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Clinical Significance of Apurinic/Apyrimidinic Endodeoxyribonuclease 1 and MicroRNA Axis in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2023年第6期11卷 1291-1307页

作者： Giovanna Mangiapane Devis Pascut emiliano dalla Giulia Antoniali Monica Degrassi Lory Saveria Crocè Veronica De Sanctis Silvano Piazza Giulia Canarutto Claudio Tiribelli Gianluca Tell Laboratory of Molecular Biology and DNA Repair Department of MedicineUniversity of UdineUdineItaly Fondazione Italiana Fegato-ONLUS Liver Cancer UnitTriesteItaly Department of Medical Sciences University of TriesteTriesteItaly Clinica Patologie Fegato Azienda Sanitaria Universitaria Giuliano Isontina(ASUGI)TriesteItaly NGS Core Facility Department CIBIOUniversity of TrentoTrentoItaly Computational Biology International Centre for Genetic Engineering and BiotechnologyICGEBTriesteItaly

Background and Aims:Identification of prognostic factors for hepatocellular carcinoma(HCC)opens new perspectives for *** and cellular onco-miRNAs are noncoding RNAs which can control the expression of genes involved in oncogenesis through post-transcriptional *** microRNAs(miRNAs)are considered novel prognostic and predictive factors in *** apurinic/apyrimidinic endodeoxyribonuclease 1(APE1)contributes to the quality control and processing of specific onco-miRNAs and is a negative prognostic factor in several *** present work aims to:a)define APE1 prognostic value in HCC;b)identify miRNAs regulated by APE1 and their relative target genes and c)study their prognostic ***:We used The Cancer Genome Atlas(commonly known as TCGA)data analysis to evaluate the expression of APE1 in *** identify differentially-expressed miRNAs(DEmiRNAs)upon APE1 depletion through specific small interfering RNA,we used NGS and nanostring approaches in the JHH-6 HCC tumor cell *** analyses were performed to identify signaling pathways involving APE1-regulated *** analysis was performed to identify miRNAs correlating with serum APE1 ***:APE1 is considerably overexpressed in HCC tissues compared to normal liver,according to the TCGA-liver HCC(known as LIHC)*** analyses showed that APE1-regulated miRNAs are implicated in signaling and metabolic pathways linked to cell proliferation,transformation,and angiogenesis,identifying Cyclin Dependent Kinase 6 and Lysosomal Associated Membrane Protein 2 as ***-33a-5p,miR-769,and miR-877 are related to lower overall survival in HCC *** array profiling,we identified eight circulating DE-miRNAs associated with APE1 overexpression.A training phase identified positive association between sAPE1 and miR-3180-3p and ***:APE1 regulates specific miRNAs having prognostic value in HCC.

关键词： APE1 miRNAs Prognostic factors Hepatocellular carcinoma

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Recycling of reclaimed fibers from end-of-life tires in hot mix asphalt

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第5期7卷 678-687页

作者： Edoardo Bocci emiliano Prosperi Faculty of Engineering eCampus UniversityNovedrateCO 22060Italy Dipartimento di Ingegneria Civile Edile e Architettura UniversitàPolitecnica delle MarcheAncona 60131Italy

Nowadays, the disposal of end-of-life tires(ELT) is worldwide one of the major concerns for the environment as well as for public health. Crumb rubber and steel wires, the main byproducts(in terms of weight) deriving from the ELT processing, can be recycled in several ways. However, the textile fiber, representing about 10% of the waste by weight, is typically not reused and ends up in landfills or incinerators. The present paper deals with the use of reclaimed fibers from ELT in hot mix asphalt(HMA), with the aim to improve its performance. The study included the preliminary characterization of the fiber through microscope observation and Fourier trans form infrared(FTIR) spectroscopy and then the investigation of the mechanical properties of HMA containing ELT fibers, in comparison with an ordinary HMA with no fibers. In particular, indirect tensile strength(ITS), indirect tensile stiffness modulus(ITSM), semi-circular bending(SCB), three point bending(3PB)and indirect tensile fatigue(ITF) tests were carried out. The results showed that the use of ELT fibers does not reflect in a significant improvement in terms of strength and stiffness properties. However, the ELT fibers determine a noticeable increase of the HMA resistance to fatigue, probably related to the ability of the fibers in sewing the micro-crack edges and contrasting the macro-crack opening.

