检索结果-南通市图书馆

The Optimal Suture Technique for Mitral Valve Replacement in an <i>Ex Vivo</i>Animal Model

Open Journal of Thoracic Surgery 2021年第1期11卷 36-45页

作者： emilie Schultz Hougaard Marie Schäfer Lars Peter Riber Department of Cardiac Thoracic and Vascular Surgery at Odense University Hospital Odense Denmark

Objective: This study compared and evaluated three suture methods in order to find the method with the best durability for mitral valve replacement. The methods evaluated are horizontal mattress suture with subanular pledgets, horizontal mattress suture with supraanular pledgets and continuous running suture. Methods: Thirty hearts were explanted from newly terminated pigs. The hearts were randomized in the three groups. After an atriotomy, the mitral valve was cut out, and a patch was sutured into its place. An air pump model was connected to a balloon which was placed in the left ventricle through aorta and continuously filled with air to a maximum of 300 mmHg. The peak pressure at rupture was noted. If no rupture occurred before reaching 300 mmHg, the suture was found competent. Results: Two out of ten hearts in the continuous running suture-group had myocardial rupture within a pressure of 300 mmHg. In the remaining eight hearts there were no ruptures within 300 mmHg. In the two groups sutured with horizontal mattress with pledgets placed either subanular or supraanular, no rupture of myocardium occurred. When comparing continuous running suture with the horizontal mattress with subanular pledgets or the horizontal mattress with supraanular pledgets, the 1-sided Fishers’ exact was 0.237. At 5% significance level, there was no difference between the three suture methods. Conclusion: There was no statistically significant difference between the durability of the three suture methods, though rupture was only evident in the continuous running suture line. Since it is the surgeon’s choice to select the optimal suture technique, our study should be a reminder for the surgeon to reflect on the suturing factors that have an influence on successful mitral valve replacement.

关键词： Mitral Valve Mitral Valve Replacement Suture Technique

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Molecular Framework for the Control of Adventitious Rooting by TIR1/AFB2-Aux/IAADependent Auxin Signaling in Arabidopsis

引用

Molecular Plant 2019年第11期12卷 1499-1514页

作者： Abdellah Lakehal Salma Chaabouni emilie Cavel Rozenn Le Hir Alok Ranjan Zahra Raneshan Ondrej Novak Daniel IPacurar Irene Perrone Frangois Jobert Laurent Gutierrez Laszlo Bako Catherine Bellini Umea Plant Science Centre Department of Plant PhysiologyUmea University90736 UmeaSweden lnstitut Jean-Pierre Bourgin INRAAgroParisTechCNRSUniversite Paris-Saclay78000 VersaillesFrance Department of Biology Faculty of ScienceShahid Bahonar UniversityKermanIran Laboratory of Growth Regulators Faculty of SciencePalacky University and Institute of Experimental BotanyThe Czech Academy of Sciences78371 OlomoucCzech Republic Umea Plant Science Centre Department of Forest Genetics and PhysiologySwedish Agriculture University90183 UmeaSweden Centre de Ressources Regionales en Biologie Moleculaire(CRRBM) Universite de Picardie Jules Verne80039 AmiensFrance Present address:Centre de Ressources Regionales en Biologie Moleculaire(CRRBM) Universite de Picardie Jules Verne80039 AmiensFrance Present address:Institute for Sustainable Plant Protection National Research Council of ItalyTurinItaly Present address:Umea Plant Science Center Department of Forest Genetics and Plant PhysiologySLU90736 UmeaSweden

