检索结果-南通市图书馆

Acute and recurring pericarditis: More colchicine,less corticosteroids

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiology 2010年第12期2卷 403-407页

作者： Paul Farand Francis Bonenfant emilie P Belley-Cté Nicholas Tzouannis Division of Cardiology Sherbrooke University Hospital CenterEtienne-Lebel Research Center

Acute and recurring pericarditis are frequently encountered clinical *** that severe complications such as tamponade and constrictive pericarditis occur rarely,the majority of patients suffering from acute pericarditis will have a benign clinical ***,pericarditis recurrence,with its painful symptoms,is *** effect,recent studies have demonstrated a beneficial role of colchicine in preventing recurrence,while also suggesting an increase in recurrences with the use of corticosteroids,the traditional first-line agent.

关键词： Pericarditis Colchicine Corticosteroids Recurring pericarditis Pericardium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

你长大之后想干什么?

英语画刊(高中版) 2018年第33期 3-5页

作者： emilie Wapnick

"长大后你想成什么样的人?"这个问题伴随着我们的成长。如果你对于这辈子要做什么事没有一个特定目标,别担心,你不是例外。让我们在作家兼艺术家emilie Wapnick的演讲中一同找寻答案,或许,你会从中重新认识自己。

关键词：

Multiparametric characterization of red blood cell physiology after hypotonic dialysis based drug encapsulation process

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第4期12卷 2089-2102页

作者： Mélanie Robert Bastien Laperrousaz Diana Piedrahita emilie-Fleur Gautier Travis Nemkov Florian Dupuy Elie Nader Virginie Salnot Patrick Mayeux Angelo D’Alessandro Catherine Lavazec Philippe Joly Alexander Scheer Philippe Connes Agnès Cibiel Erytech Pharma Lyon 69008France Laboratoire interuniversitaire de Biologie de la Motricité(LIBM)EA7424 Team«Vascular Biology and Red Blood Cell»Universite´Claude Bernard Lyon 1Universite´de LyonLyon 69008France Labex GR-Ex Paris 75015France 3P5 proteom’IC facility Universitéde ParisInstitut CochinINSERMCNRSParis 75014France University of Colorado Anschutz Medical CampusAuroraCO 80045USA Omix Technologies Inc.AuroraCO 80045USA Inserm U1016 CNRS 8104Universitéde ParisInstitut CochinParis 75014France Laboratoire de Biochimie et de Biologie Moléculaire UF de biochimie des pathologies e´rythrocytairesCentre de Biologie et de Pathologie EstHospices Civils de LyonBron 69500France

Red blood cells(RBCs)can act as carriers for therapeutic agents and can substantially improve the safety,pharmacokinetics,and pharmacodynamics of many *** RBCs integrity and lifespan is important for the efficacy of RBCs as drug *** investigated the impact of drug encapsulation by hypotonic dialysis on RBCs physiology and *** parameters were compared between processed RBCs loaded with l-asparaginase(“eryaspase”),processed RBCs without drug and non-processed *** RBCs were less hydrated and displayed a reduction of intracellular *** observed a change in the metabolomic but not in the proteomic profile of processed *** process caused moderate morphological changes and was accompanied by an increase of RBCs-derived Extracellular Vesicles *** a decrease in deformability,processed RBCs were not mechanically retained in a spleen-mimicking device and had increased surface-to-volume ratio and osmotic *** RBCs half-life was not significantly affected in a mouse model and our previous phase 1 clinical study showed that encapsulation of asparaginase in RBCs prolonged its in vivo half-life compared to free *** study demonstrated that encapsulation by hypotonic dialysis may affect certain characteristics of RBCs but does not significantly affect the in vivo longevity of RBCs or their drug carrier function.

关键词： Red blood cells Drug carrier Hypotonic dialysis L-Asparaginase Omics Rheology Morphology Senescence markers

An Intentional Poisoning by Lormetazepam in a Patient Treated with Nordiazepam

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Forensic Medicine and Anatomy Research 2014年第4期2卷 107-112页

作者： Phak-Rop Pos Pok emilie Berland Michel Mauras Magali Valès Erika Kuhlmann Laboratoire de Police Scientifique de Marseille Section Toxicologie Institut National de Police Scientifique France

A case of suspected poisoning by benzodiazepines is presented in this paper. Toxicological analyses were applied on the blood collected 48 hours after the facts. GC-MS and HPLC-DAD have detected only nordiazepam which was prescribed in the treatment. Therefore, LC-MS/MS has detected lormetazepam and lorazepam (major metabolite of lormetazepam) in addition of nordiazepam. The concentrations of lormetazepam, lorazepam and nordiazepam measured in blood were 6.8, 6.3, and 16.2 ng/mL, respectively. The initial concentration of each drug at the relevant time, has been calculated from these residual concentrations, using an extrapolation approach. According to estimates, only lormetazepam (189 ng/mL) and lorazepam (68 ng/mL), were active at the target moment. A poisoning by lormetazepam was then considered. The more technology we have, the greater chance we have to get an outcome that is favorable to justice.