关键词： Road engineering Hot mix asphalt End-of-life tire Fiber Fatigue Recycling

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Secular dynamics of navigation satellites in the MEO and GSO regions

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Astrodynamics 2022年第4期6卷 357-374页

作者： Hanlun Lei emiliano Ortore Christian Circi School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics in Ministry of Education Nanjing UniversityNanjing 210023China Department of Astronautical Electrical and Energy EngineeringSapienza University of RomeVia Salaria 851Rome 00138Italy

In this study,a dynamical model is developed to describe the secular evolution of navigation satellites under the geocentric reference frame with the Laplace orbit as the fundamental *** disturbing function,involving the effects of Earth's oblateness and lunisolar gravitational attraction,is averaged over the orbital periods of both the satellite and the *** the regions of medium-Earth orbits and geosynchronous orbits,there are varieties of lunisolar resonances for governing the secular dynamics of navigation *** these resonances,we are interested in the ones occurring at the critical inclinations as well as the lunar node *** each resonance of interest,the resonant center and width are identified ***,dynamical maps are compared with the analytical results.

关键词： secular resonances Laplace plane navigation satellites dynamical maps

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Cross-Layer Framework for Fine-Grained Channel Access in Next Generation High-Density Wi Fi Networks

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China Communications 2016年第2期13卷 55-67页

作者： ZHAO Haitao ZHANG Shaojie emiliano Garcia-Palacios College of Electronic Science and Engineering National University of Defense Technology ECIT Institute Queen's University Belfast

Densely deployed Wi Fi networks will play a crucial role in providing the capacity for next generation mobile internet. However, due to increasing interference, overlapped channels in Wi Fi networks and throughput efficiency degradation, densely deployed Wi Fi networks is not a guarantee to obtain higher throughput. An emergent challenge is how to effi ciently utilize scarce spectrum resources, by matching physical layer resources to traffi c demand. In this aspect, access control allocation strategies play a pivotal role but remain too coarse-grained. As a solution, this research proposes a flexible framework for fine-grained channel width adaptation and multi-channel access in Wi Fi networks. This approach, named SFCA(Subcarrier Fine-grained Channel Access), adopts DOFDM(Discontinuous Orthogonal Frequency Division Multiplexing) at the PHY layer. It allocates the frequency resource with a subcarrier granularity, which facilitates the channel width adaptation for multi-channel access and thus brings more fl exibility and higher frequency efficiency. The MAC layer uses a frequencytime domain backoff scheme, which combines the popular time-domain BEB scheme with a frequency-domain backoff to decrease access collision, resulting in higher access probability for the contending nodes. SFCA is compared with FICA(an established access scheme)showing significant outperformance. Finally we present results for next generation 802.11 ac Wi Fi networks.

关键词： channel width adaptation channel access high-density WiFi

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Towards very high RAP content asphalt mixes:A comprehensive performance-based study of rejuvenated binders

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第6期8卷 1022-1035页

作者： Marco Pasetto Andrea Baliello Giovanni Giacomello emiliano Pasquini Department of Civil Environmental and Architectural Engineering(ICEA)University of PaduaPaduaItaly

Hot recycling of reclaimed asphalt pavement(RAP)from replacement of deteriorated asphalt pavements is a widespread technique,and able to ensure clear economic and environmental *** this reason,paving industries,agencies and researchers are spending significant efforts in order to maximize such advantages by increasing the amount of RAP within new asphalt ***,adequate performance of recycled mixtures must be guaranteed despite the re-use of high amounts of RAP which involves the presence of aged,oxidized and stiffened *** this perspective,the present study aimed at evaluating the rheological properties at mid-service and high-service temperatures of bituminous blends composed by 40%of virgin binder and 60%of aged rejuvenated bitumen(simulating the aged hard bitumen coming from the RAP).Such proportion was selected to represent a high recycling rate of RAP(about 60%of the total weight of aggregates,RAP included).A chemical commercial additive at the liquid state was selected as rejuvenator;it was dosed at the optimum content based on empirical and rheological preliminary *** performance of the recycled blend was then compared to that of a virgin reference *** shear rheometer tests were carried out to determine the master curves and the failure characteristics(at mid and high service temperatures)of the selected *** effect of aging(related to the durability over the material lifetime)was also studied analyzing binders’responses in unaged,shortterm and long-term aged ***,experimental findings demonstrated the efficacy of the rejuvenation of recycled binders containing very high amount of aged bitumen.