In Arabidopsis thaliana,canonical auxin-dependent gene regulation is mediated by 23 transcription factors from the AUXIN RESPONSE FACTOR(ARF)family that interact with auxin/indole acetic acid repressors(Aux/IAAs),which themselves form co-receptor complexes with one of six TRANSPORT INHIBITOR*!/AUXIN-SIGNALLING F-BOX(TIR1/AFB)*** combinations of co-receptors drive specific sensing outputs,allowing auxin to control a myriad of ***6 and ARF8 are positive regulators of adventitious root initiation upstream of jasmonate,but the exact auxin co-receptor complexes controlling the transcriptional activity of these proteins has remained ***,using loss-of-function mutants we show that three Aux/IAA genes,IAA6,IAA9,and IAA17,act additively in the control of adventitious root(AR)*** three IAA proteins interact with ARF6 and/or ARF8 and likely repress their activity in AR *** show that TIR1 and AFB2 are positive regulators of AR formation and TIR1 plays a dual role in the control of jasmonic acid(JA)biosynthesis and conjugation,as several JA biosynthesis genes are up-regulated in the tir1-1 *** results lead us to propose that in the presence of auxin,TIR1 and AFB2 form specific sensing complexes with IAA6,IAA9,and/or IAA17 to modulate JA homeostasis and control AR initiation.

关键词： TIR1/AFB AuxIAA jasmonate adventitious roots Arabidopsis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Effects of the Quantum and Finesse Bridles on Equine M. Brachiocephalicus and M. Splenius Function at Three Different Speeds

引用

Open Journal of Veterinary Medicine 2020年第6期10卷 65-79页

作者： emilie Gertz Katia Gebara Vibeke Elbrønd Adrian Harrison PAS (Physiology) Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark

Badly designed and fitted tack induces physiological stress responses in horses, and may compromise animal welfare. Moreover, horses, just like humans, comprise a series of interconnected myofascial lines. However, to date there are no measurements of the effects of horse tack, such as bridles on muscle parameters. This study used acoustic myography to test whether two commercial anatomically designed and fitted bridles, have a measurable and positive effect on both equine muscle-function and performance. A Quantum bridle was tested on 12 Icelandic horses, whilst a Finesse bridle was tested on 8 Icelandic horses, and results compared with data from a standard bridle (n = 12) tested at the same time and under identical conditions. Sensors were placed on M. Brachiocephalicus and M. Splenius, and the horses exercised following a set protocol at three speeds. The results revealed statistically significant improvements in muscle performance as assessed by both the regularity of the recording at each speed, and the number of transient powerful contractions (spikes) for the anatomically designed and fitted bridles, compared with the standard bridle. It is concluded that the effect of anatomically designed bridles can not only be measured in the neck muscles of exercising horses, but that they appear to have a positive effect on muscle performance.

关键词： Horse Exercise Myofascial Lines Welfare Icelandic Anatomical Bridle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spinal alignment evolution with age:A prospective gait analysis study

引用

World Journal of Orthopedics 2017年第3期8卷 256-263页

作者： Sébastien Pesenti Benjamin Blondel emilie Peltier Elke Viehweger Vincent Pomero Guillaume Authier Stéphane Fuentes Jean-Luc Jouve Pediatric orthopedics Timone Enfants Aix-Marseille University Institute of Movement Sciences (CNRS UMR 7287) Gait Analysis Laboratory Hopital Timone Enfants Aix-Marseille University Spine Unit Hopital de la Timone Spine unit Timone Aix-Marseille University Neurosurgery Timone Enfants Aix-Marseille University

AIM To describe,using gait analysis,the development of spinal motion in the growing *** Thirty-six healthy children aged from 3 to 16 years old were included in this study for a gait analysis(9m-walk).Various kinematic parameters were recorded and analyzed such as thoracic angle(TA),lumbar angle(LA)and sagittal vertical axis(SVA).The kinetic parameters were the net reaction moments(N.m/kg)at the thoracolumbar and lumbosacral *** TA and LA curves were not statistically correlated to the age(respectively,P=0.32 and P=0.41).SVA increased significantly with age(P<0.001).Moments in sagittal plane at the lumbosacral junction were statistically correlated to the age(P=0.003),underlining the fact that sagittal mechanical constraints at the lumbosacral junction increase with *** in transversal plane at the thoracolumbar and lumbosacral junctions were statistically correlated to the age(P=0.0002and P=0.0006),revealing that transversal mechanical constraints decrease with *** The kinetic analysis showed that during growth,a decrease of torsional constraint occurs while an increase of sagittal constraint is *** changes in spine biomechanics are related to the crucial role of the trunk for bipedalism acquisition,allowing stabilization despite lower limbs *** the acquisition of mature gait,the spine will mainly undergo constraints in the sagittal plane.