关键词： Benzodiazepines Discrimination between Poison and Medication LC-MS/MS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

如何选用正确等级的钢材

现代制造 2008年第20期 72-73页

作者： emilie Doucet

利用硼冶金技术．可提高钢材等级，这将有助于加工车间降低内部生产成本，并能使生产过程中的失败风险降低到最低。

关键词：钢材冶金技术生产成本加工车间生产过程

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

图坦卡蒙墓密室之谜

新发现 2016年第5期 78-84页

作者： emilie Rauscher 苏迪

215年11月，在一片惊愕中，埃及当局不无激动地宣布。图坦卡蒙墓仍存有未知墓窒的可能性超过九成……证据来自雷达和热成像仪。埃及当局正计划对位于吉萨和代赫舒尔的胡夫金字塔、哈夫拉金字塔和斯尼夫鲁金字塔进行大规模勘探。

关键词：胡夫金字塔热成像可能性埃及

Cytotoxic T cells isolated from healthy donors and cancer patients kill TGFβ-expressing cancer cells in a TGFβ-dependent manner

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第2期18卷 415-426页

作者： Morten Orebo Holmström Rasmus Erik Johansson Mortensen Angelos Michail Pavlidis Evelina Martinenaite Stine emilie Weis-Banke Mia Aaboe-Jørgensen Simone Kloch Bendtsen Özcan Met Ayako Wakatsuki Pedersen Marco Donia Inge Marie Svane Mads Hald Andersen Department of Oncology National Center for Cancer Immune TherapyCopenhagen University HospitalHerlevDenmark IO Biotech ApS CopenhagenDenmark Institute for Immunology and Microbiology Copenhagen UniversityCopenhagenDenmark

Transforming growth factor-beta(TGFβ)is a highly potent immunosuppressive *** TGFβis a tumor suppressor in early/premalignant cancer lesions,the cytokine has several tumor-promoting effects in advanced cancer;abrogation of the antitumor immune response is one of the most important tumor-promoting *** several immunoregulatory mechanisms have recently been shown to be targets of specific T cells,we hypothesized that TGFβis targeted by naturally occurring specific T cells and thus could be a potential target for immunomodulatory cancer ***,we tested healthy donor and cancer patient T cells for spontaneous T-cell responses specifically targeting 3820-mer epitopes derived from TGFβ*** identified numerous CD4^(+)and CD8^(+)T-cell responses against several epitopes in TGFβ.Additionally,several ex vivo responses were *** enriching specific T cells from different donors,we produced highly specific cultures specific to several TGFβ-derived *** CD8^(+)T-cell clones specific for both a 20-mer epitope and a 9-mer HLA-A2 restricted killed epitope peptide were pulsed in HLA-A2+target cells and killed the HLA-A2+cancer cell lines THP-1 and ***,stimulation of THP-1 cancer cells with cytokines that increased TGFβexpression increased the fraction of killed *** conclusion,we have shown that healthy donors and cancer patients harbor CD4^(+)and CD8^(+)T cells specific for TGFβ-derived epitopes and that cytotoxic T cells with specificity toward TGFβ-derived epitopes are able to recognize and kill cancer cell lines in a TGFβ-dependent manner.

关键词： Immune regulation TGFbeta cancer T cells adaptive immunity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新级别钢改善模具性能

现代塑料 2008年第10期 72-73页

作者： emilie Doucet

对于摸具翻造商而言，选用一种含硼的新的钢级别来制造注塑摸具，可收到降低内部成本．降低潮造失败风险的效果。

关键词：钢级性能模具

GeSnOI mid-infrared laser technology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2021年第12期10卷 2408-2420页

作者： Binbin Wang emilie Sakat Etienne Herth Maksym Gromovyi Andjelika Bjelajac Julien Chaste Gilles Patriarche Philippe Boucaud Frédéric Boeuf Nicolas Pauc Vincent Calvo Jérémie Chrétien Marvin Frauenrath Alexei Chelnokov Vincent Reboud Jean-Michel Hartmann Moustafa El Kurdi UniversitéParis-Saclay CNRSC2N10 boulevard Thomas Gobert91120 PalaiseauFrance UniversitéCôte d’Azur CNRSCRHEARue Bernard Grégory06905 Sophia-AntipolisFrance STMicroelectronics Rue Jean Monnet38054 CrollesFrance UniversitéGrenoble Alpes CEAIRIG-DePhy17 rue des Martyrs38000 GrenobleFrance UniversitéGrenoble Alpes CEALeti17 rue des Martyrs38000 GrenobleFrance

GeSn alloys are promising materials for CMOS-compatible mid-infrared lasers ***,Sn alloying and tensile strain can transform them into direct bandgap *** growing laser technology however suffers from a number of limitations,such as poor optical confinement,lack of strain,thermal,and defects management,all of which are poorly discussed in the ***,a specific GeSn-on-insulator(GeSnOI)stack using stressor layers as dielectric optical claddings is demonstrated to be suitable for a monolithically integration of planar Group-IV semiconductor lasers on a versatile photonic platform for the near-and mid-infrared spectral ***-shape resonators on mesa structures were fabricated from GeSnOI,after bonding a Ge_(0.9)Sn_(0.1) alloy layer grown on a Ge strain-relaxed-buffer,itself on a Si(001)*** GeSnOI microdisk mesas exhibited significantly improved optical gain as compared to that of conventional suspended microdisk resonators formed from the as-grown *** further show enhanced vertical out-coupling of the disk whispering gallery mode in-plane radiation,with up to 30%vertical out-coupling *** a result,the GeSnOI approach can be a valuable asset in the development of silicon-based mid-infrared photonics that combine integrated sources in a photonic platform with complex lightwave engineering.

关键词： GeSn OI coupling