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Oncologic Trogocytosis Protects Tumour Stromal Cells from γδ Cell Cytotoxicity

Journal of Life Sciences 2011年第12期5卷 986-995页

作者： emilie Decaup Pej man Mirshahi Arash Rafii Massoud Mirshahi Jean-Jacques Foumie Mary Poupot INSERM UMR1037-Cancer Research Center of Toulouse CNRS ERL CHU Purpan Toulouse 31024 France University of Toulouse 3 Toulouse 31000 France UMRS 872 INSERA/L University of Pierre et Marie Curie-Paris 6 and University of Paris Descartes Team 18 CRC 15 Rue del ＇Ecole de Mddecine Paris Cedex 06 75270 France Department of Genetic Medecine and Obstetrics and Gynecology WCMC-Qatar Doha Qatar

Tumours progressively develop chemoresistance and immunoescape abilities thanks to support from their stromal microenvironment. In ovarian carcinomas, for instance, tumour-associated mesenchymal stem cells （TAMC） can transfer multi-drug-resistant proteins to develop metastases. However, since the microenvironment of such carcinomas is frequently infiltrated by both TAMC and γδ T lymphocytes, the consequences of interactions between these cell types were unclear. Here, we report that whilst γδ T lymphocytes were not activated when co-incubated in vitro with TAMC, their cell membranes were trogocytosed by the TAMC. Since TAMC constitutively express a low level of HLA class I, which is increased by trogocytosis of γδ cell-derived HLA class I, the interaction increased the expression of HLA class-I molecules on TAMC. In addition, γδ T lymphocytes are HLA-unrestricted cytolytic cells and their activity is regulated by inhibitory receptors （KIR） for self-HLA class I. Hence, although the lytic activity of γδ T lymphocytes for unrelated target cells was unaffected by trogocytosis, it spared the TAMC. Therefore, interactions between TAMC and cytolytic γδ T cells avoided the killing of these stromal cells due to an active transfer of their protective HLA class-I molecules. These results suggest that trogocytosis contributes to the maintenance of cancer-associated stromal cells.

关键词： Membrane transfer tumour microenvironment stromal cells HLA-class I molecules

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Potato (Solanum tuberosum L.) Flour Enriched with Date Palm Fruit (Phoenix dactylifera L.) Powder and Bean Milk for Cookies Production

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Agricultural Sciences 2022年第9期13卷 973-988页

作者： Mikhaïl Akhobakoh Bertrand Zing Zing Alban Ngatchou Josiane emilie Germaine Mbassi Eileen Bogweh Nchanji Laboratory of Food Science and Technology Institute of Agricultural Research for Development (IRAD) Yaounde Cameroon International Center for Tropical Agriculture Nairobi Kenya

This study emphasizes the formulation of three types of cookies viz potato flour with date powder and bean milk (PDBM), potato flour with sugar and bean milk (PSBM), and potato flour, sugar, and eggs as control. After the substitution, the highest protein content was observed in PDBM (1.78 ± 0.12)% followed by PSBM, (1.35 ± 0.01)% and the lowest was in the control (0.91 ± 0.55)%. Moreover, cookies fortified with date palm powder increased the carbohydrate and fat contents compared to the control and significantly increased the calorific value of PDBM. The formulated cookies were significantly higher (p < 0.05) in iron (39.95 ± 3.00) mg/100 g and zinc (13.65 ± 1.61) mg/100 g in PDBM compared to other cookies. The date palm powder incorporated in cookies significantly increases the darkening of biscuits during cooking. The organoleptic characteristics of PDBM and PSBM were rated overall best when specific parameters were tested. With the shortage of wheat and importation constraints, an alternative provides a great market opportunity for local products like potatoes and beans. In addition, fortifying food products as cookies eaten by all will contribute to a more food and nutrition-secured world.

关键词： Potato Flour Date Palm Cookies Bean Milk Physical Color Sensory Evaluation Food and Nutrition Security

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Quantitative interactomic of CD40 in primary B cells

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hLife 2024年第2期2卷 88-93页

作者： Jeremy Argenty emilie Maturin Mylene Camus Valentin Mellado Jeanne Perroteau Benoit Pasquier Guillaume Voisinne Odile Burlet-Schiltz Lih-Ling Lin Anne Gonzalez de Peredo Romain Roncagalli Bernard Malissen Centre d’Immunologie de Marseille-Luminy Aix Marseille UniversitéINSERMCNRSMarseilleFrance Centre d’Immunophénomique Aix Marseille UniversitéINSERMCNRS UMRMarseilleFrance Institut de Pharmacologie et de Biologie Structurale Département Biologie Structurale BiophysiqueProtéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089205 Route de NarbonneToulouse CedexFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiVitryFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiCambridgeUSA

INTRODUCTION Over the past few decades,antibody-based therapies have emerged as an additional tool to treat patients developing cancer and auto-immune *** natural properties of the developed antibodies may lead to agonist or blocking functions for the targeted ***,antibodies developed for clinical trials are extensively analyzed in vitro and in vivo for safety and efficacy,yet they are not routinely evaluated for their potential signaling effectiveness.