关键词： Sagittal balance Spine biomechanics Gait analysis Thorcic kyphosis Spine growth

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TREM-1 multimerization is essential for its activation on monocytes and neutrophils

引用

Cellular & Molecular Immunology 2019年第5期16卷 460-472页

作者： Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive INOTREM Vandœuvre-les-NancyFrance UMR-S 1116 Defaillance cardiovasculaire aigue et chroniqueVandœuvre-les-NancyFrance UMR7365 Ingénierie Moléculaire et Physiopathologie Articulaire(IMoPA)CNRS-Universitéde LorraineVandœuvre-les-NancyFrance Biomolecular Mass Spectrometry and Proteomics Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences and Netherlands Proteomics CenterUtrecht UniversityUtrechtThe Netherlands Innate Immunity German Cancer Research Center(DKFZ)HeidelbergGermany CovalX ZurichSwitzerland Service Commun de Biophysique Interactions Moléculaires(SCBIM) FR3209Biopole de l’Universitede LorraineVandœuvre-les-NancyFrance Inatherys Evry CedexFrance

The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune *** promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel ***,the molecular events leading to the activation of TREM-1 in innate immune cells remain ***,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 ***-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and *** addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its *** further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and ***-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 *** results provide evidence for ligand-induced,receptor-mediated dimerization of ***,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils.

关键词： TREM-1 multimerization activation monocytes neutrophils

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Low cholesterol biosynthesis favors epithelial-to-mesenchymal transition maintenance and influences tumor molecular subtyping and disease-free survival in colon cancer patients

引用

Cancer Communications 2022年第8期42卷 793-797页

作者： Anaïs Aulas Maria Lucia Liberatoscioli Pascal Finetti Olivier Cabaud David JBirnbaum Lucas Usclade Daniel Birnbaum François Bertucci emilie Mamessier Predictive Oncology Laboratory Cancer Research Center of MarseilleInstitut Paoli-Calmettes“Ligue contre le cancer”labelAix-Marseille UniversityMarseille 13009France Department of Digestive Surgery Hospital NordChemin des BourrelyAix-Marseille UniversityMarseille 13015France Department of Medical Oncology Institut Paoli-CalmettesAix-Marseille UniversityMarseille 13009France

Dear Editor,To metastasize,epithelial cancer cells undergo an epithelial-to-mesenchymal transition(EMT)during migration,whereupon they activate a mesenchymal-toepithelial transition(MET)when colonizing the new niche[1].Targeting EMT or MET inducers might thus impair the metastatic process[2,3].However,the identification of genes involved in epithelium-mesenchyme switches(EMS)is difficult in complex samples such as human *** overcome this problem,we used spheroids of a colorectal cancer(CRC)cell line,HT29,to mimic EMS in a controlled environment.

关键词： cancer colon epithelium

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cholesteryl ester storage disease of clinical and genetic characterisation: A case report and review of literature

引用

World Journal of Clinical Cases 2020年第9期8卷 1642-1650页

作者： Elias Badal Rashu Anders Ellekær Junker Karen Vagner Danielsen emilie Dahl Ole Hamberg Line Borgwardt Vibeke Brix Christensen Nicolai J Wewer Albrechtsen Lise L Gluud Gastrounit Copenhagen University Hospital HvidovreHvidovre 2650Denmark Department of Hepatology RigshospitaletCopenhagen UniversityCopenhagen 2100Denmark Centre of Genomic Medicine RigshospitaletCopenhagen UniversityCopenhagen 2100Denmark Department of Paediatrics and Adolescent Medicine RigshospitaletCopenhagen UniversityCopenhagen 2100Denmark Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen 2200Denmark Department for Clinical Biochemistry RigshospitaletUniversity of CopenhagenCopenhagen 2200Denmark

