrium for the congestion game under investigation, and the players actions generated by the ASFP with inertia(players reluctance to change their previous actions) converge to a Nash equilibrium almost surely. For the case without broadcasting, a consensus protocol is introduced for individual agents to estimate the percentage of players choosing each resource, and the convergence property of players action profile is still ensured. The results are applied to road pricing design to achieve socially local optimal trip timing. Simulation results are provided based on the real traffic data for the Singapore case study.

关键词： Average strategy fictitious play(ASFP) gametheory multi-agent consensus road pricing

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Periprocedural management of hemostatic alterations in patients with cirrhosis and vascular liver disorders: a step forward of the American Association for the Study of Liver Diseases

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 105-109页

作者： Jose Ignacio Fortea Angela Puente Javier Crespo emilio Fabrega Gastroenterology and Hepatology Department Clinical and Translational Research in Digestive DiseasesValdecilla Research Institute(IDIVAL)Marques de Valdecilla University HospitalSantanderSpain

“Time flies over us,but leaves its shadow behind”(Nathaniel Hawthorne,1860,The Marble Faun).The shadow that separates the latest guidance on vascular liver disorders of the American Association for the Study of Liver Diseases(AASLD)from its former counterpart is 12 years long(1,2).Along the course,several guidelines from different societies have been published on this topic(3-7).As acknowledged in the preamble,the lack of high-quality evidence in the field led the AASLD to commission a guidance from an expert panel based on formal review and analysis of the *** thus differs from other guidelines that perform systematic reviews with explicit methods of searching,selection,and rating the quality of evidence and,if appropriate,meta-analysis on certain clinical questions(2).

关键词： Portal hypertension cirrhosis vascular liver disorders hemostasis bleeding thrombosis

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Obstructive shock secondary to fungal prosthetic aortic valve endocarditis

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World Journal of Emergency Medicine 2018年第3期9卷 227-228页

作者： emilio Rodriguez-Ruiz Diego Iglesias-Alvarez Carlos Pena-Gil Intensive Care Medicine Department University Clinical Hospital of Santiago de Compostela.Santiago de CompostelaGaliciaSpain Cardiology Department University Clinical Hospital of Santiago de Compostela.Santiago de CompostelaGaliciaSpain

Dear editor,Fungal endocarditis is a rare disease with a poor prognosis,suboptimal diagnostic tools responsible for long diagnostic delays in most cases,and poorly defined activity of most antifungal agents in endocar... 详细信息

关键词： Obstructive shock secondary fungal prosthetic aortic valve endocarditis

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Treatment of posterior urethral distractions defects following pelvic fracture

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Asian Journal of Urology 2018年第3期5卷 164-171页

作者： emilio Ríos Luís Martínez-Pineiro Department of Urology Universitary Hospital Infanta SofiaMadridSpain Department of Urology Universitary Hospital La PazMadridSpain

Posterior urethral injuries typically arise in the context of a pelvic *** urethrography is the preferred diagnostic test in trauma patients with pelvic fracture where a posterior urethral rupture is *** fractures however preclude the adequate positioning of the patient on the X-ray table on admission and computed tomography scan with intravenous contrast and delayed films generally performed *** bladder catheter placement under ultrasound guidance should be performed whenever a posterior urethral disruption is *** diagnosis and proper acute management decrease the associated complications,such as strictures,urinary incontinence and erectile *** correct and appropriate initial treatment of associated urethral rupture is critical to the proper healing of the *** of a suprapubic cystostomy on admission and delayed anastomotic urethroplasty after 3e6 months continues to be the gold standard of *** this paper,we provide a comprehensive review of the literature with a special emphasis on the various treatments available:Open or endoscopic primary realignment,immediate or delayed urethroplasty after suprapubic cystostomy,and delayed optical urethrotomy.

关键词： Posterior urethral injuries Distractions defects Pelvic fracture Realignment Urethroplasty Optical urethrotomy

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Evolving role of FDG-PET/CT in prognostic evaluation of resectable gastric cancer

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World Journal of Gastroenterology 2017年第38期23卷 6923-6926页

作者： emilio De Raffele Mariateresa Mirarchi Dajana Cuicchi Ferdinando Lecce Bruno Cola Unità Operativa di Chirurgia Generale Dipartimento dell’Apparato Digerente Azienda Ospedaliero-Universitaria di Bologna U.O. di Chirurgia Generale Dipartimento Strutturale Chirurgico Ospedale 'SS Antonio e Margherita'

Gastric cancer (GC) remains a leading cause of cancer death worldwide. Radical gastrectomy is the only potentially curative treatment, and perioperative adjuvant therapies may improve the prognosis after curative resection. Prognosis largely depends on the tumour stage and histology, but the host systemic inflammatory response (SIR) to GC may contribute as well, as has been determined for other malignancies. In GC patients, the potential utility of positron emission tomography/computed tomography (PET/CT) with the imaging radiopharmaceutical 18F-fluorodeoxyglucose (FDG) is still debated, due to its lower sensitivity in diagnosing and staging GC compared to other imaging modalities. There is, however, growing evidence that FDG uptake in the primary tumour and regional lymph nodes may be efficient for predicting prognosis of resected patients and for monitoring tumour response to perioperative treatments, having prognostic value in that it can change therapeutic strategies. Moreover, FDG uptake in bone marrow seems to be significantly associated with SIR to GC and to represent an efficient prognostic factor after curative surgery. In conclusion, PET/CT technology is efficient in GC patients, since it is useful to integrate other imaging modalities in staging tumours and may have prognostic value that can change therapeutic strategies. With ongoing improvements, PET/CT imaging may gain further importance in the management of GC patients.

关键词： Gastric cancer Prognosis 18F-fluorodeoxyglucose Positron emission tomography-computed tomography Bone marrow

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