关键词： Pavement engineering Hot recycling Reclaimed asphalt Rejuvenation DSR Rheology

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Reconfigurable elastomeric graded-index optical elements controlled by light

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Light(Science & Applications) 2018年第1期7卷 964-972页

作者： Angelo Angelini Federica Pirani Francesca Frascella emiliano Descrovi Department of Applied Science and Technology(DISAT) Politecnico di TorinoC.so Duca degli Abruzzi 24Torino IT-10129Italy Center for Sustainable Future Technologies@PoliTo Istituto Italiano di TecnologiaC.so Trento 21Torino IT-10129Italy

In many optical applications,there is an increasing need for dynamically tunable optical elements that are able to shape the wavefront of light‘on demand’.In this work,an elastomeric easy-to-fabricate optical element whose transmission functions can be reversibly phase configured by visible light is *** light responsivity of proper azopolymers incorporated within an elastomeric matrix is exploited to induce a light-controlled graded refractive index(GRIN)distribution within the bulk *** induced refractive index distribution is continuous and conformal to the intensity profile of the illumination at moderate power.A 100mW doubled-frequency Nd:YAG Gaussian beam focused to a 650μm waist is shown to induce a maximum relative refractive index change of~0.4%in the elastomeric matrix,with an approximately parabolic *** restoring characteristics of the elastomeric matrix enable full recovery of the initial homogeneous refractive index distribution within a few seconds when the incident laser is switched *** an exemplary application,the configurable GRIN element is used in a microscope-based imaging system for light control of the effective focal length.

关键词： optical switched index

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Probe lifetime around natural satellites with obliquity

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Astrodynamics 2022年第4期6卷 429-439页

作者： Marco Cinelli Hanlun Lei emiliano Ortore Christian Circi Istituto di Astrofisica e Planetologia Spaziali(IAPS) Istituto Nazionale di Astrofisica(INAF)Roma 00133Italy School of Astronomy and Space Science and Key Laboratory of Modern Astronomy and Astrophysics Ministry of EducationNanjing UniversityNanjing 210046China School of Aerospace Engineering Sapienza University of RomeRome 00138Italy Department of Astronautical Electricaland Energy EngineeringSapienza University of RomeRome 00138Italy

The dynamics of a probe orbiting a moon can be significantly influenced by the non-coincidence between the moon's equatorial and orbital ***,we performed a general analysis about the effects of the angle(obliquity)between the above-mentioned planes and of the angle(nodal phasing)between the nodal lines of the mother planet's apparent orbit and the probe orbit on the lifetime of the *** lifetime,strictly correlated to the variations in eccentricity of the probe orbit,was evaluated starting from low values of the semi-major axis,moderate eccentricity,and high inclination to offer high ground spatial resolution and extend latitudinal coverage of the natural *** investigation,carried out through numerical simulations,may be useful for identifying the optimal initial conditions of the probe's orbit elements,leading to an important increase in the probe lifetime in missions devoted to the exploration of natural satellites.