BACKGROUND Cholesteryl ester storage disease(CESD)is a rare genetic *** symptoms and severity are highly *** is a systemic disease that can lead to the accumulation of fat and inflammation in the liver,as well as gastrointestinal and cardiovascular *** majority of patients require liver transplantation due to decompensated *** replacement therapy has been approved based on a randomized *** study aims to clinically and genetically evaluate two siblings with CESD who underwent liver transplantation,as well as their first-degree family *** SUMMARY The siblings were compound heterozygous for the missense variant in LIPA exon 8,c.894G>A,(***298Gln)and a single base pair deletion,c.482del(***161Ilefs*19).Analyses of single nucleotide polymorphisms showed variants with an increased risk of fatty liver disease and fibrosis for both ***,both patients show signs of recurrence of CESD in the liver after transplantation and additional gastrointestinal and cardiovascular signs of *** family members who were LIPA heterozygous had a lysosomal acid lipase activity below the reference *** of these carriers,a seven-year-old boy,was found to have severe dyslipidemia and was subsequently treated with *** Our study underlines that CESD is a multi-organ disease,the progression of which may occur post-liver *** findings underline the need for monitoring of complications and assessment of possible further treatment.

关键词： Lysosomal acid lipase deficiency Lysosomal storage disease Non-alcoholicfatty liver disease Liver transplantation Sebelipase alfa Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of time to diagnosis on the occurrence of cardiogenic shock in MIS‑C post‑COVID-19 infection

引用

World Journal of Pediatrics 2023年第6期19卷 595-604页

作者： Said Bichali Mathilde Bonnet Marie‑emilie Lampin Jean‑Benoit Baudelet Heloise Reumaux Olivia Domanski Thameur Rakza Alexandre Delarue Morgan Recher Jerome Soquet Francois Dubos Stephane Leteurtre Ali Houeijeh Francois Godart Pediatric Cardiology Univ.LilleCHU Lille2 Avenue Oscar Lambret59000 LilleFrance Pediatric Intensive Care Univ.LilleCHU Lille59000 LilleFrance ULR 2694‑Metrics:Evaluation des Technologies de Sante et des Pratiques Medicales Univ.Lille59000 LilleFrance Pediatric Rhumatology Univ.LilleCHU Lille59000 LilleFrance Cardiac Surgery Univ.LilleCHU Lille59000 LilleFrance Pediatric Emergency Univ.LilleCHU Lille59000 LilleFrance

Background In multisystem inflammatory syndrome in children(MIS-C),diagnostic delay could be associated with *** study aims to measure the time to diagnosis in MIS-C,assess its impact on the occurrence of cardiogenic shock,and specify its *** A single-center prospective cohort observational study was conducted between May 2020 and July 2022 at a tertiary care *** meeting the World Health Organization MIS-C criteria were included.A long time to diagnosis was defined as six days or *** on time to diagnosis were collected by two independent *** primary outcome was the occurrence of cardiogenic *** regression and receiver operating characteristic curve analysis were used for outcomes,and a Cox proportional hazards model was used for *** Totally 60 children were assessed for inclusion,and 31 were finally analyzed[52%males,median age 8.8(5.7-10.7)years].The median time to diagnosis was 5.3(4.2-6.2)*** univariable analysis,age above the median,time to diagnosis,high C-reactive protein,and high N-terminal pro-B-type natriuretic peptide(NT-proBNP)were associated with cardiogenic shock[odds ratio(OR)6.13(1.02-36.9),2.79(1.15-6.74),2.08(1.05-4.12),and 1.70(1.04-2.78),respectively].In multivariable analysis,time to diagnosis≥6 days was associated with cardiogenic shock[adjusted OR(aOR)21.2(1.98-227)].Time to diagnosis≥6 days had a sensitivity of 89% and a specificity of 77% in predicting cardiogenic shock;the addition of age>8 years and NT-proBNP at diagnosis≥11,254 ng/L increased the specificity to 91%.Independent determinants of short time to diagnosis were age<8.8 years[aHR 0.34(0.13-0.88)],short distance to tertiary care hospital[aHR 0.27(0.08-0.92)],and the late period of the COVID-19 pandemic[aHR 2.48(1.05-5.85)].Conclusions Time to diagnosis≥6 days was independently associated with cardiogenic shock in *** diagnosis and treatment are crucial to avoid the use of inotropes and