关键词： routine antibodies clinical

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Comment on: Should a colonoscopy be offered routinely to patients with CT proven acute diverticulitis? A retrospective cohort study and meta-analysis of best available evidence

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World Journal of Gastrointestinal Endoscopy 2020年第9期12卷 320-322页

作者： Jeremy Meyer Nicolas Christian Buchs Boris Schiltz emilie Liot Frédéric Ris Division of Digestive Surgery University Hospitals of GenevaGenève 1211Switzerland

Latest evidence indicates that patients with acute diverticulitis have higher prevalence of colorectal cancer than reference ***,colonoscopy should be offered after an episode of acute diverticulitis.

关键词： Colorectal cancer Adenoma Polyp Diverticulitis Colonoscopy Endoscopy

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仙女的新年礼物

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新东方英语(中学生) 2012年第2期 54-55页

作者： emilie Poulsson 赵越不详

一天,两个小男孩正在玩耍,一位仙女突然出现在他们面前,对他们说:"我是被派来给你们送新年礼物的。"她递给他俩每人一个包裹,顷刻间就消失了。卡尔和菲利普打开包裹,发现里面

关键词：菲利普时光老人

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超自然体验大破解

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新发现 2015年第11期 28-48页

作者： emilie Raushcher 周佩琼

读心术、预测未来、回忆前世……大家都承认，这些体验“不正常”。尽管如此，我们的独家调查发现，许多人见证过这些现象，而且相信这些现象的人更多。

关键词：自然体心理学心理学家人的精神

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昆虫总动员

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新发现 2015年第6期 54-63页

作者： emilie Fauscher 左志祥

29个目．600个科，超过100万个种……集一百多名生物学家和遗传学家之力，令人目眩的昆虫系谱图如今终于准确成形，而昆虫的起源亦随之有了明确的时间节点：4．79亿年前。

关键词：昆虫生物学家博物学家多学科研究

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Patient Reported Outcomes Instruments in Schizophrenia: A Review of Psychometric Properties

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Open Journal of Medical Psychology 2014年第2期3卷 141-156页

作者： Aurelie Millier emilie Clay Insaf Charaf Deven Chauhan Venkatesha Murthy Mondher Toumi Nadia Cadi-Soussi Creativ-Ceutical Paris France Creativ-Ceutical Tunis Tunisia Takeda Pharmaceuticals London UK Takeda Pharmaceuticals Zurich Switzerland University Claude Bernard Lyon I Lyon France

Background: Interest in the self-perception of patients with mental illness is increasing because of the gap between the physician and patient perceptions of symptoms and drug side effects. Schizophrenia is one of the mental illnesses that cause the greatest difficulty in understanding the various physical and psychological impacts related to both symptoms and drug treatment. Thus, several patient-reported outcomes (PRO) have been developed to get a clearer understanding of patients’ experience with their own illness and the treatment that they receive. Objective: The aim of this study was to identify all PRO questionnaires used in the evaluation of patients with schizophrenia, and to assess the quality of these questionnaires based on psychometric evidence. Methods: All PRO questionnaires used in the evaluation of patients with schizophrenia were identified using a search strategy in Pubmed, Medline, and the ISPOR website. PRO psychometric properties were extracted, and their level of validation was assessed. Results: The literature search resulted in the identification of 70 generic, mental health-specific or schizophrenia-specific instruments. These questionnaires were categorized according to measured domains. Six major domains were identified: health related quality of life (HRQoL), insight, depression/ feelings, treatment related, illness symptoms, and caregiver/family. Questionnaires measuring other dimensions were classified as other (related to personality measurement, communication between patients and clinicians and services satisfaction). The review shows that the HRQoL questionnaires demonstrate the best psychometric properties. Conclusion: The assessments of these questionnaires, based on their psychometric evidence level, will allow researchers to choose the most appropriate PRO instruments, based on the instruments’ ability to respond to the objectives of the study and on the rigor of their psychometric qualities. As schizophrenia is a multidimension

关键词： Schizophrenia PRO Validation Psychometric Properties

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不是生命，胜似生命

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新发现 2014年第6期 74-83页

作者： emilie Rauscher 唐恬恬(编译)

当生物学家依旧纠结于生命定义之时，化学家、物理学家和计算机专家已众无到有地创造出一些实体，它们或许还算不上真正意义上的生命，却也并非完全死气沉沉：“准生命”的存在足以模糊生命与非生命的边界。

关键词：生命计算机专家生物学家物理学家化学家

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三维透视圣米歇尔山修道院

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新发现 2019年第1期 78-86页

作者： emilie Rauscher 邹沁(编译) 不详

三维扫描、探地雷达……这些新兴技术将这座著名修道院中被人遗忘以及未为人知的宝藏呈现于世人眼前。让我们踏上一场数字之旅,发掘“奇迹”教学地基下的秘密。

关键词：三维透视修道院探地雷达

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