关键词： third-body effect natural satellite probe lifetime

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Geometrical approach for an optimal inter-satellite visibility

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Astrodynamics 2021年第3期5卷 237-248页

作者： Marco Cinelli emiliano Ortore Giovanni Laneve Christian Circi Department of Mathematics University of Rome Tor VergataRome 00133Italy Department of Astronautical Electrical and Energy EngineeringSapienza University of RomeRome 00138Italy Scuola di Ingegneria Aerospaziale Sapienza University of RomeRome 00138Italy

In the eld of satellite constellations,an important requirement is often represented by the possibility to exchange data among the satellites or exploit mutual visibility to carry out measurements on the parameters of the Earth's ***,recursive and routing algorithms are usually implemented to evaluate inter-satellite visibility ***,to design the con guration of the constellation,it is important to consider the orbital conditions that guarantee the mutual visibility between couples of ***,in this study,a geometric analysis was performed to identify the optimal inter-satellite visibility conditions,expressed in terms of the di erence in the true anomaly between satellites characterized by di erent orbital con *** approach allows a handy constellation design,without performing a numerical *** is particularly useful in the case of a high number of satellites,when numerical techniques require signi cant computational e ***,it is possible to considerably simplify the design of a constellation in which the mutual visibility between couples of satellites is always *** type of constellation,usually referred to as satellite chain,can be exploited in several network services and remote sensing systems devoted to enhancing the knowledge of atmospheric parameters.

关键词： satellite constellation interlink visibility

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Breeding next generation tree fruits: technical and legal challenges

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Horticulture Research 2017年第1期4卷 42-52页

作者： Lorenza dalla Costa Mickael Malnoy Ivana Gribaudo Research and Innovation Centre Fondazione Edmund Machvia E Mach 1San Michele a/Adige38010Italy IPSP-CNR Institute for Sustainable Plant ProtectionNational Research CouncilStrada delle Cacce 73TorinoI-10135Italy

The new plant breeding technologies(NPBTs)have recently emerged as powerful tools in the context of‘green’*** have wide potential compared to classical genetic engineering and they are attracting the interest of politicians,stakeholders and citizens due to the revolutionary impact they may have on *** and genome editing potentially allow to obtain pathogen-resistant plants or plants with enhanced qualitative traits by introducing or disrupting specific genes in shorter times compared to traditional breeding programs and by means of minimal modifications in the plant ***,the most important fruit crop in the world from an economical point of view,is a peculiar case for NPBTs because of the load of cultural aspects,varietal traditions and consumer demands,which hinder the use of classical breeding techniques and,furthermore,the application of genetic engineering to wine grape *** we explore the technical challenges which may hamper the application of cisgenesis and genome editing to this perennial plant,in particular focusing on the bottlenecks of the Agrobacterium-mediated gene *** addition,strategies to eliminate undesired sequences from the genome and to choose proper target sites are discussed in light of peculiar features of this *** is reported an update of the international legislative frameworks regulating NPBT products which shows conflicting positions and,in the case of the European Union,a prolonged lack of regulation.

关键词： breeding legal furthermore

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Long-noncoding RNAs as epigenetic regulators in neurodegenerative diseases

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Neural Regeneration Research 2023年第6期18卷 1243-1248页

作者： Paola Ruffo Francesca De Amicis emiliano Giardina Francesca Luisa Conforti Medical Genetics Laboratory Department of PharmacyHealth and Nutritional SciencesUniversity of CalabriaRendeItaly Department of Pharmacy Health and Nutritional SciencesUniversity of CalabriaRendeItaly Genomic Medicine Laboratory UILDM IRCCS Fondazione Santa LuciaRomeItaly Department of Biomedicine&Prevention Tor Vergata University of RomeRomeItaly

The growing and rapid development of high-throughput sequencing technologies have allowed a greater understanding of the mechanisms underlying gene expression *** the epigenome and epitranscriptome directs the fate of the transcript influencing the functional outcome of each *** this context,non-coding RNAs play a decisive role in addressing the expression regulation at the gene and chromosomal ***-noncoding RNAs,consisting of more than 200 nucleotides,have been shown to act as epigenetic regulators in several key molecular processes involving neurodegenerative disorders,such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis and Huntington’s ***-noncoding RNAs are abundantly expressed in the central nervous system,suggesting that their deregulation could trigger neuronal degeneration through RNA *** evaluation of their diagnostic significance and therapeutic potential could lead to new treatments for these diseases for which there is no cure.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis epigenetic mechanism Huntington’s disease long-noncoding RNAs neurodegenerative disease non-coding RNAs Parkinson’s disease

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