关键词： COVID-19 Delay in diagnosis Heart failure MIS-C SARS-CoV-2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Humanitarian action in academic institutions:a case study in the ethical stewardship of unidentified forensic cases

引用

Forensic Sciences Research 2022年第3期7卷 358-365页

作者： Justin Z.Goldstein Mariah E.Moe emilie L.Wiedenmeyer Petra M.Banks Sophia R.Mavroudas Michelle D.Hamilton Department of Anthropology Texas State UniversitySan MarcosTXUS

Forensic anthropologists are often responsible for the management of long-term unidentified *** have contextualised these decedents—many of whom likely belonged to socially,politically,and/or economically marginalised groups in life—as part of a larger identification crisis in the ***,there has been little discussion surrounding how this humanitarian crisis has manifested in academic institutions,where anthropologists often provide medicolegal consultation and act as long-term stewards of the *** Identification&Repatriation Initiative was created at the Forensic Anthropology Centre at Texas State University(FACTS)to recognise and investigate unidentified human remains in long-term *** paper outlines common challenges that were encountered during our initial reassessment of unidentified cases at FACTS,emphasising the detrimental impacts of inconsistent procedures,loss of context,and case *** is likely that other academic institutions face similar challenges,and by highlighting these issues we hope to help initiate a larger conversation concerning ethical stewardship of human remains in these *** incorporating humanitarian perspectives into forensic casework,anthropologists in academia can better advocate for the long-term unidentified.

关键词： Forensic sciences forensic anthropology unidentified persons long-term unidentified identification academic institutions standardisation humanitarian action

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

论敦达古鲁-巴哈里亚地区的陆相夹层及非洲其他地层中早白垩世恐龙化石的时代

引用

地层学杂志 2012年第2期36卷 486-502页

作者： Jean LE LOEUFF emilie LANG Lionel CAVIN Eric BUFFETAUT 恐龙博物馆法国奥德省埃斯佩拉扎11226 自然历史博物馆瑞士日内瓦CP64341211 师范大学自然科学研究中心地质学实验室法国巴黎75231

列举并尝试对比了非洲早白垩世脊椎动物化石的主要产地。晚侏罗世(坦桑尼亚的敦达古鲁基默里奇期提塘期)至白垩纪最早期(南非的阿尔戈阿盆地凡兰吟期)的组合中含有剑龙、腕龙和梁龙,到前阿普特期(欧特里沃期巴列姆期?)被另一组合所取代... 详细信息

列举并尝试对比了非洲早白垩世脊椎动物化石的主要产地。晚侏罗世(坦桑尼亚的敦达古鲁基默里奇期提塘期)至白垩纪最早期(南非的阿尔戈阿盆地凡兰吟期)的组合中含有剑龙、腕龙和梁龙,到前阿普特期(欧特里沃期巴列姆期?)被另一组合所取代。这一更年轻的组合中含有重爪龙亚科棘龙类、大头鳄类鳄鱼Sarcosuchus以及大型禽龙,它们主要来自尼日尔(ElRhaz组和喀麦隆(Koum组),部分来自利比亚(Cabao组)和突尼斯(Douiret组),后两组中还含有鲨鱼Priohybodus ar ambourgi。阿普特期(?)至早阿尔必期组合中仍含有禽龙,但是棘龙科棘龙类取代了重爪龙亚科。早塞诺曼期组合(Bahariya,Kem Kem)以恐龙Spinosaurus、Carcharodonto saurus,鲨鱼(Onchopris tisnumidus)和鳄鱼(利比亚鳄类、无棘腔鳄类)为特征。由此可知,中非的一些原先被认为是早白垩世的地层(坦桑尼亚的Galula组、马拉维的含恐龙层)为晚白垩世。脊椎动物化石在非洲陆相地层的对比中具有重要作用。

关键词：生物地层学脊椎动物恐龙白垩纪非洲

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：